Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1993-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.90.16.7568PMID 8356058PMCID PMC47183
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins.

  1993cited by this paper
• Association between GTPase activators for Rho and Ras families

  1992cited by this paper
• Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

  1992cited by this paper
• Microfilament assembly modulates phospholipase C-mediated signal transduction by the TCR/CD3 in murine T helper lymphocytes.

  1992cited by this paper
• The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

  1992cited by this paper
• Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins.

  1992cited by this paper
• Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.

  1992cited by this paper
• A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs.

  1992cited by this paper
• Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus.

  1992cited by this paper
• Lymphocyte adhesion can be regulated by cytoskeleton-associated, PMA-induced capping of surface receptors.

  1992cited by this paper
• Antigen-receptor complex stimulation triggers protein kinase C- dependent CD11a/CD18-cytoskeleton association in T lymphocytes

  1992cited by this paper
• Interleukin-2 promoter activation in T-cells expressing activated Ha-ras.

  1992cited by this paper
• p21ras mediates control of IL‐2 gene promoter function in T cell activation.

  1992cited by this paper
• The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

  1992cited by this paper
• Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

  1991cited by this paper
• Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

  1991cited by this paper
• Regulation of binding of rhoB p20 to membranes by its specific regulatory protein, GDP dissociation inhibitor.

  1991cited by this paper
• Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.

  1991cited by this paper
• Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP.

  1991cited by this paper
• Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1.

  1991cited by this paper
• Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes.

  1991cited by this paper
• Stimulation of p21ras upon T-cell activation

  1990cited by this paper
• Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation.

  1990cited by this paper
• Identification of a nucleotide exchange-promoting activity for p21ras.

  1990cited by this paper
• The GTPase superfamily: a conserved switch for diverse cell functions

  1990cited by this paper
• The cellular functions of small GTP-binding proteins.

  1990cited by this paper
• Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein

  1990cited by this paper
• A cytosolic protein catalyzes the release of GDP from p21ras.

  1990cited by this paper
• Purification of a factor capable of stimulating the guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small molecular mass G proteins.

  1990cited by this paper
• Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

  1990cited by this paper
• Application for PCR technology to subtractive cDNA cloning: identification of genes expressed specifically in murine plasmacytoma cells.

  1990cited by this paper
• Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.

  1990cited by this paper
• rac, a novel ras-related family of proteins that are botulinum toxin substrates.

  1989cited by this paper
• The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

  1989cited by this paper
• Contingent genetic regulatory events in T lymphocyte activation.

  1989cited by this paper
• Molecular cloning : a laboratory manual. Cold Spring Harbor, NY

  1989cited by this paper
• Characterization and expression of the human rhoH12 gene product

  1989cited by this paper
• Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

  1988cited by this paper
• Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

  1988cited by this paper
• Molecular cloning and characterization of the human dbl proto‐oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

  1988cited by this paper
• A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants.

  1987cited by this paper
• Nucleotide sequence of human rho cDNA clone 12.

  1987cited by this paper
• The ras-related YPT1 gene product in yeast: a GTP-binding protein that might be involved in microtubule organization.

  1986cited by this paper
• The structure of an antigenic determinant in a protein.

  1984cited by this paper
• Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

  1983cited by this paper

• Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice

  2025cites this paper
• Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma

  2024cites this paper
• Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness

  2023cites this paper
• The Dual Function of RhoGDI2 in Immunity and Cancer

  2023cites this paper
• Rho-GDP-dissociation inhibitor-γ negatively regulates NF-κB signaling by promoting the degradation of TAK1 in miiuy croaker (Miichthys miiuy).

  2022cites this paper
• RhoGDI2 induced malignant phenotypes of pancreatic cancer cells via regulating Snail expression

  2022cites this paper
• RhoGDI2-Mediated Rac1 Recruitment to Filamin A Enhances Rac1 Activity and Promotes Invasive Abilities of Gastric Cancer Cells

  2022cites this paper
• RhoA: a dubious molecule in cardiac pathophysiology

  2021cites this paper
• A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases

  2021cites this paper
• Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions

  2021cites this paper
• Molecular subversion of Cdc42 signalling in cancer

  2021cites this paper
• CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2

  2021cites this paper
• Underappreciated roles for Rho GDP Dissociation Inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell.

  2021cites this paper
• MicroRNA Regulation of the Small Rho GTPase Regulators—Complexities and Opportunities in Targeting Cancer Metastasis

  2020cites this paper
• When Actin is Not Actin’ Like It Should: A New Category of Distinct Primary Immunodeficiency Disorders

  2020cites this paper
• A Review on the Function and Regulation of ARHGDIB/RhoGDI2 Expression Including the Hypothetical Role of ARHGDIB/RhoGDI2 Autoantibodies in Kidney Transplantation

  2020cites this paper
• Cullin 3/KCTD5 Promotes the Ubiqutination of Rho Guanine Nucleotide Dissociation Inhibitor 1 and Regulates Its Stability

  2020cites this paper
• Peer Review #3 of "Protein expression profile changes of lung tissue in patients with pulmonary hypertension (v0.2)"

  2020cites this paper
• Antibodies Against ARHGDIB and ARHGDIB Gene Expression Associate With Kidney Allograft Outcome

  2020cites this paper
• Protein expression profile changes of lung tissue in patients with pulmonary hypertension

  2020cites this paper
• Effect of the Rho GTPase inhibitor-1 on the entry of dengue serotype 2 virus into EAhy926 cells

  2020cites this paper
• Rho GDP-Dissociation Inhibitor 2 Inhibits C-X-C Chemokine Receptor Type 4-Mediated Acute Lymphoblastic Leukemia Cell Migration

  2020influential citation
• NFκB2 p52 stabilizes rhogdiβ mRNA by inhibiting AUF1 protein degradation via a miR‐145/Sp1/USP8‐dependent axis

  2019cites this paper
• A Method Based on Differential Entropy-Like Function for Detecting Differentially Expressed Genes Across Multiple Conditions in RNA-Seq Studies

  2019cites this paper
• Regulation of Rho GTPases by RhoGDIs in Human Cancers

  2019cites this paper
• In silico interaction analysis of cannabinoid receptor interacting protein 1b (CRIP1b) - CB1 cannabinoid receptor.

  2017cites this paper
• Quantitative Shotgun Proteomics Unveils Candidate Novel Esophageal Adenocarcinoma (EAC)-specific Proteins *

  2017cites this paper
• A Transcriptomic Comparison of Two Bambara Groundnut Landraces under Dehydration Stress

  2017cites this paper
• Rho GDP dissociation inhibitor-β in renal cell carcinoma.

  2017cites this paper
• Apoptosis-independent cleavage of RhoGDIβ at Asp19 during PMA-stimulated differentiation of THP-1 cells to macrophages

  2017cites this paper
• EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1

  2017cites this paper
• Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells

  2016cites this paper
• Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα

  2016cites this paper
• Caractérisation de ARHGAP19, une nouvelle GAP de Rho impliquée dans la mitose des Lymphocytes T

  2016cites this paper
• Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis

  2015cites this paper
• Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs

  2015cites this paper
• Triple negative breast cancer: a multi-omics network discovery strategy for candidate targets and driving pathways.

  2015cites this paper
• LB-ARHGDIB-1R as a novel minor histocompatibility antigen for therapeutic application

  2015cites this paper
• Caractérisation de Fam65b, un nouvel inhibiteur de RhoA, impliqué dans la réponse des lymphocytes T en aval de CCR7

  2015cites this paper
• Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma.

  2015cites this paper
• Autoantibodies specific to D4GDI modulate Rho GTPase mediated cytoskeleton remodeling and induce autophagy in T lymphocytes.

  2015cites this paper
• RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach cancer

  2014cites this paper
• Mechanisms of RhoGDI2 Mediated Lung Cancer Epithelial-Mesenchymal Transition Suppression

  2014cites this paper
• RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer

  2014influential citation
• Functional study of popx2 phosphatase in breast cancer metastasis

  2014cites this paper
• RhoGDI2 Is Expressed in Human Trophoblasts and Involved in Their Migration by Inhibiting the Activation of RAC11

  2014cites this paper
• VEGF‐C mediates RhoGDI2‐induced gastric cancer cell metastasis and cisplatin resistance

  2014cites this paper
• Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia/lymphoma

  2014cites this paper
• Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma.

  2014cites this paper
• Classical Rho Proteins: Biochemistry of Molecular Switch Function and Regulation

  2014cites this paper
• RhoGDI2 Expression in Astrocytes After an Excitotoxic Lesion in the Mouse Hippocampus

  2014cites this paper
• Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II‐induced cardiac fibrosis in vitro

  2014cites this paper
• Strategies to identify novel therapeutic targets for oesophageal adenocarcinoma

  2014cites this paper
• Reduced expression of Rho GDP dissociation inhibitor 2 mRNA is associated with lymph node metastasis in gastric carcinoma

  2013cites this paper
• Loss of RhoGDI is a novel independent prognostic factor in hepatocellular carcinoma.

  2013cites this paper
• FERM Domain Containing Protein 7 Interacts with the Rho GDP Dissociation Inhibitor and Specifically Activates Rac1 Signaling

  2013cites this paper
• Regulation of Neural Stem Cell Differentiation by Transcription Factors HNF4-1 and MAZ-1

  2013cites this paper
• The faces and friends of RhoGDI2

  2012cites this paper
• Effect of Akt1 phosphorylation on RhoC GTPase activity in inflammatory breast cancer

  2012cites this paper
• Analysis of the role of RhoGDI1 and isoprenylation in the degradation of RhoGTPases.

  2012cites this paper
• Proteomics-based strategy to delineate the molecular mechanisms of RhoGDI2-induced metastasis and drug resistance in gastric cancer.

  2012cites this paper
• 642 VEGF-C Mediates RhoGDI2-induced Gastric Cancer Cell Metastasis and Cisplatin Resistance

  2012cites this paper
• Differential proteomic analysis of HL60 cells treated with secalonic acid F reveals caspase 3-induced cleavage of Rho GDP dissociation inhibitor 2.

  2012cites this paper
• Centrosomal localization of RhoGDIβ and its relevance to mitotic processes in cancer cells

  2012cites this paper
• PKCα phosphorylation of RhoGDI2 at Ser 31 disrupts interactions with Rac1 and decreases GDI activity

  2012cites this paper
• Concordance and interaction of guanine nucleotide dissociation inhibitor (RhoGDI) with RhoA in oogenesis and early development of the sea urchin

  2011cites this paper
• PLCγ is required for RhoGDI2-mediated cisplatin resistance in gastric cancer.

  2011cites this paper
• RhoGDI2 confers gastric cancer cells resistance against cisplatin-induced apoptosis by upregulation of Bcl-2 expression.

  2011cites this paper
• Association of D4-GDI expression with breast cancer progression

  2011cites this paper
• Overexpression of RhoGDI2 Correlates with Tumor Progression and Poor Prognosis in Colorectal Carcinoma

  2011cites this paper
• Regulation of small GTPases at epithelial cell-cell junctions

  2011cites this paper
• The 'invisible hand': regulation of RHO GTPases by RHOGDIs

  2011cites this paper
• Molecular Analysis of Regulation of Macrophage Fcγ Receptor Function: Implications for Tumor Immunotherapy

  2011cites this paper
• LyGDI, a Novel SHIP-Interacting Protein, Is a Negative Regulator of FcγR-Mediated Phagocytosis

  2011cites this paper
• Aus der Abteilung Nephrologie und Rheumatologie

  2011cites this paper
• Tyrosine kinase modulation of trafficking and biological functions of the atypical Rho GTPase, Wrch-1

  2010cites this paper
• Expression profile of RhoGDI2 in lung cancers and role of RhoGDI2 in lung cancer metastasis.

  2010cites this paper
• RhoGDI2 as a therapeutic target in cancer

  2010cites this paper
• Proteomic analysis of host responses to Marek's disease virus infection in spleens of genetically resistant and susceptible chickens.

  2010cites this paper
• Identification of novel therapeutic approaches and targets for the treatment of ovarian carcinoma

  2010cites this paper
• Differential Proteomic Analysis of Lymphocytes Treated With Mycophenolic Acid Reveals Caspase 3-Induced Cleavage of Rho GDP Dissociation Inhibitor 2

  2009cites this paper
• The RhoGDI-alpha/JNK signaling pathway plays a significant role in mycophenolic acid-induced apoptosis in an insulin-secreting cell line.

  2009cites this paper
• RhoGDIβ-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK

  2009cites this paper
• CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex

  2009cites this paper
• Prediction of Differentiation-ralated Pathways Induced by Rho-GDI γ ∗

  2009cites this paper
• RhoGDI2 Expression Is Associated with Tumor Growth and Malignant Progression of Gastric Cancer

  2009cites this paper
• Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function

  2009cites this paper
• Inflammation and behavior following irradiation-induced injury in the developing brain

  2009cites this paper
• IRRADIATION-INDUCED INJURY IN THE DEVELOPING BRAIN

  2009cites this paper
• Silencing of D4-GDI Inhibits Growth and Invasive Behavior in MDA-MB-231 Cells by Activation of Rac-dependent p38 and JNK Signaling

  2009cites this paper
• Mutated D4-guanine diphosphate-dissociation inhibitor is found in human leukemic cells and promotes leukemic cell invasion.

  2008cites this paper
• Proteomics Analysis Identifies Molecular Targets Related to Diabetes Mellitus-associated Bladder Dysfunction *S

  2008cites this paper
• Transcriptional Profiling of Native Inner Medullary Collecting Duct Cells from Rat Kidney

  2008cites this paper
• Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53

  2008cites this paper
• Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival.

  2008cites this paper
• Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer.

  2008cites this paper
• Manipulation of isoprenoid biosynthesis in mevalonate kinase deficiency

  2008cites this paper
• Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI).

  2008cites this paper
• Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells.

  2007cites this paper
• Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis.

  2007cites this paper