Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature reviews. Immunology

• Publication date

  2009-09-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nri2629PMID 19763148
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Innate immunity to virus infection

  2009cited by this paper
• Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place?

  2009cited by this paper
• Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

  2009cited by this paper
• Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination.

  2008cited by this paper
• Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

  2008cited by this paper
• Detection of Th1/Th2 cytokine signatures in yellow fever 17DD first-time vaccinees through ELISpot assay.

  2008cited by this paper
• Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines.

  2008cited by this paper
• A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus.

  2008cited by this paper
• Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes.

  2008cited by this paper
• Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

  2008cited by this paper
• Immune response during adverse events after 17D-derived yellow fever vaccination in Europe.

  2008cited by this paper
• Signal integration in the endoplasmic reticulum unfolded protein response

  2007cited by this paper
• Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells.

  2007cited by this paper
• Functional properties and genomics of glucose transporters.

  2007cited by this paper
• Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease

  2007cited by this paper
• Gene expression patterns in blood leukocytes discriminate patients with acute infections.

  2007cited by this paper
• Taking dendritic cells into medicine

  2007cited by this paper
• Mammalian stress granules and processing bodies.

  2007cited by this paper
• Genomic signatures to guide the use of chemotherapeutics

  2006cited by this paper
• BLyS and B cell homeostasis.

  2006cited by this paper
• Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

  2006cited by this paper
• Dengue Virus Induces Expression of CXC Chemokine Ligand 10/IFN-γ-Inducible Protein 10, Which Competitively Inhibits Viral Binding to Cell Surface Heparan Sulfate1

  2006cited by this paper
• Antiviral effect of the mammalian translation initiation factor 2α kinase GCN2 against RNA viruses

  2006cited by this paper
• Regulation of cap-dependent translation by eIF4E inhibitory proteins

  2005cited by this paper
• Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes

  2005cited by this paper
• The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I1

  2005cited by this paper
• Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors1

  2005cited by this paper
• Concurrent and consecutive infection and immunisation with yellow fever and UGMP-359 viruses

  2005cited by this paper
• Yellow fever vaccine: an updated assessment of advanced age as a risk factor for serious adverse events.

  2005cited by this paper
• Growing roles for the mTOR pathway.

  2005cited by this paper
• Yellow fever vaccine

  2005cited by this paper
• Science : Conjectures and Refutations

  2005cited by this paper
• Different chemokine expression in lethal and non‐lethal murine west nile virus infection

  2004cited by this paper
• A Single Amino Acid Substitution in the Envelope Protein of Chimeric Yellow Fever-Dengue 1 Vaccine Virus Reduces Neurovirulence for Suckling Mice and Viremia/Viscerotropism for Monkeys

  2004cited by this paper
• Human cytotoxic T lymphocyte responses to live attenuated 17D yellow fever vaccine: identification of HLA-B35-restricted CTL epitopes on nonstructural proteins NS1, NS2b, NS3, and the structural protein E.

  2002cited by this paper
• Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated Vaccines

  2002cited by this paper
• Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

  2001cited by this paper
• Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil.

  2001cited by this paper
• Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

  2000cited by this paper
• Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.

  1999cited by this paper
• Development of viremia and humoral and cellular parameters of immune activation after vaccination with yellow fever virus strain 17D: A model of human flavivirus infection

  1998cited by this paper
• Antigenic variants of yellow fever virus with an altered neurovirulence phenotype in mice.

  1997cited by this paper
• Replication of yellow fever virus in the mouse central nervous system: comparison of neuroadapted and non-neuroadapted virus and partial sequence analysis of the neuroadapted strain.

  1996cited by this paper
• Science on Trial: The Clash of Medical Evidence and the Law in the Breast Implant Case

  1996cited by this paper
• Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it.

  1987cited by this paper
• Yellow Fever Vaccine. II. Antigenicity and Neurovirulence of a Vaccine Seed Free from Avian Leukosis Virus

  1969cited by this paper
• Research on dengue during World War II.

  1952cited by this paper
• THE USE OF YELLOW FEVER VIRUS MODIFIED BY IN VITRO CULTIVATION FOR HUMAN IMMUNIZATION

  1937cited by this paper
• THE EFFECT OF PROLONGED CULTIVATION IN VITRO UPON THE PATHOGENICITY OF YELLOW FEVER VIRUS

  1937cited by this paper

• Arboviruses in Cancer therapy: pros and cons

  2026cites this paper
• Yellow fever vaccine propagation in primary human hepatocytes triggers antiviral and cytolytic responses

  2026cites this paper
• Yellow fever in children and adolescents amid the South American outbreak, 2024/2025

  2025cites this paper
• Kinetically activating nanovaccine mimicking multidimensional immunomodulation of natural infection for broad protection against heterologous viruses in animal models

  2025cites this paper
• Intérêt et limites des corrélats immunologiques de protection

  2025cites this paper
• Mitochondrial hyperactivity and reactive oxygen species drive innate immunity to the yellow fever virus-17D live-attenuated vaccine

  2025influential citation
• Immunological and transcriptomic profile of chimeric live-attenuated Zika vaccine linked to protection in non-human primates

  2025cites this paper
• Nanostructures for Virus Detection and Tracking: An Overview

  2025cites this paper
• Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer

  2025cites this paper
• Antibiotic-induced gut microbiome perturbation alters the immune responses to the rabies vaccine.

  2025cites this paper
• Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

  2025cites this paper
• Dengue and severe dengue

  2025cites this paper
• Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion.

  2024cites this paper
• Applications of Flow Cytometry in Drug Discovery and Translational Research

  2024cites this paper
• Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

  2024cites this paper
• Systems vaccinology studies - achievements and future potential.

  2024cites this paper
• The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer

  2024cites this paper
• mRNA vaccines against arthropod-borne orthofaviviruses

  2024cites this paper
• Next generation yellow fever vaccine induces an equivalent immune and transcriptomic profile to the current vaccine: observations from a phase I randomised clinical trial

  2024cites this paper
• Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis

  2024cites this paper
• Evaluation of humoral immune response after yellow fever infection: an observational study on patients from the 2017–2018 sylvatic outbreak in Brazil

  2024cites this paper
• Profiling of Early Immune Responses to Vaccination Using THP-1-Derived Dendritic Cells

  2024cites this paper
• Systems Immunology Approaches to Understanding Immune Responses in Acute Infection of Yellow Fever Patients

  2024cites this paper
• Safety of the yellow fever vaccine in people living with HIV: a longitudinal study exploring post-vaccination viremia and hematological and liver kinetics

  2024cites this paper
• Spatiotemporal Nano‐Regulator Unleashes Anti‐Tumor Immunity by Overcoming Dendritic Cell Tolerance and T Cell Exhaustion in Tumor‐Draining Lymph Nodes

  2024cites this paper
• Advancing molecular modeling and reverse vaccinology in broad-spectrum yellow fever virus vaccine development

  2024cites this paper
• Extracellular Vesicles in Flaviviridae Pathogenesis: Their Roles in Viral Transmission, Immune Evasion, and Inflammation

  2024cites this paper
• MVA-based SARS-CoV-2 vaccine candidates encoding different spike protein conformations induce distinct early transcriptional responses which may impact subsequent adaptive immunity

  2024cites this paper
• YF17D‐based vaccines – standing on the shoulders of a giant

  2024cites this paper
• Thymidine kinase-expressing yellow fever 17D reporter virus facilitates prodrug activation and bioorthogonal labelling of infected cells

  2024cites this paper
• Yellow Fever: Global Impact, Epidemiology, Pathogenesis, and Integrated Prevention Approaches.

  2024cites this paper
• System vaccinology: Applications, trends, and perspectives

  2024cites this paper
• Deciphering the Potential of Probiotics in Vaccines

  2024cites this paper
• Influence of Microbiota on Vaccine Effectiveness: “Is the Microbiota the Key to Vaccine-induced Responses?”

  2023cites this paper
• Immunological factors linked to geographical variation in vaccine responses

  2023cites this paper
• Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission

  2023cites this paper
• Bridging the immunogenicity of a tetravalent dengue vaccine (TAK-003) from children and adolescents to adults

  2023cites this paper
• Intertwined Dysregulation of Ribosomal Proteins and Immune Response Delineates SARS-CoV-2 Vaccination Breakthroughs

  2023cites this paper
• Single-dose YF17D-vectored Ebola vaccine candidate protects mice against both lethal surrogate Ebola and yellow fever virus challenge

  2023cites this paper
• YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge

  2023cites this paper
• A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion

  2023cites this paper
• An experimental medicine decipher of a minimum correlate of cellular immunity: Study protocol for a double-blind randomized controlled trial

  2023cites this paper
• ScholarWorks @ Georgia State University ScholarWorks @ Georgia State University Systems Biology from Virus to Humans Systems Biology from Virus to Humans

  2022cites this paper
• Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID‐19 and after yellow fever vaccination

  2022cites this paper
• Mathematical Modeling on Yellow Fever with Effect of Awareness Through Media

  2022cites this paper
• Systems Vaccinology in HIV Vaccine Development

  2022cites this paper
• Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus.

  2022cites this paper
• Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation

  2022cites this paper
• Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

  2022cites this paper
• Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster models

  2022cites this paper
• Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmission

  2022cites this paper
• A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice

  2022cites this paper
• A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice

  2022cites this paper
• The dengue virus 4 component of NIAID’s tetravalent TV003 vaccine drives its innate immune signature

  2022cites this paper
• Pattern recognition receptor ligand-induced differentiation of human transitional B cells

  2022cites this paper
• FluoRNT: A robust, efficient assay for the detection of neutralising antibodies against yellow fever virus 17D

  2022cites this paper
• Biodistribution and environmental safety of a live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

  2022cites this paper
• Model for predicting age-dependent safety and immunomodulatory effects of STING ligands in non-human primates

  2022cites this paper
• Evaluation of Two Adjuvant Formulations for an Inactivated Yellow Fever 17DD Vaccine Candidate in Mice

  2022cites this paper
• Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

  2022cites this paper
• A heterogenic membrane-based biomimetic hybrid nanoplatform for combining radiotherapy and immunotherapy against breast cancer.

  2022cites this paper
• An innate immune activation state prior to vaccination predicts responsiveness to multiple vaccines

  2021cites this paper
• Systems immunology of flavivirus infection

  2021cites this paper
• Vaccines and Senior Travellers

  2021cites this paper
• What Constitutes Protective Immunity Following Yellow Fever Vaccination?

  2021influential citation
• Yellow fever virus vaccination: an emblematic model to elucidate robust human immune responses

  2021cites this paper
• The interplay between environmental factors, vector competence and vaccine immunodynamics as possible explanation of the 2019 yellow fever re-emergence in Nigeria

  2021cites this paper
• In-Silico Designing a Multi-Peptide Vaccine: Against Vibrio Cholera

  2021cites this paper
• Activation probability of a single naïve T cell upon TCR ligation is controlled by T cells interacting with the same antigen‐presenting cell

  2021cites this paper
• A synthetic pathogen mimetic molecule induces a highly amplified synergistic immune response via activation of multiple signaling pathways†

  2021cites this paper
• VaximmutorDB: A Web-Based Vaccine Immune Factor Database and Its Application for Understanding Vaccine-Induced Immune Mechanisms

  2021cites this paper
• Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A

  2021influential citation
• Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice

  2021cites this paper
• A Yellow Fever 17D Virus Replicon-Based Vaccine Platform for Emerging Coronaviruses

  2021cites this paper
• Shared acute phase traits in effector and memory human CD8 T cells

  2021cites this paper
• A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice

  2021cites this paper
• Acute disseminated encephalomyelitis (ADEM) associated with mosquito-borne diseases: Chikungunya virus X yellow fever immunization

  2020cites this paper
• Nanovaccines integrating endogenous antigens and pathogenic adjuvants elicit potent antitumor immunity

  2020cites this paper
• The Attenuated Pseudorabies Virus Vaccine Strain Bartha K61: A Brief Review on the Knowledge Gathered during 60 Years of Research

  2020cites this paper
• The science and medicine of human immunology

  2020cites this paper
• Live vaccine infection burden elicits adaptive humoral and cellular immunity required to prevent Zika virus infection

  2020cites this paper
• Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine

  2020cites this paper
• The Impact of the Microbiome on Immunity to Vaccination in Humans

  2020cites this paper
• The Application of Single-Cell RNA Sequencing in Vaccinology

  2020cites this paper
• RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus

  2020cites this paper
• STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

  2020cites this paper
• Cross-Reactive Immunity Among Flaviviruses

  2020cites this paper
• Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus

  2020cites this paper
• Systems Biological Approaches for Mucosal Vaccine Development

  2020cites this paper
• Tuning Subunit Vaccines with Novel TLR Triagonist Adjuvants to Generate Protective Immune Responses against Coxiella burnetii

  2019cites this paper
• Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen

  2019cites this paper
• Gene Expression Signatures Associated With Immune and Virological Responses to Therapeutic Vaccination With Dendritic Cells in HIV-Infected Individuals

  2019cites this paper
• 17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil

  2019cites this paper
• REGULATION OF VACCINE IMMUNITY — FROM MYELOID CELL FUNCTIONS TO ANTIBODY RESPONSES

  2019cites this paper
• Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development.

  2019cites this paper
• Vaccine development

  2019cites this paper
• Multi-epitope based vaccine against yellow fever virus applying immunoinformatics approaches

  2019cites this paper
• VIO: ontology classification and study of vaccine responses given various experimental and analytical conditions

  2019cites this paper
• Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses

  2019cites this paper
• Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination.

  2019cites this paper