S-palmitoylation: An oily modification guardinggenome stability.

No abstract is available for this paper.

• Publication year

  2025

• Venue

  DNA Repair

• Publication date

  2025-08-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.dnarep.2025.103883PMID 40815872
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy

  2025cited by this paper
• UVA-light-induced mutagenesis in the exome of human nucleotide excision repair-deficient cells

  2025cited by this paper
• Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity

  2025cited by this paper
• Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response

  2024cited by this paper
• Targeting the DNA damage response in cancer

  2024cited by this paper
• Investigating PPT2’s role in ovarian cancer prognosis and immunotherapy outcomes

  2024cited by this paper
• Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders

  2024cited by this paper
• Inhibiting S-palmitoylation arrests metastasis by relocating Rap2b from plasma membrane in colorectal cancer

  2024cited by this paper
• Long non-coding RNA MIR4435-2HG promotes pancreatic cancer progression by regulating ABHD17C through sponging miR-128-3p

  2024cited by this paper
• Type VII secretion system extracellular protein B targets STING to evade host anti–Staphylococcus aureus immunity

  2024cited by this paper
• zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma

  2024cited by this paper
• When pyro(ptosis) meets palm(itoylation).

  2024cited by this paper
• Correction: Palmitoylated APP Forms Dimers, Cleaved by BACE1

  2024cited by this paper
• Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities

  2024cited by this paper
• Mechanisms and functions of protein S-acylation

  2024cited by this paper
• Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy.

  2024cited by this paper
• PPT1 Promotes Growth and Inhibits Ferroptosis of Oral Squamous Cell Carcinoma Cells.

  2024cited by this paper
• The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway

  2024cited by this paper
• ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma

  2024cited by this paper
• AMPKα1-mediated ZDHHC8 phosphorylation promotes the palmitoylation of SLC7A11 to facilitate ferroptosis resistance in glioblastoma.

  2024cited by this paper
• Targeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma

  2024cited by this paper
• High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT

  2024cited by this paper
• Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging

  2024cited by this paper
• Identification and prognostic biomarkers among ZDHHC4/12/18/24, and APT2 in lung adenocarcinoma

  2024cited by this paper
• Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer’s disease

  2024cited by this paper
• ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma.

  2024cited by this paper
• Control of mitochondria-associated endoplasmic reticulum membranes by protein S-palmitoylation：novel therapeutic targets for neurodegenerative diseases.

  2023cited by this paper
• STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice

  2023cited by this paper
• USP35 promotes HCC development by stabilizing ABHD17C and activating the PI3K/AKT signaling pathway

  2023cited by this paper
• Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma

  2023cited by this paper
• Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy.

  2023cited by this paper
• Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction.

  2023cited by this paper
• Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond

  2023cited by this paper
• 4-Octyl itaconate restricts STING activation by blocking its palmitoylation.

  2023cited by this paper
• Intratumoral PPT1-positive macrophages determine immunosuppressive contexture and immunotherapy response in hepatocellular carcinoma

  2023cited by this paper
• S‐palmitoylation regulates innate immune signaling pathways: molecular mechanisms and targeted therapies

  2023cited by this paper
• RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

  2023cited by this paper
• Stapled peptide PROTAC induced significantly greater anti-PD-L1 effects than inhibitor in human cervical cancer cells

  2023cited by this paper
• Palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.

  2023cited by this paper
• Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer

  2023cited by this paper
• ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma

  2023cited by this paper
• ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma

  2023cited by this paper
• Involvement of ZDHHC9 in lung adenocarcinoma: regulation of PD-L1 stability via palmitoylation

  2023cited by this paper
• Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models

  2023cited by this paper
• Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis.

  2023cited by this paper
• Genetic and Epigenetic Regulation of the Innate Immune Response to Gout

  2023cited by this paper
• RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1.

  2023cited by this paper
• AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis.

  2023cited by this paper
• The Role of the MYC/miR-150/MYB/ZDHHC11 Network in Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma

  2022cited by this paper
• Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

  2022cited by this paper
• ALKBH5 promotes PD-L1-mediated immune escape through m6A modification of ZDHHC3 in glioma

  2022cited by this paper
• Identification of ZDHHC1 as a Pyroptosis Inducer and Potential Target in the Establishment of Pyroptosis-Related Signature in Localized Prostate Cancer

  2022cited by this paper
• ZDHHC9 promotes colon tumor growth by inhibiting effector T cells

  2022cited by this paper
• Post-Translational Modifications by Lipid Metabolites during the DNA Damage Response and Their Role in Cancer

  2022cited by this paper
• The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma

  2022cited by this paper
• Flotillin-1 palmitoylation turnover by APT-1 and ZDHHC-19 promotes cervical cancer progression by suppressing IGF-1 receptor desensitization and proteostasis

  2022cited by this paper
• HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

  2022cited by this paper
• Protein palmitoylation in cancer: molecular functions and therapeutic potential

  2022cited by this paper
• S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway.

  2022cited by this paper
• Mechanisms and inhibition of Porcupine-mediated Wnt acylation

  2022cited by this paper
• Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy

  2022cited by this paper
• GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis

  2022cited by this paper
• Nucleotide excision repair: a versatile and smart toolkit

  2022cited by this paper
• Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression

  2022cited by this paper
• Walking a tightrope: The complex balancing act of R-loops in genome stability.

  2022cited by this paper
• ZDHHC18 negatively regulates cGAS‐mediated innate immunity through palmitoylation

  2022cited by this paper
• Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins

  2022cited by this paper
• ZDHHC22-mediated mTOR palmitoylation restrains breast cancer growth and endocrine therapy resistance

  2022cited by this paper
• Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth

  2022cited by this paper
• The p53 network: cellular and systemic DNA damage responses in cancer and aging.

  2022cited by this paper
• SEDT2 palmitoylation mediated by ZDHHC16 in EGFR-mutated glioblastoma promotes ionizing radiation-induced DNA damage.

  2022cited by this paper
• ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

  2021cited by this paper
• GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

  2021cited by this paper
• Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability.

  2021cited by this paper
• Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease

  2021cited by this paper
• Palmitoylation as a Key Regulator of Ras Localization and Function

  2021cited by this paper
• The cGAS–STING pathway as a therapeutic target in inflammatory diseases

  2021cited by this paper
• Intracellular mRNA transport and localized translation

  2021cited by this paper
• Genomic instability in cancer: molecular mechanisms and therapeutic potentials.

  2021cited by this paper
• RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1

  2021cited by this paper
• Types of nuclear localization signals and mechanisms of protein import into the nucleus

  2021cited by this paper
• Depalmitoylation Rewires FLT3-ITD Signaling and Exacerbates Leukemia Progression.

  2021cited by this paper
• Cancer cells escape p53’s tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation

  2021cited by this paper
• Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma

  2021cited by this paper
• DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis

  2021cited by this paper
• Insights into auto-S-fatty acylation: targets, druggability, and inhibitors

  2021cited by this paper
• RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair

  2021cited by this paper
• Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation

  2021cited by this paper
• RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity

  2021cited by this paper
• Palmitoylation in Crohn’s disease: Current status and future directions

  2021cited by this paper
• Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression

  2020cited by this paper
• Protein palmitoylation and its pathophysiological relevance

  2020cited by this paper
• Regulatory effects of post-translational modifications on zDHHC S-acyltransferases

  2020cited by this paper
• Rif1 regulates telomere length through conserved HEAT repeats

  2020cited by this paper
• Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

  2020cited by this paper
• Control of the chromatin response to DNA damage: Histone proteins pull the strings.

  2020cited by this paper
• ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression

  2020cited by this paper
• RIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner

  2020cited by this paper
• Molecular mechanisms and cellular functions of cGAS–STING signalling

  2020cited by this paper
• DNA Damage/Repair Management in Cancers

  2020cited by this paper

• A special issue: DNA damage response in disease and therapy.

  2026cites this paper
• The Causal Relationship Between Palmitoylation Genes and Parkinson’s Disease: A Mendelian Randomization Study

  2025cites this paper