Lipoprotein(a) and inflammation: A dangerous duet leading to endothelial loss of integrity

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Pharmacological Research

• Publication date

  2017-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.phrs.2017.02.001PMID 28185944
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ENDOTHELIAL DYSFUNCTION: A CARDIOVASCULAR RISK FACTOR

  2018cited by this paper
• Oxidized phospholipids and lipoprotein-associated phospholipase A2 as important determinants of Lp(a) functionality and pathophysiological role

  2018cited by this paper
• Oxidized Phospholipids, Lipoprotein(a), and Progression of Calci fi c Aortic Valve Stenosis

  2017cited by this paper
• Effects of a nutraceutical combination on lipids, inflammation and endothelial integrity in patients with subclinical inflammation: a randomized clinical trial

  2016cited by this paper
• Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis.

  2016cited by this paper
• Inflammation-inducing Factors of Mycoplasma pneumoniae

  2016cited by this paper
• Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis

  2016cited by this paper
• Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials

  2016cited by this paper
• Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology.

  2016cited by this paper
• Future Directions to Establish Lipoprotein(a) as a Treatment for Atherosclerotic Cardiovascular Disease

  2016cited by this paper
• Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans

  2016cited by this paper
• Endothelial Dysfunction in Rheumatoid Arthritis: Mechanistic Insights and Correlation with Circulating Markers of Systemic Inflammation

  2016cited by this paper
• Lipoprotein (a), an independent cardiovascular risk marker

  2016cited by this paper
• High lipoprotein(a) concentrations are associated with impaired endothelial function in children.

  2015cited by this paper
• Expression of vascular cell adhesion molecule-1 in the aortic tissues of atherosclerotic patients and the associated clinical implications

  2015cited by this paper
• Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.

  2015cited by this paper
• IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans[S]

  2015cited by this paper
• Evaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X

  2015cited by this paper
• Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-/-) Mice.

  2015cited by this paper
• Irbesartan attenuates TNF-α-induced ICAM-1, VCAM-1, and E-selectin expression through suppression of NF-κB pathway in HUVECs.

  2015cited by this paper
• Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.

  2015cited by this paper
• Systemic inflammation and imbalance between endothelial injury and repair in patients with psoriasis are associated with preclinical atherosclerosis

  2015cited by this paper
• Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

  2015cited by this paper
• Correlation of Inflammation and Lipoprotein (a) with Hypercoagulability in Hemodialysis Patients

  2015cited by this paper
• Tibolone decreases Lipoprotein(a) levels in postmenopausal women: A systematic review and meta-analysis of 12 studies with 1009 patients.

  2015cited by this paper
• Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve

  2015cited by this paper
• Interleukin-10 overexpression improves the function of endothelial progenitor cells stimulated with TNF-α through the activation of the STAT3 signaling pathway.

  2015cited by this paper
• Lipoprotein(a) hyperlipidemia as cardiovascular risk factor: pathophysiological aspects

  2015cited by this paper
• Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population.

  2014cited by this paper
• Lp(a)/apo(a) modulate MMP-9 activation and neutrophil cytokines in vivo in inflammation to regulate leukocyte recruitment.

  2014influential reference
• Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials.

  2014cited by this paper
• Lysosomal acid lipase deficiency: diagnosis and treatment of Wolman and Cholesteryl Ester Storage Diseases.

  2014cited by this paper
• Lipoprotein (a): Structure, Pathophysiology and Clinical Implications

  2014cited by this paper
• Higher serum uric acid and lipoprotein(a) are correlated with coronary spasm

  2014cited by this paper
• Effects of anti‐TNF‐α agents on circulating endothelial‐derived and platelet‐derived microparticles in psoriasis

  2014cited by this paper
• Role of tumour necrosis factor receptor-1 and nuclear factor-κB in production of TNF-α-induced pro-inflammatory microparticles in endothelial cells

  2014cited by this paper
• Endothelial Dysfunction in Chronic Inflammatory Diseases

  2014cited by this paper
• Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies

  2014cited by this paper
• Genetic associations with valvular calcification and aortic stenosis.

  2013cited by this paper
• Lipoprotein(a) inhibits EPCs neovascularization of hindlimb ischemia tissues in rabbit

  2013cited by this paper
• MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma

  2013cited by this paper
• Serum levels of lipoprotein(a) and E-selectin are reduced in rheumatoid arthritis patients treated with methotrexate or methotrexate in combination with TNF-α-inhibitor.

  2013cited by this paper
• Oxidized Lipoprotein(a) Increases Endothelial Cell Monolayer Permeability via ROS Generation

  2013cited by this paper
• The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.

  2013cited by this paper
• Apolipoprotein (a) Impairs Endothelial Progenitor Cell-Mediated Angiogenesis

  2013cited by this paper
• Endothelial Dysfunction, But Not Structural Atherosclerosis, Is Evident Early in Children With Heterozygous Familial Hypercholesterolemia

  2013cited by this paper
• An evolving new paradigm: endothelial cells – conditional innate immune cells

  2013cited by this paper
• Biological properties of bone marrow-derived early and late endothelial progenitor cells in different culture media.

  2013influential reference
• Apolipoprotein(a) stimulates nuclear translocation of β-catenin: a novel pathogenic mechanism for lipoprotein(a)

  2013cited by this paper
• Serum lipid profile in psoriatic patients: correlation between vascular adhesion protein 1 and lipoprotein (a)

  2013cited by this paper
• High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation.

  2013cited by this paper
• Imbalance between endothelial injury and repair in patients with polymyalgia rheumatica: improvement with corticosteroid treatment

  2012influential reference
• Endothelial function improves within 6 weeks of treatment with methotrexate or methotrexate in combination with a TNF-α inhibitor in rheumatoid arthritis patients

  2012cited by this paper
• Inhibition of Lp(a)-induced functional impairment of endothelial cells and endothelial progenitor cells by hepatocyte growth factor.

  2012cited by this paper
• Role of Phospholipid Oxidation Products in Atherosclerosis

  2012cited by this paper
• Circulating CD62E+ Microparticles and Cardiovascular Outcomes

  2012cited by this paper
• The Many Faces of Endothelial Microparticles

  2011cited by this paper
• The structural biology of Toll-like receptors.

  2011cited by this paper
• Effects of tumour necrosis factor‐alpha on activity and nitric oxide synthase of endothelial progenitor cells from peripheral blood

  2011cited by this paper
• Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events.

  2011cited by this paper
• Distinct phenotypes and regenerative potentials of early endothelial progenitor cells and outgrowth endothelial progenitor cells derived from umbilical cord blood

  2011influential reference
• Lipoprotein (a) as an acute phase reactant in patients on chronic hemodialysis.

  2010cited by this paper
• Long-Term Anti-TNF-α Treatments Reverse the Endothelial Dysfunction in Rheumatoid Arthritis: The Biological Coherence between Synovial and Endothelial Inflammation

  2010cited by this paper
• Lipoprotein(a), inflammation, and peripheral arterial disease in a community-based sample of older men and women (the InCHIANTI study).

  2010cited by this paper
• Lipoprotein(a) as a cardiovascular risk factor: current status

  2010cited by this paper
• Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia.

  2009cited by this paper
• Influence of Short-term Rosuvastatin Therapy on Endothelial Progenitor Cells and Endothelial Function

  2009cited by this paper
• Genetically elevated lipoprotein(a) and increased risk of myocardial infarction.

  2009cited by this paper
• MEKK3 is required for lysophosphatidic acid-induced NF-kappaB activation.

  2009cited by this paper
• CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

  2009cited by this paper
• p38 mitogen‐activated protein kinase targets the production of proinflammatory endothelial microparticles

  2009cited by this paper
• The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity

  2008cited by this paper
• Infliximab improves vascular stiffness in patients with rheumatoid arthritis

  2008cited by this paper
• Apolipoprotein(a), through Its Strong Lysine-binding Site in KIV10, Mediates Increased Endothelial Cell Contraction and Permeability via a Rho/Rho Kinase/MYPT1-dependent Pathway*

  2008cited by this paper
• High levels of inflammatory biomarkers are associated with increased allele-specific apolipoprotein(a) levels in African-Americans.

  2008cited by this paper
• Human endothelial impairment in sepsis.

  2008cited by this paper
• Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

  2008cited by this paper
• Endothelial progenitor cells in patients with essential hypertension

  2007cited by this paper
• Response to anti-tumour necrosis factor alpha blockade is associated with reduction of carotid intima-media thickness in patients with active rheumatoid arthritis.

  2007cited by this paper
• Dyslipidemia inhibits Toll-like receptor–induced activation of CD8α-negative dendritic cells and protective Th1 type immunity

  2007cited by this paper
• Oxidized Phospholipids, Lipoprotein(a), Lipoprotein-Associated Phospholipase A2 Activity, and 10-Year Cardiovascular Outcomes: Prospective Results From the Bruneck Study

  2007cited by this paper
• Prognostic value of elevated white blood cell count in hypertension.

  2007cited by this paper
• Reduced number of circulating endothelial progenitors and HOXA9 expression in CD34+ cells of hypertensive patients

  2007cited by this paper
• Lipoproteins in inflammation and sepsis. II. Clinical aspects

  2006cited by this paper
• Stat3 Mediates Interelukin-6 Inhibition of Human Endothelial Nitric-oxide Synthase Expression*

  2006cited by this paper
• Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression.

  2006cited by this paper
• Increased Ratio of CD31+/CD42− Microparticles to Endothelial Progenitors as a Novel Marker of Atherosclerosis in Hypercholesterolemia

  2006cited by this paper
• Lipoprotein(a), lipids and proinflammatory cytokines in patients undergoing major abdominal surgery

  2006cited by this paper
• Inflammatory markers and long-term risk of ischemic heart disease in men A 13-year follow-up of the Quebec Cardiovascular Study.

  2005cited by this paper
• Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis: serum levels and relationship to inflammation

  2005cited by this paper
• NF-κB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program

  2005cited by this paper
• Endothelial Dysfunction: Cardiovascular Risk Factors, Therapy, and Outcome

  2005cited by this paper
• The inflammation: lipoprotein cycle.

  2005cited by this paper
• Does statin monotherapy address the multiple lipid abnormalities in type 2 diabetes?

  2005cited by this paper
• Lipoprotein(a): biology and clinical importance.

  2004cited by this paper
• Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung.

  2004cited by this paper
• Interleukin-6 Induces Oxidative Stress and Endothelial Dysfunction by Overexpression of the Angiotensin II Type 1 Receptor

  2004cited by this paper
• Reduced PAF-acetylhydrolase activity associated with Lp(a) in patients with coronary artery disease.

  2004cited by this paper
• High lipoprotein(a) levels and small apolipoprotein(a) sizes are associated with endothelial dysfunction in a multiethnic cohort.

  2004cited by this paper
• Attenuation of inflammation with short-term dietary intervention is associated with a reduction of arterial stiffness in subjects with hypercholesterolaemia

  2004cited by this paper

• Presumed Mechanisms Underlying Lipoprotein(a)-caused Atherosclerosis

  2026cites this paper
• Predictive value of combined MHR and Lp(a) for in-stent restenosis in coronary heart disease patients: a study based on GEE model

  2026cites this paper
• Serum lipoprotein(a) and risk of contrast-induced nephropathy in patients with type 2 diabetes mellitus

  2026cites this paper
• Association of Coronary Microvascular Dysfunction with Lipoprotein (a) levels in Patients with Non-Obstructive Coronary Artery Disease.

  2026cites this paper
• Association of metabolic score for visceral fat with the prevalence, new-onset, and progression of aortic valve calcification: evidence from a prospective observational study and genetic analyses

  2025cites this paper
• The Lipoprotein(a) rs3798220 and rs10455872 polymorphisms and coronary heart disease: a meta-analysis of 55,647 participants.

  2025cites this paper
• Lipoprotein(a) levels predict endothelial dysfunction in maintenance hemodialysis patients: evidence from vascular reactivity index assessment

  2025cites this paper
• The complex interplay of lipoprotein(a) and cancer in the era of emerging therapeutics.

  2025cites this paper
• Lipoprotein(a) and Blood Monocytes as Factors for Progression of Carotid Atherosclerosis in Patients with Premature Coronary Heart Disease

  2025cites this paper
• Lipoprotein (a) in the Development and Progression of Diabetic Retinopathy: A Systematic Review and Meta-Analysis

  2025influential citation
• The Association of Lipoprotein(a) with Major Adverse Cardiovascular Events after Acute Myocardial Infarction: A Meta-Analysis of Cohort Studies

  2025cites this paper
• siRNA‐based therapeutics for lipoprotein (a) lowering: A path toward precision cardiovascular medicine

  2025cites this paper
• Lipoprotein(a) as a Risk Factor for Recurrent Ischemic Stroke in Type 2 Diabetes

  2025cites this paper
• PCSK‐9 Inhibitors Can Significantly Improve the Coronary Slow Flow Caused by Elevated Lipoprotein (a) in ST‐Elevation Myocardial Infarction Patients With Chronic Kidney Disease

  2025cites this paper
• Atherogenic index of plasma as a novel predictor for acute kidney injury and disease severity in acute pancreatitis: a retrospective cohort study

  2025cites this paper
• The relevance of endoplasmic reticulum lumen and Anoctamin-8 for major depression: Results from a systems biology study.

  2025cites this paper
• Impact of Elevated Lipoprotein A on Major Adverse Cardiovascular Events and the Role of Traditional Risk Factors in Patients Undergoing Percutaneous Coronary Intervention

  2025cites this paper
• Evidence for a causal link between lipoprotein (a) and mental disorders: A retrospective and Mendelian randomization study.

  2025cites this paper
• The nonlinear association between lipoprotein(a) and major adverse cardiovascular events in acute coronary syndrome patients with three-vessel disease

  2025cites this paper
• Expression of Monocytes Subsets in Patients Diagnosed With Coronary Artery Atherosclerosis and Their Impact on Disease Severity

  2024cites this paper
• Impact of elevated lipoprotein(a) levels on the functional outcomes of ischemic stroke patients: A systematic review and meta‐analysis

  2024cites this paper
• Lipoprotein(a) among normotensive patients and risk of incident hypertension

  2024cites this paper
• Lipoprotein (a)-Related Inflammatory Imbalance: A Novel Horizon for the Development of Atherosclerosis

  2024influential citation
• Extracellular vesicles and endothelial dysfunction in infectious diseases

  2024cites this paper
• High lipoprotein(a) concentration is associated with moyamoya disease

  2024cites this paper
• Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values

  2024cites this paper
• Spring Meeting of the Young Researchers of SID, SIIA, SIMI, SIPREC, SISA

  2023cites this paper
• Circulating lipoprotein (a) and all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis

  2023cites this paper
• Lipoprotein(a) Does Not Predict Thrombotic Events and In-Hospital Outcomes in Patients with COVID-19

  2023cites this paper
• Porphyromonas gingivalis regulates atherosclerosis through an immune pathway

  2023cites this paper
• The ins and outs of lipoprotein(a) assay methods

  2023cites this paper
• Case report: lipoprotein apheresis reduces the risk of cardiovascular events and prolongs pregnancy in a woman with severely elevated lipoprotein(a), cardiovascular disease, and a high risk of preeclampsia

  2023cites this paper
• Bibliometric research on analysis of links between periodontitis and cardiovascular diseases

  2023cites this paper
• Lipoprotein(a) is a new prognostic factor in patients with psoriasis and coronary artery disease: a retrospective cohort study

  2023cites this paper
• Predictors of functional and morphological arterial wall properties in coronary artery disease patients with increased lipoprotein (a) levels before and after treatment with proprotein convertase subtilisin-kexin type 9 inhibitors

  2023cites this paper
• Study on the relationship between lipoprotein (a) and diabetic kidney disease.

  2022cites this paper
• Increased estimated remnant-like particle cholesterol is associated with impaired coronary collateralization in patients with coronary chronic total occlusions

  2022cites this paper
• Role of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis

  2022cites this paper
• High lipoprotein(a) levels predict severity of coronary artery disease in patients hospitalized for acute myocardial infarction. Data from the French RICO survey.

  2022cites this paper
• Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

  2022cites this paper
• Gout and risk of venous thromboembolism: A systematic review and meta‐analysis of cohort studies

  2022cites this paper
• Association Between Uric Acid, Carotid Intima‐Media Thickness, and Cardiovascular Events: Prospective Results From the IMPROVE Study

  2021cites this paper
• Lipoprotein(a) Where Do We Stand? From the Physiopathology to Innovative Terapy

  2021cites this paper
• Variability In Non-HDL-C and Lp(a) Affect The Neutrophil To Lymphocyte Ratio In Patients Undergoing Elective Percutaneous Coronary Intervention

  2021cites this paper
• Lipoprotein(a)—The Crossroads of Atherosclerosis, Atherothrombosis and Inflammation

  2021cites this paper
• The Association of Lipoprotein(a) and Circulating Monocyte Subsets with Severe Coronary Atherosclerosis

  2021cites this paper
• The lipid paradox in neuroprogressive disorders: Causes and consequences.

  2021cites this paper
• The effect of baicalin on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Haemophilus parasuis

  2020cites this paper
• Why patients with familial hypercholesterolemia are at high cardiovascular risk? Beyond LDL-C levels.

  2020cites this paper
• Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk

  2020cites this paper
• Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule

  2020cites this paper
• Serum lipoprotein(a) and risk of mortality in patients on peritoneal dialysis.

  2020cites this paper
• Familial hypercholesterolemia and elevated lipoprotein(a): double heritable risk and new therapeutic opportunities

  2020cites this paper
• Impact of flaxseed supplementation on plasma lipoprotein(a) concentrations: A systematic review and meta‐analysis of randomized controlled trials

  2020cites this paper
• Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner

  2020cites this paper
• Usefulness of Lipoprotein (a) for Predicting Outcomes after Percutaneous Coronary Intervention for Stable Angina Pectoris in Patients on Hemodialysis.

  2020cites this paper
• Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Pathways Associated With Clinical Outcome in Hepatocellular Carcinoma

  2020cites this paper
• The cholesterol-lowering effect of unripe Rubus coreanus is associated with decreased oxidized LDL and apolipoprotein B levels in subjects with borderline-high cholesterol levels: a randomized controlled trial

  2020cites this paper
• Blocking protein phosphatase 2A with a peptide protects mice against bleomycin-induced pulmonary fibrosis

  2020cites this paper
• Effect of Statin Therapy on Arterial Wall Inflammation Based on 18F-FDG PET/CT: A Systematic Review and Meta-Analysis of Interventional Studies

  2019cites this paper
• Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction.

  2019cites this paper
• Impact of Lipoprotein(a) on Long-Term (Mean 6.2 Years) Outcomes in Patients With Three-Vessel Coronary Artery Disease.

  2019cites this paper
• Cross-Talk between Lipoproteins and Inflammation: The Role of Microvesicles

  2019cites this paper
• Impact of phytosterol supplementation on plasma lipoprotein(a) and free fatty acid (FFA) concentrations: A systematic review and meta-analysis of randomized controlled trials.

  2019cites this paper
• Hyperlipoprotein(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project.

  2019cites this paper
• Dietary natural products as emerging lipoprotein(a)‐lowering agents

  2019cites this paper
• Lipoprotein(a): A missing culprit in the management of athero‐thrombosis?

  2018cites this paper
• Effect of Ezetimibe Monotherapy on Plasma Lipoprotein(a) Concentrations in Patients with Primary Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  2018cites this paper
• Impact of ezetimibe on plasma lipoprotein(a) concentrations as monotherapy or in combination with statins: a systematic review and meta-analysis of randomized controlled trials

  2018cites this paper
• Association of Plasma Lipoprotein(a) With Long-Term Adverse Events in Patients With Chronic Kidney Disease Who Underwent Percutaneous Coronary Intervention.

  2018cites this paper
• Present therapeutic role of cholesteryl ester transfer protein inhibitors

  2018cites this paper
• Effect of Rosuvastatin on Cholesterol Efflux Capacity and Endothelial Function in Type 2 Diabetes Mellitus and Dyslipidemia.

  2017cites this paper
• Effect of soy isoflavone supplementation on plasma lipoprotein(a) concentrations: A meta-analysis.

  2017cites this paper
• Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial.

  2017cites this paper