Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Circulation Research

• Publication date

  2015-04-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.116.305374PMID 25858064
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A predictive computational framework for direct reprogramming between human cell types

  2016cited by this paper
• Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions

  2015cited by this paper
• Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes

  2015cited by this paper
• MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function.

  2015cited by this paper
• High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling

  2015cited by this paper
• Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming

  2015cited by this paper
• Stoichiometry of transcription factors is critical for cardiac reprogramming.

  2015cited by this paper
• Induced Pluripotent Stem Cells for Post–Myocardial Infarction Repair: Remarkable Opportunities and Challenges

  2014cited by this paper
• Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells

  2014cited by this paper
• The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

  2014cited by this paper
• Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.

  2014cited by this paper
• Direct reprogramming of fibroblasts into myocytes to reverse fibrosis.

  2014cited by this paper
• Chemically defined generation of human cardiomyocytes

  2014cited by this paper
• Inhibition of TGFβ Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes

  2014cited by this paper
• Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4.

  2014cited by this paper
• Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming.

  2014cited by this paper
• MiR‐133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures

  2014cited by this paper
• CellNet: network biology applied to stem cell engineering.

  2014cited by this paper
• Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

  2014cited by this paper
• Dissecting engineered cell types and enhancing cell fate conversion via CellNet.

  2014cited by this paper
• Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors

  2014cited by this paper
• Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.

  2014cited by this paper
• Direct Conversion of Adult Skin Fibroblasts to Endothelial Cells by Defined Factors

  2014cited by this paper
• Engineering Adolescence: Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes

  2014cited by this paper
• Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate Non-Human Primate Hearts

  2014cited by this paper
• Direct Reprogramming of Murine Fibroblasts to Hematopoietic Progenitor Cells

  2014cited by this paper
• Induced regeneration—the progress and promise of direct reprogramming for heart repair

  2013cited by this paper
• Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success.

  2013cited by this paper
• Direct Reprogramming of Mouse Fibroblasts into Cardiac Myocytes

  2013cited by this paper
• Hippo pathway effector Yap promotes cardiac regeneration

  2013cited by this paper
• Reprogramming of human fibroblasts toward a cardiac fate

  2013cited by this paper
• Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

  2013cited by this paper
• Deterministic direct reprogramming of somatic cells to pluripotency

  2013cited by this paper
• Nanog-dependent function of Tet1 and Tet2 in establishment of pluripotency

  2013cited by this paper
• Reprogramming paces the heart

  2013cited by this paper
• Heart repair by cardiac reprogramming

  2013cited by this paper
• Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the MyoD transactivation domain.

  2013cited by this paper
• Transcription Factors MYOCD, SRF, Mesp1 and SMARCD3 Enhance the Cardio-Inducing Effect of GATA4, TBX5, and MEF2C during Direct Cellular Reprogramming

  2013cited by this paper
• Induction of human cardiomyocyte-like cells from fibroblasts by defined factors

  2013cited by this paper
• Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

  2013cited by this paper
• Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro

  2013cited by this paper
• Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

  2013cited by this paper
• Cardiac stem cell therapy and the promise of heart regeneration.

  2013cited by this paper
• Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

  2013cited by this paper
• Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State

  2013cited by this paper
• Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts

  2013cited by this paper
• Cardiac Gene Activation Analysis in Mammalian Non-Myoblasic Cells by Nkx2-5, Tbx5, Gata4 and Myocd

  2012cited by this paper
• Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors

  2012cited by this paper
• MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

  2012cited by this paper
• MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development

  2012cited by this paper
• Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

  2012cited by this paper
• Small molecules enable highly efficient neuronal conversion of human fibroblasts

  2012cited by this paper
• Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

  2012cited by this paper
• Heart repair by reprogramming non-myocytes with cardiac transcription factors

  2012cited by this paper
• Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

  2012cited by this paper
• Myocardial Notch Signaling Reprograms Cardiomyocytes to a Conduction-Like Phenotype

  2012cited by this paper
• hESC-Derived Cardiomyocytes Electrically Couple and Suppress Arrhythmias in Injured Hearts

  2012cited by this paper
• Mammalian Heart Renewal by Preexisting Cardiomyocytes

  2012cited by this paper
• Labor pains of new technology: direct cardiac reprogramming.

  2012cited by this paper
• Critical factors for cardiac reprogramming.

  2012cited by this paper
• A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells.

  2012cited by this paper
• Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5

  2012influential reference
• An emerging strategy of gene therapy for cardiac disease.

  2012cited by this paper
• In Vivo Cardiac Cellular Reprogramming Efficacy Is Enhanced by Angiogenic Preconditioning of the Infarcted Myocardium With Vascular Endothelial Growth Factor

  2012cited by this paper
• Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18

  2012cited by this paper
• Regenerative medicine: Reprogramming the injured heart

  2012cited by this paper
• Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

  2012cited by this paper
• T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

  2012cited by this paper
• A molecular roadmap of reprogramming somatic cells into iPS cells.

  2012cited by this paper
• Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase.

  2012cited by this paper
• Induction of human neuronal cells by defined transcription factors

  2011cited by this paper
• Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.

  2011cited by this paper
• Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

  2011cited by this paper
• Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

  2011cited by this paper
• Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells.

  2011cited by this paper
• Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

  2011cited by this paper
• Abstract 10466: In Vivo Reprogramming of Murine Cardiac Fibroblasts into Induced Cardiomyocytes

  2011cited by this paper
• The Registry of the International Society for Heart and Lung Transplantation: Twenty-eighth Adult Heart Transplant Report--2011.

  2011cited by this paper
• Direct reprogramming of mouse fibroblasts to neural progenitors

  2011cited by this paper
• Direct conversion of human fibroblasts to dopaminergic neurons

  2011cited by this paper
• Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy

  2011cited by this paper
• Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

  2011cited by this paper
• MicroRNA-mediated conversion of human fibroblasts to neurons

  2011cited by this paper
• Conversion of mouse and human fibroblasts into functional spinal motor neurons.

  2011cited by this paper
• Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.

  2011cited by this paper
• Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.

  2010cited by this paper
• Structure and functions of powerful transactivators: VP16, MyoD and FoxA.

  2010cited by this paper
• Direct conversion of fibroblasts to functional neurons by defined factors

  2010cited by this paper
• Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.

  2010cited by this paper
• A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.

  2010cited by this paper
• MicroRNA regulatory networks in cardiovascular development.

  2010cited by this paper
• Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury

  2010cited by this paper
• Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.

  2010cited by this paper
• Direct conversion of human fibroblasts to multilineage blood progenitors

  2010cited by this paper
• Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.

  2009cited by this paper
• iPS cells can support full-term development of tetraploid blastocyst-complemented embryos.

  2009cited by this paper
• Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

  2009cited by this paper
• Adult mice generated from induced pluripotent stem cells

  2009cited by this paper
• iPS cells produce viable mice through tetraploid complementation

  2009cited by this paper
• A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

  2009cited by this paper

• Cellular Senescence in Heart Failure: A Review

  2026cites this paper
• Enhancing Cardiomyocyte Purity through Lactate-Based Metabolic Selection

  2025cites this paper
• Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction

  2025cites this paper
• In situ monitoring of mitochondrial redox dynamics during cardiac reprogramming using a poly-l-lysine/Matrigel-coated gold nanostructured composite platform

  2025cites this paper
• A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering

  2025cites this paper
• Drug-induced regeneration of pancreatic beta cells: An approach to cellular therapeutic targets

  2025cites this paper
• FGF4 and ascorbic acid enhance the maturation of induced cardiomyocytes by activating JAK2–STAT3 signaling

  2024cites this paper
• Basic and translational endocrinology

  2024cites this paper
• Advances in neuronal reprogramming for neurodegenerative diseases: Strategies, controversies, and opportunities.

  2024cites this paper
• Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application

  2024cites this paper
• Modifying miRs for effective reprogramming of fibroblasts to cardiomyocytes

  2024cites this paper
• Direct Reprogramming of Resident Non-Myocyte Cells and Its Potential for In Vivo Cardiac Regeneration

  2023cites this paper
• Exploring the Inner Workings of Direct Cardiac Reprogramming

  2023cites this paper
• A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present

  2023cites this paper
• Recent advances and future prospects in direct cardiac reprogramming

  2023cites this paper
• Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart—Part II: Molecular Mechanisms of Cardiac Regeneration

  2023cites this paper
• Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture

  2022cites this paper
• Engineered human cardiac tissues for modeling heart diseases

  2022cites this paper
• MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin

  2022cites this paper
• Generation and Maturation of Human iPSC-derived Cardiac Organoids in Long Term Culture

  2022cites this paper
• In vitro generation of human embryonic stem cell-derived heart organoids possessing physiological ion currents

  2022cites this paper
• Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo.

  2022cites this paper
• Myocardial Infarction: The Protective Role of MiRNAs in Myocardium Pathology

  2021cites this paper
• Direct reprogramming with Sendai virus vectors repaired infarct hearts at the chronic stage.

  2021cites this paper
• The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair

  2021cites this paper
• Signaling pathways influencing stem cell self-renewal and differentiation—Special emphasis on cardiomyocytes

  2021cites this paper
• BMI1 in the heart: Novel functions beyond tumorigenesis

  2021cites this paper
• Defining a therapeutic range for regeneration of ischemic myocardium via shock waves

  2021cites this paper
• Cardiac regeneration by direct reprogramming in this decade and beyond

  2021cites this paper
• Commentary: Cardiac cellular “time travel” to when it was bouncing

  2021cites this paper
• Bioengineering Methods in MicroRNA-Mediated Direct Reprogramming of Fibroblasts Into Cardiomyocytes

  2021cites this paper
• Mechanism-Based Cardiac Regeneration Strategies in Mammals

  2021cites this paper
• In vivo reprogramming as a new approach to cardiac regenerative therapy.

  2021cites this paper
• Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia

  2020cites this paper
• Research progress on myocardial regeneration: what is new?

  2020cites this paper
• Acellular bioscaffolds redirect cardiac fibroblasts and promote functional tissue repair in rodents and humans with myocardial injury

  2020cites this paper
• Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity

  2020cites this paper
• The lateral plate mesoderm

  2020cites this paper
• Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

  2020cites this paper
• In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix

  2020cites this paper
• Safety and efficacy of direct Cardiac Shockwave Therapy in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting (the CAST-HF trial): study protocol for a randomized controlled trial

  2020cites this paper
• Subtype‐specific cardiomyocytes for precision medicine: Where are we now?

  2020cites this paper
• Recombinant Protein IGF1-24 Stimulates Rat Cardiomyocytes Proliferation and Repairs Myocardial Injury

  2020cites this paper
• Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials

  2019cites this paper
• Unique Transcription Factor Functions Regulate Epigenetic and Transcriptional Dynamics During Cardiac Reprogramming

  2019cites this paper
• Design Approaches for Generating Organ Constructs.

  2019cites this paper
• La investigación con células troncales y la creatividad científica

  2019cites this paper
• Key Regulators of Cardiovascular Differentiation and Regeneration: Harnessing the Potential of Direct Reprogramming to Treat Heart Failure.

  2019cites this paper
• Cardiac Pacemaker Cells Generate Cardiomyocytes from Fibroblasts in Long-Term Cultures

  2019cites this paper
• Direct Cardiac Reprogramming　― Converting Cardiac Fibroblasts to Cardiomyocytes ―

  2019cites this paper
• Multicellularity in the Cardiovascular System

  2019cites this paper
• The therapeutic potential of induced hepatocyte-like cells generated by direct reprogramming on hepatic fibrosis

  2019cites this paper
• Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

  2019cites this paper
• Direct Reprogramming to Vascular Cells: A Mini-Review

  2018cites this paper
• Advances in Functional Restoration of the Lacrimal Glands.

  2018cites this paper
• In vivo reprogramming: A new approach for tissue repair in chronic diseases

  2018cites this paper
• Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.

  2018cites this paper
• Deriving Cardiomyocytes from Human Amniocytes

  2018cites this paper
• Ca diac Injury After Myocardial Infarctio : Effect of

  2018cites this paper
• Autophagic Regulation of Cardiomyocyte Survival and Heart Regeneration

  2018cites this paper
• Therapeutic approaches for cardiac regeneration and repair

  2018cites this paper
• Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling

  2018cites this paper
• Cardiac Regenerative Strategies for Advanced Heart Failure

  2018cites this paper
• High content analysis identifies unique morphological features of reprogrammed cardiomyocytes

  2018cites this paper
• Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction.

  2018influential citation
• Regenerating the Cardiovascular System Through Cell Reprogramming; Current Approaches and a Look Into the Future

  2018cites this paper
• Direct Cardiac Reprogramming: A Novel Approach for Heart Regeneration

  2018cites this paper
• On the Problem of Cardiogenic Differentiation: Extracellular Matrix as an Emerging Clue

  2017cites this paper
• In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology.

  2017cites this paper
• Regenerating the human heart: direct reprogramming strategies and their current limitations

  2017cites this paper
• In vivo reprogramming for heart regeneration: A glance at efficiency, environmental impacts, challenges and future directions.

  2017cites this paper
• Discovery and progress of direct cardiac reprogramming

  2017cites this paper
• Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming

  2017cites this paper
• Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo

  2017cites this paper
• Global position paper on cardiovascular regenerative medicine

  2017cites this paper
• Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity

  2017cites this paper
• Less may be more: Using small molecules to reprogram human cells into functional cardiomyocytes.

  2017cites this paper
• Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression

  2017cites this paper
• Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells

  2017cites this paper
• Generation of induced cardiac progenitor cells via somatic reprogramming

  2017cites this paper
• Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro

  2017cites this paper
• One-Step piggyBac Transposon-Based CRISPR/Cas9 Activation of Multiple Genes

  2017cites this paper
• Boosters and barriers for direct cardiac reprogramming

  2017cites this paper
• Pathophysiology and therapeutic potential of cardiac fibrosis

  2017cites this paper
• Engineering cardiac stem cells for the treatment of the damaged heart

  2017cites this paper
• Recent Advances in Hypertrophic Cardiomyopathy: A System Review

  2017cites this paper
• Functional analysis of cardiomyocytes carrying mutations in SCN5A gene

  2017cites this paper
• Three-Dimensional and Biomimetic Technology in Cardiac Injury After Myocardial Infarction: Effect of Acellular Devices on Ventricular Function and Cardiac Remodelling

  2017cites this paper
• Cell Reprogramming for Cardiac Regeneration and Rare Disease Modeling

  2017cites this paper
• Gene position affects protein expression in a 2A polycistronic vector system

  2017cites this paper
• Direct Cardiac Cellular Reprogramming for Cardiac Regeneration

  2016cites this paper
• In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells.

  2016cites this paper
• Mitochondrial resetting and metabolic reprogramming in induced pluripotent stem cells and mitochondrial disease modeling.

  2016cites this paper
• Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations

  2016cites this paper
• Mending a Faltering Heart.

  2016cites this paper
• Heart regeneration for clinical application update 2016: from induced pluripotent stem cells to direct cardiac reprogramming

  2016cites this paper
• Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

  2016cites this paper
• A chemical approach to myocardial protection and regeneration.

  2016cites this paper
• Gaining myocytes or losing fibroblasts: Challenges in cardiac fibroblast reprogramming for infarct repair.

  2016cites this paper
• Spatiotemporal regulation of enhancers during cardiogenesis

  2016cites this paper