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Apoptosis, senescence and cancer (cancer drug discovery and development)

D. Gewirtz,S. Holt

Published 2009 in British Journal of Cancer

ABSTRACT

As part of the Cancer Drug Discovery and Development series, this book aims to explain basic biological processes and signalling pathways and to link that knowledge to the anticancer drugs associated with those pathways. Each chapter begins with a detailed introduction to the basic science of the specific process, pathway or drug family before entering into their clinical applications. The book is divided into six parts and, although not officially stated, these roughly divide into two halves. The first half deals with the mechanisms of apoptosis and other modes of cell death; telomeres and senescence; and the DNA damage response. In addition to apoptosis, other modes of cell death dealt with within this half of the book include alternative cancer therapy targets such as autophagy, anoikis and mitotic catastrophe. The clinical aspects of the earlier chapters nicely links to the second half of the book, which is more pharmacologically/therapeutically orientated with three parts dealing with tumour resistance and sensitisation, established cancer therapies and developing cancer therapies. A flavour of the chapters in this half of the book include, ‘perturbation of cellular functions by Topoisomerase II inhibitors' and ‘monoclonal antibodies in lymphomas'. With some 28 chapters, the book covers a wide range of topics within the title's remit, from information on the mechanisms of apoptosis to antimetabolite and tyrosine kinase inhibitor therapies.

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