Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans

The molecular chaperone Hsp90 regulates morphogenesis of the leading human fungal pathogen Candida albicans. Hsp90 inhibition induces filaments with a delay in mitotic exit mediated by the checkpoint protein Bub2. Hsp90 depletion destabilizes the cyclin-dependent kinase Cdc28, providing a link between Hsp90, cell cycle regulation, and morphogenesis.

• Publication year

  2012

• Venue

  Molecular Biology of the Cell

• Publication date

  2012-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E11-08-0729PMID 22090345PMCID 3258172
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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