The multiple lives of NMD factors: balancing roles in gene and genome regulation

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Nature reviews genetics

• Publication date

  2008-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrg2402PMID 18679436PMCID PMC3711694
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

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• Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

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• NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.

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• Telomere dysfunction, genome instability and cancer.

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• hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress

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• Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay.

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• NMD resulting from encephalomyocarditis virus IRES‐directed translation initiation seems to be restricted to CBP80/20‐bound mRNA

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• Regulation of Multiple Core Spliceosomal Proteins by Alternative Splicing-Coupled Nonsense-Mediated mRNA Decay

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• Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail.

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• A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis*

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• Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends

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  2007cited by this paper
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  2007cited by this paper
• Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

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  2006cited by this paper
• Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.

  2006cited by this paper
• Nonsense-mediated mRNA decay.

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• Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1.

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  2005cited by this paper
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• Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay.

  2005cited by this paper
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  2005cited by this paper
• in Saccharomyces cerevisiae

  2005cited by this paper
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