Intracellular Machinery for Matrix Degradation in Bone‐Resorbing Osteoclasts

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Bone and Mineral Research

• Publication date

  2004-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1359/JBMR.040603PMID 15312243
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tartrate-resistant acid phosphatase 5B circulates in human serum in complex with alpha2-macroglobulin and calcium.

  2003cited by this paper
• Stable expression of human tartrate-resistant acid phosphatase isoforms by CHO cells.

  2002cited by this paper
• Serum Tartrate-Resistant Acid Phosphatase 5b, but not 5a, Correlates with Other Markers of Bone Turnover and Bone Mineral Density

  2002cited by this paper
• Serum tartrate-resistant acid phosphatase isoforms in rheumatoid arthritis.

  2002cited by this paper
• Phosphatase and oxygen radical-generating activities of mammalian purple acid phosphatase are functionally independent.

  2002cited by this paper
• Osteoclasts from mice deficient in tartrate-resistant acid phosphatase have altered ruffled borders and disturbed intracellular vesicular transport.

  2002cited by this paper
• Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells

  2002cited by this paper
• Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption.

  2001cited by this paper
• Mice lacking tartrate‐resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus

  2001cited by this paper
• Mutational analysis of the interaction between active site residues and the loop region in mammalian purple acid phosphatases.

  2001cited by this paper
• Alendronate Disturbs Vesicular Trafficking in Osteoclasts

  2001cited by this paper
• Cystatin C inhibits osteoclast formation and activation via different mechanisms

  2001cited by this paper
• Generation of hydroxyl radicals by the antiviral compound phosphonoformic acid (foscarnet).

  2001influential reference
• Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice.

  2001cited by this paper
• Downregulation of Small GTPase Rab7 Impairs Osteoclast Polarization and Bone Resorption* 210

  2001cited by this paper
• Tartrate-resistant acid phosphatase facilitates hydroxyl radical formation and colocalizes with phagocytosed Staphylococcus aureus in alveolar macrophages.

  2001cited by this paper
• The cell biology of osteoclast function.

  2000cited by this paper
• Structure, function, and regulation of tartrate-resistant acid phosphatase.

  2000cited by this paper
• Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium.

  2000cited by this paper
• Tartrate‐Resistant Acid Phosphatase 5b: A Novel Serum Marker of Bone Resorption

  2000cited by this paper
• Transgenic Mice Overexpressing Tartrate‐Resistant Acid Phosphatase Exhibit an Increased Rate of Bone Turnover

  2000cited by this paper
• Recurrence of Vertebral Fracture with Cyclical Etidronate Therapy in Osteoporosis: Histomorphometry and X‐Ray Microanalysis Evaluation

  1999cited by this paper
• Crystal structure of mammalian purple acid phosphatase.

  1999cited by this paper
• Intracellular Fragmentation of Bone Resorption Products by Reactive Oxygen Species Generated by Osteoclastic Tartrate-resistant Acid Phosphatase*

  1999cited by this paper
• Crystal structure of a mammalian purple acid phosphatase.

  1999cited by this paper
• Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 A resolution with a mu-(hydr)oxo bridged di-iron center.

  1999cited by this paper
• Tartrate-resistant purple acid phosphatase is synthesized as a latent proenzyme and activated by cysteine proteinases.

  1999cited by this paper
• Tartrate‐Resistant Bone Acid Phosphatase: Large‐Scale Production and Purification of the Recombinant Enzyme, Characterization, and Crystallization

  1999cited by this paper
• The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases*

  1998cited by this paper
• A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits.

  1998cited by this paper
• Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts.

  1997cited by this paper
• Clathrin-coated vesicle formation and protein sorting: an integrated process.

  1997cited by this paper
• Protein Oxidation in Aging, Disease, and Oxidative Stress*

  1997cited by this paper
• Removal of osteoclast bone resorption products by transcytosis.

  1997cited by this paper
• Trafficking of matrix collagens through bone-resorbing osteoclasts.

  1997cited by this paper
• Endocytosis.

  1997cited by this paper
• Bone-resorbing osteoclasts reveal a dynamic division of basal plasma membrane into two different domains.

  1996cited by this paper
• Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis.

  1996cited by this paper
• Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

  1996influential reference
• The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure.

  1995cited by this paper
• EEA1, an Early Endosome-Associated Protein.

  1995cited by this paper
• Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network

  1994cited by this paper
• Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro.

  1994cited by this paper
• NADPH-oxidase expression and in situ production of superoxide by osteoclasts actively resorbing bone

  1994cited by this paper
• Immunohistochemical localization of vacuolar H(+)-ATPase in osteoclasts of rat tibiae.

  1994influential reference
• Rab9 functions in transport between late endosomes and the trans Golgi network.

  1993cited by this paper
• The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway.

  1992cited by this paper
• Ultrastructural localization of tartrate-resistant acid phosphatase (purple acid phosphatase) activity in chicken cartilage and bone.

  1991influential reference
• Selective internalization of the apical plasma membrane and rapid redistribution of lysosomal enzymes and mannose 6-phosphate receptors during osteoclast inactivation by calcitonin.

  1990cited by this paper
• Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts

  1990cited by this paper
• Ultrastructural localization of a tartrate‐resistant acid ATPase in bone

  1990cited by this paper
• Organization of osteoclast microfilaments during the attachment to bone surface in vitro

  1989cited by this paper
• Ultrastructural localization of tartrate‐resistant, purple acid phosphatase in rat osteoclasts by histochemistry and immunocytochemistry

  1989influential reference
• Osteoclastic bone resorption by a polarized vacuolar proton pump.

  1989influential reference
• Receptor‐mediated uptake of a mannose‐6‐phosphate bearing glycoprotein by isolated chicken osteoclasts

  1988cited by this paper
• Polarized secretion of lysosomal enzymes: co-distribution of cation- independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway

  1988cited by this paper
• Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure.

  1987cited by this paper
• Hydroxyl radical formation and iron-binding proteins. Stimulation by the purple acid phosphatases.

  1987cited by this paper
• Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border

  1985cited by this paper
• Evidence for a spin-coupled binuclear iron unit at the active site of the purple acid phosphatase from beef spleen.

  1982cited by this paper
• Bone acid phosphatase: Tartrate-resistant acid phosphatase as a marker of osteoclast function

  1982cited by this paper

• Si Inhibited Osteoclastogenesis: The Role of Fe and the Fenton Reaction

  2025cites this paper
• Spondyloenchondrodysplasia: An enigmatic immuno-osseus type I interferonopathy

  2025cites this paper
• From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases

  2025cites this paper
• Evaluation of Biomarkers of Bone Metabolism on Salivary Matrix in the Remodeling of Periodontal Tissue during Orthodontic Treatment

  2024cites this paper
• The mineralization of osteonal cement line depends on where the osteon is formed

  2024cites this paper
• Molecular characterization and innate immune defense functional analysis of tartrate-resistant acid phosphatase 5 in Trachinotus ovatus

  2024cites this paper
• Lysosomal biogenesis and function in osteoclasts: a comprehensive review

  2024cites this paper
• Modulation of osteoclastogenesis by macrogeometrically designed hydrophilic dual acid-etched titanium surfaces

  2024cites this paper
• Osteoclasts control endochondral ossification via regulating acetyl-CoA availability

  2024cites this paper
• Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice

  2024cites this paper
• Tartrate resistant acid phosphatases and osteodystrophy in chronic renal failure as related to oxidative stress: - tartrate resistant acid phosphatase is a proxidant

  2023cites this paper
• Ulmus macrocarpa Hance trunk bark extracts inhibit RANKL-induced osteoclast differentiation and prevent ovariectomy-induced osteoporosis in mice.

  2023cites this paper
• Effects of acupotomy on the activity of osteoclasts and osteoblasts in the subchondral bone of rabbits with early and mid-stage knee osteoarthritis models

  2023cites this paper
• Aussagekraft von Prokollagen Typ I aminoterminales Propeptid (P1NP) als Knochenaufbaumarker

  2023cites this paper
• Sesamin inhibits RANKL‐induced osteoclastogenesis and attenuates LPS‐induced osteolysis via suppression of ERK and NF‐κB signalling pathways

  2023cites this paper
• Mechanisms of bone resorption.

  2022cites this paper
• Impact of Sr2+ and hypoxia on 3D triple cultures of primary human osteoblasts, osteocytes and osteoclasts.

  2022cites this paper
• Crocus sativus L. Petal Extract Inhibits Inflammation and Osteoclastogenesis in RAW 264.7 Cell Model

  2022cites this paper
• SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway

  2022cites this paper
• Current use of bone turnover markers in the management of osteoporosis.

  2022cites this paper
• Monocytes, Macrophages and Joint Inflammation in Osteoarthritis

  2021cites this paper
• Introduction of a Cys360Tyr Mutation in ANO5 Creates a Mouse Model for Gnathodiaphyseal Dysplasia

  2021cites this paper
• Practical Considerations for the Clinical Application of Bone Turnover Markers in Osteoporosis

  2021cites this paper
• The Osteocyte as the New Discovery of Therapeutic Options in Rare Bone Diseases

  2020cites this paper
• Advances and prospects on acid phosphatase biosensor.

  2020cites this paper
• Characterisation of ACP5 missense mutations encoding tartrate-resistant acid phosphatase associated with spondyloenchondrodysplasia

  2020influential citation
• Bone: Functions, Structure and Physiology

  2020cites this paper
• The Role of Cathepsins in the Growth of Primary and Secondary Neoplasia in the Bone

  2020cites this paper
• Creating In Vitro Three-Dimensional Tumor Models: A Guide for the Biofabrication of a Primary Osteosarcoma Model

  2020cites this paper
• “Take My Bone Away?” Hypoxia and bone: A narrative review

  2020cites this paper
• Osteoclasts’ Ability to Generate Trenches Rather Than Pits Depends on High Levels of Active Cathepsin K and Efficient Clearance of Resorption Products

  2020cites this paper
• A Novel Sandwich ELISA for Tartrate-Resistant Acid Phosphatase 5a and 5b Protein Reveals that Both Isoforms are Secreted by Differentiating Osteoclasts and Correlate to the Type I Collagen Degradation Marker CTX-I In Vivo and In Vitro

  2019influential citation
• [Research progress in the mechanism of protein factors in regulating bone remodeling].

  2019cites this paper
• Ameloblastin attenuates RANKL‐mediated osteoclastogenesis by suppressing activation of nuclear factor of activated T‐cell cytoplasmic 1 (NFATc1)

  2018cites this paper
• Simulated Inflammation by Hypochlorous Acid and the Corrosion and Tribocorrosion of Orthopedic Alloys: Feedback between Corrosion and Inflammation

  2018cites this paper
• 73-deoxychondropsin A : a novel inhibitor of bone resorption sourced from a Great Barrier Reef sponge

  2018cites this paper
• Influence of weight gain on the modulation of wound healing following tooth extraction.

  2018cites this paper
• RANKL release from self-assembling nanofiber hydrogels for inducing osteoclastogenesis in vitro.

  2017cites this paper
• Ketogenic Diet Compromises Both Cancellous and Cortical Bone Mass in Mice

  2017cites this paper
• Metabolic properties of the osteoclast.

  2017cites this paper
• Biochemical Effects of Quercetin on MMP-2, BAP and TRAP 5b During Orthodontic Retention Period

  2017cites this paper
• Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

  2017cites this paper
• Berberine alleviates oxidative stress in rats with osteoporosis through receptor activator of NF-kB/receptor activator of NF-kB ligand/osteoprotegerin (RANK/RANKL/OPG) pathway.

  2017cites this paper
• Osteoclasts: Essentials and Methods

  2017cites this paper
• TARTRATE-RESISTANT ACID PHOSPHATASE / ACP 5 AS A DRIVER OF CANCER : DISSECTION OF ITS ONCOGENIC MECHANISMS AND IDENTIFICATION OF SMALL MOLECULE INHIBITORS

  2017cites this paper
• Monocytes/Macrophages Upregulate the Hyaluronidase HYAL1 and Adapt Its Subcellular Trafficking to Promote Extracellular Residency upon Differentiation into Osteoclasts

  2016cites this paper
• From disease to treatment: from rare skeletal disorders to treatments for osteoporosis

  2016cites this paper
• Sinusoidal electromagnetic fields promote bone formation and inhibit bone resorption in rat femoral tissues in vitro

  2016cites this paper
• Osteoporosis during the hormonal therapy of prostate cancer and markers of bone tissue remodeling

  2016cites this paper
• Oxidative Stress, Inflammation, and the Corrosion of Metallic Biomaterials: Corrosion Causes Biology and Biology Causes Corrosion

  2016cites this paper
• Alexidine dihydrochloride and Thonzonium bromide: Novel Modulators of Osteoclast Formation & Function

  2016cites this paper
• Osteoporosis, Mineral Metabolism and Arthritis

  2016cites this paper
• Osteoclasts and Remodeling Based Bone Formation.

  2016cites this paper
• Role of odanacatib in reducing bone loss due to endodontic disease: An overview

  2016influential citation
• Hypoxic regulation of osteoclast differentiation and bone resorption activity

  2015cites this paper
• Perspectives on osteoporosis therapies

  2015cites this paper
• The role of osteoclasts in osteoarthritis - tissue-dependent phenotypes and inhibition

  2015cites this paper
• Novel therapies for osteoporosis.

  2015cites this paper
• VU Research Portal Functional differences between site-specific osteoclasts

  2015cites this paper
• The effect of cathepsin K inhibitor on osteoclastic activity compared to alendronate and enamel matrix protein.

  2015cites this paper
• Drynaria total flavonoids decrease cathepsin K expression in ovariectomized rats.

  2014cites this paper
• Down-Regulation of Acid and Alkaline Phosphatases Induced After Prolonged Diclofenac Use in Experimental Mouse Bone

  2014cites this paper
• Reprint of: The Great Beauty of the osteoclast.

  2014cites this paper
• New therapeutics for osteoporosis.

  2014cites this paper
• Tartrate-resistant acid phosphatase (TRAP) co-localizes with receptor activator of NF-KB ligand (RANKL) and osteoprotegerin (OPG) in lysosomal-associated membrane protein 1 (LAMP1)-positive vesicles in rat osteoblasts and osteocytes

  2014cites this paper
• Mirkka Hirvonen VESICULAR TRAFFICKING IN OSTEOCLASTS

  2014influential citation
• Expression, characterization, and evaluation of a RANK-binding single chain fraction variable: an osteoclast targeting drug delivery strategy.

  2014cites this paper
• Implications of Osteoblast-Osteoclast Interactions in the Management of Osteoporosis by Antiresorptive Agents Denosumab and Odanacatib

  2014cites this paper
• Increased Tartrate-Resistant Acid Phosphatase Expression in Osteoblasts and Osteocytes in Experimental Osteoporosis in Rats

  2014cites this paper
• News on biomarkers in CKD-MBD.

  2014cites this paper
• Bone toxicity of persistent organic pollutants

  2014cites this paper
• Osteoclastic Bone Resorption Trafficking Pathway That Is Required for Rab3D Regulates a Novel Vesicular

  2014cites this paper
• The Great Beauty of the osteoclast.

  2014cites this paper
• Effect of Early Life Vitamin D Supplementation on Bone Development

  2013cites this paper
• Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

  2013cites this paper
• Odanacatib in postmenopausal women with low bone mineral density: a review of current clinical evidence

  2013cites this paper
• Novel perspectives on the transcytotic route in osteoclasts

  2013cites this paper
• Characterization of bone mineral-resembling biomaterials for optimizing human osteoclast differentiation and resorption.

  2013cites this paper
• Molecular mechanisms implicated in bone resorption

  2013cites this paper
• Antibody mediated “Universal” Osteoclast targeting platform

  2013cites this paper
• Potential role of odanacatib in the treatment of osteoporosis

  2012cites this paper
• Therapeutic inhibition of cathepsin K-reducing bone resorption while maintaining bone formation.

  2012cites this paper
• Potential role of odanacatib in the treatment of osteoporosis

  2012cites this paper
• A Molecular Description of Acid Phosphatase

  2012cites this paper
• Altered Bone Resorption In Type 1 And Type 2 Diabetes

  2012cites this paper
• Effect of estrogen and dietary loading on condylar cartilage.

  2012cites this paper
• Rab13 Is Upregulated During Osteoclast Differentiation and Associates with Small Vesicles Revealing Polarized Distribution in Resorbing Cells

  2012cites this paper
• Fluorescence imaging of osteoclasts using confocal microscopy.

  2012cites this paper
• Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption.

  2012cites this paper
• Immune and Inflammatory Pathways are Involved in Inherent Bone Marrow Ossification

  2012cites this paper
• Significance and regulation of CD68 expression in the osteoclast

  2011cites this paper
• Applications and performance of monoclonal antibodies to human tartrate resistant acid phosphatase.

  2011cites this paper
• Methods in Bone Biology in Animals: Biochemical Markers

  2011cites this paper
• Antibody-Mediated “Universal” Osteoclast Targeting Platform using Calcitonin as a Model Drug

  2011cites this paper
• New and emerging antiresorptive treatments in osteoporosis.

  2011cites this paper
• The regulation of osteoclast function and bone resorption by small GTPases

  2011cites this paper
• Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices--a simple method for identifying polarized osteoclasts.

  2011cites this paper
• The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking.

  2011cites this paper
• Measurement by vertical scanning profilometry of resorption volume and lacunae depth caused by osteoclasts on dentine slices

  2011cites this paper
• Biogenesis of tartrate-resistant acid phosphatase isoforms 5a and 5b in stably transfected MDA-MB-231 breast cancer epithelial cells.

  2010cites this paper