Blockade of the L‐arginine/NO synthase pathway worsens hepatic apoptosis and liver transplant preservation injury

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Hepatology

• Publication date

  2002-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1053/jhep.2002.35058PMID 12198649
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanism of cell death during warm hepatic ischemia‐reperfusion in rats: Apoptosis or necrosis?

  2001cited by this paper
• Modulation of cerebellar and hepatic nitric oxide synthase by exogenous arginine and endotoxin.

  2001cited by this paper
• Mechanism of hepatocyte death after ischemia: Apoptosis versus necrosis

  2001cited by this paper
• Protective role of the L-arginine-nitric oxide synthase pathway on preservation injury after rat liver transplantation.

  2001cited by this paper
• Nitric oxide and hepatic ischemia-reperfusion injury.

  2000cited by this paper
• Reactive oxygen and mechanisms of inflammatory liver injury

  2000cited by this paper
• Role of arginine in immunonutrition.

  2000cited by this paper
• Preservation injury of the liver: mechanisms and novel therapeutic strategies.

  2000cited by this paper
• Circulating autoantibodies against purified colonic mucin in ulcerative colitis

  2000cited by this paper
• Role of sodium nitroprusside in the improvement of rat liver preservation in University of Wisconsin solution: A study in the isolated perfused liver model.

  1999cited by this paper
• Dietary amino acids as new and novel agents to enhance allograft survival.

  1999cited by this paper
• An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle.

  1999cited by this paper
• Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism.

  1999cited by this paper
• IV. Determinants of nitric oxide protection and toxicity in liver.

  1999cited by this paper
• Hepatoprotective effect of endogenous nitric oxide during ischemia‐reperfusion in the rat

  1999cited by this paper
• Beneficial effects of FK409, a novel nitric oxide donor, on reperfusion injury of rat liver.

  1998cited by this paper
• Induction of Mn SOD in human monocytes without inflammatory cytokine production by a mutant endotoxin.

  1998cited by this paper
• Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells.

  1998cited by this paper
• Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation

  1998cited by this paper
• Arginine metabolism: nitric oxide and beyond.

  1998cited by this paper
• Liver-type arginase in serum during and after liver transplantation: a novel index in monitoring conditions of the liver graft and its clinical significance.

  1998cited by this paper
• Protective role of nitric oxide in ischemia and reperfusion injury of the liver.

  1998cited by this paper
• Induction of Mn SOD in human monocytes without inflammatory cytokine production by a mutant endotoxin.

  1998cited by this paper
• Protective effect of ischemic preconditioning on liver preservation-reperfusion injury in rats.

  1998cited by this paper
• Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells.

  1998cited by this paper
• Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression.

  1997cited by this paper
• Endogenous synthesis of arginine plays an important role in maintaining arginine homeostasis in postweaning growing pigs.

  1997cited by this paper
• Inhibition of nitric oxide synthesis in ischemia/reperfusion of the rat liver is followed by impairment of hepatic microvascular blood flow.

  1997cited by this paper
• Apoptosis after ischemia-reperfusion in human liver allografts.

  1997cited by this paper
• Improvement of cardiac output and liver blood flow and reduction of pulmonary vascular resistance by intravenous infusion of L-arginine during the early reperfusion period in pig liver transplantation.

  1997cited by this paper
• Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia.

  1997cited by this paper
• The protective effects of L‐arginine after liver ischaemia/reperfusion injury in a pig model

  1997cited by this paper
• Protective effect of L-arginine on liver ischemia-reperfusion injury.

  1997cited by this paper
• Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-kappaB binding to DNA.

  1997cited by this paper
• Role of exogenous L-arginine in hepatic ischemia-reperfusion injury.

  1997cited by this paper
• Taurine attenuates nitric oxide- and reactive oxygen intermediate-dependent hepatocyte injury.

  1996cited by this paper
• Cellular localization and effect of nitric oxide synthesis in a rat model of orthotopic liver transplantation.

  1996cited by this paper
• Sources of arginine for induced nitric oxide synthesis in the isolated perfused liver.

  1995cited by this paper
• Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds.

  1995cited by this paper
• In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

  1995cited by this paper
• Reperfusion injury to donor livers stored for transplantation.

  1995cited by this paper
• A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis.

  1995cited by this paper
• The delicate balance of nitric oxide and superoxide in liver pathology.

  1995cited by this paper
• Role of endogenous nitric oxide in ischemia-reperfusion injury in rat liver.

  1995cited by this paper
• Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion.

  1995cited by this paper
• Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide.

  1995cited by this paper
• Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury.

  1995cited by this paper
• L-Arginine deficiency after liver transplantation as an effect of arginase efflux from the graft. Influence on nitric oxide metabolism.

  1994cited by this paper
• Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

  1993cited by this paper
• Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

  1993cited by this paper
• Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies.

  1992cited by this paper
• Superoxide Anion Generation in the Liver During the Early Stage of Endotoxemia in Rats

  1990cited by this paper
• Modulation of Nitrogen Oxide Synthesis In Vivo: NG‐Monomethyl‐L‐Arginine Inhibits Endotoxin‐Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

  1990cited by this paper
• Reperfusion injury to endothelial cells following cold ischemic storage of rat livers

  1989cited by this paper
• SINUSOIDAL LINING CELL DAMAGE: THE CRITICAL INJURY IN COLD PRESERVATION OF LIVER ALLOGRAFTS IN THE RAT

  1988cited by this paper
• A surgical experience with five hundred thirty liver transplants in the rat.

  1983cited by this paper

• Gut microbiome dynamics and Enterobacterales infection in liver transplant recipients: A prospective observational study

  2024cites this paper
• Protective effect of the combined use of L-carnitine and L-arginine against hepatic ischemia-reperfusion injury in rats

  2022cites this paper
• FXR/ASS1 axis attenuates the TAA-induced liver injury through arginine metabolism.

  2022cites this paper
• N-3 Polyunsaturated Fatty Acids and Their Lipid Mediators as A Potential Immune–Nutritional Intervention: A Molecular and Clinical View in Hepatic Disease and Other Non-Communicable Illnesses

  2021cites this paper
• HTK-N: Modified Histidine-Tryptophan-Ketoglutarate Solution—A Promising New Tool in Solid Organ Preservation

  2020cites this paper
• The role of machine perfusion in liver xenotransplantation

  2020cites this paper
• The effect of melatonin in rats with uterine torsion on uterus contractions, and the levels of ADMA, SDMA, arginine, Hsp90, TLR4, and NF-κB

  2019cites this paper
• Xenotransplantation literature update, March/April 2019

  2019cites this paper
• Cerebrovascular reactivity and cerebral perfusion of rats with acute liver failure: role of L‐glutamine and asymmetric dimethylarginine in L‐arginine‐induced response

  2018cites this paper
• Amino acid and lipid profiles following pig‐to‐primate liver xenotransplantation

  2018cites this paper
• Nitric Oxide and the Liver

  2017cites this paper
• Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft?

  2017cites this paper
• Nitric oxide synthase inhibitors protect against brain and liver damage caused by acute malathion intoxication.

  2017cites this paper
• Urea production during normothermic machine perfusion: Price of success?

  2015cites this paper
• Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart

  2015cites this paper
• Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart.

  2015cites this paper
• Correlation of Histopathologic Findings of Non-Graft Threatening Preservation/Reperfusion Injury in Time-Zero Liver Needle Biopsies With Short-Term Post-transplantation Laboratory Alterations

  2015cites this paper
• A Systematic Review of Pharmacological Treatment Options Used to Reduce Ischemia Reperfusion Injury in Rat Liver Transplantation

  2015cites this paper
• A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

  2015cites this paper
• Supplemental dietary l-arginine attenuates intestinal mucosal disruption during a coccidial vaccine challenge in broiler chickens

  2014cites this paper
• Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure.

  2014cites this paper
• Changes in ADMA/DDAH Pathway after Hepatic Ischemia/Reperfusion Injury in Rats: The Role of Bile

  2014cites this paper
• Metabolomic analysis of arginine metabolism in acute hepatic injury in rats.

  2014cites this paper
• Tolerogenic dendritic cells: molecular and cellular mechanisms in transplantation

  2014cites this paper
• Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.

  2012cites this paper
• Carbon monoxide, a two-face for the protection of the liver.

  2012cites this paper
• The nitric oxide pathway – evidence and mechanisms for protection against liver ischaemia reperfusion injury

  2012cites this paper
• HTK-N, a modified HTK solution, decreases preservation injury in a model of microsteatotic rat liver transplantation

  2012cites this paper
• L-arginine in the ischemic phase protects against liver ischemia-reperfusion injury.

  2012cites this paper
• How to protect liver graft with nitric oxide.

  2011cites this paper
• Assessment of a chloride‐poor versus a chloride‐containing version of a modified histidine‐tryptophan‐ketoglutarate solution in a rat liver transplantation model

  2011cites this paper
• The role of nitric oxide in hindlimb remote ischaemic preconditioning of the liver

  2011influential citation
• Regulation of hepatocyte fate by interferon-γ.

  2011cites this paper
• Estrategias para proteger el injerto esteatósico en el trasplante hepático

  2011cites this paper
• Inhibition of inducible nitric oxide synthase worsens liver damage regardless of lipopolysaccharide treatment in small-for-size liver transplantation.

  2010cites this paper
• Alterations in L-Arginine Metabolism After Lung Transplantation

  2010cites this paper
• The L-arginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: biological and analytical ramifications.

  2009cites this paper
• Pharmacological preconditioning using intraportal infusion of L-arginine protects against hepatic ischemia reperfusion injury.

  2009cites this paper
• Effect of Obstructive Jaundice and Nitric Oxide on the Profiles of Intestinal Bacterial Flora in Wild and iNOS−/− Mice

  2009cites this paper
• RESEARCH REVIEW Factors in the Pathophysiology of the Liver Ischemia-Reperfusion Injury

  2008cites this paper
• Protection of transplant-induced hepatic ischemia/reperfusion injury with carbon monoxide via MEK/ERK1/2 pathway downregulation.

  2008cites this paper
• Factors in the pathophysiology of the liver ischemia-reperfusion injury.

  2008cites this paper
• Attenuated cold storage injury of rat livers using a modified HTK solution.

  2008cites this paper
• Arginase blockade protects against hepatic damage in warm ischemia-reperfusion.

  2008cites this paper
• Molecular Mediators of Liver Ischemia and Reperfusion Injury: A Brief Review

  2008cites this paper
• Mechanism of Liver Injury during Obstructive Jaundice: Role of Nitric Oxide, Splenic Cytokines, and Intestinal Flora

  2007cites this paper
• Perioperative kinetics of the nitric oxide derivatives nitrite/nitrate during orthotopic liver transplantation.

  2007cites this paper
• Gene Transduction of an Active Mutant of Akt Exerts Cytoprotection and Reduces Graft Injury After Liver Transplantation

  2007cites this paper
• Arginine metabolism: boundaries of our knowledge.

  2007cites this paper
• Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA).

  2007cites this paper
• Pathogenesis of Fulminant Hepatic Failure

  2007cites this paper
• Reduzierung des Konservierungsschaden der Rattenleber durch Modifikationen der HTK-Lösung

  2007cites this paper
• Liver I/R injury is improved by the arginase inhibitor, Nω-hydroxy-nor-l-arginine (nor-NOHA)

  2007cites this paper
• Cytoprotective function of tetrahydrobiopterin in rat liver ischemia/reperfusion injury.

  2006cites this paper
• Nitric oxide inhibits T cell adhesion and migration by down-regulation of beta1-integrin expression in immunologically liver-injured mice.

  2006cites this paper
• Linking proximal and downstream signalling events in hepatic ischaemia/reperfusion injury.

  2006cites this paper
• Efeitos do precondicionamento isquêmico e do precondicionamento farmacológico com a infusão de L-arginina intraportal sobre as lesões de isquemia e reperfusão hepática normotérmica : estudo experimental em suínos

  2006cites this paper
• Interleukin-12p70 Prolongs Allograft Survival by Induction of Interferon Gamma and Nitric Oxide Production

  2006cites this paper
• FK330, a Novel Inducible Nitric Oxide Synthase Inhibitor, Prevents Ischemia and Reperfusion Injury in Rat Liver Transplantation

  2006cites this paper
• Endothelial nitric oxide synthase protects transplanted mouse livers against storage/reperfusion injury: Role of vasodilatory and innate immunity pathways.

  2006cites this paper
• PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation.

  2006cites this paper
• Donor graft adenoviral iNOS gene transfer ameliorates rat liver transplant preservation injury and improves survival

  2006cites this paper
• Nitric oxide synthase distribution and expression with ischemic preconditioning of the rat liver

  2005cites this paper
• NF‐κB inhibitors stabilize the mRNA of high‐affinity type‐2 cationic amino acid transporter in LPS‐stimulated rat liver

  2005cites this paper
• Protective effect of L-arginine preconditioning on ischemia and reperfusion injury associated with rat small bowel transplantation.

  2005cites this paper
• Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO.

  2005cites this paper
• Beneficial effect of tetrahydrobiopterin on the survival of rats exposed to hepatic ischemia-reperfusion injury.

  2005cites this paper
• Principles of Liver Preservation

  2005cites this paper
• 87 – Ischemia-Reperfusion Injury of the Liver

  2005cites this paper
• Remnant liver injury after hepatectomy with the pringle maneuver and its inhibition by an iNOS inhibitor (ONO-1714) in a pig model.

  2005cites this paper
• A Study of the Metabolites of Ischemia-Reperfusion Injury and Selected Amino Acids in the Liver Using Microdialysis during Transplantation

  2005cites this paper
• Is Ischemic Preconditioning a Useful Strategy in Steatotic Liver Transplantation?

  2004cites this paper
• Pros and cons of L-arginine supplementation in disease

  2004cites this paper
• Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies.

  2004cites this paper
• FK 409 Ameliorates Small-for-Size Liver Graft Injury by Attenuation of Portal Hypertension and Down-Regulation of Egr-1 Pathway

  2004cites this paper
• The transplanted liver graft is capable of clearing asymmetric dimethylarginine

  2004cites this paper
• Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity

  2004cites this paper
• Nitric oxide synthesis in ornithine transcarbamylase deficiency: possible involvement of low no synthesis in clinical manifestations of urea cycle defect.

  2004cites this paper
• Nitric Oxide in Early Ischaemia Reperfusion Injury during Human Orthotopic Liver Transplantation

  2004cites this paper
• Mechanisms of Hepatocyte Injury, Multiorgan Failure, and Prognostic Criteria in Acute Liver Failure

  2003cites this paper
• Role of Nitric Oxide Synthase (NOS) During Ex Vivo Warm Kidney Perfusion Prior to Renal Transplantation

  2003cites this paper
• Normalization of nitric oxide flux improves physiological parameters of porcine kidneys maintained on pulsatile perfusion.

  2003cites this paper
• Mechanisms of hepatocyte injury, multiorgan failure, and prognostic criteria in acute liver failure.

  2003cites this paper
• The nitric oxide donor, V‐PYRRO/NO, protects against acetaminophen‐induced hepatotoxicity in mice

  2003cites this paper