The mechanism of action of chlorpromazine. Reduced diphosphopyridine nucleotidecytochrome c reductase and coupled phosphorylation.

No abstract is available for this paper.

• Publication year

  1959

• Venue

  Biochemical Journal

• Publication date

  1959-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ0730016PMID 13814569PMCID PMC1197005
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effect of chlorpromazine on the respiratory chain; cytochrome oxidase.

  1959cited by this paper
• Mechanism of Oxidative Phosphorylation

  1958cited by this paper
• Oxidative phosphorylation.

  1958cited by this paper
• Organization of mitochondrial DPN-linked systems. II. Regulation of alternative electron transfer pathways.

  1956cited by this paper
• The respiratory chain and oxidative phosphorylation.

  1956cited by this paper
• Phosphorylation coupled to the oxidation of ferrocytochrome c.

  1955cited by this paper
• Phosphorylation coupled to reduction of cytochrome c by beta-hydroxybutyrate.

  1955cited by this paper
• Mechanism of action of carbon tetrachloride on liver cells

  1954cited by this paper
• Reversal and Mechanism of Oxidative Phosphorylation

  1954cited by this paper
• Synthesis of phosphatides in isolated mitochondria.

  1953cited by this paper
• Oxidative phosphorylation.

  1953cited by this paper
• Oxidative phosphorylations; rôle of inorganic phosphate and acceptor systems in control of metabolic rates.

  1952cited by this paper
• The action of 2:4-dinitrophenol on oxidative phosphorylation.

  1951cited by this paper
• The inhibition of oxidative phosphorylation.

  1951cited by this paper
• Intracellular distribution of enzymes. VIII. The distribution of diphosphopyridine nucleotidecytochrome C reductase in normal mouse liver and mouse hepatoma.

  1950cited by this paper

• Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

  2017cites this paper
• Mutation of Rv2887, a marR-Like Gene, Confers Mycobacterium tuberculosis Resistance to an Imidazopyridine-Based Agent

  2015influential citation
• Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.

  2014cites this paper
• Preclinical evidence of mitochondrial nicotinamide adenine dinucleotide as an effective alarm parameter under hypoxia

  2014cites this paper
• Protection Against Cellular Injury by Drugs

  2008cites this paper
• Appraising Enzymic Actions of Central Depressants by Examining Cerebral Tissues

  2008cites this paper
• Degradative versatility ofCorynebacterium pseudodiphtheriticum NCIB 10803 which uses amides as carbon source

  2007cites this paper
• The mechanisms of microbial oxidations of petroleum hydrocarbons.

  2006cites this paper
• Degradation of sevin (1-naphthyl-N-methyl carbamate by Achrombacter sp.

  2004cites this paper
• Quantum chemical studies of dioxygen activation by mononuclear non-heme iron enzymes with the 2-His-1-carboxylate facial triad.

  2004cites this paper
• Beeinflussung des Kohlenhydratstoffwechsels des Rattenhirns durch Psychopharmaka mit sedativer Wirkung

  2004cites this paper
• Mechanism for catechol ring-cleavage by non-heme iron extradiol dioxygenases.

  2004cites this paper
• Aliphatic and aromatic inhibitors binding to the active site of catechol 2,3‐dioxygenase from Pseudomonas putida mt‐2

  1994cites this paper
• Tyrosinase-catalysed oxidation of the new melanocytotoxic agent N-4-hydroxyphenylglycine : unusual cleavage of the 4-aminophenol ring to muconic semialdehyde derivatives

  1992cites this paper
• 2,3- and 4,5-Secodopa, the Biosynthetic Intermediates Generated from L-Dopa by an Enzyme System Extracted from the Fly Agaric, Amanita muscaria L., and Their Spontaneous Conversion to Muscaflavin and Betalamic Acid, Respectively, and Betalains

  1991cites this paper
• Hypothyroidism and tumor regression.

  1988cites this paper
• [Toxicity of etmozin under extreme conditions].

  1985cites this paper
• Donor Heart Storage

  1984cites this paper
• Effect of chlorpromazine on isolated rat hepatocytes.

  1982cites this paper
• [Toxicity of phenothiazine drugs].

  1981cites this paper
• Effect of clozapine on the oxygen, glucose uptake and oxidative phosphorylation of rat brain in vitro.

  1980cites this paper
• Oxygenases and dioxygenases.

  1979cites this paper
• The effect of chlorpromazine on bioenergetic processes in chromaffin granule membranes.

  1979cites this paper
• In vitro inhibition of rat brain ATPase, pNPPase, and ATP-32Pi exchange by chlorinated-diphenyl ethanes and cyclodiene insecticides

  1978cites this paper
• [Effect of dextropoxyphene on oxidative phosphorylation in brain and liver of rat (author's transl)].

  1977cites this paper
• Biochemistry of the bacterial catabolism of aromatic compounds in anaerobic environments

  1977cites this paper
• Effect of dibenzepin hydrochloride on the oxygen, glucose uptake and oxidative phosphorylation of rat brain in vitro.

  1977cites this paper
• Action of the antipsychotic drugs thiotixene and thioridazine on isolated mitochondria.

  1976cites this paper
• Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo.

  1976cites this paper
• Effect of Drugs on Energy Metabolism of the Brain and on Cerebral Transport

  1975cites this paper
• Oxygen Uptake by Treponema pallidum

  1974cites this paper
• INTERACTION OF SOME DRUGS, METAL IONS, AND ALCOHOLS WITH RAT LIVER MICROSOMES AS STUDIED WITH A FLUORESCENT PROBE

  1974cites this paper
• [Oxidative phosphorylation of rat hepatic mitochondria in the presence of tricyclic derivatives. Study of molecules belonging to the phenothiazine, iminodibenzyl, thioxanthene and thiophenylpyridylamine series].

  1974cites this paper
• Chapter 16 – OXYGENASES

  1974cites this paper
• 4 – NONHEME IRON DIOXYGENASE

  1974cites this paper
• Einfache Methoden zur Konservierung der Schweineleber

  1973cites this paper
• Effect of chloropromazine on growth of transplantable melanomas and on their response to x-ray irradiation

  1973cites this paper
• [Simple method for the preservation of swine liver. I. 3-hour intermittent perfusion in hypothermia].

  1973cites this paper
• Einfache Methoden zur Konservierung der Schweineleber

  1973cites this paper
• [Effect of several psychotropic drugs on the oxygen and glucose uptake by brain tissue, in vitro (author's transl)].

  1973cites this paper
• The β-Ketoadipate Pathway

  1973cites this paper
• Polytetrafluorethylene toxicity.

  1972cites this paper
• [Influence of phenothiazines on mitochondrial K + transport].

  1972cites this paper
• Chlorpromazines and cancer.

  1972cites this paper
• Apo- and reconstituted holoenzymes of metapyrocatechase from Pseudomonas putida.

  1971cites this paper
• Catabolism of aromatic compounds by micro-organisms.

  1971cites this paper
• Chapter XI Assay of Enzymes of Aromatic Metabolism

  1971cites this paper
• Specificity of monohydric phenol oxidations by meta cleavage pathways in Pseudomonas aeruginosa T1

  1970cites this paper
• [65] Metapyrocatechase (Pseudomonas)☆

  1970cites this paper
• Co-metabolism of methyl- and chloro-substituted catechols by an Achromobacter sp. possessing a new meta-cleaving oxygenase.

  1970cites this paper
• [Ecochemical capacities of higher plants].

  1970cites this paper
• Degradation of phenols by intact cells and cell-free preparations of Trichosporon cutaneum.

  1970cites this paper
• Ökochemische Leistungen höherer Pflanzen

  1970cites this paper
• Preservation of the heart.

  1969cites this paper
• Oxygen Metabolism by Micro-organisms

  1969cites this paper
• Inhibition of the growth of mouse melanoma by chlorpromazine.

  1969cites this paper
• Uptake of 32p-orthophosphate and incorporation into phospholipids in Tetrahymena pyriformis W exposed to phenothiazine derivatives.

  1968cites this paper
• The effects of 1-(1-phenylcyclohexyl)piperidine HC1 (phencyclidine, Sernyl) on respiration and related reactions of liver mitochondria in vitro.

  1968cites this paper
• Characteristics of Penicillinase Release by Washed Cells of Bacillus licheniformis

  1968cites this paper
• Metabolism of arylsulphonates by micro-organisms.

  1968cites this paper
• Action mechanism of phenothiazine derivatives on mitochondrial respiration.

  1968cites this paper
• Microbial degradation of aromatic compounds.

  1968cites this paper
• Inhibition of uridine diphosphate glucose dehydrogenase by a free radical formed from chlorpromazine.

  1967cites this paper
• The formation and reactivity of peroxidase compound 3.

  1967cites this paper
• Bacterial degradation of aromatic compounds

  1967cites this paper
• The effects of laurylamine on respiration and related reactions of liver mitochondria in vitro.

  1967cites this paper
• Michael John Ransford Dawkins 5 April 1931-27 June 1965.

  1967cites this paper
• Extended survival of the normothermic anoxic heart with metabolic inhibitors.

  1967cites this paper
• [Studies on the resistivity of lysosomal membranes. 3. Protection by riboflavin of liver lysosomes against the damaging effect of chlorpromazine in vivo].

  1967cites this paper
• The effect of the dietary lipids upon the ability of chlorpromazine to inhibit oxidative phosphorylation in liver mitochondria

  1967cites this paper
• Mode of attack on phenol by a Micrococcus sp. isolated from coir rets.

  1966cites this paper
• Effect of inhibitors and uncouplers on the Na pump of the Maia muscle fibre

  1966cites this paper
• Crystalline oxygenases of pseudomonads.

  1966cites this paper
• The influence of pH on the effects in vitro of some organic cations and anions on oxidative phosphorylation.

  1965cites this paper
• A comparative study of the influence of chlorpromazine and imipramine on mitochondrial activity. DNP- and Mg2+-activated ATPase, succinate dehydrogenase and aspartate transaminase.

  1965cites this paper
• Studies on succinate-tetrazolium reductase systems IV. Histochemical aspects

  1965cites this paper
• STUDIES ON AGRANULOCYTOSIS. VII. LIMITED PROLIFERATIVE POTENTIAL OF CPZ-SENSITIVE PATIENTS.

  1965cites this paper
• STUDIES OF FLAVIN ADENINE DINUCLEOTIDE-REQUIRING ENZYMES AND PHENOTHIAZINES-I. INTERACTIONS OF CHLORPROMAZINE AND D-AMINO ACID OXIDASE.

  1965cites this paper
• MODE OF ACTION OF THE PHENOTHIAZINES

  1965cites this paper
• SUCCESSFUL IN VITRO PRESERVATION OF THE SMALL BOWEL, INCLUDING MAINTENANCE OF MUCOSAL INTEGRITY WITH CHLORPROMAZINE, HYPOTHERMIA, AND HYPERBARIC OXYGENATION.

  1965cites this paper
• The action of drugs on phospholipid metabolism.

  1965cites this paper
• EFFECTS OF DRUGS ON METABOLISM OF THE BRAIN IN VITRO.

  1965cites this paper
• Biochemical Effects of Drugs Acting on the Central Nervous System

  1965cites this paper
• SUPPRESSION OF GLYCOLYSIS IN RAT BRAIN IN VIVO CHLORPROMAZINE, RESERPINE, AND PHENOBARBITAL.

  1965cites this paper
• [PHYSIOLOGICAL AND BIOCHEMICAL STUDIES ON THE DEGRADATION OF SALICYLIC ACID BY ASPERGILLUS NIGER. 2. STUDIES ON THE DEGRADATION PATHWAY OF SALICYLIC ACID].

  1964cites this paper
• Degradation of the Benzene Nucleus by Bacteria

  1964cites this paper
• Uncouplers of Oxidative Phosphorylation and Teratogenic Activity of Insulin

  1964cites this paper
• PHYSIOLOGICAL AND BIOCHEMICAL STUDIES ON THE DEGRADATION OF SALICYLIC ACID BY ASPERGILLUS NIGER. 2. STUDIES ON THE DEGRADATION PATHWAY OF SALICYLIC ACID

  1964cites this paper
• THE PHENOTHIAZINETRANQUILIZERS: BIOCHEMICAL AND BIOPHYSICAL ACTIONS.

  1964cites this paper
• Oxidative metabolism of naphthalene by soil pseudomonads. The ring-fission mechanism.

  1964cites this paper
• A COMPARATIVE STUDY OF THE INFLUENCE OF CHLORPROMAZINE AND IMIPRAMINE ON MITOCHONDRIAL ACTIVITY; CYTOCHROME OXIDASE AND NADH2-CYTOCHROME C REDUCTASE.

  1964cites this paper
• METABOLISM OF P-HYDROXYPHENYLACETIC ACID IN PSEUDOMONAS OVALIS.

  1964cites this paper
• Physiologische und biochemische Studien über den Abbau von Salicylsäure durch Aspergillus niger 2. Untersuchungen über den Abbauweg der Salicylsäure

  1964cites this paper
• A COMPARATIVE STUDY OF THE INFLUENCE OF CHLORPROMAZINE AND IMIPRAMINE ON MITOCHONDRIAL ACTIVITY

  1964cites this paper
• [Alteration of carbohydrate metabolism in the rat brain by psychopharmacological agents with sedative effect].

  1963cites this paper
• THE SURFACE ACTIVITY OF TRANQUILIZERS.

  1963cites this paper
• Mitochondrial phosphoprotein metabolism.

  1963cites this paper
• The effect of chlorpromazine on respiration of brain mitochondria as a function of metabolic state.

  1963cites this paper
• The effect of chlorpromazine, trifluoperazine and promethazine on brain sulfalipids.

  1963cites this paper
• MICROBIAL OXIDATION OF KYNURENIC, XANTHURENIC AND PICOLINIC ACIDS.

  1963cites this paper