Behavioral pharmacology of buprenorphine, with a focus on preclinical models of reward and addiction

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Psychopharmacology

• Publication date

  2002-03-06

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/s00213-002-1003-8PMID 11967625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dopaminergic neurons: Effect of acute and chronic morphine administration on single cell activity and transmitter metabolism

  2005cited by this paper
• Environmental modification of tolerance to morphine discriminative stimulus properties in rats

  2005cited by this paper
• Effects of buprenorphine on self-administration of cocaine and a nondrug reinforcer in rats

  2005cited by this paper
• Interactions between mu and kappa opioid agonists in the rat drug discrimination procedure

  2005cited by this paper
• Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine

  2004cited by this paper
• Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

  2004cited by this paper
• Kappa antagonist properties of buprenorphine in non-tolerant and morphine-tolerant rats

  2004cited by this paper
• A comparison of the stimulus effects of codeine in rhesus monkeys under the contingencies of a two lever discrimination task and a cross self-administration paradigm: tests of generalization to pentazocine, buprenorphine, tilidine, and different doses of codeine

  2004cited by this paper
• Trends in drug discrimination research analysed with a cross-indexed bibliography, 1984–1987

  2004cited by this paper
• HS‐599: a novel long acting opioid analgesic does not induce place‐preference in rats

  2001cited by this paper
• The role of withdrawal in heroin addiction: enhances reward or promotes avoidance?

  2001cited by this paper
• Methoclocinnamox: time course of changes in alfentanil-reinforced responding in rhesus monkeys

  2000cited by this paper
• Blockade of behavioral sensitization by MK-801: fact or artifact?

  2000cited by this paper
• Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

  2000cited by this paper
• Are NMDA receptors involved in opiate-induced neural and behavioral plasticity?

  2000cited by this paper
• Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor.

  2000cited by this paper
• Conditioned place preference: what does it add to our preclinical understanding of drug reward?

  2000cited by this paper
• Sensitization to the morphine-like discriminative stimulus effects of buprenorphine in rats.

  2000cited by this paper
• Effects of buprenorphine on motility in morphine post-dependent rats.

  1999cited by this paper
• Assessment of opioid partial agonist activity with a three-choice hydromorphone dose-discrimination procedure.

  1999cited by this paper
• Opioids, reward and addiction: An encounter of biology, psychology, and medicine.

  1999cited by this paper
• Effect of gonadectomy on discriminative stimulus effects of morphine in female versus male rats.

  1999cited by this paper
• Agonistic effect of buprenorphine in a nociceptin/OFQ receptor-triggered reporter gene assay.

  1999cited by this paper
• Sensitivity to the discriminative stimulus and antinociceptive effects of mu opioids: role of strain of rat, stimulus intensity, and intrinsic efficacy at the mu opioid receptor.

  1999cited by this paper
• The mu opioid irreversible antagonist beta-funaltrexamine differentiates the discriminative stimulus effects of opioids with high and low efficacy at the mu opioid receptor.

  1998cited by this paper
• Drug discrimination in neurobiology.

  1998cited by this paper
• The effects of buprenorphine on self-administration of cocaine and heroin "speedball" combinations and heroin alone by rhesus monkeys.

  1998cited by this paper
• The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants.

  1998cited by this paper
• Does the noncompetitive NMDA receptor antagonist dizocilpine (MK801) really block behavioural sensitization associated with repeated drug administration? .

  1998cited by this paper
• Drug addiction as a physical disease: the role of physical dependence and other chronic drug-induced neurophysiological changes in compulsive drug self-administration.

  1998cited by this paper
• Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues.

  1998cited by this paper
• Abuse liability of buprenorphine--a study among experienced drug users.

  1998cited by this paper
• Motivational properties of buprenorphine as assessed by place and taste conditioning in rats

  1997cited by this paper
• The Neurobiology of Addiction

  1997cited by this paper
• Discriminative stimulus effects of l-alpha-acetylmethadol (LAAM), buprenorphine and methadone in morphine-treated rhesus monkeys.

  1997cited by this paper
• A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants.

  1997cited by this paper
• Discriminative stimulus effects of buprenorphine in the rat

  1997cited by this paper
• A protocol to switch high-dose, methadone-maintained subjects to buprenorphine.

  1997cited by this paper
• Discriminative stimulus effects of opioids in pigeons trained to discriminate fentanyl, bremazocine and water: evidence of pharmacological selectivity.

  1997cited by this paper
• Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists.

  1997cited by this paper
• Effects of kappa opioids on cocaine self-administration by rhesus monkeys.

  1997cited by this paper
• Effects of methadone or buprenorphine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans.

  1996cited by this paper
• Addictive drugs and brain stimulation reward.

  1996cited by this paper
• Effects of buprenorphine on behaviour maintained by heroin and alfentanil in rhesus monkeys.

  1996cited by this paper
• Neurobiology of addiction.

  1996cited by this paper
• Sensitization to the conditioned rewarding effects of morphine: pharmacology and temporal characteristics.

  1996cited by this paper
• kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.

  1996cited by this paper
• Respiratory effects of opioid full and partial agonists in rhesus monkeys.

  1996cited by this paper
• Combined effects of buprenorphine and a nondrug alternative reinforcer on IV cocaine self-administration in rats maintained under FR schedules

  1996cited by this paper
• The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity

  1995cited by this paper
• Buprenorphine antagonism of mu opioids in the rhesus monkey tail-withdrawal procedure.

  1995cited by this paper
• Buprenorphine treatment of opioid dependence: A review.

  1995cited by this paper
• The effects of chronic morphine on the generalization of buprenorphine stimulus control: an assessment of kappa antagonist activity.

  1995cited by this paper
• Interaction of buprenorphine with cocaine-morphine combinations.

  1995cited by this paper
• Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics.

  1995cited by this paper
• Buprenorphine-induced alterations of cocaine's reinforcing effects in rhesus monkey: a dose-response analysis.

  1995cited by this paper
• Drug discrimination: no evidence for tolerance to opiates.

  1995cited by this paper
• Acute administration of buprenorphine in humans: partial agonist and blockade effects.

  1995cited by this paper
• Buprenorphine: combatting drug abuse with a unique opioid

  1995cited by this paper
• Kappa agonist and antagonist properties of mixed action opioids in a pigeon drug discrimination procedure.

  1994cited by this paper
• In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats.

  1994cited by this paper
• Phencyclidine (PCP) self-administration and withdrawal in rhesus monkeys: effects of buprenorphine and dizocilpine (MK-801) pretreatment.

  1994cited by this paper
• Effects of buprenorphine on the self‐administration of cocaine by humans

  1994cited by this paper
• Comparison of buprenorphine and methadone in the treatment of opioid dependence.

  1994cited by this paper
• Molecular and cellular mechanisms of opiate action: studies in the rat locus coeruleus.

  1994cited by this paper
• Drug discrimination assessment of agonist-antagonist opioids in humans: a three-choice saline-hydromorphone-butorphanol procedure.

  1994cited by this paper
• Buprenorphine: duration of blockade of effects of intramuscular hydromorphone.

  1994cited by this paper
• Interactions of opioids with caffeine: evaluation by ambulatory activity in mice

  1994cited by this paper
• Effects of morphine, naloxone, buprenorphine, butorphanol, haloperidol and imipramine on morphine withdrawal signs in cynomolgus monkeys

  1994cited by this paper
• Dissociation of buprenorphine-induced locomotor sensitization and conditioned place preference in rats.

  1994cited by this paper
• Effects of concurrent saccharin availability and buprenorphine pretreatment on demand for smoked cocaine base in rhesus monkeys

  1994cited by this paper
• Sensitization and tolerance to the discriminative stimulus effects of mu-opioid agonists

  1994cited by this paper
• Buprenorphine and morphine produce equivalent increases in extracellular single unit activity of dopamine neurons in the ventral tegrnental area in vivo

  1994cited by this paper
• Clinical pharmacology of buprenorphine: Ceiling effects at high doses

  1994cited by this paper
• Buprenorphine prevents and reverses the expression of chronic etorphine-induced sensitization of adenylyl cyclase in SK-N-SH human neuroblastoma cells.

  1993cited by this paper
• Naltrexone–Buprenorphine Interactions: Effects on Cocaine Self-Administration

  1993cited by this paper
• Tolerance and sensitization to the behavioral effects of drugs.

  1993cited by this paper
• Incentive-sensitization As The Basis Of Drug Craving

  1993cited by this paper
• Buprenorphine and cocaine effects on social behavior of monkeys.

  1993cited by this paper
• Agonist and antagonist effects of mixed action opioids in the pigeon drug discrimination procedure: influence of training dose, intrinsic efficacy and interanimal differences.

  1993cited by this paper
• Effects of intermittent buprenorphine administration on cocaine self-administration by rhesus monkeys.

  1993cited by this paper
• Discriminative-stimulus effects of the low efficacy mu agonist nalbuphine.

  1993cited by this paper
• Subjective and physiologie effects of intravenous buprenorphine in humans

  1993cited by this paper
• The neural basis of drug craving: an incentive-sensitization theory of addiction.

  1993cited by this paper
• Buprenorphine: dose-related effects on cocaine and opioid use in cocaine-abusing opioid-dependent humans.

  1993cited by this paper
• Buprenorphine as a stimulus in drug discrimination learning: an assessment of mu and kappa receptor activity.

  1993cited by this paper
• Consumption of buprenorphine and other drugs among heroin addicts under ambulatory treatment: results from cross-sectional studies in 1988 and 1990.

  1993cited by this paper
• Psychomotor-stimulant sensitization: a unitary phenomenon?

  1993cited by this paper
• Effects of buprenorphine on motility in chronically morphine treated rats.

  1993cited by this paper
• Acute effects of buprenorphine, hydromorphone and naloxone in methadone-maintained volunteers.

  1992cited by this paper
• Buprenorphine's effects on self-administration of smoked cocaine base and orally delivered phencyclidine, ethanol and saccharin in rhesus monkeys.

  1992cited by this paper
• Assessment and management of opioid withdrawal symptoms in buprenorphine-dependent subjects.

  1992cited by this paper
• The effects of chronic buprenorphine treatment on cocaine and food self-administration by rhesus monkeys.

  1992cited by this paper
• Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids.

  1992cited by this paper
• Opioids excite dopamine neurons by hyperpolarization of local interneurons

  1992cited by this paper
• Behavioral pharmacology of buprenorphine: issues relevant to its potential in treating drug abuse.

  1992cited by this paper
• Buprenorphine attenuates the effects of cocaine on adrenocorticotropin (ACTH) secretion and mood states in man.

  1992cited by this paper
• A controlled trial of buprenorphine treatment for opioid dependence.

  1992cited by this paper
• Effects of buprenorphine and other opioid agonists and antagonists on alfentanil- and cocaine-reinforced responding in rhesus monkeys.

  1992cited by this paper
• The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.

  1992cited by this paper

• Primary Mucosal Routes of Opioid Administration for Treating Terminal Cancer Pain: Rectal, Buccal, and Intranasal Delivery

  2026cites this paper
• Systematic review of real-world data associated with opioid scheduling and nonmedical use.

  2026cites this paper
• The Effectiveness and Safety of Buprenorphine in Palliative Care: A systematic review of randomized controlled trials, prospective and retrospective studies.

  2025cites this paper
• Stability Indicating Analytical Method Development and Validation for the Simultaneous Determination of Degradation Impurities of Buprenorphine and Naloxone in Combination Pharmaceutical Dosage Form by RP-HPLC

  2025cites this paper
• Buprenorphine Pharmacodynamics: A Bridge to Understanding Buprenorphine Clinical Benefits

  2025cites this paper
• Clinical Therapy Dose Optimization of Sublingual Buprenorphine in Poorly Adherent Pregnant Patients: A PBPK Translational Modelling Study

  2024cites this paper
• Insurmountable antagonism of human mu opioid receptors by buprenorphine is due to hemi-equilibrium.

  2024cites this paper
• Continuing Chronic Buprenorphine Perioperatively is Associated With Reduced Postoperative Opioid Use.

  2022cites this paper
• Abuse liability, antinociceptive, and discriminative stimulus properties of IBNtxA

  2020cites this paper
• Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.

  2020cites this paper
• Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.

  2020cites this paper
• Buprenorphine buccal film for chronic pain management.

  2020cites this paper
• Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression

  2019cites this paper
• Approach to buprenorphine use for opioid withdrawal treatment in the emergency setting

  2019cites this paper
• Stammesspezifische Unterschiede in der analgetischen Wirkung von Buprenorphin bei der Maus

  2018influential citation
• Essential pharmacologic options for acute pain management in the emergency setting

  2018cites this paper
• 2 Animal Models of Drug Addiction

  2018influential citation
• Route Evaluation and Analytical HPLC Method Development of Buprenorphine, Naloxone, and Comparison Overall Efficiency of Naltrexone Nalbuphine Traces the Evolution of Various Approaches

  2018cites this paper
• Naltrexone- or Nalmefene-Related Buprenorphine Withdrawal: Treat It With… More Buprenorphine.

  2017cites this paper
• Methadone versus buprenorphine-naloxone as a treatment for opiod dependent individuals

  2017cites this paper
• Editor’s Highlight: Neurorespiratory Effects of Buprenorphine and Ethanol in Combination A Mechanistic Study of Drug–Drug Interactions in the Rat

  2017cites this paper
• Existing and Future Drugs for the Treatment of the Dark Side of Addiction.

  2016cites this paper
• Benzodiazepines increase the reward effects of buprenorphine in a conditioned place preference test in the mouse

  2014cites this paper
• Buprenorphine: Side Effects and Tolerability

  2013cites this paper
• Buprenorphine in the treatment of non-suicidal self-injury: a case series and discussion of the literature

  2013cites this paper
• Opioid addiction and abuse in primary care practice: a comparison of methadone and buprenorphine as treatment options.

  2012cites this paper
• Agents in Development for the Management of Cocaine Abuse

  2012cites this paper
• Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives.

  2012cites this paper
• Animal Models of Drug Addiction

  2012influential citation
• Animal Models in Addiction Research

  2012cites this paper
• Analytical Method Development and Validation for the Simultaneous Estimation of Buprenorphine Hydrochloride and Naloxone Hydrochloride in Pharmaceutical Dosage Forms By RP-HPLC

  2011cites this paper
• Transdermal Buprenorphine for Oropharyngeal Mucositis-Associated Pain in Patients Treated with Radiotherapy for Head and Neck Cancer

  2010cites this paper
• Transdermal Buprenorphine for Central Neuropathic Pain: Clinical Reports

  2010cites this paper
• Buprenorphine Is a Weak Partial Agonist That Inhibits Opioid Receptor Desensitization

  2009cites this paper
• Long-Acting Opioid-Agonists in the Treatment of Heroin Addiction: Why Should We Call Them “Substitution”?

  2009cites this paper
• Novel transdermal delivery of Timolol maleate using sugar esters: preclinical and clinical studies.

  2009cites this paper
• The role of transdermal buprenorphine in the treatment of cancer pain: an expert panel consensus

  2009cites this paper
• Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions.

  2009cites this paper
• Development of pharmacotherapies for drug addiction: a Rosetta Stone approach

  2009cites this paper
• Long-Acting Opioid-Agonists in the Treatment of Heroin Addiction: Why Should We Call Them "Substitution"?

  2009cites this paper
• Anxiolytic-like effects of morphine and buprenorphine in the rat model of fear-potentiated startle: tolerance, cross-tolerance, and blockade by naloxone

  2008cites this paper
• Effects of chronic buprenorphine treatment on levels of nucleus accumbens glutamate and on the expression of cocaine-induced behavioral sensitization in rats

  2008cites this paper
• A Case of Dependence on the Combination Use of Sublingual Buprenorphine, Scopolamine, and Promethazine

  2008cites this paper
• Abuse of Buprenorphine in the United States

  2007cites this paper
• Pharmacological Treatment of Substance Abuse in Correctional Facilities: Prospects and Barriers to Expanding Access to Evidence-Based Therapy

  2007cites this paper
• Dépendance au cannabis chez l'adolescent en rupture de formation

  2007cites this paper
• The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference.

  2007cites this paper
• REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

  2007cites this paper
• Chronic buprenorphine reduces the response to sucrose-associated cues in non food-deprived rats.

  2007cites this paper
• Blockade of morphine‐induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments

  2007cites this paper
• Simultaneous determination of thienorphine and its active metabolite thienorphine glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies.

  2007cites this paper
• Public health behind bars

  2007cites this paper
• The effects of long-term chronic buprenorphine treatment on the locomotor and nucleus accumbens dopamine response to acute heroin and cocaine in rats.

  2006cites this paper
• Development of tolerance and sensitization to different opioid agonists in rats

  2006cites this paper
• Impaired decision-making in opiate-dependent subjects: effect of pharmacological therapies.

  2006cites this paper
• Interactions of buprenorphine and dipotassium clorazepate on anxiety and memory functions in the mouse.

  2006cites this paper
• Reversibility of opioid receptor occupancy of buprenorphine in vivo.

  2006cites this paper
• Effect of acute and subchronic administration of desipramine and venlafaxine on abuse liability of heroin in rats

  2006cites this paper
• Transdermal buprenorphine in the management of persistent pain – safety aspects

  2006cites this paper
• Smoking Cessation With Varenicline, a Selective α4β2 Nicotinic Receptor Partial Agonist: Results From a 7-Week, Randomized, Placebo- and Bupropion-Controlled Trial With 1-Year Follow-up

  2006cites this paper
• Smoking cessation with varenicline, a selective alpha4beta2 nicotinic receptor partial agonist: results from a 7-week, randomized, placebo- and bupropion-controlled trial with 1-year follow-up.

  2006cites this paper
• Smoking Cessation With Varenicline, a Selective ±422 Nicotinic Receptor Partial Agonist: Results From a 7-Week, Randomized, Placebo- and Bupropion-Controlled Trial With 1-Year Follow-up

  2006cites this paper
• A highly selective κ-opioid receptor agonist with low addictive potential and dependence liability

  2006cites this paper
• Unlimited Access to Heroin Self-Administration: Independent Motivational Markers of Opiate Dependence

  2006cites this paper
• Simultaneous determination of buprenorphine and its prodrug, buprenorphine propionate, by high-performance liquid chromatography with fluorescence detection: application to pharmacokinetic studies in rabbits.

  2005cites this paper
• Buprenorphine and a CRF1 Antagonist Block the Acquisition of Opiate Withdrawal-Induced Conditioned Place Aversion in Rats

  2005cites this paper
• Discriminative Stimulus Effects of Acute Morphine Followed by Naltrexone in the Squirrel Monkey: A Further Characterization

  2005cites this paper
• Rats Maintained Chronically on Buprenorphine Show Reduced Heroin and Cocaine Seeking in Tests of Extinction and Drug-Induced Reinstatement

  2005influential citation
• Condiciones de prescripción y financiación de la buprenorfina-Subutex® según la autorización de comercialización en España de 2000 a 2004

  2005cites this paper
• Research Note — Review of Corrections-Based Therapy for Opiate-Dependent Patients: Implications for Buprenorphine Treatment among Correctional Populations

  2004cites this paper
• Buprenorphine in the treatment of opioid dependence.

  2004cites this paper
• Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations

  2004cites this paper
• beta-Phenylethylamines and the isoquinoline alkaloids.

  2004cites this paper
• Medicines and the drug control treaties: is buprenorphine for opioid addiction at risk of being lost?

  2004cites this paper
• The use of polymers for dermal and transdermal delivery.

  2004cites this paper
• Sex differences in opioid-induced enhancement of contact hypersensitivity.

  2003cites this paper
• Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey

  2003cites this paper
• Buprenorphine-Induced Antinociception Is Mediated by μ-Opioid Receptors and Compromised by Concomitant Activation of Opioid Receptor-Like Receptors

  2003cites this paper
• We are IntechOpen, the world’s leading publisher of Open Access books Built by scientists, for scientists

  year unknowncites this paper