SCIENCE@home

Brain functional connectivity in individuals with callosotomy and agenesis of the corpus callosum: a systematic review.

L. Mancuso,L. Uddin,Andrea Nani,T. Costa,F. Cauda

Published 2019 in Neuroscience and Biobehavioral Reviews

ABSTRACT

In the absence of the corpus callosum due to either surgical transection or congenital agenesis, the interhemispheric exchange of information is disrupted, as emphasized by several clinical studies. In such cases, a reduction of interhemispheric functional connectivity, that is, an increased independence of the functional signals of the two disconnected hemispheres, is expected to occur. A growing literature has investigated this hypothesis, and a number of studies were able to confirm it. However, this increased independence is not always observed, especially in congenital agenesis, in which the functional signals of the two hemispheres are often found to be characterized by synchronization or correlation. The extent of these counterintuitive findings and possible explanations are discussed. Overall, these findings highlight both methodological and theoretical considerations that emphasize the importance of subcortical structures, the preservation of which may underlie alternative pathways of functional connectivity and interhemispheric communication.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-100 of 212 references · Page 1 of 3

123
Next

CITED BY

Showing 1-39 of 39 citing papers · Page 1 of 1