Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2018. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.

• Publication year

  2018

• Venue

  Critical Care

• Publication date

  2018-03-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/s13054-018-1996-yPMID 29558975PMCID 5861638
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Efficacy and safety of vitamin C for atrial fibrillation after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials.

  2017cited by this paper
• Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before‐After Study

  2017cited by this paper
• Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock

  2016cited by this paper
• Dehydroascorbic Acid Attenuates Ischemic Brain Edema and Neurotoxicity in Cerebral Ischemia: An in vivo Study

  2015cited by this paper
• The effect of intravenous vitamin C infusion on periprocedural myocardial injury for patients undergoing elective percutaneous coronary intervention.

  2014cited by this paper
• EuReCa ONE - ONE month - ONE Europe - ONE goal.

  2014cited by this paper
• Combination of intravenous ascorbic acid administration and hypothermia after resuscitation improves myocardial function and survival in a ventricular fibrillation cardiac arrest model in the rat.

  2014cited by this paper
• High-protein enteral nutrition enriched with immune-modulating nutrients vs standard high-protein enteral nutrition and nosocomial infections in the ICU: a randomized clinical trial.

  2014cited by this paper
• Vitamin C Compromises Cardiac Resuscitability in a Rat Model of Ventricular Fibrillation

  2014cited by this paper
• Vitamin C revisited

  2014cited by this paper
• Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

  2014cited by this paper
• Reanimatie buiten het ziekenhuis in Noord-Holland en Twente: resultaten ARREST-onderzoek over 2006-2011

  2012cited by this paper
• Combined intravenous treatment with ascorbic acid and desferrioxamine to reduce myocardial reperfusion injury in an experimental model resembling the clinical setting of primary PCI.

  2012cited by this paper
• Ascorbic acid mitigates the myocardial injury after cardiac arrest and electrical shock

  2011cited by this paper
• Ascorbic acid and N-acetyl cysteine prevent uncoupling of nitric oxide synthase and increase tolerance to ischemia/reperfusion injury in diabetic rat heart

  2011cited by this paper
• Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.

  2011cited by this paper
• Postresuscitation syndrome: Potential role of hydroxyl radical-induced endothelial cell damage*

  2011cited by this paper
• Vitamin C and percutaneous coronary intervention.

  2010cited by this paper
• Influence of vitamin C on markers of oxidative stress in the earliest period of ischemic stroke

  2010cited by this paper
• Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers.

  2010cited by this paper
• Effect of intravenous administration of antioxidants alone and in combination on myocardial reperfusion injury in an experimental pig model.

  2008cited by this paper
• Ventricular arrhythmias and antioxidative medication: experimental study.

  2008cited by this paper
• Phase I clinical trial of i.v. ascorbic acid in advanced malignancy.

  2008cited by this paper
• A Cerebroprotective Dose of Intravenous Citrate/Sorbitol-stabilized Dehydroascorbic Acid is Correlated with Increased Cerebral Ascorbic Acid and Inhibited Lipid Peroxidation after Murine Reperfused Stroke

  2006cited by this paper
• The effects of a high dose of ascorbate on ischemia-reperfusion-induced mitochondrial dysfunction in canine hearts

  2005cited by this paper
• Dehydroascorbic acid prevents oxidative cell death through a glutathione pathway in primary astrocytes

  2005cited by this paper
• Ascorbic acid and focal cerebral ischaemia in a primate model

  2005cited by this paper
• Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts.

  2004cited by this paper
• Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat.

  2004cited by this paper
• Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: a double-blinded, randomized, controlled study.

  2003cited by this paper
• Ascorbic acid dynamics in the seriously ill and injured.

  2003cited by this paper
• Attenuation of ischemic preconditioning in pigs by scavenging of free oxyradicals with ascorbic acid.

  2003cited by this paper
• Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury.

  2002cited by this paper
• Oxidative stress and cardiac microvascular structure in ischemia and reperfusion: the protective effect of antioxidant vitamins.

  2002cited by this paper
• Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

  2001cited by this paper
• Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study.

  2000cited by this paper
• Ascorbic acid is neuroprotective against global ischaemia in striatum but not hippocampus: histological and voltammetric data.

  1999cited by this paper
• Time course of free radical production after primary coronary angioplasty for acute myocardial infarction and the effect of vitamin C.

  1999cited by this paper
• Effect of Ascorbic Acid on Infarct Size in Experimental Focal Cerebral Ischaemia and Reperfusion in a Primate Model

  1998cited by this paper
• Ischemia/reperfusion‐induced arrhythmias in the isolated rat heart: Prevention by melatonin

  1998cited by this paper
• Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk.

  1996cited by this paper
• High Levels of Ascorbic Acid, Not Glutathione, in the CNS of Anoxia‐Tolerant Reptiles Contrasted with Levels in Anoxia‐Intolerant Species

  1995cited by this paper
• Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting.

  1995cited by this paper
• The Protective Effects of High-Dose Ascorbic Acid on Myocardium against Reperfusion Injury During and After Cardiopulmonary Bypass

  1994cited by this paper
• Experimental conditions determine effects of ascorbic acid on reperfusion injury: comparison of tissue damage with hemodynamic parameters in rat isolated hearts.

  1992cited by this paper
• Myocardial salvage with trolox and ascorbic acid for an acute evolving infarction.

  1989cited by this paper
• Combined treatment with vitamins E and C in experimental myocardial infarction in pigs.

  1989cited by this paper
• Effect of some free radical scavengers on reperfusion induced arrhythmias in the isolated rat heart.

  1985cited by this paper
• Free radicals in cerebral ischemia.

  1978cited by this paper

• cEEG and rEEG detection rates of prognostic indicators in cardiac arrest patients: a systematic review and diagnostic meta-analysis.

  2026cites this paper
• Association between oxidative balance score and systemic immune-inflammation index: NHANES 2003–2018

  2025cites this paper
• Possible role of vitamins C and E co-administration in the prevention of testicular ischemia–reperfusion injury following surgical repair of torsion of the testis

  2025cites this paper
• Postoperative Delirium and Vitamin C: Rethinking Unfavorable Outcomes Through the Lens of Underdosing

  2025cites this paper
• The pharmacology of vitamin C.

  2025cites this paper
• Neuroprotective effects of vitamin C on hypoxic-ischemic brain injury in neonatal mice

  2025cites this paper
• Effect of Ascorbic Acid on the Incidence of Postoperative Delirium Among Elderly Patients Undergoing Cardiovascular Surgery: A Pilot Study

  2025cites this paper
• High-dose intravenous vitamin C reduce C-reactive protein levels, fluid retention, and APACHE II scores in patients with moderately severe acute pancreatitis: a prospective, randomized, double-blinded, placebo-controlled study

  2025cites this paper
• Steroid, thiamine, and ascorbic acid during post-resuscitation period for comatose out-of-hospital cardiac arrest survivors (STAR) trial: Protocol for a clinical trial

  2025cites this paper
• Nutritional Support for Necrotizing Soft Tissue Infection Patients: From ICU to Outpatient Care

  2025cites this paper
• Traditional, complementary, and integrative medicine in the management of ischemic stroke: a narrative review

  2025cites this paper
• High-dose vitamin C: A promising anti-tumor agent, insight from mechanisms, clinical research, and challenges

  2025cites this paper
• Vitamin C reduces the loss of retinal ganglion cells in chronic glaucoma by inhibiting neuroinflammation

  2025cites this paper
• Vitamin C for all?

  2024cites this paper
• Early intravenous high-dose vitamin C in postcardiac arrest shock (VICEPAC): study protocol for a randomised, single-blind, open-label, multicentre, controlled trial

  2024cites this paper
• The Effect of Ascorbic Acid on Hepatic Ischaemia–Reperfusion Injury in Wistar Rats: An Experimental Study

  2024cites this paper
• Usefulness of Vitamin C in critically ill patients: A systematic review

  2024cites this paper
• Vitamin C Drives Reentrant Actin Phase Transition: Biphasic Exocytosis Regulation Revealed by Single-Vesicle Electrochemistry.

  2024cites this paper
• Perioperative prophylaxis of renal ischemia‑reperfusion injury

  2024cites this paper
• Preoperative and postoperative administration of vitamin C in cardiac surgery patients – settings, dosages, duration, and clinical outcomes: a narrative review

  2024influential citation
• Clinical Efficacy of Megadose Vitamin C in Sepsis: Protocol for a Multicenter Randomized Single-Blind Placebo-Controlled Clinical Trial

  2024cites this paper
• The Influence of High-Dose Parenteral Vitamin C on the Incidence and Severity of Postoperative Pulmonary Complications in Cardiac Surgery with Extracorporeal Circulation: A Randomized Controlled Trial

  2024cites this paper
• Effect of high-dose vitamin C on renal ischemia-reperfusion injury.

  2024cites this paper
• Neuroprotective and Anti-Inflammatory Activities of Hybrid Small-Molecule SA-10 in Ischemia/Reperfusion-Induced Retinal Neuronal Injury Models

  2024cites this paper
• The effect of thiamine and ascorbic acid on neurological outcomes after out-of-hospital cardiac arrest.

  2024cites this paper
• Addition of Vitamin C Does Not Decrease Neuron-Specific Enolase Levels in Adult Survivors of Cardiac Arrest—Results of a Randomized Trial

  2024cites this paper
• Impact of intravenous vitamin C as a monotherapy on mortality risk in critically ill patients: A meta-analysis of randomized controlled trials with trial sequential analysis

  2023cites this paper
• Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit

  2023cites this paper
• Effect of high-dose intravenous vitamin C therapy on the prognosis in patients with moderately severe and severe acute pancreatitis: protocol of a prospective, randomized, double-blinded, placebo-controlled study

  2023cites this paper
• Effect of adjuvant Thiamine and Ascorbic acid administration on the neurologic outcomes of out-of-hospital cardiac arrest patients: a before-and-after study.

  2023cites this paper
• Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis

  2023influential citation
• Effect of intravenous vitamin C on adult septic patients: a systematic review and meta-analysis

  2023cites this paper
• Risk of Hypovitaminosis and Vitamin C Deficiency in Pediatric Patients Undergoing Cardiopulmonary Bypass

  2023cites this paper
• Association between Plasma Ascorbic Acid Levels and Postoperative Delirium in Older Patients Undergoing Cardiovascular Surgery: A Prospective Observational Study

  2023cites this paper
• Vitamin C in critical illness: end of the story or still a place?

  2023cites this paper
• Epigenetic dysregulation of autophagy in sepsis-induced acute kidney injury: the underlying mechanisms for renoprotection

  2023cites this paper
• An update of the effects of vitamins D and C in critical illness

  2023cites this paper
• Effect of Vitamin C Infusion on Cerebral Oximetry During General Anesthesia for Carotid Endarterectomy in Diabetic Patients

  2023cites this paper
• History of scurvy and use of vitamin C in critical illness: A narrative review.

  2022cites this paper
• High-dose vitamin C on sepsis: Protocol of a prospective, multi-centered, double-blinded, randomized, and placebo-controlled superiority study

  2022cites this paper
• Pharmacological Basis for Abrogating Myocardial Reperfusion Injury Through a Multi-Target Combined Antioxidant Therapy

  2022cites this paper
• The effect of intravenous vitamin C on clinical outcomes in patients with sepsis or septic shock: A meta-analysis of randomized controlled trials

  2022cites this paper
• An Overview of Therapy Guidelines for Cardiac Arrest and the Potential Benefits of Hemoglobin-Based Oxygen Carriers

  2022cites this paper
• Sepsis and Resuscitation: The Importance of Time.

  2022cites this paper
• Perioperative micronutrients, macroscopic benefits?

  2022cites this paper
• Vitamin C Improves the Outcomes of Cardiopulmonary Resuscitation and Alters Shedding of Syndecan‐1 and p38/MAPK Phosphorylation in a Rat Model

  2022cites this paper
• Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis

  2022cites this paper
• Histopathological effects of β-hCG and vitamin C on the detorsioned testicle in rats with unilateral testicular torsion.

  2022cites this paper
• Intravenöse Vitamin-C-Gabe: 28-Tage-Ergebnis septischer Patienten verschlechtert

  2022cites this paper
• Vitamin C supplementation attenuates oxidative stress and improves erythrocyte deformability in cardiac surgery with cardiopulmonary bypass

  2022cites this paper
• NETosis in ischemic/reperfusion injuries: An organ-based review.

  2021cites this paper
• Vitamin C and kidney transplantation: Nutritional status, potential efficacy, safety, and interactions.

  2021cites this paper
• Neuroprotective Properties of Vitamin C: A Scoping Review of Pre-Clinical and Clinical Studies

  2021cites this paper
• DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury

  2021cites this paper
• Ascorbate uptake enables tubular mitophagy to prevent septic AKI by PINK1-PARK2 axis.

  2021cites this paper
• Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide–Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C

  2021cites this paper
• The efficacy of intravenous vitamin C in critically ill patients: A meta-analysis of randomized controlled trials.

  2021cites this paper
• Pharmacologic neuroprotection in ischemic brain injury after cardiac arrest

  2021cites this paper
• Engineered Biomimetic Nanoplatform Protects the Myocardium Against Ischemia/Reperfusion Injury by Inhibiting Pyroptosis.

  2021cites this paper
• Vitamin therapy in sepsis

  2021cites this paper
• The Role of Supplementation with Natural Compounds in Post-Stroke Patients

  2021cites this paper
• Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation–reduction potential measurement

  2021cites this paper
• Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

  2021cites this paper
• [Ischemia-reperfusion syndrome].

  2021cites this paper
• Joint Cardioprotective Effect of Vitamin C and Other Antioxidants against Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

  2021cites this paper
• High dose vitamin C in sepsis (HDVCIS): study protocol for a randomized controlled trial

  2021cites this paper
• Increased plasma disequilibrium between pro- and anti-oxidants during the early phase resuscitation after cardiac arrest is associated with increased levels of oxidative stress end-products

  2021cites this paper
• Study of compatibility of components of a new combined drug for treatment of alcoholic intoxication and its hepatoprotective effect on a model of alcoholic liver injury

  2021cites this paper
• Interaction of surfactants with poloxamers 338 and its effect on some properties of cream base

  2021cites this paper
• Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: a retrospective case series study.

  2020cites this paper
• The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis

  2020cites this paper
• Vitamin C supplementation in cardiopulmonary bypass: a review

  2020influential citation
• A New Perspective on Covid-19 Treatment: When a Paradigm Changes in Infectiology Become Necessary against an Emerging Virus as the SARS-Cov2

  2020cites this paper
• Novel Combination of COX-2 Inhibitor and Antioxidant Therapy for Modulating Oxidative Stress Associated with Intestinal Ischemic Reperfusion Injury and Endotoxemia

  2020cites this paper
• Power for the Sickest: Vitamin C for Vasoplegia after Cardiac Surgery.

  2020cites this paper
• DDDT_A_254150 3263..3270

  2020cites this paper
• Correction: Hill, A.; et al. Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis. Nutrients 2019, 11, 2103

  2020cites this paper
• Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial

  2020cites this paper
• High-dose vitamin C alleviates pancreatic injury via the NRF2/NQO1/HO-1 pathway in a rat model of severe acute pancreatitis.

  2020cites this paper
• Evaluation of the effect of high dose intravenous vitamin C on delayed allograft function in deceased donor kidney transplantation: a preliminary report

  2020cites this paper
• Therapeutic strategies for ischemia reperfusion injury in emergency medicine

  2020cites this paper
• Letter on Update to the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Protocol

  2020cites this paper
• In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol

  2020cites this paper
• Favorable Effects of Astaxanthin on Brain Damage due to Ischemia-Reperfusion Injury.

  2020cites this paper
• Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review

  2020cites this paper
• Nutrition in Sepsis: A Bench-to-Bedside Review

  2020cites this paper
• Hydrocortisone-Ascorbic Acid-Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock.

  2020cites this paper
• Vitamin C: a misunderstood ally?

  2020cites this paper
• Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

  2019cites this paper
• Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis

  2019cites this paper
• Efficacy of vitamin C in patients with sepsis: A updated meta-analysis.

  2019cites this paper
• Vitamin C measurement in critical illness: challenges, methodologies and quality improvements

  2019cites this paper
• Comparison of Propofol and Dexmedetomidine Sedation in Septic Shock.

  2019cites this paper
• Dosing Matters! Vitamin C in Critical Illness.

  2019cites this paper
• The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery

  2019cites this paper
• Perioperative Vitamin C and E levels in Cardiac Surgery Patients and Their Clinical Significance

  2019cites this paper
• α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury

  2019cites this paper
• Influence of Vitamin C on Antioxidant Capacity of In Vitro Perfused Porcine Kidneys

  2019cites this paper
• Potential Role of Vitamin C Intracoronary Administration in Preventing Cardiac Injury After Primary Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction

  2019cites this paper
• Reduced Plasma Ascorbic Acid Levels in Recipients of Myeloablative Conditioning & Hematopoietic Cell Transplantation

  2019cites this paper