Liquid chromatography-tandem mass spectrometry applications in endocrinology.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been recognized as a primary methodology for the accurate analysis of endogenous steroid hormones in biological samples. This review focuses on the use of LC-MS/MS in clinical laboratories to assist with the diagnosis of diverse groups of endocrine and metabolic diseases. Described analytical methods use on-line and off-line sample preparation and analytical derivatization to enhance analytical sensitivity, specificity, and clinical utility. Advantages of LC-MS/MS as an analytical technique include high specificity, possibility to simultaneously measure multiple analytes, and the ability to assess the specificity of the analysis in every sample. All described analytical methods were extensively validated, utilized in routine diagnostic practice, and were applied in a number of clinical and epidemiological studies, including a study of the steroidogenesis in ovarian follicles.

• Publication year

  2009

• Venue

  Mass spectrometry reviews (Print)

• Publication date

  2009-08-25

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/mas.20264PMID 19708015
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reference Information for the Clinical Laboratory

  2012influential reference
• Establishment and Use of Reference Values

  2012cited by this paper
• Chapter-04 Regulation of the Menstrual Cycle

  2012cited by this paper
• Disorders of sexual differentiation

  2011cited by this paper
• Steroid profiles in ovarian follicular fluid from regularly menstruating women and women after ovarian stimulation.

  2009influential reference
• Clinical practice. Precocious puberty.

  2008cited by this paper
• Sex hormone-binding globulin influences gene expression of LNCaP and MCF-7 cells in response to androgen and estrogen treatment.

  2008cited by this paper
• Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatization.

  2008cited by this paper
• Ion mobility-mass spectrometry.

  2008cited by this paper
• High-sensitivity tandem mass spectrometry assay for serum estrone and estradiol.

  2008influential reference
• Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology Study.

  2008cited by this paper
• State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography-tandem mass spectrometry.

  2008cited by this paper
• Adrenal Steroid Concentrations in Children Seven to Seventeen Years of Age

  2007cited by this paper
• Standardization of Steroid Hormone Assays: Why, How, and When?

  2007cited by this paper
• Disorders of Sexual Differentiation

  2007cited by this paper
• Column-switching LC-MS/MS analysis for quantitative determination of testosterone in human serum.

  2007cited by this paper
• Methodology and Applications of Disease Biomarker Identification in Human Serum

  2007cited by this paper
• Handbook of affinity chromatography

  2007cited by this paper
• Methanol-associated matrix effects in electrospray ionization tandem mass spectrometry.

  2007cited by this paper
• High sensitivity tandem mass spectrometry test for serum estrogens

  2007cited by this paper
• Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement.

  2007cited by this paper
• Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk?

  2007cited by this paper
• Measurement of serum testosterone using high-performance liquid chromatography/tandem mass spectrometry

  2006cited by this paper
• Development and performance evaluation of a tandem mass spectrometry assay for 4 adrenal steroids.

  2006influential reference
• Comparison of methods to measure low serum estradiol levels in postmenopausal women.

  2006influential reference
• Simultaneous determination of 12 steroids by isotope dilution liquid chromatography-photospray ionization tandem mass spectrometry.

  2006cited by this paper
• Menopausal estrogen therapy counteracts normal aging effects on intima thickness, media thickness and intima/media ratio in carotid and femoral arteries. An investigation using noninvasive high-frequency ultrasound.

  2006cited by this paper
• Errors in clinical laboratories or errors in laboratory medicine?

  2006cited by this paper
• Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients.

  2006cited by this paper
• Performance characteristics of a novel tandem mass spectrometry assay for serum testosterone.

  2006influential reference
• Novel Mechanisms for Estrogen-Induced Neuroprotection

  2006cited by this paper
• Free Testosterone is an Independent Predictor of BMD and Prevalent Fractures in Elderly Men: MrOS Sweden

  2006cited by this paper
• Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency.

  2006cited by this paper
• Pharmacokinetics of a testosterone gel in healthy postmenopausal women.

  2006cited by this paper
• Tietz Textbook of Clinical Chemistry and Molecular Diagnostics

  2005cited by this paper
• Role of endocytosis in cellular uptake of sex steroids.

  2005cited by this paper
• The use of receiver operating characteristic curves in biomedical informatics

  2005cited by this paper
• Assessing analytical specificity in quantitative analysis using tandem mass spectrometry.

  2005cited by this paper
• Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays.

  2005cited by this paper
• Segmented post-column analyte addition; a concept for continuous response control of liquid chromatography/mass spectrometry peaks affected by signal suppression/enhancement.

  2005cited by this paper
• Testosterone measurement by isotope-dilution liquid chromatography-tandem mass spectrometry: validation of a method for routine clinical practice.

  2005cited by this paper
• Affinity Chromatography of Enzymes

  2005cited by this paper
• Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives.

  2005cited by this paper
• Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss.

  2005cited by this paper
• Increased 2-hydroxylation of estrogen in women with a family history of osteoporosis.

  2005cited by this paper
• Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays.

  2005cited by this paper
• Measuring seven endogenous ketolic estrogens simultaneously in human urine by high-performance liquid chromatography-mass spectrometry.

  2004cited by this paper
• Simultaneous quantitative analysis of isobars by tandem mass spectrometry from unresolved chromatographic peaks.

  2004influential reference
• Cortisol and cortisone analysis in serum and plasma by atmospheric pressure photoionization tandem mass spectrometry.

  2004cited by this paper
• Atmospheric pressure photoionization. 1. General properties for LC/MS.

  2004cited by this paper
• Serum testosterone assays--accuracy matters.

  2004cited by this paper
• Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.

  2004cited by this paper
• Selecting clinically relevant populations for reference intervals

  2004cited by this paper
• Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma.

  2004cited by this paper
• Measuring fifteen endogenous estrogens simultaneously in human urine by high-performance liquid chromatography-mass spectrometry.

  2004cited by this paper
• Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study.

  2004cited by this paper
• Improved specificity of newborn screening for congenital adrenal hyperplasia by second-tier steroid profiling using tandem mass spectrometry.

  2004cited by this paper
• Evaluation of a candidate reference measurement procedure for serum free testosterone based on ultrafiltration and isotope dilution-gas chromatography-mass spectrometry.

  2004cited by this paper
• Improving neonatal screening for congenital adrenal hyperplasia.

  2004cited by this paper
• Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography–mass spectrometry

  2004cited by this paper
• The evolution of the reference value concept

  2004cited by this paper
• Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry.

  2004cited by this paper
• Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).

  2004cited by this paper
• The IFCC recommendation on estimation of reference intervals. The RefVal Program

  2004cited by this paper
• Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome.

  2004cited by this paper
• Liquid chromatography-tandem mass spectrometry analysis of urinary free cortisol.

  2003cited by this paper
• Immunoassays for testosterone in women: better than a guess?

  2003cited by this paper
• Principles of Extraction and the Extraction of Semivolatile Organics from Liquids

  2003cited by this paper
• Comparison of conventional and enhanced mass resolution triple-quadrupole mass spectrometers for discovery bioanalytical applications.

  2003cited by this paper
• Hormonal Therapy of the Infertile Woman

  2003influential reference
• Endocrine Replacement Therapy in Clinical Practice

  2003cited by this paper
• Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.

  2003cited by this paper
• Pseudo-Cushing syndrome caused by fenofibrate interference with urinary cortisol assayed by high-performance liquid chromatography.

  2003influential reference
• Ion suppression in mass spectrometry.

  2003cited by this paper
• Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children.

  2003influential reference
• Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis.

  2002cited by this paper
• Derivatization of ethinylestradiol with dansyl chloride to enhance electrospray ionization: application in trace analysis of ethinylestradiol in rhesus monkey plasma.

  2002cited by this paper
• Serum acylcarnitines and vitamin B12 deficiency.

  2002cited by this paper
• Validation of a high-throughput liquid chromatography-tandem mass spectrometry method for urinary cortisol and cortisone.

  2002cited by this paper
• Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative Randomized Controlled Trial. Writing Group for the Women's Health Initiative Investigators. JAMA 2002; 288(3): 321-333

  2002cited by this paper
• Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.

  2002cited by this paper
• Limitations of steroid determination by direct immunoassay.

  2002cited by this paper
• Clinical chemistry since 1800: growth and development.

  2002cited by this paper
• Congenital adrenal hyperplasia owing to 3 beta-hydroxysteroid dehydrogenase deficiency.

  2001cited by this paper
• CONGENITAL ADRENAL HYPERPLASIA OWING TO 3β-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY

  2001cited by this paper
• Simultaneous determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human plasma by liquid chromatography-tandem mass spectrometry employing derivatization with a Cookson-type reagent.

  2001cited by this paper
• Analysis of dicarboxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine.

  2001influential reference
• Genome and Hormones : Gender Differences in Physiology Invited Review : Gender issues related to spaceflight : a NASA perspective

  2001cited by this paper
• Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry.

  2001cited by this paper
• Cardiovascular protective effects of 17beta-estradiol metabolites.

  2001cited by this paper
• Practical aspects of ultrahigh pressure capillary liquid chromatography.

  2001cited by this paper
• A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry.

  2001cited by this paper
• Invited Review: Cardiovascular protective effects of 17β-estradiol metabolites

  2001cited by this paper
• Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework

  2001cited by this paper
• Efavirenz interference in estradiol ELISA assay.

  2000influential reference
• Diagnosis of Central Precocious Puberty: Endocrine Assessment

  2000cited by this paper
• Atmospheric pressure photoionization: an ionization method for liquid chromatography-mass spectrometry

  2000cited by this paper
• Subclinical Cushing's syndrome.

  2000cited by this paper
• Mechanistic investigation of ionization suppression in electrospray ionization

  2000cited by this paper
• Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range.

  2000cited by this paper

• [Development of an LC-MS/MS method for 32 steroid hormones and exploration of their gestational variations].

  2026cites this paper
• Advancing Clinical Liquid Chromatography-Mass Spectrometry Analysis: Rational Design and Optimization of Derivatization Techniques for Enhanced Sensitivity and Throughput

  2025cites this paper
• An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisol in human serum and plasma

  2025cites this paper
• Development and application of an LC-MS/MS method for urinary DNA adduct profiling in residents of environmentally vulnerable areas.

  2025cites this paper
• The Time of the Hypertonic Saline Infusion Test for the Diagnosis of AVP Deficiency Can Be Shortened With LC-MS/MS

  2025cites this paper
• Diagnostic cut-offs of 17-hydroxyprogesterone by LC-MS/MS in children with non-classical congenital adrenal hyperplasia

  2025cites this paper
• Extensive evaluation of a new LC-MS/MS method to quantify monofluoroacetate toxin in the kidney.

  2024cites this paper
• An LC-MS/MS assay for simultaneous determination of 13 steroid hormones and two synthetic steroids in saliva: potential utility for paediatric population and beyond

  2024cites this paper
• Vitamin D receptor expression in sperm of males with unexplained infertility

  2023cites this paper
• Identification of the Putative Binding Site of a Benzimidazole Opioid (Etazene) and Its Metabolites at µ-Opioid Receptor: A Human Liver Microsomal Assay and Systematic Computational Study

  2023cites this paper
• EVALUATION OF β-HYDROXYBUTYRATE, AMINO ACIDS, AND SELECTED CHEMISTRY VALUES IN THE PLASMA OF FREE-RANGING RED-TAILED HAWKS (BUTEO JAMAICENSIS)

  2023cites this paper
• Comparative estrogen exposure from compounded transdermal estradiol creams and Food and Drug Administration-approved transdermal estradiol gels and patches

  2023cites this paper
• Integration of artificial intelligence and plasma steroidomics with laboratory information management systems: application to primary aldosteronism

  2022cites this paper
• Trace determination of imidacloprid and its major metabolites in wheat-soil system.

  2022cites this paper
• Adrenal steroid profiling as a diagnostic tool to differentiate polycystic ovary syndrome from nonclassic congenital adrenal hyperplasia: pinpointing easy screening possibilities and normal cutoff levels using liquid chromatography tandem mass spectrometry.

  2022cites this paper
• Quantification of cortisol and its metabolites in human urine by LC-MSn: applications in clinical diagnosis and anti-doping control

  2022cites this paper
• Mapping the Secretome of Dental Pulp Stem Cells Under Variable Microenvironmental Conditions

  2021cites this paper
• Mass spectrometry‐based cortisol profiling during adrenal venous sampling reveals misdiagnosis for subtyping primary aldosteronism

  2021cites this paper
• Plasma androgens and the presence and course of depression in a large cohort of women

  2021cites this paper
• Plasma androgens and the presence and course of depression in a large cohort of men.

  2021cites this paper
• The Relationship Between Suicide Attempt and Gonadotropins, Gonadal Hormones, and Cortisol in Females

  2021cites this paper
• Mass Spectrometry-Based Determination of Thyroid Hormones and Their Metabolites in Endocrine Diagnostics and Biomedical Research - Implications for Human Serum Diagnostics.

  2020cites this paper
• Quantitative determination of human serum testosterone via isotope dilution ultra-performance liquid chromatography tandem mass spectrometry

  2020cites this paper
• Advanced High-Coverage Targeted Metabolomics Method (SWATHtoMRM) for Exploring the Relationship of Follicular Fluid Components with Age

  2020cites this paper
• Podocyte sphingomyelin phosphodiesterase acid-like 3b decreases among children with idiopathic nephrotic syndrome

  2020cites this paper
• Mass Spectrometry Methods for In Situ Analysis of Clinical Biomolecules

  2020cites this paper
• Associations of plasma androgens with suicidality among men and women: A 9-year longitudinal cohort study.

  2020cites this paper
• Correlation between glucose metabolism and serum steroid hormones in patients with polycystic ovary syndrome

  2020cites this paper
• Prospective Evaluation of Aldosterone LC-MS/MS-specific Cutoffs for the Saline Infusion Test.

  2020cites this paper
• Developmental low-dose exposure to bisphenol A induces chronic inflammation, bone marrow fibrosis and reduces bone stiffness in female rat offspring only.

  2019cites this paper
• Metabolomics Analysis of Mesenchymal Stem Cells

  2019cites this paper
• Physiological and drug-induced changes in blood levels of adrenal steroids and their precursors in cynomolgus monkeys: An application of steroid profiling by LC-MS/MS for evaluation of the adrenal toxicity.

  2019cites this paper
• Analysis of steroids in urine by gas chromatography-capillary photoionization-tandem mass spectrometry.

  2019cites this paper
• A brief update on mass spectrometry applications to routine clinical endocrinology.

  2019cites this paper
• Association of differential symptoms of stress to hair cortisol and cortisone concentrations among pregnant women in Kenya

  2019cites this paper
• Development and evaluation of protein quantitation assays for use in health care

  2018cites this paper
• A practical ID-LC-MS/MS method for the most commonly analyzed steroid hormones in clinical laboratories

  2018cites this paper
• Determination of testosterone esters in the hair of male greyhound dogs using liquid chromatography-high resolution mass spectrometry.

  2018cites this paper
• Serum Cortisol Levels via Radioimmunoassay vs Liquid Chromatography Mass Spectrophotometry in Healthy Control Subjects and Patients With Adrenal Incidentalomas

  2018cites this paper
• Critical Review on the Analytical Methods for the Estimation of Clofazimine in Bulk, Biological Fluids and Pharmaceutical Formulations

  2018cites this paper
• Testosterone in human studies: Modest associations between plasma and salivary measurements

  2018cites this paper
• The Short Cosyntropin Test Revisited: New Normal Reference Range Using LC-MS/MS

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• GC/MS in Recent Years Has Defined the Normal and Clinically Disordered Steroidome: Will It Soon Be Surpassed by LC/Tandem MS in This Role?

  2018cites this paper
• Low-dose exposure to Bisphenol A during development has limited effects on male reproduction in midpubertal and aging Fischer 344 rats.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Sports supplements and Anabolic Androgenic Steroids

  2018cites this paper
• Validation, quality control, and compliance practice for mass spectrometry assays in the clinical laboratory

  2017cites this paper
• Multiplexed steroid profiling of gluco- and mineralocorticoids pathways using a liquid chromatography tandem mass spectrometry method.

  2017cites this paper
• Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder

  2017cites this paper
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  2017cites this paper
• Matrix effect management in liquid chromatography mass spectrometry: the internal standard normalized matrix effect.

  2017cites this paper
• Hydrocortisone dose in adrenal insufficiency : Balancing harms and benefits

  2017cites this paper
• Sample preparation techniques for mass spectrometry in the clinical laboratory

  2017cites this paper
• Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial.

  2017cites this paper
• Characterizing Triacylglycerol in Cell Culture: Can LCMS replace HPTLC when assessing the effect of metformin in salmon in-vitro fatty liver model?

  2017cites this paper
• Development and Validation of Quantitative Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Assay for Anticoagulant Rodenticides in Liver.

  2017cites this paper
• Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS/MS: Impact of gender, age, oral contraceptives, body mass index and blood pressure status

  2017cites this paper
• MASS SPECTROMETRY IN MEDICINE

  2017cites this paper
• A New Era Predicted for LC-MS in the Clinical Lab

  2016cites this paper
• Evaluation of steroidomics by liquid chromatography hyphenated to mass spectrometry as a powerful analytical strategy for measuring human steroid perturbations.

  2016cites this paper
• Finding a Needle in a Haystack: the Advantages of Liquid Chromatography--Tandem Mass Spectrometry (LC-MS/MS) in Determination of Sex Hormones in Children.

  2016cites this paper
• Evaluación del perfil hormonal en pacientes con cáncer de mama precoz sometidas a hormonoterapia adyuvante

  2016cites this paper
• Bioanalytical LC-MS Method for the Quantification of Plasma Androgens and Androgen Glucuronides in Breast Cancer.

  2016cites this paper
• Mass spectrometry methods measured androgen and estrogen concentrations during pregnancy and in newborns of mothers with polycystic ovary syndrome.

  2016cites this paper
• Targeted analysis of bioactive steroids and oxycholesterols : Method development and application

  2016cites this paper
• A multiplexed targeted assay for high-throughput quantitative analysis of serum methylamines by ultra performance liquid chromatography coupled to high resolution mass spectrometry.

  2016cites this paper
• The clinical utility of mass spectrometry based protein assays.

  2016cites this paper
• Diurnal Variations of Endogenous Steroids in the Follicular Phase of the Menstrual Cycle

  2016cites this paper
• Changes in plasma concentrations of corticosterone and its precursors after ketoconazole administration in rats: An application of simultaneous measurement of multiple steroids using LC-MS/MS.

  2016cites this paper
• Altered adrenal and gonadal steroids biosynthesis in patients with burn injury

  2016cites this paper
• LC-MS based analysis of endogenous steroid hormones in human hair.

  2016influential citation
• Exploratory study of the association of steroid profiles in stimulated ovarian follicular fluid with outcomes of IVF treatment.

  2016cites this paper
• Development of a multi-class steroid hormone screening method using Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

  2016cites this paper
• Androgen synthesis, metabolism and action in the developing ovarian follicle

  2016cites this paper
• Impact of automation on mass spectrometry.

  2015cites this paper
• Feasibility of desorption atmospheric pressure photoionization and desorption electrospray ionization mass spectrometry to monitor urinary steroid metabolites during pregnancy.

  2015cites this paper
• Hormonal Regulation of Vaginal Mucosa

  2015cites this paper
• Derivatization of steroids in biological samples for GC-MS and LC-MS analyses.

  2015cites this paper
• Mass spectrometric analysis of medical samples and aspects of clinical diagnostics

  2015cites this paper
• Liquid Chromatography Tandem Mass Spectrometry Measurements of Steroids in Biological Samples for Clinical Research Studies: Methodology and Application

  2015cites this paper
• Salivary cortisol and cortisone by LC-MS/MS: validation, reference intervals and diagnostic accuracy in Cushing's syndrome.

  2015cites this paper
• High mass accuracy assay for trimethylamine N-oxide using stable-isotope dilution with liquid chromatography coupled to orthogonal acceleration time of flight mass spectrometry with multiple reaction monitoring

  2015cites this paper
• Mid-pregnancy, perinatal, and neonatal reproductive endocrinology: a prospective cohort study in twins and singleton control subjects.

  2015cites this paper
• Urinary Sex Steroids and Anthropometric Markers of Puberty - A Novel Approach to Characterising Within-Person Changes of Puberty Hormones

  2015cites this paper
• Consequences of rape : injuries, posttraumatic stress and neuroendocrinological changes

  2015cites this paper
• Accurate and sensitive liquid chromatography/tandem mass spectrometry simultaneous assay of seven steroids in monkey brain.

  2015cites this paper
• Biomarker Characterization by MALDI-TOF/MS.

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Modeling Most Blood Biomarkers Related to Vitamin Status , One-Carbon Metabolism , and the Kynurenine Pathway Show Adequate Preanalytical Stability and Within-Person Reproducibility to Allow Assessment of Exposure or Nutritional Status in Healthy Women and Cardiovascular Patients 1 – 3

  2014cites this paper
• Androgen levels during adjuvant endocrine therapy in postmenopausal breast cancer patients

  2014cites this paper
• LC–MS/MS in the routine clinical laboratory: has its time come?

  2014cites this paper
• Investigation of endogenous corticosteroids profiles in human urine based on liquid chromatography tandem mass spectrometry.

  2014cites this paper
• Most blood biomarkers related to vitamin status, one-carbon metabolism, and the kynurenine pathway show adequate preanalytical stability and within-person reproducibility to allow assessment of exposure or nutritional status in healthy women and cardiovascular patients.

  2014cites this paper
• A metabonomics study of Chinese miniature pigs with acute liver failure treated with transplantation of placental mesenchymal stem cells

  2014influential citation
• A sensitive, simple and robust LC-MS/MS method for the simultaneous quantification of seven androgen- and estrogen-related steroids in postmenopausal serum.

  2014cites this paper