Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Development

• Publication date

  2009-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.037986PMID 19666821PMCID PMC2723064
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008influential reference
• A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

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  2000cited by this paper
• Neuronal specification in the spinal cord: inductive signals and transcriptional codes

  2000influential reference
• A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube.

  2000cited by this paper
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  1999influential reference
• Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9.

  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.

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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes.

  1994cited by this paper
• Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1.

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