Strategies in the discovery of novel antifungal scaffolds.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Future Medicinal Chemistry

• Publication date

  2016-07-27

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4155/fmc-2016-0020PMID 27463376
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex.

  2015cited by this paper
• Targeting the adaptability of heterogeneous aneuploids.

  2015cited by this paper
• Global analysis of fungal morphology exposes mechanisms of host cell escape

  2015cited by this paper
• Isavuconazole

  2015cited by this paper
• Synergistic Antifungal Meroterpenes and Dioxolanone Derivatives from the Endophytic Fungus Guignardia sp.

  2015cited by this paper
• 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents.

  2015cited by this paper
• The re-emergence of natural products for drug discovery in the genomics era

  2015cited by this paper
• Antipodal crambescin A2 homologues from the marine sponge Pseudaxinella reticulata. Antifungal structure-activity relationships.

  2015cited by this paper
• The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine.

  2015cited by this paper
• A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance

  2015cited by this paper
• Mechanisms of Antifungal Drug Resistance.

  2015cited by this paper
• Non-toxic antimicrobials that evade drug resistance

  2015cited by this paper
• LC-MS- and (1)H NMR Spectroscopy-Guided Identification of Antifungal Diterpenoids from Sagittaria latifolia.

  2015cited by this paper
• Recent Advances in The Discovery of N‐Myristoyltransferase Inhibitors

  2014cited by this paper
• Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

  2014cited by this paper
• Acetohydroxyacid synthase: a target for antimicrobial drug discovery.

  2014cited by this paper
• Discovery and development of first in class antifungal caspofungin (CANCIDAS®)--a case study.

  2014cited by this paper
• Bioactive metabolites from the endophytic fungus Alternaria alternata.

  2014cited by this paper
• Genomic identification of potential targets unique to Candida albicans for the discovery of antifungal agents.

  2014cited by this paper
• Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.

  2014cited by this paper
• Early State Research on Antifungal Natural Products

  2014cited by this paper
• Inhibitors of amino acids biosynthesis as antifungal agents

  2014cited by this paper
• Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans.

  2014cited by this paper
• In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections

  2014cited by this paper
• Antifungal drug development: challenges, unmet clinical needs, and new approaches.

  2014cited by this paper
• A High-Throughput Screening Assay for Fungicidal Compounds against Cryptococcus neoformans

  2014cited by this paper
• Antifungal drug discovery: the process and outcomes.

  2014cited by this paper
• Antifungal terpenoids from Hyalis argentea var. latisquama.

  2014cited by this paper
• The Investigational Agent E1210 Is Effective in Treatment of Experimental Invasive Candidiasis Caused by Resistant Candida albicans

  2014cited by this paper
• Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

  2014cited by this paper
• Antifungal Application of Nonantifungal Drugs

  2013cited by this paper
• Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite.

  2013cited by this paper
• Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents

  2013cited by this paper
• Chitin synthase inhibitors as antifungal agents.

  2013cited by this paper
• Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.

  2013cited by this paper
• Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.

  2013cited by this paper
• Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins.

  2013cited by this paper
• Candida albicans biofilms: building a heterogeneous, drug-tolerant environment.

  2013cited by this paper
• Coniochaetones E-I, new 4H-chromen-4-one derivatives from the Cordyceps-colonizing fungus Fimetariella sp.

  2013cited by this paper
• Antifungal therapy with an emphasis on biofilms.

  2013cited by this paper
• Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis

  2013cited by this paper
• High-Throughput Screening of a Collection of Known Pharmacologically Active Small Compounds for Identification of Candida albicans Biofilm Inhibitors

  2013cited by this paper
• Facile construction of structurally diverse thiazolidinedione-derived compounds via divergent stereoselective cascade organocatalysis and their biological exploratory studies.

  2013cited by this paper
• Heptaketides with antiviral activity from three endolichenic fungal strains Nigrospora sp., Alternaria sp. and Phialophora sp.

  2012cited by this paper
• The Antidepressant Sertraline Provides a Promising Therapeutic Option for Neurotropic Cryptococcal Infections

  2012cited by this paper
• A Repurposing Approach Identifies Off-Patent Drugs with Fungicidal Cryptococcal Activity, a Common Structural Chemotype, and Pharmacological Properties Relevant to the Treatment of Cryptococcosis

  2012cited by this paper
• Tackling Human Fungal Infections

  2012cited by this paper
• Antifungal Drug Discovery: Something Old and Something New

  2012cited by this paper
• Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.

  2012cited by this paper
• Risk Factors and Outcomes of Candidemia Caused by Biofilm-Forming Isolates in a Tertiary Care Hospital

  2012cited by this paper
• Amino Acid-Derived 1,2-Benzisothiazolinone Derivatives as Novel Small-Molecule Antifungal Inhibitors: Identification of Potential Genetic Targets

  2012cited by this paper
• Drug repurposing programmes get lift off

  2012cited by this paper
• A new antifungal coumarin from Clausena excavata.

  2012cited by this paper
• Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment.

  2012cited by this paper
• Natural products as sources of new drugs over the 30 years from 1981 to 2010.

  2012cited by this paper
• Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species.

  2012cited by this paper
• In vitro antifungal activities of longan (Dimocarpus longan Lour.) seed extract.

  2012cited by this paper
• Diversity-oriented synthesis: producing chemical tools for dissecting biology.

  2012cited by this paper
• Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives.

  2011cited by this paper
• In Vitro Activity of E1210, a Novel Antifungal, against Clinically Important Yeasts and Molds

  2011cited by this paper
• Activities of E1210 and Comparator Agents Tested by CLSI and EUCAST Broth Microdilution Methods against Fusarium and Scedosporium Species Identified Using Molecular Methods

  2011cited by this paper
• Discovery of a Novel Class of Orally Active Antifungal β-1,3-d-Glucan Synthase Inhibitors

  2011cited by this paper
• Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods.

  2011cited by this paper
• Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms.

  2011cited by this paper
• Efficacy of Oral E1210, a New Broad-Spectrum Antifungal with a Novel Mechanism of Action, in Murine Models of Candidiasis, Aspergillosis, and Fusariosis

  2011cited by this paper
• Importance of Candida-bacterial polymicrobial biofilms in disease.

  2011cited by this paper
• Triazole Antifungal Agents in Invasive Fungal Infections

  2011cited by this paper
• In Vitro Activity of a Novel Broad-Spectrum Antifungal, E1210, Tested against Aspergillus spp. Determined by CLSI and EUCAST Broth Microdilution Methods

  2011cited by this paper
• New lead structures in antifungal drug discovery.

  2011cited by this paper
• A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis

  2010cited by this paper
• Discovery and characterization of ß-1,6-glucan inhibitors

  2010cited by this paper
• Guignardones A-C: Three Meroterpenes from Guignardia mangiferae

  2010cited by this paper
• In vitro antifungal activities of D11-2040, a beta-1,6-glucan inhibitor, with or without currently available antifungal drugs.

  2010cited by this paper
• The current role of the reference procedures by CLSI and EUCAST in the detection of resistance to antifungal agents in vitro

  2010cited by this paper
• Natural products as antifungal agents against clinically relevant pathogens.

  2010cited by this paper
• Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis.

  2010cited by this paper
• Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives.

  2010cited by this paper
• Comparison of European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Etest Methods with the CLSI Broth Microdilution Method for Echinocandin Susceptibility Testing of Candida Species

  2010cited by this paper
• Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis.

  2010cited by this paper
• Synthesis and biological evaluation of amphotericin B derivatives.

  2010cited by this paper
• Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

  2009cited by this paper
• Antifungal Activity of Tamoxifen: In Vitro and In Vivo Activities and Mechanistic Characterization

  2009cited by this paper
• Effect of β-1,6-Glucan Inhibitors on the Invasion Process of Candida albicans: Potential Mechanism of Their In Vivo Efficacy

  2009cited by this paper
• Probing the Active Site of Candida glabrata Dihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors

  2009cited by this paper
• Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay

  2009cited by this paper
• Organic chemistry: Molecular diversity by design

  2009cited by this paper
• Current challenges in the management of invasive fungal infections

  2008cited by this paper
• Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility.

  2008cited by this paper
• A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing

  2008cited by this paper
• Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis

  2008cited by this paper
• Genomic and genetic approaches for the identification of antifungal drug targets.

  2008cited by this paper
• Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.

  2008cited by this paper
• Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.

  2008cited by this paper
• Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay

  2007cited by this paper
• Hetero Analogues of the Antimicrobial Alkaloids Cleistopholine and Sampangine

  2007cited by this paper
• Biofilm Production by Candida Species and Inadequate Antifungal Therapy as Predictors of Mortality for Patients with Candidemia

  2007cited by this paper
• Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking.

  2006cited by this paper
• Genomics, molecular targets and the discovery of antifungal drugs.

  2005cited by this paper
• Results from the ARTEMIS DISK Global AntifungalSurveillance Study: a 6.5-Year Analysis of Susceptibilitiesof Candida and Other Yeast Species to Fluconazole andVoriconazole by Standardized Disk Diffusion Testing

  2005cited by this paper
• Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.

  2004cited by this paper

• Development of machine learning models to predict the risk of fungal infection following flexible ureteroscopy lithotripsy

  2025cites this paper
• Redefining Antifungal Treatment: The Innovation of Metal-Based Compounds

  2025cites this paper
• Uniqueness of Candida auris cell wall in morphogenesis, virulence, resistance, and immune evasion.

  2024cites this paper
• Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors

  2023cites this paper
• Medicines for Malaria Venture Pandemic Box In Vitro Screening Identifies Compounds Highly Active against the Tachyzoite Stage of Toxoplasma gondii

  2023cites this paper
• Discovery of a new chemical scaffold for the treatment of superbug Candida auris infections

  2023cites this paper
• Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

  2022cites this paper
• Screening of Pandemic Response Box Library Reveals the High Activity of Olorofim against Pathogenic Sporothrix Species

  2022cites this paper
• Discovery of evodiamine derivatives as potential lead antifungal agents for the treatment of superficial fungal infections.

  2022cites this paper
• One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy

  2021cites this paper
• Antifungal azoles and azole resistance in the environment: current status and future perspectives—a review

  2021cites this paper
• Anticapsular and Antifungal Activity of α-Cyperone

  2021cites this paper
• Antifungal activity of extracts and purified saponins from the rhizomes of Chamaecostus cuspidatus against Candida and Trichophyton species

  2020cites this paper
• A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise.

  2020cites this paper
• A New Antifungal Agent (4-phenyl-1, 3-thiazol-2-yl) Hydrazine Induces Oxidative Damage in Candida albicans

  2020cites this paper
• Identification of two potential inhibitors of Sporothrix brasiliensis and Sporothrix schenckii in the Pathogen Box collection

  2020influential citation
• Viscosin-like lipopeptides from frog skin bacteria inhibit Aspergillus fumigatus and Batrachochytrium dendrobatidis detected by imaging mass spectrometry and molecular networking

  2019cites this paper
• The Patenting and Technological Trends in Candidiasis Treatment: A Systematic Review (2014-2018).

  2019cites this paper
• A new acridone with antifungal properties against Candida spp. and dermatophytes, and antibiofilm activity against C. albicans

  2019cites this paper
• Discovery of Simplified Sampangine Derivatives with Potent Antifungal Activities against Cryptococcal Meningitis.

  2019cites this paper
• Discovery of novel simplified isoxazole derivatives of sampangine as potent anti-cryptococcal agents.

  2019cites this paper
• Discovery of benzylthio analogs of fluconazole as potent antifungal agents.

  2018cites this paper
• Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors.

  2018cites this paper
• Emerging New Targets for the Treatment of Resistant Fungal Infections.

  2018cites this paper
• Targeting the GPI biosynthetic pathway

  2018cites this paper
• Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis.

  2018cites this paper
• Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis

  2017cites this paper
• The antifungal pipeline: a reality check

  2017cites this paper
• Synthesis and Antifungal Screening of 2-{[1-(5-Alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones †

  2016cites this paper