Acetate Metabolism in a pta Mutant ofEscherichia coli W3110: Importance of Maintaining Acetyl Coenzyme A Flux for Growth and Survival

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Bacteriology

• Publication date

  1999-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/JB.181.21.6656-6663.1999PMID 10542166PMCID PMC94129
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of the ldhA gene, encoding the fermentative lactate dehydrogenase of Escherichia coli.

  2001cited by this paper
• Acetyl phosphate and the phosphorylation of OmpR are involved in the regulation of the cell division rate in Escherichia coli

  1998cited by this paper
• Role of the GlnK signal transduction protein in the regulation of nitrogen assimilation in Escherichia coli

  1998cited by this paper
• Aerobic regulation of the sucABCD genes of Escherichia coli, which encode alpha-ketoglutarate dehydrogenase and succinyl coenzyme A synthetase: roles of ArcA, Fnr, and the upstream sdhCDAB promoter

  1997cited by this paper
• The IdhA Gene Encoding the Fermentative Lactate Dehydrogenase of Escherichia Coli

  1997cited by this paper
• Comparative studies of Escherichia coli strains using different glucose uptake systems: Metabolism and energetics.

  1997cited by this paper
• Flux analysis and control of the central metabolic pathways in Escherichia coli.

  1996influential reference
• Pathway analysis, engineering, and physiological considerations for redirecting central metabolism.

  1996cited by this paper
• Adaptation to life at micromolar nutrient levels: the regulation of Escherichia coli glucose transport by endoinduction and cAMP.

  1996cited by this paper
• Cloning, characterization, and functional expression of acs, the gene which encodes acetyl coenzyme A synthetase in Escherichia coli

  1995cited by this paper
• Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR

  1995cited by this paper
• Characterization and evaluation of a pta (phosphotransacetylase) negative mutant of Escherichia coli HB101 as production host of foreign lipase

  1994cited by this paper
• Microbial evolution in a simple unstructured environment: genetic differentiation in Escherichia coli.

  1994cited by this paper
• Construction of Pta-Ack pathway deletion mutants of Escherichia coli and characteristic growth profiles of the mutants in a rich medium.

  1994cited by this paper
• Acetyl phosphate and the activation of two-component response regulators.

  1994cited by this paper
• Expression of Escherichia coli pyruvate oxidase (PoxB) depends on the sigma factor encoded by the rpoS(katF) gene

  1994cited by this paper
• Regulation of acetyl phosphate synthesis and degradation, and the control of flagellar expression in Escherichia coli

  1994cited by this paper
• Mutations in NADH:ubiquinone oxidoreductase of Escherichia coli affect growth on mixed amino acids

  1994influential reference
• The glucose‐starvation stimulon of Escherichia coli: induced and repressed synthesis of enzymes of central metabolic pathways and role of acetyl phosphate in gene expression and starvation survival

  1994influential reference
• An integrated metabolic modeling approach to describe the energy efficiency of Escherichia coli fermentations under oxygen‐limited conditions: Cellular energetics, carbon flux, and acetate production

  1993cited by this paper
• Is acetyl phosphate a global signal in Escherichia coli?

  1993cited by this paper
• The importance of the binding-protein-dependent Mgl system to the transport of glucose in Escherichia coli growing on low sugar concentrations.

  1993cited by this paper
• Derepression of LamB protein facilitates outer membrane permeation of carbohydrates into Escherichia coli under conditions of nutrient stress

  1993cited by this paper
• Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli

  1992cited by this paper
• Stimulation of glucose catabolism in Escherichia coli by a potential futile cycle

  1992cited by this paper
• Effect of alteration of the acetic acid synthesis pathway on the fermentation pattern of escherichia coli

  1991influential reference
• Molecular analysis of the Alcaligenes eutrophus poly(3-hydroxybutyrate) biosynthetic operon: identification of the N terminus of poly(3-hydroxybutyrate) synthase and identification of the promoter

  1991cited by this paper
• Physiology of the bacterial cell : a molecular approach

  1990cited by this paper
• Control of carbon flux to acetate excretion during growth of Escherichia coli in batch and continuous cultures.

  1989cited by this paper
• Anaerobic fermentation balance of Escherichia coli as observed by in vivo nuclear magnetic resonance spectroscopy

  1989cited by this paper
• Mutants of Escherichia coli deficient in the fermentative lactate dehydrogenase

  1989cited by this paper
• Structure, Expression, and Protein Engineering of the Pyruvate Dehydrogenase Complex of Escherichia coli a

  1989cited by this paper
• The central metabolic pathways of Escherichia coli: relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate.

  1986cited by this paper
• Mass culture of Escherichia coli: Medium development for low and high density cultivation of Escherichia coli B/r in minimal and complex media

  1985cited by this paper
• 2-Oxoacid dehydrogenase complexes of Escherichia coli: cellular amounts and patterns of synthesis

  1983cited by this paper
• Regulation of Escherichia coli phosphoenolpyruvate carboxylase by multiple effectors in vivo. II. Kinetic studies with a reaction system containing physiological concentrations of ligands.

  1981cited by this paper
• Are growth rates of Escherichia coli in batch cultures limited by respiration?

  1980influential reference
• Regulation of Escherichia coli phosphoenolpyruvate carboxylase by multiple effectors in vivo. Estimation of the activities in the cells grown on various compounds.

  1980cited by this paper
• The enzymic interconversion of acetate and acetyl-coenzyme A in Escherichia coli.

  1977cited by this paper
• Determination of the efficiency of oxidative phosphorylation in continuous cultures of Aerobacter aerogenes

  1975cited by this paper
• Mechanisms of active transport in isolated bacterial membrane vesicles. 18. The mechanism of action of carbonylcyanide m-chlorophenylhydrazone.

  1974cited by this paper
• Mechanisms of active transport in isolated bacterial membrane vesicles. XV. Purification and properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli.

  1973cited by this paper
• Regulation of alpha-ketoglutarate dehydrogenase formation in Escherichia coli.

  1965cited by this paper

• Quenching corrinoid-based interactions in a model bacterial coculture

  2026cites this paper
• Integrated dynamic control and enzyme co-localization strategies enable high-efficiency stilbenoid biosynthesis.

  2026cites this paper
• Fedbatchdesigner: A User-Friendly Dashboard for Modeling and Optimizing Growth-Arrested Fed-Batch Processes

  2025cites this paper
• Deciphering Nutritional Stress Responses via Knowledge-Enriched Transcriptomics for Microbial Engineering.

  2024cites this paper
• Development of a hybrid bio-purification process of lactic acid solutions employing an engineered E. coli strain in a membrane bioreactor

  2024cites this paper
• Recent advances on the systems metabolically engineered Pseudomonas species as versatile biosynthetic platforms for the production of polyhydroxyalkanoates

  2023influential citation
• Polyhydroxybutyrate (PHB) Biosynthesis by an Engineered Yarrowia lipolytica Strain Using Co-Substrate Strategy

  2023cites this paper
• Precursor prioritization for p-cymene production through synergistic integration of biology and chemistry

  2022cites this paper
• The Expression Modulation of the Key Enzyme Acc for Highly Efficient 3-Hydroxypropionic Acid Production

  2022cites this paper
• Metabolic Engineering for Overproduction of Colanic Acid in Escherichia coli Mutant with Short Lipopolysaccharide.

  2022cites this paper
• A synthetic C2 auxotroph of Pseudomonas putida for evolutionary engineering of alternative sugar catabolic routes

  2022cites this paper
• Engineering Escherichia coli for Efficient Aerobic Conversion of Glucose to Malic Acid through the Modified Oxidative TCA Cycle

  2022cites this paper
• Re-designing Escherichia coli for high-yield production of β-alanine by metabolic engineering

  2022cites this paper
• Engineering Escherichia coli for efficient aerobic conversion of glucose to fumaric acid

  2022influential citation
• Engineering Bacteroides thetaiotaomicron to produce non-native butyrate based on a genome-scale metabolic model-guided design.

  2021cites this paper
• Effects of Lipase Addition, Hydrothermal Processing, Their Combination, and Co-Digestion with Crude Glycerol on Food Waste Anaerobic Digestion

  2021cites this paper
• Impact of Transcriptional Regulation by Crp, FruR, FlhD, and TyrR on L-tryptophan Biosynthesis in Escherichia coli

  2021cites this paper
• Acetate overflow metabolism regulates a major metabolic shift after glucose depletion in Escherichia coli

  2021cites this paper
• Inactivation of the Pta-AckA Pathway Impairs Fitness of Bacillus anthracis during Overflow Metabolism

  2021cites this paper
• Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition

  2020cites this paper
• Metabolic engineering of Escherichia coli W for isobutanol production on chemically defined medium and cheese whey as alternative raw material

  2020cites this paper
• مطالعه و بررسی اثرات مهار ژنهایackA ، pta و poxB به وسیلهی RNA ی آنتیسنس روی ترشح استات و بیان اینترفرون بتای نوترکیب در باکتری اشریشیاکلای

  2020cites this paper
• Effects of ackA, pta and poxB inhibition by antisense RNA on acetate excretion and recombinant beta interferon expression in Escherichia coli

  2020cites this paper
• Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism.

  2020cites this paper
• Autodisplay of alpha amylase from Bacillus megaterium in E. coli for the bioconversion of starch into hydrogen, ethanol and succinic acid.

  2020cites this paper
• Improvement of Streptococcus suis glutamate dehydrogenase expression in Escherichia coli through genetic modification of acetate synthesis pathway

  2020cites this paper
• Acetate formation during recombinant protein production in Escherichia coli K‐12 with an elevated NAD(H) pool

  2019cites this paper
• Metabolic Engineering and Fermentation Process Strategies for L-Tryptophan Production by Escherichia coli

  2019cites this paper
• Comparison of engineered Escherichia coli AF1000 and BL21 strains for (R)-3-hydroxybutyrate production in fed-batch cultivation

  2019cites this paper
• Strain- and bioprocess-design strategies to increase production of (R)-3-hydroxybutyrate by Escherichia coli

  2019cites this paper
• Metabolic engineering and cultivation strategies for recombinant production of (R)-3-hydroxybutyrate

  2019cites this paper
• Mechanisms, Detection, and Relevance of Protein Acetylation in Prokaryotes

  2019cites this paper
• Optimization of Culture Conditions for High Cell-Density Fermentation of Bovine Escherichia coli

  2018cites this paper
• Complete decoupling of bacterial growth from biopolymer production through proteolytic control of enzyme levels

  2018cites this paper
• Regulation of NADH Oxidase Expression via a Thermo-regulated Genetic Switch for Pyruvate Production in Escherichia coli

  2018cites this paper
• Exploring the function of bacterial chemotaxis.

  2018cites this paper
• Contributions of SpoT Hydrolase, SpoT Synthetase, and RelA Synthetase to Carbon Source Diauxic Growth Transitions in Escherichia coli

  2018cites this paper
• A Post-translational Metabolic Switch Enables Complete Decoupling of Bacterial Growth from Biopolymer Production in Engineered Escherichia coli.

  2018cites this paper
• Triple knockout of frdC gltA and pta genes enhanced pHA production in Escherichia coli

  2018cites this paper
• Metabolic engineering of carbon overflow metabolism of Bacillus subtilis for improved N-acetyl-glucosamine production.

  2018cites this paper
• Impact of poxB, pta, and ackA genes on mineral‐weathering of Enterobacter cloacae S71

  2018cites this paper
• Construction of a Synthetic Bypass for Improvement of Aerobic Synthesis of Succinic Acid through the Oxidative Branch of the Tricarboxylic Acid Cycle by Recombinant Escherichia coli Strains

  2018cites this paper
• Effect of acetate as a co-feedstock on the production of poly(lactate-co-3-hydroxyalkanoate) by pflA-deficient Escherichia coli RSC10.

  2017cites this paper
• Effect of Magnesium Acetate on the Antimold Activity of Lactobacillus.

  2017cites this paper
• Beet molasses–based feeding strategy enhances recombinant thermostable glucose isomerase production by Escherichia coli BL21 (DE3)

  2017cites this paper
• Suppression of the Escherichia coli dnaA46 mutation by changes in the activities of the pyruvate-acetate node links DNA replication regulation to central carbon metabolism

  2017cites this paper
• Analysis of gluconate metabolism for pyruvate production in engineered Escherichia coli based on genome‐wide transcriptomes

  2017cites this paper
• A simple method to control glycolytic flux for the design of an optimal cell factory

  2017cites this paper
• Gene modification of Escherichia coli and incorporation of process control to decrease acetate accumulation and increase ʟ-tryptophan production

  2017influential citation
• Gene modification of the acetate biosynthesis pathway in Escherichia coli and implementation of the cell recycling technology to increase L-tryptophan production

  2017cites this paper
• Production of L-lactic acid from metabolically engineered strain of Enterobacter aerogenes ATCC 29007.

  2017cites this paper
• CcpA and CodY Coordinate Acetate Metabolism in Streptococcus mutans

  2017cites this paper
• Refactoring the Embden–Meyerhof–Parnas Pathway as a Whole of Portable GlucoBricks for Implantation of Glycolytic Modules in Gram-Negative Bacteria

  2017cites this paper
• Metabolomics-driven approach to solving a CoA imbalance for improved 1-butanol production in Escherichia coli.

  2017cites this paper
• Construction of pyruvate producing strain with intact pyruvate dehydrogenase and genome-wide transcription analysis

  2017cites this paper
• Amino Acid Catabolism in Staphylococcus aureus and the Function of Carbon Catabolite Repression

  2017cites this paper
• Impact of gene modification of phosphotransferase system on expression of glutamate dehydrogenase protein of Streptococcus suis in Escherichia coli

  2017cites this paper
• Controlling Recombinant Escherichia coli Cultures to the Boundary of Oxidative and Overflow Metabolism (BOOM) for Robust Efficient Growth

  2017influential citation
• Precise flux redistribution to glyoxylate cycle for 5-aminolevulinic acid production in Escherichia coli.

  2017cites this paper
• ENHANCING ETHANOL TOLERANCE OF Escherichia coli RECOMBINANT BY GLUTAMATE ADDITION UNDER AN AEROBIC CONDITION

  2016cites this paper
• Metabolic engineering of Escherichia coli for itaconate production

  2016cites this paper
• Redox Imbalance Underlies the Fitness Defect Associated with Inactivation of the Pta-AckA Pathway in Staphylococcus aureus.

  2016cites this paper
• A molecular analysis of the interactions of Escherichia coli and macrophages

  2016cites this paper
• Response of Escherichia coli processes for the production of heterologous inclusion bodies by oscillating cultivation conditions in a scale-down bioreactor

  2016cites this paper
• Toward efficient microaerobic processes using engineered Escherichia coli W3110 strains

  2016cites this paper
• Synthesis of (1R,3R)-1-amino-3-methylcyclohexane by an enzyme cascade reaction

  2016cites this paper
• Quantitative proteomics of food pathogenic Bacilli - a quest for biomarkers

  2016cites this paper
• Impact of deletion of the genes encoding acetate kinase on production of L-tryptophan by Escherichia coli

  2016cites this paper
• L-Tryptophan Production in Escherichia coli Improved by Weakening the Pta-AckA Pathway

  2016cites this paper
• Insights into CO2 Fixation Pathway of Clostridium autoethanogenum by Targeted Mutagenesis

  2016cites this paper
• Rapid and high-throughput construction of microbial cell-factories with regulatory noncoding RNAs.

  2015cites this paper
• Optimization of carbon source and glucose feeding strategy for improvement of L-isoleucine production by Escherichia coli

  2015cites this paper
• Microbial acetyl-CoA metabolism and metabolic engineering.

  2015influential citation
• TENET: topological feature-based target characterization in signalling networks

  2015cites this paper
• Relation between chemotaxis and consumption of amino acids in bacteria

  2015cites this paper
• Temperature Dependence of the Proteome Profile of the Psychrotolerant Pathogenic Food Spoiler Bacillus weihenstephanensis Type Strain WSBC 10204.

  2015cites this paper
• Deletion of poxB, pta, and ackA improves 1,3-propanediol production by Klebsiella pneumoniae

  2015cites this paper
• Study on aerobic biosynthesis of 4-hydroxybutyric acid by Escherichia coli cells upon heterologous expression of the 2-ketoglutarate decarboxylase gene

  2015cites this paper
• Genetics and Physiology of Acetate Metabolism by the Pta-Ack Pathway of Streptococcus mutans

  2015cites this paper
• High cell density propionic acid fermentation with an acid tolerant strain of Propionibacterium acidipropionici

  2015cites this paper
• Effects of carbon dioxide on cell growth and propionic acid production from glycerol and glucose by Propionibacterium acidipropionici.

  2015cites this paper
• Metabolic Engineering of Escherichia coli Cells for Ethanol Production under Aerobic Conditions

  2015cites this paper
• Pengaturan Laju Oksigenasi untuk Meningkatkan Ketahanan Sel Rekombinan Escherichia coli pada Kultivasi Etanol Tinggi

  2015cites this paper
• Trecento: in silico network-driven identification of target combinations for combination therapy

  2015cites this paper
• One feature doesn't fit all: characterizing topological features of targets in signaling networks

  2014cites this paper
• Phenazine redox cycling enhances anaerobic survival in Pseudomonas aeruginosa by facilitating generation of ATP and a proton‐motive force

  2014cites this paper
• Metabolic engineering of itaconate production in Escherichia coli

  2014cites this paper
• Genome engineering for improved recombinant protein expression in Escherichia coli

  2014cites this paper
• Acetate metabolism in Geobacillus thermoglucosidasius and strain engineering for enhanced bioethanol production

  2014cites this paper
• Metabolic engineering of Escherichia coli for the production of coenzyme Q10

  2014cites this paper
• Modification of glycolysis and its effect on the production of l-threonine in Escherichia coli

  2014cites this paper
• Beet molasses based exponential feeding strategy for thermostable glucose isomerase production by recombinant Escherichia coli BL21 (DE3)

  2013cites this paper
• Strategy for pH control and pH feedback-controlled substrate feeding for high-level production of l-tryptophan by Escherichia coli

  2013cites this paper
• Metabolic responses to recombinant bioprocesses in Escherichia coli.

  2013influential citation
• Engineering of Acetate Recycling and Citrate Synthase to Improve Aerobic Succinate Production in Corynebacterium glutamicum

  2013cites this paper
• Brief overview of metabolic regulation of a bacterial cell

  2013cites this paper
• Genetic engineering of Escherichia coli to enhance production of l-tryptophan

  2013influential citation
• Evaluation on the responses of succinate dehydrogenase, isocitrate dehydrogenase, malate dehydrogenase and glucose-6-phosphate dehydrogenase to acid shock generated acid tolerance in Escherichia coli

  2013cites this paper
• Poly(4-hydroxybutyrate) (P4HB) production in recombinant Escherichia coli: P4HB synthesis is uncoupled with cell growth

  2013cites this paper
• Fermentation metabolism and its evolution in algae

  2013cites this paper