Redirecting photosynthetic electron flow into light-driven synthesis of alternative products including high-value bioactive natural compounds.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  ACS Synthetic Biology

• Publication date

  2014-01-17

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1021/sb400136fPMID 24328185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Herbal Extracts

  2016cited by this paper
• Efficient metabolic pathway engineering in transgenic tobacco and tomato plastids with synthetic multigene operons

  2013cited by this paper
• High-level semi-synthetic production of the potent antimalarial artemisinin

  2013cited by this paper
• Structural Biology

  2013cited by this paper
• Metabolic engineering of microorganisms for the synthesis of plant natural products.

  2013cited by this paper
• Optimizations to achieve high-level expression of cytochrome P450 proteins using Escherichia coli expression systems.

  2013cited by this paper
• Redirecting photosynthetic reducing power toward bioactive natural product synthesis.

  2013cited by this paper
• Human cytochromes P450 in health and disease

  2013cited by this paper
• Strategies for metabolic pathway engineering with multiple transgenes

  2013cited by this paper
• Plant chemical defense: at what cost?

  2013cited by this paper
• 14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

  2013cited by this paper
• Unusual Cytochrome P450 Enzymes and Reactions*

  2013cited by this paper
• Light-driven chemical synthesis.

  2012cited by this paper
• Downstream reactions and engineering in the microbially reconstituted pathway for Taxol

  2012cited by this paper
• Medicinal Plants: A Source of Anti-Parasitic Secondary Metabolites

  2012cited by this paper
• Plant production systems for bioactive small molecules.

  2012cited by this paper
• Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

  2012cited by this paper
• Human cytochromes P 450 in health and disease

  2012cited by this paper
• Cytochrome P450 monooxygenases: an update on perspectives for synthetic application.

  2012cited by this paper
• Synthetic biology and the development of tools for metabolic engineering.

  2012cited by this paper
• Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools.

  2012cited by this paper
• Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network

  2012cited by this paper
• Structure and dynamics of the isoprenoid pathway network.

  2012cited by this paper
• Synthetic biological approaches to natural product biosynthesis.

  2012cited by this paper
• Ingenol mebutate: an introduction.

  2012cited by this paper
• Solar hydrogen-producing bionanodevice outperforms natural photosynthesis

  2011cited by this paper
• Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

  2011cited by this paper
• Solar Hydrogen Evolution with Hydrogenases: From Natural to Hybrid Systems

  2011cited by this paper
• Comparing Photosynthetic and Photovoltaic Efficiencies and Recognizing the Potential for Improvement

  2011cited by this paper
• Cytochromes P450 as Useful Biocatalysts: Addressing the Limitations

  2011cited by this paper
• Convergent evolution in plant specialized metabolism.

  2011cited by this paper
• Homology modeling of the three membrane proteins of the dhurrin metabolon: catalytic sites, membrane surface association and protein-protein interactions.

  2011cited by this paper
• Generation of the potent anti-malarial drug artemisinin in tobacco

  2011cited by this paper
• Cytochromes P450 as useful biocatalysts: addressing the limitations.

  2011cited by this paper
• Light driven hydrogen production in protein based semi-artificial systems.

  2011cited by this paper
• Light-driven cytochrome p450 hydroxylations.

  2011cited by this paper
• Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective

  2011cited by this paper
• Methods and options for the heterologous production of complex natural products.

  2011cited by this paper
• Photocatalytic Hydrogen Production from Noncovalent Biohybrid Photosystem I/Pt Nanoparticle Complexes

  2011cited by this paper
• Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function.

  2011cited by this paper
• Convergent evolution in biosynthesis of cyanogenic defence compounds in plants and insects

  2011cited by this paper
• Photosynthetic electron partitioning between [FeFe]-hydrogenase and ferredoxin:NADP+-oxidoreductase (FNR) enzymes in vitro

  2011cited by this paper
• Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains

  2011cited by this paper
• A P450-centric view of plant evolution.

  2011cited by this paper
• Exploiting cyanobacterial P450 pathways.

  2010cited by this paper
• Wiring an [FeFe]-hydrogenase with photosystem I for light-induced hydrogen production.

  2010cited by this paper
• Dynamic Metabolons

  2010cited by this paper
• Wiring photosystem I for direct solar hydrogen production.

  2010cited by this paper
• Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism

  2010cited by this paper
• Functional diversifications of cyanogenic glucosides.

  2010cited by this paper
• UV-B Induced Changes in the Secondary Metabolites of Morus alba L. Leaves

  2010cited by this paper
• Phenylpropanoid biosynthesis.

  2010cited by this paper
• Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

  2010cited by this paper
• The physiological importance of photosynthetic ferredoxin NADP+ oxidoreductase (FNR) isoforms in wheat

  2010cited by this paper
• Plant NADPH-cytochrome P450 oxidoreductases.

  2010cited by this paper
• A new concept for ferredoxin-NADP(H) oxidoreductase binding to plant thylakoids.

  2010cited by this paper
• De Novo Biosynthesis of Vanillin in Fission Yeast (Schizosaccharomyces pombe) and Baker's Yeast (Saccharomyces cerevisiae)

  2009cited by this paper
• CYP 704 B 1 Is a Long-Chain Fatty Acid v-Hydroxylase Essential for Sporopollenin Synthesis in Pollen of Arabidopsis 1 [ W ] [ OA ]

  2009cited by this paper
• Entrapment of cytochrome P450 BM-3 in polypyrrole for electrochemically-driven biocatalysis

  2009cited by this paper
• Maximizing H2 production in Photosystem I/dithiol molecular wire/platinum nanoparticle bioconjugates.

  2009cited by this paper
• Redox Regulation in Photosynthetic Organisms: Signaling, Acclimation, and Practical Implications

  2009cited by this paper
• Solar fuels via artificial photosynthesis.

  2009cited by this paper
• Synthetic biology: understanding biological design from synthetic circuits

  2009cited by this paper
• Structural and evolutionary aspects of thioredoxin reductases in photosynthetic organisms.

  2009cited by this paper
• CYP704B1 Is a Long-Chain Fatty Acid ω-Hydroxylase Essential for Sporopollenin Synthesis in Pollen of Arabidopsis1[W][OA]

  2009cited by this paper
• Medicinally important secondary metabolites in recombinant microorganisms or plants: Progress in alkaloid biosynthesis

  2009cited by this paper
• Cyanobacterial electron carrier proteins as electron donors to CYP106A2 from Bacillus megaterium ATCC 13368.

  2009cited by this paper
• Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene.

  2009cited by this paper
• What is the maximum efficiency with which photosynthesis can convert solar energy into biomass?

  2008cited by this paper
• Biosynthesis of plant-derived flavor compounds.

  2008cited by this paper
• Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production.

  2008cited by this paper
• Oxygen activation by cytochrome P450 monooxygenase

  2008cited by this paper
• Metabolic engineering for plant natural product biosynthesis in microbes.

  2008cited by this paper
• Structural Biology and Biochemistry of Cytochrome P450 Systems in Mycobacterium tuberculosis

  2008cited by this paper
• Photosystem I/molecular wire/metal nanoparticle bioconjugates for the photocatalytic production of H2.

  2008cited by this paper
• Cytochromes P450 and drug discovery.

  2007cited by this paper
• Cytochrome P450 systems--biological variations of electron transport chains.

  2007cited by this paper
• Engineering of Artificial Plant Cytochrome P450 Enzymes for Synthesis of Isoflavones by Escherichia coli

  2007cited by this paper
• Structure and Function of Photosystems

  2007cited by this paper
• Terpenoid Indole Alkaloids Biosynthesis and Metabolic Engineering in Catharanthus roseus

  2007cited by this paper
• The cyanogenic glucoside composition of Zygaena filipendulae (Lepidoptera: Zygaenidae) as effected by feeding on wild-type and transgenic lotus populations with variable cyanogenic glucoside profiles.

  2007cited by this paper
• Production and engineering of terpenoids in plant cell culture.

  2007cited by this paper
• Engineering Escherichia coli for production of functionalized terpenoids using plant P450s.

  2007cited by this paper
• Cytochrome P450--redox partner fusion enzymes.

  2007cited by this paper
• Functional genomics and the biosynthesis of artemisinin.

  2007cited by this paper
• Taxol Biosynthesis and Molecular Genetics

  2006cited by this paper
• Heterologous expression and strategies for encapsulation of membrane-localized plant P450s

  2006cited by this paper
• Cytochrome P450 oxygenases of Taxol biosynthesis

  2006cited by this paper
• Cytochrome P450 monooxygenases: perspectives for synthetic application.

  2006cited by this paper
• Structure and function of photosystems I and II.

  2006cited by this paper
• Photoinduced Hydrogen Production by Direct Electron Transfer from Photosystem I Cross-Linked with Cytochrome c3 to [NiFe]-Hydrogenase

  2006cited by this paper
• Terpene synthases and the regulation, diversity and biological roles of terpene metabolism.

  2006cited by this paper
• Light-driven Hydrogen Production by a Hybrid Complex of a [NiFe]-Hydrogenase and the Cyanobacterial Photosystem I

  2006cited by this paper
• Arabidopsis cytochrome P450s through the looking glass: a window on plant biochemistry

  2006cited by this paper
• Structure, Function, and Regulation of Plant Photosystem I

  2006cited by this paper
• Production of the antimalarial drug precursor artemisinic acid in engineered yeast

  2006cited by this paper
• Photoinduced Hydrogen Production by Direct Electron Transfer from Photosystem I Cross‐Linked with Cytochrome c3 to [NiFe]‐Hydrogenase

  2006cited by this paper
• Plants as a source of anti-cancer agents.

  2005cited by this paper
• Gingerol content of diploid and tetraploid clones of ginger (Zingiber officinale Roscoe).

  2005cited by this paper
• Evolution of flavors and scents.

  2005cited by this paper

• Thylakoid Targeting Improves Stability of a Cytochrome P450 in the Cyanobacterium Synechocystis sp. PCC 6803

  2025cites this paper
• Methanol-driven co-metabolic enhancement of benzotriazole and 5-chlorobenzotriazole degradation by Chlorella pyrenoidosa: Mechanisms, transformation pathways, and metabolic insights.

  2025cites this paper
• Engineering the glass factory: Phaeodactylum tricornutum as a host chassis for sustainable limonene biosynthesis and co-production of high value metabolites

  2025cites this paper
• Engineering cyanobacteria for the production of aromatic natural products

  2024cites this paper
• Formation of Multiple Naturally Occurring Meroterpenoid Scaffolds by Norrish-Yang Reaction of a p-Benzoquinone.

  2024cites this paper
• A Convenient Route to Large-Scale Chemical Synthesis of p-Hydroxyphenylacetaldehyde Oxime and Its p-β-d-Glucopyranoside: Key Intermediates and Products in Plant Specialized Metabolism

  2024cites this paper
• Engineering cyanobacteria as a new platform for producing taxol precursors directly from carbon dioxide

  2024influential citation
• Exploring electron transfer: Bioinspired, biomimetics, and bioelectrochemical systems for sustainable energy and Value-Added compound synthesis

  2024cites this paper
• Pharmaceutical removal from wastewater by introducing cytochrome P450s into microalgae

  2024cites this paper
• Light-driven enzymatic conversion of mevastatin into pravastatin by coupling P450sca-2 with cyanobacterial photosynthetic system

  2024cites this paper
• Solar-powered P450 catalysis: Engineering electron transfer pathways from photosynthesis to P450s.

  2023cites this paper
• Engineering Nannochloropsis oceanica for the production of diterpenoid compounds

  2023cites this paper
• A Ubiquitin-Based Module Directing Protein–Protein Interactions in Chloroplasts

  2023cites this paper
• Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction

  2022cites this paper
• The Effects of Different Nitrogen Forms on Chlorophyll Fluorescence and Photosystem II in Lonicera japonica

  2022cites this paper
• Unraveling the key driving factors involved in cometabolism enhanced aerobic degradation of tetracycline in wastewater.

  2022cites this paper
• Artificial photosynthesis systems for solar energy conversion and storage: platforms and their realities.

  2022cites this paper
• Exploitation of Hetero- and Phototrophic Metabolic Modules for Redox-Intensive Whole-Cell Biocatalysis

  2022influential citation
• Evaluation of biotransformation capacity of transplastomic plants and hairy roots of Nicotiana tabacum expressing human cytochrome P450 2D6

  2022cites this paper
• Circular biomanufacturing through harvesting solar energy and CO2.

  2022cites this paper
• Maximizing Photosynthesis-Driven Baeyer–Villiger Oxidation Efficiency in Recombinant Synechocystis sp. PCC6803

  2022cites this paper
• Solar fuels and feedstocks: the quest for renewable black gold

  2021cites this paper
• Research progress in biosynthesis and regulation of plant terpenoids

  2021cites this paper
• Redox metabolism for improving whole-cell P450-catalysed terpenoid biosynthesis

  2021influential citation
• Integration of physiologically relevant photosynthetic energy flows into whole genome models of light‐driven metabolism

  2021cites this paper
• Overexpression of fatty acid synthesis genes in Synechocystis sp. PCC 6803 with disrupted glycogen synthesis increases lipid production with further enhancement under copper induced oxidative stress.

  2021cites this paper
• Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells

  2021cites this paper
• The Algal Chloroplast as a Testbed for Synthetic Biology Designs Aimed at Radically Rewiring Plant Metabolism

  2021cites this paper
• Research Works in Alkaloid Enhancement in Plants—A Brief Review

  2021cites this paper
• Metabolic Engineering of Photosynthetic Cells – in Collaboration with Nature

  2021cites this paper
• Advantages of Heterotrophic Microalgae as a Host for Phytochemicals Production

  2021cites this paper
• Mesoscopic to Macroscopic Electron Transfer by Hopping in a Crystal Network of Cytochromes.

  2020cites this paper
• Water-soluble chlorophyll-binding proteins from Brassica oleracea allow for stable photobiocatalytic oxidation of cellulose by a lytic polysaccharide monooxygenase

  2020cites this paper
• Enzyme Assembly for Compartmentalized Metabolic Flux Control

  2020cites this paper
• Biotechnology and Bioengineering: Volume 116, Number 10, October 2019

  2019cites this paper
• Unleashing the Synthetic Power of Plant Oxygenases: From Mechanism to Application1[OPEN]

  2019cites this paper
• Cyanobacteria: Applications in Biotechnology

  2019cites this paper
• Towards compartmentalized photocatalysis: multihaem proteins as transmembrane molecular electron conduits.

  2019cites this paper
• Solar-driven biocatalytic C-hydroxylation through direct transfer of photoinduced electrons

  2019cites this paper
• Light-Dependent and Aeration-Independent Gram-Scale Hydroxylation of Cyclohexane to Cyclohexanol by CYP450 Harboring Synechocystis sp. PCC 6803.

  2019cites this paper
• Engineered production of hapalindole alkaloids in the cyanobacterium Synechococcus sp. UTEX 2973.

  2019cites this paper
• Tunable repression of key photosynthetic processes using Cas12a CRISPR interference in the fast-growing cyanobacterium Synechococcus sp. UTEX 2973.

  2019cites this paper
• Genetic Engineering, Synthetic Biology and the Light Reactions of Photosynthesis1[OPEN]

  2018influential citation
• Elucidation of the Amygdalin Pathway Reveals the Metabolic Basis of Bitter and Sweet Almonds (Prunus dulcis)1[OPEN]

  2018cites this paper
• Structure and Functions

  2018cites this paper
• Rational engineering of photosynthetic electron flux enhances light-powered cytochrome P450 activity

  2018cites this paper
• Terpenoid Metabolic Engineering in Photosynthetic Microorganisms

  2018cites this paper
• Exploring the Potential of Algae-Bacteria Communities For Biotechnology

  2018cites this paper
• Electrochemical behavior of a Rh(pentamethylcyclopentadienyl) complex bearing an NAD+/NADH-functionalized ligand.

  2018cites this paper
• Engineering of new-to-nature halogenated indigo precursors in plants

  2018cites this paper
• The Intracellular Localization of the Vanillin Biosynthetic Machinery in Pods of Vanilla planifolia

  2017cites this paper
• Umgehung des Gas‐flüssig‐Stofftransports von Sauerstoff durch Kopplung der photosynthetischen Wasseroxidation an eine biokatalytische Oxyfunktionalisierung

  2017cites this paper
• Development of Electro-Microbial Carbon Capture and Conversion Systems

  2017cites this paper
• Overcoming the Gas–Liquid Mass Transfer of Oxygen by Coupling Photosynthetic Water Oxidation with Biocatalytic Oxyfunctionalization

  2017cites this paper
• Photosynthetic fuel for heterologous enzymes: the role of electron carrier proteins

  2017cites this paper
• Tat proteins as novel thylakoid membrane anchors organize a biosynthetic pathway in chloroplasts and increase product yield 5-fold.

  2017cites this paper
• Assembly of Dynamic P450-Mediated Metabolons—Order Versus Chaos

  2017cites this paper
• Cyanobacteria: Promising biocatalysts for sustainable chemical production

  2017cites this paper
• Sunlight-driven Environmental Benign Production of Bioactive Natural Products with Focus on Diterpenoids and the Pathways Involved in their Formation.

  2017cites this paper
• Artificial photosynthesis for production of hydrogen peroxide and its fuel cells.

  2016cites this paper
• Photochemical Properties and Reactivity of a Ru Compound Containing an NAD/NADH-Functionalized 1,10-Phenanthroline Ligand.

  2016cites this paper
• Cellular Assays for Ferredoxins: A Strategy for Understanding Electron Flow through Protein Carriers That Link Metabolic Pathways.

  2016cites this paper
• Metabolic Engineering of Synechocystis sp. PCC 6803 for Terpenoid Production

  2016cites this paper
• Transfer of the cytochrome P450-dependent dhurrin pathway from Sorghum bicolor into Nicotiana tabacum chloroplasts for light-driven synthesis

  2016cites this paper
• SorghumFDB: sorghum functional genomics database with multidimensional network analysis

  2016cites this paper
• Extending the biosynthetic repertoires of cyanobacteria and chloroplasts.

  2016cites this paper
• Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

  2016cites this paper
• In vivo assembly of DNA-fragments in the moss, Physcomitrella patens

  2016cites this paper
• Expanding the toolkit of the Chlamydomonas reinhardtii chloroplast for biotechnological applications

  2016cites this paper
• Universitet In vivo assembly of DNA-fragments in the moss , Physcomitrella patens

  2016cites this paper
• The concept of photochemical enzyme models – State of the art

  2016cites this paper
• In silico metabolic network analysis of Arabidopsis leaves

  2016cites this paper
• Variety of DNA Replication Activity Among Cyanobacteria Correlates with Distinct Respiration Activity in the Dark

  2016cites this paper
• Biotechnological optimization of microalgae for the sustainable production of biocommodities

  2016cites this paper
• General and Stereocontrolled Approach to the Chemical Synthesis of Naturally Occurring Cyanogenic Glucosides.

  2016cites this paper
• Metabolic engineering of light-driven cytochrome P450 dependent pathways into Synechocystis sp. PCC 6803.

  2016cites this paper
• Fusion of Ferredoxin and Cytochrome P450 Enables Direct Light-Driven Biosynthesis

  2016cites this paper
• Metabolic Engineering of Synechocystis sp. PCC 6803 for Production of the Plant Diterpenoid Manoyl Oxide

  2015cites this paper
• Exploiting the Molecular Genetics of Microalgae: From Strain Development Pipelines to the Uncharted Waters of Mass Production

  2015cites this paper
• Light-driven hydrogen production from Photosystem I-catalyst hybrids.

  2015cites this paper
• Plasticity of specialized metabolism as mediated by dynamic metabolons.

  2015cites this paper
• Synthetic Biology in Aid of Bioactive Molecules

  2015cites this paper
• Heterologous expression of the isopimaric acid pathway in Nicotiana benthamiana and the effect of N-terminal modifications of the involved cytochrome P450 enzyme

  2015cites this paper
• Biotechnological exploitation of microalgae.

  2015cites this paper
• Synthetic biology for pharmaceutical drug discovery

  2015cites this paper
• A Modular Cloning Toolbox for the Generation of Chloroplast Transformation Vectors

  2014cites this paper
• Cyanobacteria as an Experimental Platform for Modifying Bacterial and Plant Photosynthesis

  2014cites this paper
• Anchoring a Plant Cytochrome P450 via PsaM to the Thylakoids in Synechococcus sp. PCC 7002: Evidence for Light-Driven Biosynthesis

  2014cites this paper
• Chloroplast evolution, structure and functions

  2014cites this paper
• Engineered Transcriptional Systems for Cyanobacterial Biotechnology

  2014cites this paper
• The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia

  year unknowncites this paper