Neuropathogenic actions of cytokines assessed in transgenic mice

No abstract is available for this paper.

• Publication year

  1995

• Venue

  International Journal of Developmental Neuroscience

• Publication date

  1995-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0736-5748(94)00073-CPMID 7572281
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines.

  1995cited by this paper
• Inflammation in the nervous system.

  1995cited by this paper
• Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice.

  1994cited by this paper
• HIV, AIDS, and the Brain

  1994cited by this paper
• Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie

  1994cited by this paper
• Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice.

  1994cited by this paper
• Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis.

  1994cited by this paper
• Cytokine circuits in brain. Implications for AIDS dementia complex.

  1994cited by this paper
• Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice.

  1994cited by this paper
• Neuroendocrine-immune interactions.

  1993cited by this paper
• Transgenic mice in the study of cytokine function.

  1993cited by this paper
• Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

  1993cited by this paper
• Macrophages and inflammation in the central nervous system.

  1993cited by this paper
• Involvement of cytokines in acute neurodegeneration in the CNS.

  1993cited by this paper
• TGF-beta 1 is an organizer of responses to neurodegeneration.

  1993cited by this paper
• Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

  1993cited by this paper
• TGF‐β1 is an organizer of responses to neurodgeneration

  1993cited by this paper
• Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms

  1993cited by this paper
• Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

  1993cited by this paper
• Cytokines in health and disease.

  1993cited by this paper
• Cytokine expression in the brain during the acquired immunodeficiency syndrome

  1992cited by this paper
• The role of the acute-phase protein α1-antichymotrypsin in brain dysfunction and injury

  1992cited by this paper
• Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action.

  1992cited by this paper
• Proinflammatory and Antiinflammatory Cytokines in Multiple Sclerosis and Central Nervous System Acquired Immunodeficiency Syndrome

  1992cited by this paper
• Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: normal and pathological.

  1992cited by this paper
• The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?

  1992cited by this paper
• The role of the acute-phase protein alpha 1-antichymotrypsin in brain dysfunction and injury.

  1992cited by this paper
• Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.

  1991cited by this paper
• Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production.

  1991cited by this paper
• Functions and mechanisms of interleukin 1 in the brain.

  1991cited by this paper
• Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes

  1991cited by this paper
• Macrophage- and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome

  1991cited by this paper
• HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease

  1991cited by this paper
• Astroglia in CNS injury

  1991cited by this paper
• Cytokines and autoimmune disease.

  1991cited by this paper
• Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury.

  1991cited by this paper
• Immunoregulators in the nervous system.

  1991cited by this paper
• Neuropoietic cytokines in the hematopoietic fold.

  1991cited by this paper
• Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities.

  1991cited by this paper
• Lymphokines and immunoregulatory molecules in subacute sclerosing panencephalitis.

  1991cited by this paper
• Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis.

  1990cited by this paper
• Induction and regulation of interleukin-6 gene expression in rat astrocytes.

  1990cited by this paper
• Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

  1990cited by this paper
• Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control.

  1990cited by this paper
• Animal models for the biological effects of continuous high cytokine levels

  1990cited by this paper
• Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta.

  1990cited by this paper
• Neuroimmunology.

  1990cited by this paper
• Inflammatory and immunomodulatory roles of TGF-β

  1989cited by this paper
• Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.

  1989cited by this paper
• Transgenic mice as probes into complex systems.

  1989cited by this paper
• Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response.

  1989cited by this paper
• The cytokine network.

  1989cited by this paper
• Stress and immunity: an integrated view of relationships between the brain and the immune system.

  1989cited by this paper
• Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid.

  1989cited by this paper
• IgG1 plasmacytosis in interleukin 6 transgenic mice.

  1989cited by this paper
• Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

  1989cited by this paper
• Tumor necrosis factor identified in multiple sclerosis brain

  1989cited by this paper
• Inflammatory and immunomodulatory roles of TGF-beta.

  1989cited by this paper
• Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response

  1989cited by this paper
• On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

  1989cited by this paper
• Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6

  1988cited by this paper
• Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients

  1988cited by this paper
• Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

  1988cited by this paper
• GABAergic neurons containing the Ca2+-binding protein parvalbumin in the rat hippocampus and dentate gyrus.

  1987cited by this paper
• Germ-line transformation of mice.

  1986cited by this paper
• Interleukin 1 of the central nervous system is produced by ameboid microglia

  1986cited by this paper
• Regulation of glial fibrillary acidic protein (GFAP) expression in CNS development and in pathological states.

  1985cited by this paper
• Glial Fibrillary Acidic Protein (GFA) in Normal Neural Cells and in Pathological Conditions

  1980cited by this paper

• Increased Expression of the Neuropeptides PACAP/VIP in the Brain of Mice with CNS Targeted Production of IL-6 Is Mediated in Part by Trans-Signalling

  2024cites this paper
• BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia.

  2017cites this paper
• Perspectives Series : Cytokines and the Brain Neural-immune Interactions in Health and Disease

  2013cites this paper
• Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways

  2011cites this paper
• Building-Associated Neurological Damage Modeled in Human Cells: A Mechanism of Neurotoxic Effects by Exposure to Mycotoxins in the Indoor Environment

  2010influential citation
• Event-related oscillations in mice: effects of stimulus characteristics.

  2009cites this paper
• Genetically Engineered Animals

  2007cites this paper
• Intravenous immunoglobulin for post-polio syndrome: a randomised controlled trial.

  2006cites this paper
• Pathophysiology of Sjögren's syndrome.

  2006cites this paper
• The post-polio syndrome - studies of immunology and immunomodulatory intervention

  2005cites this paper
• The mechanisms of neurotoxicity induced by a stachybotrys chartarum trichothecene mycotoxin in an in vitro model

  2005cites this paper
• Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures.

  2004cites this paper
• Prior poliomyelitis-IVIg treatment reduces proinflammatory cytokine production.

  2004cites this paper
• Production α and TNF-β Glucocorticoids on IL-1 Counteract the Inhibitory Effect of Migration-Inhibitory Factor Secretion and 2 T Cells Augment δ 2

  2002cites this paper
• Cobalamin (vitamin B(12)) positively regulates interleukin-6 levels in rat cerebrospinal fluid.

  2002cites this paper
• Long latency event-related potentials in mice: effects of stimulus characteristics and strain.

  2002cites this paper
• Use of Genetically Engineered Mice in Drug Discovery and Development: Wielding Occam's Razor to Prune the Product Portfolio

  2002cites this paper
• Prior poliomyelitis-evidence of cytokine production in the central nervous system.

  2002cites this paper
• Human V gamma 2V delta 2 T cells augment migration-inhibitory factor secretion and counteract the inhibitory effect of glucocorticoids on IL-1 beta and TNF-alpha production.

  2002cites this paper
• Sjögren's syndrome: mechanisms ofpathogenesis involve interaction of immune and neurosecretory systems

  2002cites this paper
• Neural‐Immune Interactions in Health and Disease

  2002cites this paper
• Human Vγ2Vδ2 T Cells Augment Migration-Inhibitory Factor Secretion and Counteract the Inhibitory Effect of Glucocorticoids on IL-1β and TNF-α Production1

  2002cites this paper
• Human Vγ2Vδ2 T Cells Produce IFN-γ and TNF-α with an On/Off/On Cycling Pattern in Response to Live Bacterial Products1

  2001cites this paper
• [Etiopathogenesis of Sjögren's syndrome].

  2001cites this paper
• Etiopatogenia del síndrome de Sjögren

  2001cites this paper
• Zinc or Copper Deficiency-Induced Impaired Inflammatory Response to Brain Trauma May Be Caused by the Concomitant Metallothionein Changes

  2001influential citation
• Use of muscarinic agonists in the treatment of Sjögren's syndrome.

  2001cites this paper
• Human V gamma 2V delta 2 T cells produce IFN-gamma and TNF-alpha with an on/off/on cycling pattern in response to live bacterial products.

  2001cites this paper
• Human Immunodeficiency Virus Glycoprotein 160 Induces Cytokine mRNA Expression in the Rat Central Nervous System

  2000cites this paper
• Spatiotemporal induction patterns of cytokine and related immune signal molecule mRNAs in response to intrastriatal injection of lipopolysaccharide.

  2000cites this paper
• Spatiotemporal induction patterns of cytokine and related immune signal molecule mRNAs in response to intrastriatal injection of lipopolysaccharide.

  2000cites this paper
• Activated and Memory CD8+ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers1

  2000cites this paper
• Cytokines and hormonal regulations

  1999cites this paper
• Response of Glia, Mast Cells and the Blood Brain Barrier, in Transgenic Mice Expressing Interleukin‐3 in Astrocytes, an Experimental Model for CNS Demyelination

  1999cites this paper
• Models of experimental bacterial meningitis. Role and limitations.

  1999cites this paper
• Chronic overexpression of proinflammatory cytokines and histopathology in the brains of rats infected with Trypanosoma brucei

  1999cites this paper
• Myelinolytic lesions in spinal cord of cobalamin‐deficient rats are TNF‐α‐mediated

  1999cites this paper
• Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

  1999cites this paper
• Myelinolytic lesions in spinal cord of cobalamin-deficient rats are TNF-alpha-mediated.

  1999cites this paper
• Overview of the conference and the field.

  1998cites this paper
• Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology.

  1998cites this paper
• Transgenic Mice Expressing Cytokines in the CNS as Model Systems for the Study of Inflammatory Neurodegenerative and Demyelinating Disorders

  1998cites this paper
• Cytokines and antibodies in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis.

  1998cites this paper
• Sjögren's syndrome. Pathogenesis and new approaches to therapy.

  1998cites this paper
• Transgenic Models to Study the Actions of Cytokines in the Central Nervous System

  1998cites this paper
• Structural and Functional Impact of the Transgenic Expression of Cytokines in the CNS a

  1998cites this paper
• Introduction: Overview of the Conference and the Field

  1998cites this paper
• Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function.

  1998cites this paper
• actions of cytokines in the expression of the cytokines IL-6, 7 IL-3 8 and more

  1997cites this paper
• Neurotrophins and their receptors in nerve injury and repair.

  1997cites this paper
• Inflammatory Cytokines in the CNS

  1997cites this paper
• Physiological and pathological roles of interleukin-6 in the central nervous system

  1997cites this paper
• Possible control of cell death pathways in ataxia telangiectasia. A case report.

  1997cites this paper
• Transgenic models to assess the pathogenic actions of cytokines in the central nervous system

  1997cites this paper
• Emotions and disease: From balance of humors to balance of molecules

  1997cites this paper
• Hormonal activities of cytokines.

  1997cites this paper
• Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice.

  1996cites this paper
• Transgenic modeling of neuropsychiatric disorders.

  1996cites this paper
• Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte‐targeted interleukin‐6 expression

  1996cites this paper
• Evolution of Neuropathologic Abnormalities Associated with Blood-Brain Barrier Breakdown in Transgenic Mice Expressing lnterleukin-6 in Astrocytes

  1995cites this paper
• Sjögren's syndrome.

  1994cites this paper
• Celltransformationbythesuperoxide-generating oxidase Mox 1

  year unknowncites this paper