Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Gut

• Publication date

  2003-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1136/gut.53.1.78PMID 14684580PMCID PMC1773940
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Nuclear receptors. II. Intestinal corticosteroid receptors.

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• NUBIScan, an in silico approach for prediction of nuclear receptor response elements.

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• Effect of Lipopolysaccharide on Peptide Transporter 1 Expression in Rat Small Intestine and Its Attenuation by Dexamethasone

  2002influential reference
• Human Apical Sodium-dependent Bile Salt Transporter Gene (SLC10A2) Is Regulated by the Peroxisome Proliferator-activated Receptor α*

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• Nuclear receptors and lipid physiology: opening the X-files.

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• Transcription factor‐mediated molecular mechanisms involved in the functional cross‐talk between cytokines and glucocorticoids

  2001influential reference
• Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits.

  2000cited by this paper
• Hepatobiliary transport of bile acid amino acid, bile acid peptide, and bile acid oligonucleotide conjugates in rats

  1999cited by this paper
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  1999cited by this paper
• Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.

  1998cited by this paper
• The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

  1998influential reference
• Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.

  1998cited by this paper
• Mechanism of inhibition of Na+-bile acid cotransport during chronic ileal inflammation in rabbits.

  1998cited by this paper
• An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.

  1998influential reference
• SXR, a novel steroid and xenobiotic-sensing nuclear receptor.

  1998influential reference
• Binding kinetics of budesonide to the human glucocorticoid receptor.

  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Bile acid transport systems as pharmaceutical targets

  1996cited by this paper
• Ileal bile acid malabsorption in colonic Crohn's disease

  1994cited by this paper
• Oral Budesonide for Active Crohn's Disease

  1994cited by this paper
• Oral budesonide for active Crohn's disease. Canadian Inflammatory Bowel Disease Study Group.

  1994cited by this paper
• A comparison of budesonide with prednisolone for active Crohn's disease.

  1994cited by this paper
• From the structure to the function of villin, an actin‐binding protein of the brush border

  1990influential reference
• Structural determinants of a glucocorticoid receptor recognition element.

  1990influential reference
• Comparison of 75SeHCAT retention half-life and fecal content of individual bile acids in patients with chronic diarrheal disorders.

  1986cited by this paper
• Methylprednisolone accelerates the ontogeny of sodium-taurocholate cotransport in rat ileal brush border membranes.

  1986cited by this paper
• The Role of Glucocorticoids in the Postnatal Development of Ileal Active Bile Salt Transport

  1985cited by this paper
• The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus

  1983cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983cited by this paper
• Primary bile acid malabsorption: defective in vitro ileal active bile acid transport.

  1982cited by this paper
• Regional ileitis (Crohn's disease). I. Kinetics of bile acid absorption in the perfused ileum.

  1976cited by this paper
• Bile salt malabsorption in regional ileitis, ileal resection and mannitol-induced diarrhea.

  1968influential reference
• REGIONAL ILEITIS : CROHN'S DISEASE

  1937cited by this paper

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