Design and synthesis of compounds that extend yeast replicative lifespan

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Aging Cell

• Publication date

  2007-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1474-9726.2006.00259.xPMID 17156081PMCID PMC3545651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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