Diverse Effects of Pathogenic Mutations of Parkin That Catalyze Multiple Monoubiquitylation in Vitro*

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Biological Chemistry

• Publication date

  2006-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.M510393200PMID 16339143
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ubiquitin signalling in the NF-kappaB pathway.

  2005cited by this paper
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• α-Synuclein and Parkin Contribute to the Assembly of Ubiquitin Lysine 63-linked Multiubiquitin Chains*

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• RING Finger Ubiquitin-Protein Isopeptide Ligase Nrdp1/FLRF Regulates Parkin Stability and Activity*

  2005cited by this paper
• Ubiquitin signalling in the NF-κB pathway

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• Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease‐linked point mutations

  2005cited by this paper
• Pathogenetic mechanisms of parkin in Parkinson's disease.

  2004cited by this paper
• Ubiquitin, proteasome and parkin.

  2004cited by this paper
• The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases.

  2004cited by this paper
• How much phenotypic variation can be attributed to parkin genotype?

  2003cited by this paper
• A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes

  2003cited by this paper
• Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.

  2003cited by this paper
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  2003cited by this paper
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• Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.

  2003cited by this paper
• Are ubiquitination pathways central to Parkinson's disease?

  2003cited by this paper
• RING finger 1 mutations in Parkin produce altered localization of the protein.

  2003cited by this paper
• Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age*

  2003cited by this paper
• The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

  2003cited by this paper
• The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates.

  2003cited by this paper
• EL5, a rice N-acetylchitooligosaccharide elicitor-responsive RING-H2 finger protein, is a ubiquitin ligase which functions in vitro in co-operation with an elicitor-responsive ubiquitin-conjugating enzyme, OsUBC5b.

  2002cited by this paper
• CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

  2002cited by this paper
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• Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase.

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• E3 ubiquitin-protein ligase activity of Parkin is dependent on cooperative interaction of RING finger (TRIAD) elements.

  2001cited by this paper
• Ubiquitin in chains.

  2000cited by this paper
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  1999cited by this paper
• Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

  1999cited by this paper
• Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients

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• Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies

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• Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination

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• Repurposing the Memory-promoting Meclofenoxate Hydrochloride as a Treatment for Parkinson‘s Disease through Integrative Multi-omics analysis

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• Role of Deubiquitinases in Parkinson’s Disease—Therapeutic Perspectives

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• Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

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• Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria

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• Targeting Mitochondria as a Therapeutic Approach for Parkinson’s Disease

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• Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation

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• A mechanistic review of Parkin activation.

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• Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

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