Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease

C. Lambert,P. Benjamin,E. Zeestraten,A. Lawrence,T. Barrick,H. Markus

Published 2016 in Brain : a journal of neurology

ABSTRACT

The relationship between white matter hyperintensity (WMH) progression and brain atrophy in small vessel disease is unclear. In a longitudinal study, Lambert et al. show that WMH progression occurs more rapidly within the long association fasciculi, and is associated with accelerated cortical atrophy. Preventing WMH progression may reduce secondary degeneration.

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