A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Genes & Development

• Publication date

  1998-06-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1101/GAD.12.12.1787PMID 9637681PMCID PMC316901
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Biology of Steroid and Nuclear Hormone Receptors

  2012cited by this paper
• Nuclear receptor coactivators.

  2000cited by this paper
• Modulation of Steroid/Nuclear Receptor Dimerization and DNA Binding by Ligands

  1998cited by this paper
• Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase.

  1997cited by this paper
• Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

  1997influential reference
• RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.

  1997influential reference
• TRAM-1, A Novel 160-kDa Thyroid Hormone Receptor Activator Molecule, Exhibits Distinct Properties from Steroid Receptor Coactivator-1*

  1997influential reference
• Nuclear receptor coactivators.

  1997cited by this paper
• Retinoid X receptor:vitamin D3 receptor heterodimers promote stable preinitiation complex formation and direct 1,25-dihydroxyvitamin D3-dependent cell-free transcription

  1997influential reference
• Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro.

  1997cited by this paper
• AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.

  1997cited by this paper
• A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

  1997cited by this paper
• The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

  1997influential reference
• Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells.

  1997influential reference
• Mutations in the 1,25-Dihydroxyvitamin D3 Receptor Identifying C-terminal Amino Acids Required for Transcriptional Activation That Are Functionally Dissociated from Hormone Binding, Heterodimeric DNA Binding, and Interaction with Basal Transcription Factor IIB, in Vitro *

  1997cited by this paper
• A signature motif in transcriptional co-activators mediates binding to nuclear receptors

  1997influential reference
• Steroid receptor coactivator-1 is a histone acetyltransferase

  1997cited by this paper
• Transcriptional activation by recruitment

  1997cited by this paper
• GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors

  1997cited by this paper
• Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction.

  1997influential reference
• Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors.

  1996cited by this paper
• The transcriptional coactivators p300 and CBP are histone acetyltransferases.

  1996cited by this paper
• A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

  1996influential reference
• Nuclear receptor coactivators and corepressors.

  1996cited by this paper
• Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

  1996cited by this paper
• A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.

  1996cited by this paper
• Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.

  1996influential reference
• Methodical analysis of protein-nitrocellulose interactions to design a refined digestion protocol.

  1996influential reference
• Differential ligand‐dependent interactions between the AF‐2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.

  1996cited by this paper
• Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.

  1996cited by this paper
• TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors.

  1996cited by this paper
• Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.

  1996cited by this paper
• p300 is a component of an estrogen receptor coactivator complex.

  1996cited by this paper
• Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo

  1996cited by this paper
• Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1,25-dihydroxyvitamin D3.

  1995cited by this paper
• Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

  1995cited by this paper
• A structural role for hormone in the thyroid hormone receptor

  1995cited by this paper
• Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

  1995cited by this paper
• Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.

  1995influential reference
• Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.

  1995cited by this paper
• Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

  1995influential reference
• The N‐terminal part of TIF1, a putative mediator of the ligand‐dependent activation function (AF‐2) of nuclear receptors, is fused to B‐raf in the oncogenic protein T18.

  1995cited by this paper
• The Vitamin D Receptor Interacts with General Transcription Factor IIB (*)

  1995cited by this paper
• An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei.

  1995cited by this paper
• Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.

  1995cited by this paper
• Unique response pathways are established by allosteric interactions among nuclear hormone receptors.

  1995cited by this paper
• A transcriptional co-repressor that interacts with nuclear hormone receptors

  1995cited by this paper
• Interaction of thyroid-hormone receptor with a conserved transcriptional mediator

  1995influential reference
• Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

  1995cited by this paper
• Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

  1995influential reference
• Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

  1995cited by this paper
• DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor.

  1994cited by this paper
• Activation function 2 (AF‐2) of retinoic acid receptor and 9‐cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF‐2 activity.

  1994cited by this paper
• Improvements in Microsequencer Performance for Low Picomole Sequence Analysis

  1994influential reference
• Characterization of the ligand‐dependent transactivation domain of thyroid hormone receptor.

  1994cited by this paper
• Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

  1992cited by this paper
• Cloning and expression of full-length cDNA encoding human vitamin D receptor.

  1988cited by this paper
• How eukaryotic transcriptional activators work

  1988cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983influential reference

• Nuclear receptor coregulator interactions: beyond the switch

  2025cites this paper
• Interindividual Genetic Differences Drive Discordance Between Serum Calcidiol and Calcitriol Concentrations in Females

  2025cites this paper
• N-terminal half of MED14 is critical for Mediator-RNA polymerase II interaction and the resulting transcription

  2025cites this paper
• Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways

  2025cites this paper
• The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

  2025cites this paper
• Transcriptional Cofactors for Thyroid Hormone Receptors.

  2024cites this paper
• Vitamin D Receptor Regulates the Expression of the Grainyhead-Like 1 Gene

  2024cites this paper
• Genetically Engineered Mice Unveil In Vivo Roles of the Mediator Complex

  2023cites this paper
• Formation of ARC coactivator complex ↗

  2022cites this paper
• Formation of ARC coactivator complex ↗

  2022cites this paper
• Natural compounds targeting nuclear receptors for effective cancer therapy

  2022cites this paper
• Vitamin D receptor Fok1 polymorphism and invasive ovarian carcinoma risk - A case-control study.

  2020cites this paper
• Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer

  2020cites this paper
• Vitamin D gene regulation

  2020cites this paper
• Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing

  2019cites this paper
• Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

  2019cites this paper
• The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes: Implications for Bone Metabolism

  2019cites this paper
• Generic Transcription Pathway ↗ Stable identifier : R-HSA-212436 OVERVIEW OF TRANSCRIPTION

  2019cites this paper
• Examination of VDR/RXR/DRIP205 Interaction, Intranuclear Localization, and DNA Binding in Ras-Transformed Keratinocytes and Its Implication for Designing Optimal Vitamin D Therapy in Cancer

  2018cites this paper
• Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy

  2018cites this paper
• Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α

  2017cites this paper
• Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein (cid:2)

  2017cites this paper
• SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity.

  2017cites this paper
• Mediator and NER factors in transcription initiation

  2017cites this paper
• Inhibitors for the Vitamin D Receptor-Coregulator Interaction.

  2016influential citation
• Regulation of metabolism by the Mediator complex

  2016cites this paper
• Identificación y caracterización de genes regulados por NOR-1 (Neuron-derived Orphan Receptor-1): implicación en el remodelado vascular y la diferenciación celular

  2016cites this paper
• Chapter 2 – Control of Hormone Gene Expression

  2016cites this paper
• Chapter 67 – Genetic Defects in Vitamin D Metabolism and Action∗

  2016cites this paper
• Role of Vitamin D Metabolism and Activity on Carcinogenesis

  2015cites this paper
• Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor.

  2015cites this paper
• Development of novel Vitamin D Receptor-Coactivator Inhibitors.

  2014cites this paper
• La vitamina D regula la expresión del factor neurotrófico GDNF en cultivos neuronales estriatales y en ratas normales y hemiparkinsonianas

  2014cites this paper
• Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

  2014cites this paper
• Transcriptional study of mutations in Mediator complex subunits or his partner NIPBL causing genetic diseases

  2014cites this paper
• Mediator and its role in non-coding RNA and chromatin regualtion

  2014cites this paper
• CBP/p300 Recruitment Signaling Activates Ets-1 and Ets-2 by Ras/Mitogen-Activated Protein Kinase

  2014cites this paper
• THE INFLUENCE OF SONICATION DURING THE PURIFICATION OF THE VITAMIN D RECEPTOR PROTEIN

  2014cites this paper
• Dido3-dependent HDAC6 targeting controls cilium size

  2014cites this paper
• Cellular Action of Thyroid Hormone

  2014cites this paper
• Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.

  2013cites this paper
• Diastereotopic and deuterium effects in gemini.

  2013cites this paper
• Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population

  2013cites this paper
• Vitamin D in health and disease: a literature review

  2013cites this paper
• Mechanisms of Mediator complex action in transcriptional activation

  2013cites this paper
• The Elongation Complex Components BRD4 and MLLT3/AF9 Are Transcriptional Coactivators of Nuclear Retinoid Receptors

  2013cites this paper
• Molecular Link between Vitamin D and Cancer Prevention

  2013cites this paper
• The Mediator Complex and Lipid Metabolism.

  2013influential citation
• 2 Vitamin D

  2013cites this paper
• Retraction: Nuclear receptors as targets for drug development: crosstalk between peroxisome proliferator-activated receptor γ and cytokines in bone marrow-derived mesenchymal stem cells.

  2013cites this paper
• Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes*

  2013cites this paper
• Regulation of Secretory Phospholipase A2 by Thyroid Hormone

  2013cites this paper
• Small-Molecule Hormones: Molecular Mechanisms of Action

  2013cites this paper
• Dysregulation of the basal RNA polymerase transcription apparatus in cancer

  2013cites this paper
• Retracted: CDP/Cut is an osteoblastic coactivator of the vitamin D receptor (VDR)

  2013cites this paper
• Nuclear Receptors and Their Selective Pharmacologic Modulators

  2013cites this paper
• Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.

  2012cites this paper
• DDX5 is a multifunctional co-activator of steroid hormone receptors.

  2012cites this paper
• Minireview: progress and challenges in proteomics data management, sharing, and integration.

  2012cites this paper
• Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling.

  2012cites this paper
• Development, Molecular Biology, and Physiology of the Prostate

  2012cites this paper
• Vitamin D Biology

  2012cites this paper
• Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.

  2012cites this paper
• Vitamin D resistance and colon cancer prevention.

  2012cites this paper
• Hypovitaminosis D as Predisposing Factor for Atrophic Type A Gastritis: a Case–Control Study and Review of the Literature on the Interaction of Vitamin D with the Immune System

  2012cites this paper
• Vitamin D: Normal Function, Metabolism, Diseases, and Emerging Therapeutics

  2012cites this paper
• Hereditary vitamin D–resistant rickets (HVDRR) owing to a heterozygous mutation in the vitamin D receptor

  2011cites this paper
• Contrôle de l'expression de la protéine PHEX et rôle de PHEX et FGF23 dans la minéralisation par les cellules MC3T3

  2011cites this paper
• Fission yeast Mediator complex and its role in transcriptional regulation

  2011cites this paper
• Etude du rôle du récepteur nucléaire CAR, Constitutive Androstane Receptor, dans le métabolisme des lipides et la susceptibilité à l'athérosclérose

  2011cites this paper
• Mechanisms of Glucocorticoid Receptor Regulation of Gene Expression

  2011cites this paper
• Mediator-dependent nuclear receptor function.

  2011influential citation
• Regulated histone methyltransferase and demethylase complexes in the control of genes by nuclear receptors.

  2011cites this paper
• Live-cell fluorescence correlation spectroscopy dissects the role of coregulator exchange and chromatin binding in retinoic acid receptor mobility

  2011cites this paper
• Med12 is an essential coordinator of gene regulation during mouse development

  2011cites this paper
• Coregulators of VDR-mediated gene expression

  2011cites this paper
• CHAPTER 4 – Mechanism of Action of Hormones That Act on Nuclear Receptors

  2011cites this paper
• A dominant negative over expression model of mammalian MED12 function

  2011cites this paper
• Biological and Molecular Effects of Vitamin D on Bone

  2010cites this paper
• Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional Activation

  2010cites this paper
• Molecular aspects of thyroid hormone actions.

  2010cites this paper
• The Molecular Biology of the Vitamin D Receptor

  2010cites this paper
• Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1α,25-dihydroxyvitamin D3

  2010cites this paper
• The expanding spectrum of biological actions of vitamin D.

  2010cites this paper
• Diversity of Vitamin D Target Genes

  2010cites this paper
• Modulation of Soluble Receptor Signaling by Coregulators

  2010cites this paper
• MED14 Tethers Mediator to the N-Terminal Domain of Peroxisome Proliferator-Activated Receptor γ and Is Required for Full Transcriptional Activity and Adipogenesis

  2010cites this paper
• New Insights to Nuclear Receptor Gene Regulation from Analysis of their Response Elements in Target Genes

  2010cites this paper
• The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes.

  2009cites this paper
• Klonierung und funktionelle Analyse der 5'-flankierenden Region des humanen kardialen ERα-Gens

  2009cites this paper
• Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1 α , 25-dihydroxyvitamin

  2009cites this paper
• Investigation of the mechanisms of estrogen receptor activation by phosphorylation

  2009cites this paper
• A genomic perspective on vitamin D signaling.

  2009cites this paper
• 1,25-DIHYDROXYVITAMIN D3-INDUCED GENES IN OSTEOBLASTS: UNCOVERING NEW FUNCTIONS FOR MENINGIOMA 1 AND SEMAPHORIN 3B IN SKELETAL PHYSIOLOGY

  2009cites this paper
• Pharmacology of Glucocorticoids in Allergic Disease

  2009cites this paper
• Biochemical analyses of nuclear receptor-dependent transcription with chromatin templates.

  2009cites this paper
• The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin.

  2009cites this paper
• Modulation of Androgen Receptor Transcriptional Activity

  2009cites this paper
• Retracted: CDP/cut is an osteoblastic coactivator of the vitamin D receptor (VDR)

  2009cites this paper
• Deleted in Breast Cancer 1, a Novel Androgen Receptor (AR) Coactivator That Promotes AR DNA-binding Activity*

  2009cites this paper