SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Molecular Biology

• Publication date

  2013-12-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jmb.2013.10.022PMID 24161438
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HIV Type 1 Infection of Plasmacytoid and Myeloid Dendritic Cells Is Restricted by High Levels of SAMHD1 and Cannot be Counteracted by Vpx

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• Molecular Basis of DNA Recognition in the Immune System

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• Inhibition of CUL4A Neddylation Causes a Reversible Block to SAMHD1-Mediated Restriction of HIV-1

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• Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction*

  2013influential reference
• Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1

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• Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

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• Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply

  2013influential reference
• Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

  2013cited by this paper
• SAMHD1‐dependent retroviral control and escape in mice

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• Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

  2013cited by this paper
• STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

  2013cited by this paper
• Single-stranded nucleic acids promote SAMHD1 complex formation

  2013cited by this paper
• Erratum: SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates (Nature Immunology (2012) 13 (223-228))

  2013cited by this paper
• Structural mechanism of cytosolic DNA sensing by cGAS

  2013cited by this paper
• STING recognition of cytoplasmic DNA instigates cellular defense.

  2013cited by this paper
• Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

  2013cited by this paper
• The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.

  2013influential reference
• The cGAS-STING pathway for DNA sensing.

  2013cited by this paper
• Corrigendum: The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

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• Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis.

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• Inhibition of retroviral replication by members of the TRIM protein family.

  2013cited by this paper
• HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

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• cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

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• Cyclic‐di‐GMP and cyclic‐di‐AMP activate the NLRP3 inflammasome

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• Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

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• Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

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• Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response

  2013cited by this paper
• Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

  2013influential reference
• Immune sensing of DNA.

  2013cited by this paper
• Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.

  2013influential reference
• Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

  2013cited by this paper
• Anti-HIV Host Factor SAMHD1 Regulates Viral Sensitivity to Nucleoside Reverse Transcriptase Inhibitors via Modulation of Cellular Deoxyribonucleoside Triphosphate (dNTP) Levels*

  2013cited by this paper
• Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

  2013cited by this paper
• Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

  2013cited by this paper
• Restriction of diverse retroviruses by SAMHD1

  2013cited by this paper
• Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1

  2013influential reference
• Intracellular pathogen detection by RIG-I-like receptors.

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• The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals

  2013cited by this paper
• The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

  2013cited by this paper
• Identification of Critical Regions in Human SAMHD1 Required for Nuclear Localization and Vpx-Mediated Degradation

  2013cited by this paper
• Promoter Methylation Regulates SAMHD1 Gene Expression in Human CD4+ T Cells*

  2013cited by this paper
• Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection

  2013influential reference
• HIV-2 and SIVmac Accessory Virulence Factor Vpx Down-regulates SAMHD1 Enzyme Catalysis Prior to Proteasome-dependent Degradation*

  2013cited by this paper
• GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1*

  2013cited by this paper
• IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

  2013cited by this paper
• Frequent Incorporation of Ribonucleotides during HIV-1 Reverse Transcription and Their Attenuated Repair in Macrophages*

  2012cited by this paper
• The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus

  2012influential reference
• Vpx is Critical for SIVmne infection of pigtail macaques

  2012cited by this paper
• Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac

  2012influential reference
• HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

  2012cited by this paper
• A novel pathogenetic concept—antiviral immunity in lupus nephritis

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• STING and the innate immune response to nucleic acids in the cytosol

  2012cited by this paper
• Co-Evolution of Primate SAMHD1 and Lentivirus Vpx Leads to the Loss of the vpx Gene in HIV-1 Ancestor

  2012cited by this paper
• Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

  2012cited by this paper
• APOBEC3A, APOBEC3B, and APOBEC3H Haplotype 2 Restrict Human T-Lymphotropic Virus Type 1

  2012cited by this paper
• DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

  2012cited by this paper
• Host restriction factors in retroviral infection: promises in virus-host interaction

  2012cited by this paper
• SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

  2012cited by this paper
• SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

  2012influential reference
• SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

  2012influential reference
• The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.

  2012cited by this paper
• A novel DCAF1‐binding motif required for Vpx‐mediated degradation of nuclear SAMHD1 and Vpr‐induced G2 arrest

  2012cited by this paper
• SAMHD1 Restricts HIV-1 Cell-to-Cell Transmission and Limits Immune Detection in Monocyte-Derived Dendritic Cells

  2012cited by this paper
• Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages*

  2012cited by this paper
• SAMHD1 is a nucleic‐acid binding protein that is mislocalized due to aicardi–goutières syndrome‐associated mutations

  2012cited by this paper
• SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

  2012influential reference
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  2011influential reference
• Nef performance in macrophages: the master orchestrator of viral persistence and spread.

  2011cited by this paper
• Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase*♦

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• SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection

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• Automated Genome-Wide Visual Profiling of Cellular Proteins Involved in HIV Infection

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• HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

  2011influential reference
• Macrophages and HIV-1.

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• Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

  2011influential reference
• The IRF-3/Bax-Mediated Apoptotic Pathway, Activated by Viral Cytoplasmic RNA and DNA, Inhibits Virus Replication

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• Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?

  2010cited by this paper
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  2010cited by this paper
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• Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis

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• Coordinate regulation of histone mRNA metabolism and DNA replication

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• An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

  2009cited by this paper
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  2009cited by this paper
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• Tetherin inhibits HIV-1 release by directly tethering virions to cells.

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• Human Immunodeficiency Virus, Restriction Factors, and Interferon

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• Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

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• HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

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• The CDK Inhibitor p21Cip1/WAF1 Is Induced by FcγR Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages

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• AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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• AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC

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• Vpx Is Critical for Reverse Transcription of the Human Immunodeficiency Virus Type 2 Genome in Macrophages

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  2019influential citation
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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• Comment on Clifford et al , page 1021 SAMHD 1 : a new gene for CLL---------------------------------------------------------------------------------------------------- -

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