Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  JACC: Cardiovascular Interventions

• Publication date

  2010-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jcin.2009.10.025PMID 20170881
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Coronary microvascular dysfunction.

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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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