The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Current Biology

• Publication date

  2000-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0960-9822(00)00779-XPMID 11084339
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A mechanism for coupling exit from mitosis to partitioning of the nucleus.

  2000cited by this paper
• Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus

  1999cited by this paper
• Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex.

  1999cited by this paper
• Sister chromatid separation and chromosome re‐duplication are regulated by different mechanisms in response to spindle damage

  1999cited by this paper
• APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5

  1999cited by this paper
• Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.

  1999cited by this paper
• Budding Yeast Bub2 Is Localized at Spindle Pole Bodies and Activates the Mitotic Checkpoint via a Different Pathway from Mad2

  1999cited by this paper
• RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast

  1999cited by this paper
• Bifurcation of the mitotic checkpoint pathway in budding yeast.

  1999cited by this paper
• Regulation of the APC and the exit from mitosis

  1999cited by this paper
• A Bub2p‐dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast

  1999cited by this paper
• The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.

  1998cited by this paper
• A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein

  1998cited by this paper
• The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B.

  1998cited by this paper
• Additional modules for versatile and economical PCR‐based gene deletion and modification in Saccharomyces cerevisiae

  1998cited by this paper
• The Saccharomyces CDC13 is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere in vivo

  1996cited by this paper
• The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo.

  1996cited by this paper
• Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance

  1996cited by this paper
• Erratum: Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint (Molecular and Cellular Biology 15:11 (6128-6138))

  1996cited by this paper
• Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint

  1995cited by this paper
• The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle

  1994cited by this paper
• A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration.

  1994cited by this paper

• Mechanisms of nuclear segregation in a multinucleate multibudding yeast

  2025cites this paper
• The stn1-sz2 Mutant Provides New Insight into the Impacts of Telomeric Cdc13-Stn1-Ten1 Dysfunction on Cell Cycle Progression

  2025cites this paper
• Enhanced methanol tolerance and utilization in Pichia pastoris revealed by adaptive laboratory evolution

  2025cites this paper
• Autophagy-related protein Atg11 is essential for microtubule-mediated chromosome segregation

  2025cites this paper
• Dysfunction of Telomeric Cdc13-Stn1-Ten1 Simultaneously Activates DNA Damage and Spindle Checkpoints

  2024cites this paper
• Characterization of a novel interaction of the Nup159 nucleoporin with asymmetrically localized spindle pole body proteins and its link with autophagy

  2023cites this paper
• Cell growth and nutrient availability control the mitotic exit signaling network in budding yeast

  2023cites this paper
• The mitotic exit mediated by small GTPase Tem1 is essential for the pathogenicity of Fusarium graminearum

  2023cites this paper
• Atg11 promotes Kar9-mediated alignment of the mitotic spindle

  2022cites this paper
• LncRNAs of Saccharomyces cerevisiae bypass the cell cycle arrest imposed by ethanol stress

  2022cites this paper
• Microtubule integrity regulates budding yeast RAM pathway gene expression

  2022cites this paper
• Protein Phosphatase 1 in association with Bud 14 inhibits mitotic exit in Saccharomyces 1 cerevisiae 2

  2021cites this paper
• Autophagy-related protein Atg11 preserves asymmetric inheritance of spindle microtubule-organizing centers

  2021influential citation
• A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

  2021cites this paper
• LncRNAs of Saccharomyces cerevisiae dodge the cell cycle arrest imposed by the ethanol stress

  2021cites this paper
• Regulation of Mitotic Exit by Cell Cycle Checkpoints: Lessons From Saccharomyces cerevisiae

  2020cites this paper
• Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae

  2020cites this paper
• The DNA Damage Checkpoint and the Spindle Position Checkpoint Maintain Meiotic Commitment in Saccharomyces cerevisiae.

  2019cites this paper
• A novel method of using Deep Belief Networks and genetic perturbation data to search for yeast signaling pathways

  2018cites this paper
• Late rDNA Condensation Ensures Timely Cdc14 Release and Coordination of Mitotic Exit Signaling with Nucleolar Segregation.

  2017cites this paper
• Temporal and compartment-specific signals coordinate mitotic exit with spindle position

  2017cites this paper
• Analysis of the Functionality of the Mitotic Checkpoints.

  2017cites this paper
• A FRET-based study reveals site-specific regulation of spindle position checkpoint proteins at yeast centrosomes

  2016cites this paper
• Colletotrichum orbiculare Regulates Cell Cycle G1/S Progression via a Two-Component GAP and a GTPase to Establish Plant Infection[OPEN]

  2015cites this paper
• Affected chromosome homeostasis and genomic instability of clonal yeast cultures

  2015cites this paper
• Toward a systems-level view of mitotic checkpoints.

  2015cites this paper
• Cell Cycle Checkpoint and DNA Damage Response Defects as Anticancer Targets: From Molecular Mechanisms to Therapeutic Opportunities

  2015cites this paper
• The Mitotic Exit Network: new turns on old pathways.

  2014cites this paper
• Spatially distinct functions of Clb2 in the DNA damage response

  2014cites this paper
• The current view for the silencing of the spindle assembly checkpoint

  2014cites this paper
• Inhibition of the Mitotic Exit Network in Response to Damaged Telomeres

  2013cites this paper
• Cdc5-Dependent Asymmetric Localization of Bfa1 Fine-Tunes Timely Mitotic Exit

  2012cites this paper
• Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans

  2012cites this paper
• Dependence of Chs2 ER export on dephosphorylation by cytoplasmic Cdc14 ensures that septum formation follows mitosis

  2012cites this paper
• Mitotic Exit and Separation of Mother and Daughter Cells

  2012cites this paper
• Uncovering New Roles for Hsp90 in Candida albicans Morphogenesis

  2012cites this paper
• Proteins in the Nutrient-Sensing and DNA Damage Checkpoint Pathways Cooperate to Restrain Mitotic Progression following DNA Damage

  2011cites this paper
• DNA Damage Response Is Suppressed by the High Cyclin-dependent Kinase 1 Activity in Mitotic Mammalian Cells*

  2011cites this paper
• The Cdc48 Shp1 complex mediates cell cycle progression by positive regulation of Glc7

  2011cites this paper
• The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators

  2010cites this paper
• Monitoring spindle orientation: Spindle position checkpoint in charge

  2010cites this paper
• The spindle position checkpoint is coordinated by the Elm1 kinase

  2010cites this paper
• Cardiomyocyte Cell Cycle, Renewal and Isolation

  2010cites this paper
• Lte1, Cdc14 and MEN‐controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression

  2009cites this paper
• Dbf2–Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis

  2009cites this paper
• Multiple pathways control spindle asymmetry through asymmetric recruitment of Kar9

  2009cites this paper
• Interpreting spatial information and regulating mitosis in response to spindle orientation.

  2009cites this paper
• Orchestration of the DNA damage checkpoint response through the regulation of the protein kinase Rad53.

  2009cites this paper
• Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast

  2008cites this paper
• Chromosome instability and tumor lethality suppression in carcinogenesis

  2008cites this paper
• The role of APC activators Cdc20p and Cdh1p in regulating mitosis and morphogenesis in C. albicans

  2008cites this paper
• Chromosome instability in yeast and its implications to the study of human cancer.

  2008cites this paper
• Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.

  2008influential citation
• Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae

  2008cites this paper
• Budding yeast 14-3-3 proteins contribute to the robustness of the DNA damage and spindle checkpoints

  2008cites this paper
• DNA Damage Checkpoints Inhibit Mitotic Exit by Two Different Mechanisms

  2007cites this paper
• Étude du rôle de la protéine phosphatase de type 1 Glc7 dans l'inactivation des mécanismes de surveillance de l'ADN et analyse des interrégulations entre le mécanisme de surveillance de l'ADN et celui du fuseau mitotique chez la levure saccharomyces cerevisiae

  2007influential citation
• Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids

  2007cites this paper
• The study of Bfa1p(E438K) suggests that Bfa1 control the mitotic exit network in different mechanisms depending on different checkpoint-activating signals.

  2006cites this paper
• Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays.

  2006cites this paper
• EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.

  2006cites this paper
• A new function of Skp1 in the mitotic exit of budding yeast Saccharomyces cerevisiae.

  2006cites this paper
• The Spindle Assembly Checkpoint Regulates the Phosphorylation State of a Subset of DNA Checkpoint Proteins in Saccharomyces cerevisiae

  2006cites this paper
• Regulation of the localization of Lte1, a S. cerevisiae mitotic exit activator

  2005cites this paper
• Functional analysis of the putative BUB2 homologues of c. elegans in the spindle position checkpoint

  2005cites this paper
• Regulation of Protein Kinase Dbf2 in Mitotic Exit

  2005cites this paper
• Activation of Mrc1, a mediator of the replication checkpoint, by telomere erosion

  2005cites this paper
• The role of MEN (mitosis exit network) proteins in the cytokinesis of Saccharomyces cerevisiae.

  2005cites this paper
• DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint.

  2005cites this paper
• In Vivo Characterization of the Nonessential Budding Yeast Anaphase-Promoting Complex/Cyclosome Components Swm1p, Mnd2p and Apc9p

  2005cites this paper
• In vivo characterization of non-essential budding yeast APC/C components Swm1p, Mnd2p, and Apc9p

  2005cites this paper
• SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation.

  2005cites this paper
• Characterization of Byr4 and Cdc7 functional domains affecting the septation initiation network in Schizosaccharomyces pombe.

  2005cites this paper
• Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit.

  2005cites this paper
• The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects.

  2005cites this paper
• The C‐terminus of Bfa1p in budding yeast is essential to induce mitotic arrest in response to diverse checkpoint‐activating signals

  2004cites this paper
• The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression

  2004cites this paper
• Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.

  2004cites this paper
• The spindle assembly and spindle position checkpoints.

  2003cites this paper
• The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity.

  2003cites this paper
• Depletion of H2A-H2B dimers in Saccharomyces cerevisiae triggers meiotic arrest by reducing IME1 expression and activating the BUB2-dependent branch of the spindle checkpoint.

  2003cites this paper
• Control of Mitotic Exit in Budding Yeast

  2002cites this paper
• EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants.

  2002cites this paper
• Orchestrating the cell cycle in yeast: sequential localization of key mitotic regulators at the spindle pole and the bud neck.

  2002cites this paper
• DNA-Damage-Independent Checkpoints: Yeast and Higher Eukaryotes

  2002cites this paper
• Bub2 Is a Cell Cycle Regulated Phospho-Protein Controlled by Multiple Checkpoints

  2002cites this paper
• Monitoring cell cycle modulated gene expression in plants by means of a whole-genome-based approach

  2002cites this paper
• hMad1 in the spindle assembly checkpoint : characterization of interacting partners

  2002influential citation
• Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiae

  2002cites this paper
• The origin recognition complex: from simple origins to complex functions.

  2002cites this paper
• Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae.

  2002cites this paper
• The anaphase-promoting complex: it's not just for mitosis any more.

  2002cites this paper
• Cytokinesis in Eukaryotes

  2002cites this paper
• Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae

  2002cites this paper
• MEN, destruction and separation: mechanistic links between mitotic exit and cytokinesis in budding yeast.

  2002cites this paper
• Characterization of the Net1 Cell Cycle-dependent Regulator of the Cdc14 Phosphatase from Budding Yeast*

  2001cites this paper
• Animal cytokinesis: breaking up is hard to do.

  2001cites this paper
• Animal cell cytokinesis.

  2001cites this paper
• Mitotic exit: closing the gap.

  2001cites this paper
• Regulation of the mitotic exit protein kinases Cdc15 and Dbf2.

  2001cites this paper