Vitamin C and thiamine in critical illness.

A. S. Spoelstra-de Man,H. O. Oudemans-van Straaten,P. Elbers

Published 2019 in BJA Education

ABSTRACT

Pau UM arti during critical illness because of increased requirements, decreased intake, reduced recycling and increased urinary excretion. Both vitamins have multiple key metabolic functions and act synergistically. Vitamin C has important antioxidant, antiinflammatory, and immune-modulating effects, and is an essential cofactor for monoand dioxygenase enzymes. Thiamine is crucial for cellular energy meta-

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