Timing of endogenous activin-like signals and regional specification of the Xenopus embryo.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Development

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 11532917
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms.

  2001cited by this paper
• Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis.

  2001cited by this paper
• Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2.

  2000cited by this paper
• Endodermal Nodal-related signals and mesoderm induction in Xenopus.

  2000influential reference
• Nodal signaling patterns the organizer.

  2000cited by this paper
• Activin- and Nodal-related factors control antero–posterior patterning of the zebrafish embryo

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• Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center.

  2000cited by this paper
• Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1.

  2000cited by this paper
• The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus.

  2000cited by this paper
• Nodal signalling in vertebrate development

  2000cited by this paper
• Endogenous patterns of TGF b superfamily signaling during early Xenopus development

  2000influential reference
• A post-mid-blastula transition requirement for TGFbeta signaling in early endodermal specification.

  2000cited by this paper
• Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction.

  2000cited by this paper
• Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development.

  2000influential reference
• Regulation of the early expression of the Xenopus nodal-related 1 gene, Xnr1.

  2000cited by this paper
• Mode of action of VegT in mesoderm and endoderm formation.

  1999influential reference
• Differential expression of VegT and Antipodean protein isoforms in Xenopus.

  1999influential reference
• Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases

  1999cited by this paper
• In Xenopus embryos, BMP heterodimers are not required for mesoderm induction, but BMP activity is necessary for dorsal/ventral patterning.

  1999cited by this paper
• Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.

  1999cited by this paper
• FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo.

  1999cited by this paper
• Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.

  1999influential reference
• The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.

  1999cited by this paper
• Spatially distinct head and heart inducers within the Xenopus organizer region.

  1999cited by this paper
• derrière: a TGF-beta family member required for posterior development in Xenopus.

  1999cited by this paper
• Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways.

  1999influential reference
• The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

  1999cited by this paper
• Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis.

  1999influential reference
• Anterior Endomesoderm Specification in Xenopusby Wnt/-catenin and TGF- Signalling Pathways

  1999cited by this paper
• A two-step model for the fate determination of presumptive endodermal blastomeres in Xenopus embryos.

  1999influential reference
• Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors.

  1999cited by this paper
• Smads and early developmental signaling by the TGFbeta superfamily.

  1998cited by this paper
• Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression.

  1998cited by this paper
• BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation.

  1998cited by this paper
• Mesoderm induction: a postmodern view.

  1998influential reference
• The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse.

  1998cited by this paper
• The role of maternal VegT in establishing the primary germ layers in Xenopus embryos.

  1998influential reference
• TGF-beta signal transduction.

  1998cited by this paper
• Pre-MBT patterning of early gene regulation in Xenopus: the role of the cortical rotation and mesoderm induction.

  1998cited by this paper
• TGF- SIGNAL TRANSDUCTION

  1998cited by this paper
• The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities.

  1998cited by this paper
• The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

  1998cited by this paper
• Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo

  1998cited by this paper
• Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

  1997cited by this paper
• Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer.

  1997cited by this paper
• Developmentally regulated activation of apoptosis early in Xenopus gastrulation results in cyclin A degradation during interphase of the cell cycle.

  1997influential reference
• Patterning the Xenopus blastula.

  1997influential reference
• Zygotic transcription is required to block a maternal program of apoptosis in Xenopus embryos.

  1997cited by this paper
• Formation and function of Spemann's organizer.

  1997cited by this paper
• Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

  1997cited by this paper
• Embryonic patterning: to BMP or not to BMP, that is the question.

  1997cited by this paper
• The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds.

  1997influential reference
• Establishment of the dorsoventral axis in Xenopus embryos is presaged by early asymmetries in β-catenin that are modulated by the Wnt signaling pathway

  1997influential reference
• A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis.

  1997cited by this paper
• A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation.

  1997cited by this paper
• Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos.

  1996cited by this paper
• Short-range signaling by candidate morphogens of the TGF beta family and evidence for a relay mechanism of induction.

  1996cited by this paper
• Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

  1996cited by this paper
• The vegetal determinants required for the Spemann organizer move equatorially during the first cell cycle.

  1996cited by this paper
• The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation.

  1996influential reference
• Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

  1996cited by this paper
• Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos.

  1996cited by this paper
• The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.

  1996cited by this paper
• Signalling by TGF-beta family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin.

  1996cited by this paper
• Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation.

  1996influential reference
• Synergistic effects of Vg1 and Wnt signals in the specification of dorsal mesoderm and endoderm.

  1996cited by this paper
• Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning.

  1996cited by this paper
• Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos.

  1996influential reference
• A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation.

  1996cited by this paper
• TGF-beta signals and a pattern in Xenopus laevis endodermal development.

  1996cited by this paper
• The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development.

  1995cited by this paper
• Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation.

  1995influential reference
• The role of gsc and BMP‐4 in dorsal‐ventral patterning of the marginal zone in Xenopus: a loss‐of‐function study using antisense RNA.

  1995cited by this paper
• Molecular cloning and functional analysis of a new activin beta subunit: a dorsal mesoderm-inducing activity in Xenopus.

  1995cited by this paper
• beta-Catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning.

  1995cited by this paper
• Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.

  1995cited by this paper
• Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

  1994influential reference
• Mesoderm induction by activin requires FGF-mediated intracellular signals.

  1994cited by this paper
• Inhibition of activin receptor signaling promotes neuralization in Xenopus.

  1994cited by this paper
• The cleavage stage origin of Spemann's Organizer: analysis of the movements of blastomere clones before and during gastrulation in Xenopus.

  1994influential reference
• Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.

  1994cited by this paper
• Identification of activins A, AB, and B and follistatin proteins in Xenopus embryos.

  1994influential reference
• Occurrence of dorsal axis-inducing activity around the vegetal pole of an uncleaved Xenopus egg and displacement to the equatorial region by cortical rotation.

  1993cited by this paper
• Processed Vg1 protein is an axial mesoderm inducer in Xenopus.

  1993cited by this paper
• Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms

  1992cited by this paper
• Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus.

  1992cited by this paper
• Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.

  1992cited by this paper
• A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

  1992cited by this paper
• Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.

  1991cited by this paper
• Solutions and protocols

  1991cited by this paper
• Generation of body plan phenotypes in early embryogenesis.

  1991cited by this paper
• The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF.

  1990cited by this paper
• Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development.

  1989cited by this paper
• Localized synthesis of the Vg1 protein during early Xenopus development.

  1989cited by this paper
• The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos.

  1988cited by this paper
• A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.

  1987cited by this paper
• The midblastula cell cycle transition and the character of mesoderm in u.v.-induced nonaxial Xenopus development.

  1987cited by this paper
• The development of animal cap cells in Xenopus: a measure of the start of animal cap competence to form mesoderm

  1987influential reference
• Pattern regulation in isolated halves and blastomeres of early Xenopus laevis.

  1983cited by this paper
• Axis determination in eggs of Xenopus laevis: a critical period before first cleavage, identified by the common effects of cold, pressure and ultraviolet irradiation.

  1983cited by this paper

• Control of zygotic genome activation in Xenopus.

  2021cites this paper
• Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer

  2020cites this paper
• Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians

  2018cites this paper
• TGF-β Family Signaling in Early Vertebrate Development.

  2018cites this paper
• Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition.

  2017cites this paper
• Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development.

  2017cites this paper
• Vertebrate Axial Patterning: From Egg to Asymmetry.

  2017cites this paper
• Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.

  2017cites this paper
• Animal Cap Assay for TGF-β Signaling.

  2016cites this paper
• An investigation into the roles of p53, Nodal/ Activin and fibroblast growth factor signalling in early heart development

  2016influential citation
• Multicellular Mathematical Modelling of Mesendoderm Formation in Amphibians

  2016cites this paper
• Building the Future: Post-transcriptional Regulation of Cell Fate Decisions Prior to the Xenopus Midblastula Transition.

  2015cites this paper
• Mesendoderm Patterning by the Nodal/Lefty Activator/Inhibitor System

  2015cites this paper
• Encoding of temporal signals by the TGF-β pathway and implications for embryonic patterning.

  2014cites this paper
• Commitment to nutritional endoderm in Eleutherodactylus coqui involves altered nodal signaling and global transcriptional repression.

  2014cites this paper
• Genome-wide view of TGFβ/Foxh1 regulation of the early mesendoderm program

  2014cites this paper
• Two different network topologies yield bistability in models of mesoderm and anterior mesendoderm specification in amphibians

  2014cites this paper
• Developmental Signaling by Noggin and Wnt in the Frog Xenopus

  2013cites this paper
• Wave pinning and spatial patterning in a mathematical model of Antivin/Lefty–Nodal signalling

  2013cites this paper
• [Rbb4l enhances TGF-β/Nodal signaling and promotes zebrafish embryonic dorsolization].

  2013cites this paper
• Differential expression of nodal-signal transducers and global transcriptional repression commit vegetal cells in Eleutherodactylus coqui to form nutritional endoderm

  2013cites this paper
• Differential Diffusivity of Nodal and Lefty Underlies a Reaction-Diffusion Patterning System

  2012cites this paper
• Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine.

  2012cites this paper
• Wave pinning and spatial patterning in a mathematical model of Antivin/Lefty–Nodal signalling

  2012cites this paper
• Dynamic in vivo binding of transcription factors to cis-regulatory modules of cer and gsc in the stepwise formation of the Spemann–Mangold organizer

  2012cites this paper
• Supplementary Materials for Differential Diffusivity of Nodal and Lefty Underlies a Reaction-Diffusion Patterning System

  2012cites this paper
• Mathematical models of the gene regulatory networks underlying mesendoderm formation in amphibians

  2012influential citation
• The RNA-binding protein XSeb4R regulates maternal Sox3 at the posttranscriptional level during maternal-zygotic transition in Xenopus.

  2012cites this paper
• An essential role for transcription before the MBT in Xenopus laevis.

  2011influential citation
• Mesoderm induction in Ambystoma mexicanum, a urodele amphibian

  2011cites this paper
• Understanding the Role of SCL in Early Mammalian Development Using Mouse Embryonic Stem Cell Differentiation as a Model

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• The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo.

  2010cites this paper
• A conserved mechanism for vertebrate mesoderm specification in urodele amphibians and mammals.

  2010cites this paper
• The role of preMBT transcription in Xenopus development

  2010cites this paper
• Nodal morphogens.

  2009cites this paper
• Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish.

  2009cites this paper
• Role of the anterior endoderm in cardiac specification

  2009influential citation
• Nucleocytoplasmic shuttling of Smad proteins

  2009cites this paper
• Investigating pluripotency and primordial germ cell development in axolotl with a focus on axnanog and axblimp1

  2009cites this paper
• Transcriptional poising prior to the midblastula transition underlies dorsal cell fate specification by the Wnt/beta-catenin pathway

  2009cites this paper
• Identification of embryonic pancreatic genes using Xenopus DNA microarrays

  2009cites this paper
• Bistability in a model of mesoderm and anterior mesendoderm specification in Xenopus laevis.

  2009cites this paper
• Maternal control of pattern formation in Xenopus laevis.

  2008influential citation
• TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.

  2008cites this paper
• Expression of complement components coincides with early patterning and organogenesis in Xenopus laevis.

  2008cites this paper
• Dynamic determinations: patterning the cell behaviours that close the amphibian blastopore

  2008cites this paper
• Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation

  2008cites this paper
• Two highly related regulatory subunits of PP2A exert opposite effects on TGF-β/Activin/Nodal signalling

  2008cites this paper
• Regulation of activin/nodal signaling by Rap2-directed receptor trafficking.

  2008cites this paper
• Identification of a Novel Pool of Extracellular Pro-myostatin in Skeletal Muscle*

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• Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation

  2007cites this paper
• TGFβ–SMAD signal transduction: molecular specificity and functional flexibility

  2007cites this paper
• Nuclear accumulation of Smad complexes occurs only after the midblastula transition in Xenopus

  2007influential citation
• Nodal signaling: developmental roles and regulation

  2007cites this paper
• Xenopus Lefty requires proprotein cleavage but not N‐linked glycosylation to inhibit nodal signaling

  2007cites this paper
• Xnrs and Activin Regulate Distinct Genes during Xenopus Development: Activin Regulates Cell Division

  2007cites this paper
• Nodal signaling activates differentiation genes during zebrafish gastrulation.

  2007cites this paper
• Molecular basis of vertebrate endoderm development.

  2007cites this paper
• Kinesin-mediated transport of Smad2 is required for signaling in response to TGF-beta ligands.

  2007cites this paper
• Multiple functions of Cerberus cooperate to induce heart downstream of Nodal.

  2007cites this paper
• TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis.

  2007cites this paper
• Signaling Pathways in Embryonic Heart Induction

  2007cites this paper
• High-resolution studies of Xnr1 signaling and left-right asymmetry in Xenopus

  2007cites this paper
• The effect of post-translational modifications on Xlefty function.

  2007cites this paper
• FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development

  2006cites this paper
• Vg1 is an essential signaling molecule in Xenopus development

  2006cites this paper
• Patterning the early Xenopus embryo

  2006cites this paper
• Review Nodal signals pattern vertebrate embryos

  2006cites this paper
• Nodal signals pattern vertebrate embryos

  2006cites this paper
• Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus.

  2006cites this paper
• Nodal‐related gene Xnr5 is amplified in the Xenopus genome

  2006influential citation
• Maternal determinants of embryonic cell fate.

  2006cites this paper
• Emergence of organizer function: a lot of "stuff" involved.

  2006cites this paper
• A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos.

  2006cites this paper
• Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.

  2006cites this paper
• Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction.

  2005cites this paper
• Maternal Xenopus Zic2 negatively regulates Nodal-related gene expression during anteroposterior patterning

  2005cites this paper
• A cell cycle arrest is necessary for bottle cell formation in the early Xenopus gastrula: integrating cell shape change, local mitotic control and mesodermal patterning.

  2005cites this paper
• Notch signaling modulates the nuclear localization of carboxy-terminal-phosphorylated smad2 and controls the competence of ectodermal cells for activin A.

  2005cites this paper
• XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning

  2005cites this paper
• Summary Maternal Xenopus Zic 2 negatively regulates Nodal-related gene expression during anteroposterior patterning

  2005cites this paper
• Maternal VegT and ß-Catenin: Patterning the Xenopus Blastula

  2004cites this paper
• Regionally specific induction by the Spemann–Mangold organizer

  2004cites this paper
• BMP antagonism by Spemann's organizer regulates rostral-caudal fate of mesoderm.

  2004cites this paper
• Short-Versus Long-Range Effects of Spemann’s Organizer

  2004cites this paper
• ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.

  2004cites this paper
• Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation

  2004cites this paper
• Cloning and expression of an SH3 domain-containing protein (Xchef-1), a novel downstream target of activin/nodal signaling.

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• New roles for FoxH1 in patterning the early embryo

  2004influential citation
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  2004cites this paper
• Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction

  2003cites this paper
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  2003cites this paper
• Early Head Specification in Xenopus laevis

  2003cites this paper
• Early endoderm development in vertebrates: lineage differentiation and morphogenetic function.

  2003cites this paper
• Novel gene expression domains reveal early patterning of the Xenopus endoderm.

  2003cites this paper
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  2003influential citation
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  2003cites this paper
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  2003cites this paper