The ProDom database of protein domain families: more emphasis on 3D

C. Bru,E. Courcelle,S. Carrère,Yoann Beausse,Sandrine Dalmar,D. Kahn

Published 2004 in Nucleic Acids Res.

ABSTRACT

ProDom is a comprehensive database of protein domain families generated from the global comparison of all available protein sequences. Recent improvements include the use of three-dimensional (3D) information from the SCOP database; a completely redesigned web interface (http://www.toulouse.inra.fr/prodom.html); visualization of ProDom domains on 3D structures; coupling of ProDom analysis with the Geno3D homology modelling server; Bayesian inference of evolutionary scenarios for ProDom families. In addition, we have developed ProDom-SG, a ProDom-based server dedicated to the selection of candidate proteins for structural genomics.

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