Nod2 is required for the regulation of commensal microbiota in the intestine

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2009-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0907722106PMID 19805227PMCID PMC2747201
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
• Microbial influences in inflammatory bowel diseases.

  2008influential reference
• Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin.

  2008cited by this paper
• The NLR gene family: a standard nomenclature.

  2008cited by this paper
• Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

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• The genetics and immunopathogenesis of inflammatory bowel disease

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• Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

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• XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.

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  2008cited by this paper
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  2008cited by this paper
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  2007influential reference
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  2007cited by this paper
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  2007cited by this paper
• Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment

  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Ecological and evolutionary forces shaping microbial diversity in the human intestine.

  2006cited by this paper
• Invited review: MDP and other muropeptides — direct and synergistic effects on the immune system

  2006cited by this paper
• Microbial induction of CARD15 expression in intestinal epithelial cells via toll‐like receptor 5 triggers an antibacterial response loop

  2006cited by this paper
• Diversity of the Human Intestinal Microbial Flora

  2005cited by this paper
• Reduced Paneth cell alpha-defensins in ileal Crohn's disease.

  2005cited by this paper
• Reduced Paneth cell α-defensins in ileal Crohn's disease

  2005cited by this paper
• Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice.

  2005cited by this paper
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  2005cited by this paper
• Genotypes and phenotypes in Crohn’s disease: do they help in clinical management?

  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• Crohn's disease and the NOD2 gene: a role for paneth cells.

  2003influential reference
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  2003cited by this paper
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  2000cited by this paper
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  2000influential reference
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  1998cited by this paper
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  1995cited by this paper

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