Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Science

• Publication date

  2002-03-29

• Fields of study

  Medicine

• Identifiers
  DOI 10.1126/SCIENCE.1067100PMID 11923519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study.

  2002cited by this paper
• Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis

  2002cited by this paper
• Development of matrix metalloproteinase inhibitors in cancer therapy.

  2001cited by this paper
• Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial.

  2001cited by this paper
• Matrix metalloproteinases: they're not just for matrix anymore!

  2001cited by this paper
• Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.

  2001cited by this paper
• Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

  2001cited by this paper
• In vivo molecular target assessment of matrix metalloproteinase inhibition

  2001cited by this paper
• MMP-9 Supplied by Bone Marrow – Derived Cells Contributes to Skin Carcinogenesis

  2000cited by this paper
• Matrix metalloproteinases: multifunctional contributors to tumor progression.

  2000cited by this paper
• Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

  2000cited by this paper
• MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis.

  2000cited by this paper
• Matrix metalloproteinases as emerging targets in anticancer therapy: status and prospects

  2000cited by this paper
• Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia.

  2000cited by this paper
• Matrix metalloproteinases: biologic activity and clinical implications.

  2000cited by this paper
• Matrix metalloproteinases and TIMPs

  2000cited by this paper
• Ongoing trials with matrix metalloproteinase inhibitors

  2000cited by this paper
• In vivo visualization of gene expression using magnetic resonance imaging

  2000cited by this paper
• Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization.

  2000cited by this paper
• Clinical imaging of cancer metastasis.

  2000cited by this paper
• Marimastat in patients with advanced pancreatic cancer: a dose-finding study.

  1999cited by this paper
• Latest FDA approvals for dentistry.

  1999cited by this paper
• Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention.

  1999cited by this paper
• Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer.

  1999cited by this paper
• Design and therapeutic application of matrix metalloproteinase inhibitors.

  1999cited by this paper
• The Effects of Sustained Elevated Levels of Circulating Tissue Inhibitor of Metalloproteinases‐1 on the Development of Breast Cancer in Mice

  1999cited by this paper
• Marimastat in recurrent colorectal cancer: exploratory evaluation of biological activity by measurement of carcinoembryonic antigen

  1999cited by this paper
• The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.

  1999cited by this paper
• Effects of angiogenesis inhibitors on multistage carcinogenesis in mice.

  1999cited by this paper
• Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis

  1998cited by this paper
• The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis.

  1998cited by this paper
• In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

  1998cited by this paper
• Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies.

  1998cited by this paper
• Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.

  1997cited by this paper
• Tumour marker levels during marimastat therapy.

  1996cited by this paper
• Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix.

  1996cited by this paper
• Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice.

  1996cited by this paper
• Tumour marker levels during marimastat therapy

  1996cited by this paper
• Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis

  1995cited by this paper
• Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice.

  1995cited by this paper
• Protease inhibitors: role and potential therapeutic use in human cancer.

  1994cited by this paper
• Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1.

  1994cited by this paper
• Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line.

  1994cited by this paper
• Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth.

  1994cited by this paper
• Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases.

  1990cited by this paper
• Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells.

  1989cited by this paper
• Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells.

  1988cited by this paper
• Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

  1988cited by this paper

• The Roles of the Membrane-Anchored Glycoprotein RECK in Animal Development, Tumor Suppression, and Beyond

  2026cites this paper
• Molecular and enzymatic characterization of MMP19 in cuttlefish Sepia pharaonis: Insights into its role in Vibrio-induced skin ulceration

  2026cites this paper
• A halogenated pregnenolone analogue suppresses HepG2 proliferation and induces apoptosis via PPARγ regulation.

  2026cites this paper
• Cancer-Associated Fibroblasts in Prostate Cancer: Unraveling Mechanisms and Therapeutic Implications

  2026cites this paper
• Nuclear deformation acts as a mechanical switch to drive breast cancer cell migration in a confined microenvironment

  2026cites this paper
• Antiphotoaging effects of a group of antioxidant peptides through downregulating matrix metalloproteinases and inflammation factors

  2025cites this paper
• The hypoxic ECM and neutrophils in MIBC immunotherapy resistance.

  2025cites this paper
• Frequency-Dependent First- and Second-Order Hyperpolarizability Response and Chemical Reactivity Analyses of N-(Benzyloxycarbonyloxy) Succinimide: Experimental and Theoretical Investigations

  2025cites this paper
• CRISPR/Cas9–mediated MMP-9 silencing inhibits bladder cancer T24 cell invasion and migration in vitro

  2025cites this paper
• Potential target within the tumor microenvironment - MT1-MMP

  2025cites this paper
• Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity

  2025cites this paper
• CDKN1A and cellular senescence are associated with immune resistance in advanced lung adenocarcinoma

  2025cites this paper
• Docking studies of a Triazole-based Chalcone on Various Matrix Metalloproteinases

  2025cites this paper
• Molecular Characterization of Bovine Deltapapillomavirus in Equine Sarcoids in Egypt

  2025cites this paper
• Establishment of a Basement Membrane-Related Prognosis Model and Characterization of Tumor Microenvironment Infiltration in Acute Myeloid Leukemia

  2025cites this paper
• Serum levels of C-terminal peptides of alpha-1 antitrypsin as potential biomarkers in non-small cell lung cancer

  2025cites this paper
• Peroxynitrite self-supplied nanobomb based on the Haber-Weiss reaction for achieving tumor deep penetration and multimodal synergistic therapy

  2025cites this paper
• Lung cancer-associated fibroblasts-mediated collagen deposition drives mediastinal lymph node metastasis in non-small cell lung cancer

  2025cites this paper
• Dynamic Interplay between Deformability and Activity in Cell Entry of Soft Active Nanoparticles.

  2025cites this paper
• Development and validation of M2 macrophage-related genes in a prognostic model of lung adenocarcinoma based on bulk RNA and ScRNA datasets

  2025cites this paper
• Chrysophanol from Rheum officinale suppresses metastasis: Targeting MMP-9, p-JNK, and p-p38 in human fibrosarcoma cells

  2025cites this paper
• Matrix stiffness shapes transcriptional profiles and drug responses of pancreatic cancer cells.

  2025cites this paper
• The Role of Matrix Metalloproteinases in Liver Function and Disease.

  2025cites this paper
• Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer

  2025cites this paper
• Targeting Matrix Metalloproteinase-9 to Alleviate T Cell Exhaustion and Improve Sepsis Prognosis

  2025cites this paper
• Mechanisms of Tumor Cell-Mediated Vasculogenic Mimicry in Cancer Invasion and Metastasis: A Systematic Review.

  2025cites this paper
• Unraveling the role of deuterium in cancer: mechanisms, detection techniques, and therapeutic potential.

  2025cites this paper
• Nano-Drug Delivery Systems Targeting MMPs: A Promising Treatment for Gliomas

  2025cites this paper
• A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis

  2025cites this paper
• Catalytic enantioselective synthesis of α-C chiral sulfones enabled by merging photoactive electron donor–acceptor complexes with nickel catalysis

  2025cites this paper
• A Review of Proteases and Antiproteases for Immune Regulation and Potential Therapeutic Application in Pulmonary Fibrosis

  2025cites this paper
• Exploring the tumor microenvironment in solid cancer: From biology to therapy.

  2025cites this paper
• A tailored 4G s-triazine-based dendrimer vehicle for quercetin endowed with MMP-2/9 inhibition and VEGF downregulation for targeting breast cancer progression and liver metastasis

  2025cites this paper
• ADAM Proteases in Cancer: Biological Roles, Therapeutic Challenges, and Emerging Opportunities

  2025cites this paper
• Bioinspired Polymeric Nanomedicines with Tumor Extracellular Matrix Anchoring Capability for Prolonged Tumor Retention and Drug Delivery.

  2025cites this paper
• Does chlorotoxin target matrix metalloproteinase-2 in glioblastoma?

  2025cites this paper
• Micro/Nano-Motors for Enhanced Tumor Diagnosis and Therapy

  2025cites this paper
• Landscape analysis of matrix metalloproteinases reveals key prognostic markers for prostate cancer

  2025cites this paper
• Targeting matrix metalloproteinases activating and Indoleamine 2,3-dioxygenase suppression for triple-negative breast Cancer multimodal therapy.

  2025cites this paper
• Unveiling Matrix Metalloproteinase 13’s Dynamic Role in Breast Cancer: A Link to Physical Changes and Prognostic Modulation

  2025cites this paper
• Inflammation in cancer: therapeutic opportunities from new insights

  2025cites this paper
• MicroRNAs as behind-the-scenes molecules in breast cancer metastasis and their therapeutic role through novel microRNA-based delivery strategies.

  2025cites this paper
• Injectable Matrix Metalloproteinase-Responsive Polypeptide Hydrogels as Drug Depots for Antitumor Chemo-Immunotherapy

  2025cites this paper
• Recent advances in the design and development of small-molecule MMP-2 inhibitors.

  2025cites this paper
• Human iPSC-based disease modeling studies identify a common mechanistic defect and potential therapies for AMD and related macular dystrophies.

  2024cites this paper
• Detecting Colorectal Neoplasia Using Specific Fecal Fluorogenic Protease-Sensitive Substrates: A Pilot Study

  2024cites this paper
• Multivalent MMP-12 inhibitors as a valuable approach to counteract the intestinal epithelial barrier impairment and inflammation in an in vitro model mimicking intestinal high-fat exposure

  2024cites this paper
• Nucleic acid binding affinity and antioxidant activity of N-m-Tolyl-4-Chlorophenoxyacetohydroxamicacid

  2024cites this paper
• A Novel Approach for Apical Periodontitis Prevention Through RIPK3 Inhibition Using Organic Flavonoids

  2024cites this paper
• Diversified applications and synthesis of hydroxamic acids

  2024cites this paper
• Coupled Dynamics in Phenotype and Tissue Spaces Shape the Three-Dimensional Cancer Invasion

  2024cites this paper
• Structure optimization and molecular dynamics studies of new tumor-selective s-triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers

  2024cites this paper
• Exploratory Study Identifies Matrix Metalloproteinase-14 and -9 as Potential Biomarkers of Regorafenib Efficacy in Metastatic Colorectal Cancer

  2024cites this paper
• Benzothiazole-based Schiff base for sensing Ca2+ ions: Synthesis, DFT studies, toxicity evaluation in zebrafish embryo and in silico analysis of MMP-9 inhibition

  2024cites this paper
• The biophysics of cell motility through mechanochemically challenging environments.

  2024cites this paper
• Molecular dynamics simulations of s-triazine-based MMP-10 inhibitor with ferroptosis induction capacity and potent anti-colorectal cancer activities

  2024cites this paper
• Mirror‐Image Random Nonstandard Peptides Integrated Discovery (MI‐RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7

  2024cites this paper
• Targeting the core program of metastasis with a novel drug combination

  2024cites this paper
• Insights into the mechanobiology of cancer metastasis via microfluidic technologies

  2024cites this paper
• Deregulation of MMP-2 and MMP-9 in laryngeal cancer: A retrospective observational study

  2024cites this paper
• Targets in the Tumour Matrisome to Promote Cancer Therapy Response

  2024cites this paper
• The past and future of angiogenesis as target for cancer therapy and prevention.

  2024cites this paper
• Nucleating amoeboid cancer cell motility with Diaphanous related formins

  2024cites this paper
• PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway

  2024cites this paper
• miRNA-383-5p Regulated Migration and Invasion of Tumor Cells by Inhibiting NCKAP1 Expression in Gastric Cancer

  2024cites this paper
• Matrix metalloproteinase 9: An emerging biomarker for classification of adherent vestibular schwannoma

  2024cites this paper
• Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease

  2024cites this paper
• The cancer-associated secretory phenotype: a new frontier in targeted therapeutics

  2024cites this paper
• Antitumour mechanisms of traditional Chinese medicine elicited by regulating tumour-associated macrophages in solid tumour microenvironments

  2024cites this paper
• PI4K2A: a novel potential therapeutic target for lung cancer

  2024cites this paper
• Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.

  2024cites this paper
• Targeting cholesterol impairs cell invasion of all breast cancer types

  2024cites this paper
• Photopharmacology of Protease Inhibitors: Current Status and Perspectives.

  2024cites this paper
• Natural Products as Regulators against Matrix Metalloproteinases for the Treatment of Cancer

  2024cites this paper
• Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate

  2024cites this paper
• Chemosensitization of non-small cell lung cancer to sorafenib via non-hydroxamate s-triazinedione-based MMP-9/10 inhibitors.

  2024cites this paper
• Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications.

  2024cites this paper
• The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity.

  2024cites this paper
• Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers

  2024cites this paper
• TIE1 promotes cervical cancer progression via Basigin-matrix metalloproteinase axis

  2024cites this paper
• Unraveling the Tumor Microenvironment: Insights into Cancer Metastasis and Therapeutic Strategies.

  2024cites this paper
• CD44 and RHAMM Are Microenvironmental Sensors with Dual Metastasis Promoter and Suppressor Functions

  2024cites this paper
• Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy

  2024cites this paper
• Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer

  2024cites this paper
• Structure-specific nucleases in genome dynamics and strategies for targeting cancers

  2024cites this paper
• Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis

  2024cites this paper
• Biphenylsulfonamides as effective MMP‐2 inhibitors with promising antileukemic efficacy: Synthesis, in vitro biological evaluation, molecular docking, and MD simulation analysis

  2024cites this paper
• Engineering New Protease Inhibitors Using α2-Macroglobulin.

  2024cites this paper
• Contribution of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 to Upper Tract Urothelial Cancer Risk in Taiwan

  2024cites this paper
• Exploring the Bioactive Properties and Therapeutic Benefits of Pear Pomace

  2024cites this paper
• NK1 receptor mediates cerebral cellular and extracellular morphological changes during the LPS-induced febrile response.

  2024cites this paper
• 1,3,5-Triazine as a promising scaffold in the development of therapeutic agents against breast cancer.

  2024cites this paper
• Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer

  2024cites this paper
• Understanding the Structure–Activity Relationship through Density Functional Theory: A Simple Method Predicts Relative Binding Free Energies of Metalloenzyme Fragment-like Inhibitors

  2023cites this paper
• Collagenases and their inhibitors: a review

  2023cites this paper
• Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer.

  2023cites this paper
• The Androgen Regulation of Matrix Metalloproteases in Prostate Cancer and Its Related Tumor Microenvironment

  2023cites this paper
• Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus

  2023cites this paper
• Diagnostic, Prognostic, and Therapeutic Role for Angiogenesis Markers in Head and Neck Squamous Cell Carcinoma: A Narrative Review

  2023cites this paper
• Review of serine protease inhibitors: Development and applications

  2023cites this paper