The nuclear receptor superfamily

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Cell Science

• Publication date

  2003-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/JCS.00247PMID 12538758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bioinformatics of nuclear receptors.

  2003cited by this paper
• How many nuclear hormone receptors are there in the human genome?

  2001cited by this paper
• The genome sequence of Drosophila melanogaster.

  2000cited by this paper
• Ligand binding and nuclear receptor evolution

  2000cited by this paper
• Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid.

  2000cited by this paper
• Seeking Ligands for Lonely Orphan Receptors

  1999cited by this paper
• Orphan nuclear receptors: shifting endocrinology into reverse.

  1999cited by this paper
• A unified nomenclature system for the nuclear receptor superfamily.

  1999cited by this paper
• Slit branches out: a secreted protein mediates both attractive and repulsive axon guidance.

  1999cited by this paper
• The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes.

  1999cited by this paper
• A unified nomenclature system for the nuclear receptor superfamily

  1999cited by this paper
• The nuclear receptor ligand-binding domain: structure and function.

  1998cited by this paper
• Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

  1995cited by this paper
• Solution structure of the glucocorticoid receptor DNA-binding domain.

  1990influential reference

• Single-cell analysis reveals that the hormone T3 affects colon epithelial differentiation and induces a mixed progenitor-like cell population.

  2026cites this paper
• The slow elimination of 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene in mice leads to prolonged constitutive androstane receptor activation and hepatomegaly.

  2025cites this paper
• Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic Disorders

  2025cites this paper
• Reproductive Risk Assessment of Bisphenol A and Its Substitutes on Estrogen Receptors (ERs) in Bivalves

  2025cites this paper
• Physiological plasticity in zebra finch color varieties mitigates DNA damage under oxidative stress

  2025cites this paper
• NR1I3 modulates Wnt signaling to promote anterior–posterior axis patterning

  2025cites this paper
• An improved synthesis of TRβ-selective thyromimetic GC-1

  2025cites this paper
• Ecdysone receptor B1 isoform/ultraspiracle protein 1-mediated ecdysteroid signaling regulates the growth and development: potential targets for efficient Hyphantria cunea management.

  2025cites this paper
• Liver X Receptors: A Therapeutic Target in Demyelinating Disorders.

  2025cites this paper
• The moulting arthropod: a complete genetic toolkit review

  2024cites this paper
• Ecdysone receptor strongly influences larval–pupal–adult transition and melanization in Tuta absoluta

  2024cites this paper
• Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma

  2024cites this paper
• Vitamin D and its analogs in immune system regulation.

  2024cites this paper
• SIU: A Million-Scale Structural Small Molecule-Protein Interaction Dataset for Unbiased Bioactivity Prediction

  2024cites this paper
• The interplay of oxytocin and sex hormones.

  2024cites this paper
• Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6

  2024cites this paper
• NR4A2 as a Novel Target Gene for Developmental and Epileptic Encephalopathy: A Systematic Review of Related Disorders and Therapeutic Strategies

  2024cites this paper
• Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut.

  2024cites this paper
• Expanding the Molecular Landscape of Androgen Insensitivity Syndrome Through Next-Generation Sequencing

  2024cites this paper
• The expanding roles of Nr6a1 in development and evolution

  2024cites this paper
• Benchmarking Reverse Docking through AlphaFold2 Human Proteome

  2023cites this paper
• Deregulated transcription factors in the emerging cancer hallmarks.

  2023cites this paper
• Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6

  2023cites this paper
• Global repression by tailless during segmentation.

  2023cites this paper
• Inhibition of ecdysone receptor (DcEcR) and ultraspiracle (DcUSP) expression in Diaphorina citri increased susceptibility to pesticides.

  2023cites this paper
• Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex

  2023cites this paper
• Updated knowledge and a proposed nomenclature for nuclear receptors with two DNA binding domains (2DBD-NRs)

  2023cites this paper
• Myomectomy during pregnancy and caesarean section

  2023cites this paper
• Functional Characterization of the Nuclear Receptor Gene SaE75 in the Grain Aphid, Sitobion avenae

  2023cites this paper
• Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2

  2023cites this paper
• Development and therapeutic potential of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists for autoimmune diseases.

  2023cites this paper
• Genomic signaling of vitaminD.

  2023cites this paper
• Nuclear receptors and other molecular targets in type 2 diabetes mellitus

  2023influential citation
• Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators

  2023cites this paper
• Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases

  2023cites this paper
• : The nuclear receptor Nr2f6 represses skeletal muscle oxidative metabolism and force production.

  2023cites this paper
• Transcriptionally regulated miR-26a-5p may act as BRCAness in Triple-Negative Breast Cancer

  2023cites this paper
• Development of binary classification models for grouping hydroxylated polychlorinated biphenyls into active and inactive thyroid hormone receptor agonists

  2023cites this paper
• Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive

  2023cites this paper
• A novel scaffold long-acting selective estrogen receptor antagonist and degrader with superior preclinical profile against ER+ breast cancer.

  2023cites this paper
• Future therapeutic perspectives in nonalcoholic fatty liver disease: a focus on nuclear receptors, a promising therapeutic target

  2023cites this paper
• Brain nuclear receptors and cardiovascular function

  2023cites this paper
• Protein Condensation in the Nuclear Receptor Family; Implications for Transcriptional Output.

  2022cites this paper
• New insights into cholesterol‐mediated ERRα activation in breast cancer progression and pro‐tumoral microenvironment orchestration

  2022cites this paper
• Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells.

  2022cites this paper
• NRPreTo: A Machine Learning-Based Nuclear Receptor and Subfamily Prediction Tool

  2022cites this paper
• Identification and characterization of alternative splicing variants of buffalo LXRα expressed in mammary gland

  2022cites this paper
• Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions

  2022cites this paper
• Quantitative structure–activity relationship modeling of hydroxylated polychlorinated biphenyls as constitutive androstane receptor agonists

  2022cites this paper
• Molecular Cloning and Characterization of a Fasciola gigantica Nuclear Receptor Subfamily 1 (FgNR1)

  2022cites this paper
• Statistical Analysis of Protein-Ligand Interaction Patterns in Nuclear Receptor RORγ

  2022influential citation
• Antifouling Marine Coatings with a Potentially Safer and Sustainable Synthetic Polyphenolic Derivative

  2022cites this paper
• Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factors

  2022cites this paper
• Proteomic Analysis of the Intestinal Resistance to Thyroid Hormone Mouse Model With Thyroid Hormone Receptor Alpha Mutations

  2022influential citation
• Transcriptional control of energy metabolism by nuclear receptors

  2022cites this paper
• Comprehensive analysis of cellular estrogen signaling in representative estrogen receptor ligands.

  2022cites this paper
• Identification and characterization of alternative splicing variants of buffalo LXRα expressed in mammary gland

  2022cites this paper
• Modeling, molecular dynamics and docking studies of a full-length Echinococcus granulosus 2DBD nuclear receptor

  2022cites this paper
• RNA interference-mediated silencing of retinoid x receptor causes reproductive failure in the sea lice Caligus rogercresseyi

  2022cites this paper
• Prediction of the Endocrine disruption profile of fluorinated biphenyls and analogues: An in silico study.

  2022cites this paper
• Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle.

  2022cites this paper
• The power of the (imperfect) palindrome: Sequence‐specific roles of palindromic motifs in gene regulation

  2022cites this paper
• Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity

  2022cites this paper
• Characterization, expression, and regulatory effects of nr0b1a and nr0b1b in spotted scat (Scatophagus argus).

  2021cites this paper
• Nuclear Receptors

  2021cites this paper
• Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.

  2021cites this paper
• Biological insights into the rapid tissue regeneration of freshwater crayfish and crustaceans

  2021cites this paper
• PARP7 mono-ADP-ribosylates the Agonist Conformation of the Androgen Receptor in the Nucleus

  2021cites this paper
• Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease

  2021cites this paper
• From Extrapolation to Precision Chemical Hazard Assessment: The Ecdysone Receptor Case Study

  2021cites this paper
• Co-occupancy identifies transcription factor co-operation for axon growth

  2021cites this paper
• Systematic Pan-Cancer Characterization of Nuclear Receptors Identifies Potential Cancer Biomarkers and Therapeutic Targets

  2021influential citation
• How Protein Methylation Regulates Steroid Receptor Function

  2021cites this paper
• Peroxisome proliferator-activated receptor gamma: a novel therapeutic target for cognitive impairment and mood disorders that functions via the regulation of adult neurogenesis

  2021cites this paper
• Classical targets in drug discovery

  2021cites this paper
• Structure−Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor- Related Orphan Receptor γt

  2021cites this paper
• Antifibrotic potential of Tetracarpidium conophorum (African walnut) leaves extract on diethylstilbestrol-induced rat model of uterine fibroid

  2021cites this paper
• Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).

  2021cites this paper
• Nuclear receptors linking physiology and germline stem cells in Drosophila.

  2021cites this paper
• USING LIGAND-ACTIVATED RECEPTORS FROM ATLANIC COD (Gadus morhua) AND ZEBRAFISH (Danio rerio) TO ASSESS BIOLOGICAL EFFECTS OF PHARMACEUTICALS IN WASTEWATER IN BERGEN, NORWAY

  2021cites this paper
• Cloning and characterization of RAR s and RXR s from noble scallop Chlamys nobilis , a bivalve rich in carotenoids

  2021cites this paper
• Discovery of contaminants with antagonistic activity against retinoic acid receptor in house dust.

  2021cites this paper
• Allele-Specific Knockout by CRISPR/Cas to Treat Autosomal Dominant Retinitis Pigmentosa Caused by the G56R Mutation in NR2E3

  2021cites this paper
• Strategies to Inhibit Hepatitis B Virus Gene Transcription

  2021cites this paper
• Are paedomorphs actual larvae?

  2021cites this paper
• Strategies to Inhibit Hepatitis B Virus at the Transcript Level

  2021cites this paper
• A computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors.

  2021cites this paper
• Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action

  2021cites this paper
• Discovery of tert-amine-based RORγt agonists.

  2021cites this paper
• RORγt protein modifications and IL-17-mediated inflammation.

  2021cites this paper
• Functional roles of female sex hormones and their nuclear receptors in cervical cancer.

  2021cites this paper
• Orphan nuclear receptors in angiogenesis and follicular development.

  2021cites this paper
• Nuclear Receptors and Development of Marine Invertebrates

  2021cites this paper
• An updated evolutionary study of the nuclear receptor protein family

  2021cites this paper
• Expression of Mitochondrial Progesterone Receptor (PR-M) in Ovarian Cancer and Its Effect on Cell Metastasis Induced by Progesterone

  2021cites this paper
• Not So Slim Anymore—Evidence for the Role of SUMO in the Regulation of Lipid Metabolism

  2020cites this paper
• Assessing the Selectivity of FXR, LXRs, CAR, and RORγ Pharmaceutical Ligands With Reporter Cell Lines

  2020cites this paper
• Cross-validation of genes potentially associated with neoadjuvant chemotherapy and platinum-based chemoresistance in epithelial ovarian carcinoma

  2020cites this paper
• Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell

  2020cites this paper
• HIV-1 Sanctuary Sites—the Role of Membrane-Associated Drug Transporters and Drug Metabolic Enzymes

  2020cites this paper