Melanocyte-stimulating hormone directly enhances UV-Induced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Research

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1158/0008-5472.CAN-09-4596PMID 20388774PMCID PMC2862104
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiological factors that regulate skin pigmentation

  2009cited by this paper
• Forskolin protects keratinocytes from UVB-induced apoptosis and increases DNA repair independent of its effects on melanogenesis.

  2009cited by this paper
• α‐MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV‐induced DNA damage in human melanocytes

  2009cited by this paper
• Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin.

  2009cited by this paper
• Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.

  2008influential reference
• Central Role of p53 in the Suntan Response and Pathologic Hyperpigmentation

  2008influential reference
• The Melanocortin 1 Receptor and the UV Response of Human Melanocytes—A Shift in Paradigm †

  2008cited by this paper
• A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2‐induced potentiation of P2X3 receptor currents in inflamed rats

  2007influential reference
• Central role of p53 in the suntan response and pathologic hyperpigmentation.

  2007cited by this paper
• ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation

  2007cited by this paper
• Melanoma prevention strategy based on using tetrapeptide α‐MSH analogs that protect human melanocytes from UV‐induced DNA damage and cytotoxicity

  2006cited by this paper
• Effect of MELANOTAN®, [Nle4, D-Phe7]-α-MSH, on melanin synthesis in humans with MC1R variant alleles

  2006cited by this paper
• Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning

  2006cited by this paper
• α-Melanocyte stimulating hormone, inflammation and human melanoma

  2006cited by this paper
• Effect of MELANOTAN, [Nle(4), D-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles.

  2006cited by this paper
• Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair

  2006cited by this paper
• alpha-Melanocyte stimulating hormone, inflammation and human melanoma.

  2006cited by this paper
• Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.

  2006cited by this paper
• The relation between melanocortin 1 receptor (MC1R) variation and the generation of phenotypic diversity in the cutaneous response to ultraviolet radiation.

  2005cited by this paper
• alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes.

  2005cited by this paper
• Investigations of pyrimidine dimer glycosylases--a paradigm for DNA base excision repair enzymology.

  2005cited by this paper
• Molecular Mechanism of Nrf2 Activation by Oxidative Stress

  2005cited by this paper
• α-Melanocyte-stimulating Hormone Protects from Ultraviolet Radiation-induced Apoptosis and DNA Damage*

  2005cited by this paper
• alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage.

  2005cited by this paper
• Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

  2004cited by this paper
• Heat-separation of normal human skin for epidermal and dermal prostaglandin analysis

  2004cited by this paper
• Who's on first in the cellular response to DNA damage?

  2003cited by this paper
• Dominant role of the niche in melanocyte stem-cell fate determination

  2002cited by this paper
• Xeroderma Pigmentosum Complementation Group A Protein (XPA) Modulates RPA-DNA Interactions via Enhanced Complex Stability and Inhibition of Strand Separation Activity*

  2002cited by this paper
• UV damage, DNA repair and skin carcinogenesis.

  2002cited by this paper
• Molecular biological approaches to unravel adenylyl cyclase signaling and function.

  2001cited by this paper
• Neuroendocrinology of the skin.

  2000cited by this paper
• A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA.

  2000cited by this paper
• Enhanced expression of melanocortin-1 receptor (MC1-R) in normal human keratinocytes during differentiation: evidence for increased expression of POMC peptides near suprabasal layer of epidermis.

  1999cited by this paper
• Detection of melanocortin‐1 receptor antigenicity on human skin cells in culture and in situ

  1999cited by this paper
• DNA damage recognition during nucleotide excision repair in mammalian cells.

  1999cited by this paper
• Systematic Reviews: Synthesis of Best Evidence for Health Care Decisions

  1998influential reference
• A family of cAMP-binding proteins that directly activate Rap1.

  1998cited by this paper
• Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

  1998cited by this paper
• The Genetic Basis of Human Cancer

  1997cited by this paper
• The role of alpha-melanocyte-stimulating hormone in cutaneous biology.

  1997cited by this paper
• The standard erythema dose: a new photobiological concept

  1997cited by this paper
• Formation and Processing of UV Photoproducts: Effects of DNA Sequence and Chromatin Environment

  1997cited by this paper
• The Role of α-Melanocyte-Stimulating Hormone in Cutaneous Biology

  1997cited by this paper
• Mechanisms of Ultraviolet Light‐Induced Pigmentation

  1996cited by this paper
• Oleic acid and linoleic acid are the major determinants of changes in keratinocyte plasma membrane viscosity.

  1996cited by this paper
• Transcription of melanogenesis enzymes in melanocytes: dependence upon culture conditions and co-cultivation with keratinocytes.

  1996cited by this paper
• Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B.

  1996cited by this paper
• Proopiomelanocortin, its derived peptides, and the skin.

  1996cited by this paper
• A survey of attitudes, beliefs, and behavior regarding tanning bed use, sunbathing, and sunscreen use.

  1993cited by this paper
• p53 is required for radiation-induced apoptosis in mouse thymocytes

  1993cited by this paper
• Wild-type p53 activates transcription in vitro

  1992cited by this paper
• Molecular cloning of a mouse DNA repair gene that complements the defect of group-A xeroderma pigmentosum.

  1989cited by this paper
• Forskolin stimulates adenylate cyclase activity, adenosine 3',5'-monophosphate production and peptide release from the intermediate lobe of the rat pituitary gland.

  1984cited by this paper
• Photobiology of melanin pigmentation: dose/response of skin to sunlight and its contents.

  1983cited by this paper
• Photoprotection by melanin--a comparison of black and Caucasian skin.

  1979cited by this paper

• Skin Photodamage and Melanomagenesis: A Comprehensive Review

  2025cites this paper
• Anti‐melanogenic effects of Medicago sativa seed extracts on melanocytes

  2025cites this paper
• S-palmitoylation: An oily modification guardinggenome stability.

  2025cites this paper
• Neuropeptide alpha-Melanocyte stimulating hormone preserves corneal endothelial morphology in a murine model of Fuchs dystrophy

  2024cites this paper
• The Skin-Whitening and Antioxidant Effects of Protocatechuic Acid (PCA) Derivatives in Melanoma and Fibroblast Cell Lines

  2023cites this paper
• Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma

  2023cites this paper
• AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis.

  2023cites this paper
• Implications of Oxidative Stress in the Pathogenesis and Treatment of Hyperpigmentation Disorders

  2022cites this paper
• Does Phototherapy Influence Alpha Melanocyte Stimulating Hormone Levels?

  2021cites this paper
• Wavelengths and temporal effects on the response of mammalian cells to UV radiation: Limitations of action spectra illustrated by genotoxicity.

  2021cites this paper
• Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation

  2021cites this paper
• Size-dependent 2D nanoclay against ultraviolet B-induced damage in vitro and in vivo

  2020cites this paper
• Peptide Hormone Regulation of DNA Damage Responses.

  2020cites this paper
• Exogenous pyruvate facilitates ultraviolet B-induced DNA damage repair by promoting H3K9 acetylation in keratinocytes and melanocytes.

  2020cites this paper
• Antioxidant and Tyrosinase Inhibitory Properties of an Aqueous Extract of Garcinia atroviridis Griff. ex. T. Anderson Fruit Pericarps

  2020cites this paper
• Melanocyte differentiation and epidermal pigmentation is regulated by polarity proteins

  2020cites this paper
• Transcriptional characterization of conjunctival melanoma identifies the cellular tumor microenvironment and prognostic gene signatures

  2020cites this paper
• Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

  2019cites this paper
• Reprint of: XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage in a cell cycle dependent manner.

  2018cites this paper
• Are redheads at an increased risk of melanoma?

  2018cites this paper
• Roles of the KEAP1‐NRF2 system in mammalian skin exposed to UV radiation

  2018cites this paper
• XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage in a cell cycle dependent manner.

  2017cites this paper
• MC1R signaling. Intracellular partners and pathophysiological implications.

  2017cites this paper
• Palmitoylation-dependent activation of MC1R prevents melanomagenesis

  2017cites this paper
• Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

  2016cites this paper
• Ultraviolet B, melanin and mitochondrial DNA: Photo-damage in human epidermal keratinocytes and melanocytes modulated by alpha-melanocyte-stimulating hormone

  2016cites this paper
• The Neurotropic, Anti-Inflammatory, and Antitumor Properties of the Hopantenic Acid Molecule Based on Chemoinformatic Analysis

  2016cites this paper
• p21-activated kinase 4 critically regulates melanogenesis via activation of the CREB/MITF and β-catenin/MITF pathways.

  2015cites this paper
• [Neurotropic, anti-inflammatory and antitumor properties of hopantenic acid: a chemoinformatic analysis of its molecule].

  2015cites this paper
• Afamelanotide (CUV1647) in dermal phototoxicity of erythropoietic protoporphyria

  2015cites this paper
• Melanoma: Historical Context

  2015cites this paper
• Paulownia tomentosa (Princess Tree) Extract Reduces DNA Damage and Induces DNA Repair Processes in Skin Cells

  2015cites this paper
• Molecular Regulation of UV‐Induced DNA Repair

  2015cites this paper
• Skin phototype: a new perspective

  2015cites this paper
• PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage.

  2014influential citation
• Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile

  2014cites this paper
• The functional role of MITF in DNA damage response pathways and its potential modulation of the immune system by regulating NFkB phosphorylation

  2014cites this paper
• Melanocortin 1 receptor and skin pathophysiology: beyond colour, much more than meets the eye

  2014cites this paper
• In vitro models for investigating keratinocyte responses to ultraviolet B radiation

  2013cites this paper
• Is Mc1r an important regulator of non‐pigmentary responses to UV radiation?

  2013cites this paper
• Additional Roles of A-MSH/MC1R Signaling in Melanomagenesis Beyond Melanogenesis

  2013cites this paper
• MC1R is a potent regulator of PTEN after UV exposure in melanocytes.

  2013cites this paper
• Regulation of DNA Repair Process by the Pro-Inflammatory NF-κB Pathway

  2013cites this paper
• Plant hormone signaling and modulation of DNA repair under stressful conditions

  2013cites this paper
• MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells.

  2013cites this paper
• Is MC1 dispensable for regulation of cutaneous inflammatory and immune responses?

  2013cites this paper
• A tan in a test tube –in vitro models for investigating ultraviolet radiation–induced damage in skin

  2012cites this paper
• A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear targeting of RNA polymerase II, is necessary and sufficient for nuclear export.

  2012cites this paper
• Dermal Melanocortin Receptor Rebound in Diffuse Systemic Sclerosis after Anti‐TGFβ1 Antibody Therapy

  2012cites this paper
• Melanocyte-stimulating hormone-related diphtheria toxin targets to lung adenocarcinoma.

  2012cites this paper
• Noise exposure potentiates the subcellular distribution of nucleotide excision repair proteins within spiral ganglion neurons.

  2012cites this paper
• Etude des mécanismes de mort cellulaire et de résis tance des cellules cancéreuses pour le développement de nouvelles approches thérapeutiques : modèle du mélanome

  2011cites this paper
• Cytotoxicity of serum protein-adsorbed visible-light photocatalytic Ag/AgBr/TiO2 nanoparticles.

  2011cites this paper
• A neuroendocrinological perspective on human hair follicle pigmentation

  2011cites this paper
• Silymarin Protects Epidermal Keratinocytes from Ultraviolet Radiation-Induced Apoptosis and DNA Damage by Nucleotide Excision Repair Mechanism

  2011cites this paper
• FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription

  2011cites this paper
• Genetics of pigmentation in skin cancer--a review.

  2010cites this paper
• [What's new in dermatological research?].

  2010cites this paper
• Quoi de neuf en recherche dermatologique

  2010cites this paper
• Afamelanotide, an agonistic analog of α-melanocyte-stimulating hormone, in dermal phototoxicity of erythropoietic protoporphyria

  2010cites this paper
• Proanthocyanidins Inhibit Photocarcinogenesis through Enhancement of DNA Repair and Xeroderma Pigmentosum Group A–Dependent Mechanism

  2010cites this paper