RPA coordinates DNA end resection and prevents formation of DNA hairpins.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecules and Cells

• Publication date

  2013-05-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molcel.2013.04.032PMID 23706822PMCID PMC3855855
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Methods in yeast genetics

  2013cited by this paper
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  2012influential reference
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  2012influential reference
• Increased chromosome mobility facilitates homology search during recombination

  2012cited by this paper
• The MRE11 complex: starting from the ends

  2011cited by this paper
• BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.

  2011influential reference
• BRCA1 and BRCA2: different roles in a common pathway of genome protection

  2011cited by this paper
• Replication protein A promotes 5′→3′ end processing during homology-dependent DNA double-strand break repair

  2011cited by this paper
• Ku prevents Exo1 and Sgs1‐dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

  2010cited by this paper
• Mre11–Rad50–Xrs2 and Sae2 promote 5’ strand resection of DNA double-strand breaks

  2010influential reference
• Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

  2010influential reference
• DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2

  2010influential reference
• Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

  2010influential reference
• Rad51 Inhibits Translocation Formation by Non-Conservative Homologous Recombination in Saccharomyces cerevisiae

  2010cited by this paper
• RecQ helicases: multifunctional genome caretakers

  2009cited by this paper
• Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

  2008influential reference
• Differential regulation of the cellular response to DNA double-strand breaks in G1.

  2008cited by this paper
• Reconstitution of DNA Strand Exchange Mediated by Rhp51 Recombinase and Two Mediators

  2008cited by this paper
• Rad52 promotes postinvasion steps of meiotic double-strand-break repair.

  2008cited by this paper
• Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends.

  2008influential reference
• Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

  2008influential reference
• Processing of G4 DNA by Dna2 Helicase/Nuclease and Replication Protein A (RPA) Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition*

  2008cited by this paper
• Molecular Anatomy of the Recombination Mediator Function of Saccharomyces cerevisiae Rad52*

  2008cited by this paper
• DNA helicases Sgs1 and BLM promote DNA double-strand break resection.

  2008cited by this paper
• Saccharomyces cerevisiae Sae2- and Tel1-Dependent Single-Strand DNA Formation at DNA Break Promotes Microhomology-Mediated End Joining

  2007cited by this paper
• Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.

  2007cited by this paper
• RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells.

  2007cited by this paper
• Surviving the breakup: the DNA damage checkpoint.

  2006cited by this paper
• Evidence Suggesting that Pif1 Helicase Functions in DNA Replication with the Dna2 Helicase/Nuclease and DNA Polymerase δ

  2006cited by this paper
• Srs2 and Sgs1 DNA Helicases Associate with Mre11 in Different Subcomplexes following Checkpoint Activation and CDK1-Mediated Srs2 Phosphorylation

  2005cited by this paper
• Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual

  2005cited by this paper
• Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

  2005cited by this paper
• A mechanism of palindromic gene amplification in Saccharomyces cerevisiae.

  2005influential reference
• The Pol32 Subunit of DNA Polymerase δ Contains Separable Domains for Processive Replication and Proliferating Cell Nuclear Antigen (PCNA) Binding*

  2004influential reference
• The CDK regulates repair of double‐strand breaks by homologous recombination during the cell cycle

  2004cited by this paper
• Recombination proteins in yeast.

  2004influential reference
• Telomerase- and recombination-independent immortalization of budding yeast.

  2004cited by this paper
• DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

  2004cited by this paper
• Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.

  2004influential reference
• Rapid Depletion of Budding Yeast Proteins by Fusion to a Heat-Inducible Degron

  2004cited by this paper
• Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro.

  2003cited by this paper
• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

  2003influential reference
• Functional Cross-talk among Rad51, Rad54, and Replication Protein A in Heteroduplex DNA Joint Formation*

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements.

  2002cited by this paper
• Replication protein A is required for meiotic recombination in Saccharomyces cerevisiae.

  2002cited by this paper
• Functional Interactions among Yeast Rad51 Recombinase, Rad52 Mediator, and Replication Protein A in DNA Strand Exchange*

  2000cited by this paper
• Characterization of the Enzymatic Properties of the Yeast Dna2 Helicase/Endonuclease Suggests a New Model for Okazaki Fragment Processing*

  2000cited by this paper
• Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

  1999cited by this paper
• An allele of RFA1 suppresses RAD52-dependent double-strand break repair in Saccharomyces cerevisiae.

  1999cited by this paper
• Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage.

  1999cited by this paper
• Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual

  1998cited by this paper
• Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism.

  1998cited by this paper
• Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage.

  1998cited by this paper
• DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA.

  1998cited by this paper
• Stimulation by Rad52 of yeast Rad51- mediated recombination

  1998cited by this paper
• Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes.

  1998cited by this paper
• Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

  1998cited by this paper
• The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.

  1998cited by this paper
• Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism.

  1997cited by this paper
• Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase*

  1997cited by this paper
• Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae

  1997cited by this paper
• A Single-stranded DNA-binding Protein Is Needed for Efficient Presynaptic Complex Formation by the Saccharomyces cerevisiae Rad51 Protein*

  1997cited by this paper
• DNA strand annealing is promoted by the yeast Rad52 protein.

  1996cited by this paper
• A novel allele of Saccharomyces cerevisiae RFA1 that is deficient in recombination and repair and suppressible by RAD52

  1995cited by this paper
• DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA.

  1995cited by this paper
• Replication factor A is required in vivo for DNA replication, repair, and recombination

  1994cited by this paper
• Replication factor-A from Saccharomyces cerevisiae is encoded by three essential genes coordinately expressed at S phase.

  1991cited by this paper
• Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site.

  1991cited by this paper
• Intermediates of recombination during mating type switching in Saccharomyces cerevisiae.

  1990cited by this paper

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