Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Genes & Development

• Publication date

  1998-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.12.18.2912PMID 9744867PMCID PMC317163
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996cited by this paper
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  1995influential reference
• Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing.

  1995cited by this paper
• Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

  1993cited by this paper
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  1992cited by this paper
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  1981cited by this paper
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  1979cited by this paper
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  1965cited by this paper

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