N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Nature Immunology

• Publication date

  2005-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ni1259PMID 16227985
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori.

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• Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation

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• The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant.

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• Human Corneal GlcNAc 6-O-Sulfotransferase and Mouse Intestinal GlcNAc 6-O-Sulfotransferase Both Produce Keratan Sulfate*

  2001cited by this paper
• Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase.

  2001cited by this paper
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  2001cited by this paper
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• Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.

  2001cited by this paper
• Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase.

  2000cited by this paper
• Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities.

  2000cited by this paper
• Sulfation of N-Acetylglucosamine by Chondroitin 6-Sulfotransferase 2 (GST-5)*

  2000cited by this paper
• Sulfation of a High Endothelial Venule–Expressed Ligand for L-Selectin

  1999cited by this paper
• Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA.

  1999cited by this paper
• Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue.

  1999cited by this paper
• Commentary Endothelial Ligands for L-Selectin From Lymphocyte Recirculation to Allograft Rejection

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
• Molecular Cloning and Characterization of anN-Acetylglucosamine-6-O-sulfotransferase*

  1998cited by this paper
• Molecular Cloning and Characterization of Human Keratan Sulfate Gal-6-Sulfotransferase*

  1997cited by this paper
• Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice.

  1996cited by this paper
• Adhesion through L-selectin requires a threshold hydrodynamic shear

  1996cited by this paper
• Purification and quantification of L-selectin-reactive GlyCAM-1 from mouse serum.

  1996cited by this paper
• The Route of Antigen Entry Determines the Requirement for L-selectin during Immune Responses

  1996cited by this paper
• Lymphocyte Homing and Homeostasis

  1996influential reference
• The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

  1996cited by this paper
• Structure of the O-Glycans in GlyCAM-1, an Endothelial-derived Ligand for L-selectin

  1995cited by this paper
• L-selectin and alpha 4 beta 7 integrin homing receptor pathways mediate peripheral lymphocyte traffic to AKR mouse hyperplastic thymus.

  1995cited by this paper
• Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC.

  1995cited by this paper
• Sulfation-dependent recognition of high endothelial venules (HEV)- ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody

  1994cited by this paper
• Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice.

  1994cited by this paper
• Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.

  1994cited by this paper
• Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice.

  1994influential reference
• Sulphation requirement for GlyCAM-1, an endothelial ligand for L-selectin

  1993cited by this paper
• Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.

  1993cited by this paper
• α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

  1993cited by this paper
• Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium.

  1993cited by this paper
• The human peripheral lymph node vascular addressin. An inducible endothelial antigen involved in lymphocyte homing.

  1993cited by this paper
• The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide

  1992cited by this paper
• Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes

  1988cited by this paper
• Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation.

  1985cited by this paper
• Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transport.

  1984cited by this paper
• Tolerance and contact sensitivity to DNFB in mice. II. Specific in vitro stimulation with a hapten, 2,4-dinitrobenzene sulfonic acid (DNB-SO3Na).

  1974cited by this paper
• Tolerance and contact sensitivity to DNFB in mice. I. In vivo detection by ear swelling and correlation with in vitro cell stimulation.

  1974cited by this paper

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• Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins

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