Rhesus monkey TRIM5α restricts HIV-1 production through rapid degradation of viral Gag polyproteins

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature Medicine

• Publication date

  2007-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nm1562PMID 17435772
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor.

  2006cited by this paper
• HIV-1 Vpu Promotes Release and Prevents Endocytosis of Nascent Retrovirus Particles from the Plasma Membrane

  2006cited by this paper
• Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente

  2006cited by this paper
• Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells

  2006cited by this paper
• Retrovirus restriction by TRIM5alpha variants from Old World and New World primates.

  2005cited by this paper
• TRIM family proteins: retroviral restriction and antiviral defence

  2005cited by this paper
• Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and Specificity

  2005cited by this paper
• A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction.

  2005cited by this paper
• Retrovirus Restriction by TRIM5α Variants from Old World and New World Primates

  2005cited by this paper
• A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV‐1 and HIV‐2 Vif proteins

  2004cited by this paper
• The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys

  2004cited by this paper
• Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

  2004cited by this paper
• The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities.

  2004cited by this paper
• Continuous high-titer HIV-1 vector production

  2003cited by this paper
• Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors

  2003cited by this paper
• A dominant block to HIV-1 replication at reverse transcription in simian cells

  2002cited by this paper
• Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

  2002cited by this paper
• Faculty Opinions recommendation of Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.

  2002cited by this paper
• Restriction of lentivirus in monkeys

  2002cited by this paper
• Inhibition of Retroviral RNA Production by ZAP, a CCCH-Type Zinc Finger Protein

  2002cited by this paper
• Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism

  2002cited by this paper
• Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates, Like HIV-1 Isolates, Frequently Use CCR5 but Show Promiscuity in Coreceptor Usage

  1999cited by this paper
• A full-length and replication-competent proviral clone of SIVAGM from tantalus monkeys.

  1997cited by this paper
• Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

  1997cited by this paper
• Positional cloning of the mouse retrovirus restriction gene Fvl

  1996cited by this paper
• Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes

  1995cited by this paper
• An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

  1992cited by this paper
• Genetic and Biological Comparisons of Pathogenic and Nonpathogenic Molecular Clones of Simian Immunodeficiency Virus (SIVMAC)

  1992cited by this paper
• Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism

  1992cited by this paper
• Host range mutant of human immunodeficiency virus type 1: modification of cell tropism by a single point mutation at the neutralization epitope in the env gene

  1991cited by this paper
• Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

  1986cited by this paper

• Human cellular restriction factors that target SARS-CoV-2 replication

  2024cites this paper
• Exploring HIV-1 Maturation: A New Frontier in Antiviral Development

  2024cites this paper
• Host cell restriction factors of equine infectious anemia virus

  2023cites this paper
• Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell‐mediated immune surveillance

  2023cites this paper
• Ubiquitin-protein ligase E3A (UBE3A) mediation of viral infection and human diseases

  2023cites this paper
• Comparative Evaluation of the Activity of Various Lentiviral Vectors Containing Three Anti-HIV Genes

  2023cites this paper
• The Titer of the Lentiviral Vector Encoding Chimeric TRIM5α-HRH Gene is Reduced Due to Expression of TRIM5α-HRH in Producer Cells and the Negative Effect of Ef1α Promoter

  2022cites this paper
• Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus‐induced demyelination

  2021cites this paper
• Production of Vesicular Stomatitis Virus Glycoprotein-Pseudotyped Lentiviral Vector Is Enhanced by Ezrin Silencing

  2020cites this paper
• Retrovirus Restriction Factor TRIM5α: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection

  2020cites this paper
• Post-translational modifications inducing proteasomal degradation to counter HIV-1 infection.

  2020cites this paper
• How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain

  2020cites this paper
• Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1

  2019cites this paper
• Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

  2019cites this paper
• HIV-1 Impairment via UBE3A and HIV-1 Nef Interactions Utilizing the Ubiquitin Proteasome System

  2019cites this paper
• Protection of Lymphocytes Against HIV using Lentivirus Vector Carrying a Combination of TRIM5α-HRH Genes and microRNA Against CCR5

  2018cites this paper
• Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis

  2017cites this paper
• Interferons and beyond: Induction of antiretroviral restriction factors

  2017cites this paper
• Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication.

  2017cites this paper
• Rhesus monkey TRIM5alpha SPRY domain contributes to AP-1 activation

  2017cites this paper
• 7 Retroviral Host Cell Factors : TRIM 5 , APOBEC 3 G and Cyclophilins

  2017influential citation
• The influence of HIV-1 genomic target region selection and sequence length on the accuracy of inferred phylogenies and clustering outcomes.

  2017cites this paper
• Rhesus monkey TRIM5α protein SPRY domain contributes to AP-1 activation

  2017cites this paper
• Retroviral restriction: nature's own solution

  2016cites this paper
• Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation.

  2016influential citation
• An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating

  2016cites this paper
• Identification de facteurs de régulation du VIH-1 chez les macrophages humains

  2016cites this paper
• Factor 6 Pathways along with TNFR-Associated B κ That Stimulates Type I IFN and NF-Homolog of TRIM 5 , Is a Ubiquitin Ligase Tripartite Motif ( TRIM ) 12 c , a Mouse

  2015cites this paper
• Potent restriction of HIV-1 and SIVmac239 Replication by African Green Monkey TRIM5α

  2015cites this paper
• Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6

  2015cites this paper
• Molecular Characterization of HERC5: A Novel Multifunctional Antiviral Protein

  2015cites this paper
• Overexpression of feline tripartite motif-containing 25 interferes with the late stage of feline leukemia virus replication.

  2015cites this paper
• Adaptation of HIV-1 to rhTrim5α-mediated restriction in vitro.

  2015cites this paper
• Paediatric HIV infection in the ‘omics era: defining transcriptional signatures of viral control and vaccine responses

  2015cites this paper
• Suppressor of Cytokine Signaling 1 Counteracts Rhesus Macaque TRIM5α-Induced Inhibition of Human Immunodeficiency Virus Type-1 Production

  2014cites this paper
• Unraveling the Convoluted Biological Roles of Type I Interferons in Infection and Immunity: A Way Forward for Therapeutics and Vaccine Design

  2014cites this paper
• TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque, negatively modulates TRIM5α activity.

  2014cites this paper
• Virus-host interactions in an ovine model of lung cancer

  2014cites this paper
• A novel aminoacid determinant of HIV-1 restriction in the TRIM5α variable 1 region isolated in a random mutagenic screen.

  2013cites this paper
• Using TRIM5α as an HIV therapeutic: the alpha gene?

  2013cites this paper
• TRIM/RBCC Proteins

  2013cites this paper
• Viral Attachment Induces Rapid Recruitment of an Innate Immune Sensor (TRIM5α) to the Plasma Membrane

  2013cites this paper
• The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import

  2013cites this paper
• TRIM proteins as RING finger E3 ubiquitin ligases.

  2012cites this paper
• Role of Human TRIM5α in Intrinsic Immunity

  2012influential citation
• Molecular Mechanism of Arenavirus Assembly and Budding

  2012cites this paper
• SIV replication in human cells

  2012influential citation
• Characterization of a monoclonal anti-capsid antibody that cross-reacts with three major primate lentivirus lineages.

  2012cites this paper
• TRIM proteins and the innate immune response to viruses.

  2012cites this paper
• Targeting strategies for Human immunodeficiency virus: a combinatorial approach.

  2012cites this paper
• Adenovirus E4-ORF3-dependent relocalization of TIF1α and TIF1γ relies on access to the Coiled-Coil motif.

  2012cites this paper
• Distinct gene expression profiles associated with the susceptibility of pathogen-specific CD4+ T cells to HIV-1 infection

  2012cites this paper
• Synthetic Strategies for the Construction of δ-Carbolines. A Chemical Ladder in Search of Novel Drugs

  2012cites this paper
• Lentiviral gene therapy for HIV using TRIM-cyclophilin restriction factors

  2012cites this paper
• Restriction of HIV-1 replication by unique TRIM22 isoforms.

  2012cites this paper
• Determinants of HIV-1 Gag Localization to Uropods in Polarized T Cells and the Role Uropods Play in Virus Spread.

  2012cites this paper
• Restriction of HIV-1 replication by unique TRIM22 isoforms.

  2012cites this paper
• The function and diversity of the antiretroviral restriction factors TRIM5alpha and TRIMCyp in Old World primates

  2012cites this paper
• The evolution of HIV: Inferences using phylogenetics

  2011cites this paper
• Cell-to-cell transmission of retroviruses: Innate immunity and interferon-induced restriction factors

  2011cites this paper
• TRIM E3 ligases in HIV infection: Can these intrinsic immunity factors be harnessed for novel vaccines or therapies?

  2011cites this paper
• Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish

  2011cites this paper
• Rhesus monkey TRIM5α represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-κB activation

  2011cites this paper
• Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag

  2011cites this paper
• Rhesus Monkey TRIM5α Has Distinct HIV-1 Restriction Activity Among Different Mammalian Cell Lines

  2011cites this paper
• Modulation of TRIM5α Activity in Human Cells by Alternatively Spliced TRIM5 Isoforms

  2011cites this paper
• The Antiviral Spectra of TRIM5α Orthologues and Human TRIM Family Proteins against Lentiviral Production

  2011cites this paper
• Cellular Restriction Factors: Exploiting the Body’s Antiviral Proteins to Combat HIV-1/AIDS

  2011cites this paper
• Retroviral Host Cell Factors: TRIM5, APOBEC3G and Cyclophilins

  2011cites this paper
• Viral and non-viral approaches for transient delivery of mRNA and proteins.

  2011cites this paper
• Interleukin-4 inhibits an early phase in the HIV-1 life cycle in the human colorectal cell line HT-29.

  2010cites this paper
• Restriction factors of retroviral replication: the example of Tripartite Motif (TRIM) protein 5α and 22

  2010influential citation
• Molecular cloning and characterization of bloodthirsty from Atlantic cod (Gadus morhua).

  2010cites this paper
• Inhibitory effect of human TRIM5alpha on HIV-1 production.

  2010cites this paper
• A new functional role of HIV-1 integrase during uncoating of the viral core

  2010cites this paper
• Funktionelle Bedeutung der Lymphotoxin-beta-Rezeptor-Aktivierung in Entzündungsreaktionen

  2010cites this paper
• Cellular HIV-1 restriction factors: a new avenue for AIDS therapy?

  2010cites this paper
• Cytoplasmic Body Component TRIM5α Requires Lipid-enriched Microdomains for Efficient HIV-1 Restriction*

  2010cites this paper
• [Host genetic factors associated with susceptibility to HIV infection and progression of infection].

  2009cites this paper
• Human TRIM5 (cid:1) Expression Levels and Reduced Susceptibility to HIV-1 Infection

  2009cites this paper
• Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species

  2009cites this paper
• Restriction of HIV-1 Replication in Monocytes Is Abolished by Vpx of SIVsmmPBj

  2009cites this paper
• Determinants for the Rhesus Monkey TRIM5α-mediated Block of the Late Phase of HIV-1 Replication*

  2009cites this paper
• HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.

  2009cites this paper
• Human TRIM5alpha expression levels and reduced susceptibility to HIV-1 infection.

  2009cites this paper
• Evasion from CypA- and APOBEC-mediated restrictions is insufficient for HIV-1 to efficiently grow in simian cells.

  2009cites this paper
• Host Factors that Restrict Retrovirus Replication

  2009cites this paper
• Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type

  2009cites this paper
• Identification of the Function of the Vpx Protein of Primate Lentiviruses: A Dissertation

  2009cites this paper
• LABORATORY PRIMATE NEWSLETTER

  2009cites this paper
• A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish

  2009cites this paper
• The capsid protein of human immunodeficiency virus: interactions of HIV‐1 capsid with host protein factors

  2009cites this paper
• Hepadnaviruses have a narrow host range — do they?

  2008cites this paper
• Reply to: No effect of endogenous TRIM5α on HIV-1 production

  2008cites this paper
• Host factors involved in resistance to retroviral infection

  2008cites this paper
• The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22

  2008cites this paper
• TRIM 30 a negatively regulates TLR-mediated NF-j B activation by targeting TAB 2 and TAB 3 for degradation

  2008cites this paper
• Mode of Transmission Affects the Sensitivity of Human Immunodeficiency Virus Type 1 to Restriction by Rhesus TRIM5α

  2008cites this paper
• Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth.

  2008cites this paper
• Novel targets for HIV therapy.

  2008cites this paper