Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal‐regulated kinase activation

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Neurochemistry

• Publication date

  2004-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.2004.02563.xPMID 15312169
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stimulation of the ERK Pathway by GTP-loaded Rap1 Requires the Concomitant Activation of Ras, Protein Kinase C, and Protein Kinase A in Neuronal Cells*

  2003cited by this paper
• Group‐I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal‐regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways

  2002cited by this paper
• β-Eudesmol Induces Neurite Outgrowth in Rat Pheochromocytoma Cells Accompanied by an Activation of Mitogen-Activated Protein Kinase

  2002cited by this paper
• Uptake and metabolism of epicatechin and its access to the brain after oral ingestion.

  2002cited by this paper
• Beta-eudesmol induces neurite outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase.

  2002cited by this paper
• Fruit Polyphenolics and Brain Aging

  2002cited by this paper
• Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits.

  2002cited by this paper
• Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms.

  2001cited by this paper
• Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins

  2001cited by this paper
• Constitutive Association of c-N-Ras with c-Raf-1 and Protein Kinase Cε in Latent Signaling Modules*

  2001cited by this paper
• Induction of Neurite Outgrowth in PC12 Cells by α-Phenyl-N-tert-butylnitron through Activation of Protein Kinase C and the Ras-Extracellular Signal-regulated Kinase Pathway*

  2001influential reference
• Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

  2001influential reference
• The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

  2000cited by this paper
• SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

  2000cited by this paper
• Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors

  2000cited by this paper
• Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-κB dependent pathway

  1999cited by this paper
• Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells

  1999cited by this paper
• Human dopamine D(3) receptors mediate mitogen-activated protein kinase activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism.

  1999cited by this paper
• Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product.

  1999cited by this paper
• Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells.

  1999cited by this paper
• p38 Mitogen-activated Protein Kinase Activation Is Required for Fibroblast Growth Factor-2-stimulated Cell Proliferation but Not Differentiation*

  1999cited by this paper
• Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C.

  1998cited by this paper
• Modulating protein kinase C signal transduction.

  1998cited by this paper
• Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

  1998cited by this paper
• Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships.

  1997cited by this paper
• Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.

  1997cited by this paper
• cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway.

  1997cited by this paper
• Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

  1997cited by this paper
• Butylated Hydroxyanisole and Its Metabolitetert-Butylhydroquinone Differentially Regulate Mitogen-activated Protein Kinases

  1997influential reference
• The Fibroblast Growth Factor Receptor-1 Is Necessary for the Induction of Neurite Outgrowth in PC12 Cells by aFGF

  1996cited by this paper
• Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation*

  1996cited by this paper
• Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.

  1996cited by this paper
• Suppression of Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells

  1996cited by this paper
• Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor(*)

  1995cited by this paper
• Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.

  1994cited by this paper
• Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

  1994cited by this paper
• Signal transduction pathways in neuronal differentiation.

  1993influential reference
• Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

  1993cited by this paper
• Inhibition of tyrosine phosphorylation potentiates substrate-induced neurite growth.

  1992cited by this paper
• Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases.

  1992cited by this paper
• Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells

  1992cited by this paper
• Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases

  1986cited by this paper
• Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists

  1985cited by this paper
• Alterations in the surface properties of cells responsive to nerve growth factor

  1978cited by this paper
• Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

  1976cited by this paper
• INTERNATIONAL SOCIETY FOR NEUROCHEMISTRY

  1976cited by this paper

• Unveiling the therapeutic potential of Fisetin: Bridging traditional knowledge with modern medicine

  2025cites this paper
• Fisetin: hormesis accounts for many of its chemoprotective effects

  2025cites this paper
• Nerve Guide Conduits Integrated with Fisetin-Loaded Chitosan Hydrogels for Reduces Oxidative Stress, Inflammation And Nerve Regeneration.

  2024cites this paper
• Exploring Medicinal Herbs’ Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer’s Disease Treatment

  2023cites this paper
• The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review

  2023cites this paper
• Evaluation of fisetin as a potential inducer of mitochondrial biogenesis in SH-SY5Y neuronal cells

  2023cites this paper
• Heterodimers with a cucurbitane-type triterpenoid skeleton from the branches of Elaeocarpus dubius.

  2022cites this paper
• The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress

  2022cites this paper
• Pharmacological Approaches to Decelerate Aging: A Promising Path

  2022cites this paper
• Nanoparticles for neurotrophic factor delivery in nerve guidance conduits for peripheral nerve repair.

  2022cites this paper
• Plant-Derived Compounds and Their Potential Role in Drug Development

  2022cites this paper
• Loading and Release of Quercetin from Contact-Drawn Polyvinyl Alcohol Fiber Scaffolds.

  2022cites this paper
• Neuroregenerative Potential of Prenyl- and Pyranochalcones: A Structure-Activity Study.

  2021cites this paper
• Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth

  2021cites this paper
• Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia

  2021cites this paper
• Mechanistic new insights of flavonols on neurodegenerative diseases.

  2021cites this paper
• Nanotechnology Innovations to Enhance the Therapeutic Efficacy of Quercetin

  2021cites this paper
• Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

  2021cites this paper
• Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review.

  2021cites this paper
• The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols

  2020cites this paper
• Molecular mechanism of nur77 gene expression and downstream target genes in the early stage of forskolin-induced differentiation in PC12 cells

  2020cites this paper
• How CD40L reverse signaling regulates axon and dendrite growth

  2020cites this paper
• Using Plants as a Source of Potential Therapeutics for the Treatment of Alzheimer’s Disease

  2020cites this paper
• Roles of Fisetin on Skin Barrier Function and Anti-aging in Epidermal Keratinocyte

  2020cites this paper
• Preventing and Treating Neurological Disorders with the Flavonol Fisetin

  2020cites this paper
• RVG29-Functionalized Lipid Nanoparticles for Quercetin Brain Delivery and Alzheimer’s Disease

  2020cites this paper
• Food Components with the Potential to be Used in the Therapeutic Approach of Mental Diseases.

  2019cites this paper
• Ginkgo biloba extract increases neurite outgrowth and activates the Akt/mTOR pathway

  2019cites this paper
• The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

  2019cites this paper
• Superparamagnetic iron oxide nanoparticles combined with NGF and quercetin promote neuronal branching morphogenesis of PC12 cells

  2019influential citation
• Flavonoids and Their Biological Secrets

  2019cites this paper
• Cardiovascular effects of flavonoids.

  2019cites this paper
• Apios americana Medik flowers extract protects PC12 cells against H2O2 induced neurotoxicity via regulating autophagy.

  2019cites this paper
• Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

  2018cites this paper
• Pharmacokinetics and Biliary Excretion of Fisetin in Rats.

  2018cites this paper
• Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects.

  2018cites this paper
• Human Urine Extract Cell Differentiation Agent 2 Protects PC12 Cells from Serum Deprivation-Induced Apoptosis Accompanied with Priming of Extracellular Signal-Regulated Kinase Activation and Differentiation Induction

  2018cites this paper
• Protective Effects of Fisetin Against 6-OHDA-Induced Apoptosis by Activation of PI3K-Akt Signaling in Human Neuroblastoma SH-SY5Y Cells

  2018cites this paper
• Enhanced Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells in Insulin-Producing Cells by the Extract of Nigella sativa Seeds

  2018cites this paper
• A synthetic snake‐venom‐based tripeptide (Glu‐Val‐Trp) protects PC12 cells from MPP+ toxicity by activating the NGF‐signaling pathway

  2018cites this paper
• Fisetin is a senotherapeutic that extends health and lifespan

  2018cites this paper
• Antiepileptic effect of fisetin in iron-induced experimental model of traumatic epilepsy in rats in the light of electrophysiological, biochemical, and behavioral observations

  2017cites this paper
• Cyclin dependent kinase 5: A novel avenue for Alzheimer's disease.

  2017cites this paper
• Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo.

  2017cites this paper
• Derivatives of caffeic acid, a natural antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic agents.

  2017cites this paper
• Protective effects of fisetin and other berry flavonoids in Parkinson's disease.

  2017cites this paper
• Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways.

  2017cites this paper
• Solid-state studies and antioxidant properties of the γ-cyclodextrin·fisetin inclusion compound

  2017cites this paper
• Differentiation of Mesenchymal Stem Cells to Insulin Producing Cells Using the Extracts of Allium ursinum and Silybum marianum

  2017cites this paper
• Evaluation of Phenolic Compounds and Neurotrophic/neuroprotective Activity of Cultivar Extracts Derived from Chrysanthemum morifolium Flowers

  2017cites this paper
• Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

  2016cites this paper
• Natural Compounds and Neuroprotection: Mechanisms of Action and Novel Delivery Systems.

  2016cites this paper
• Phytochemicals for the Management of Melanoma.

  2016cites this paper
• Tea Flavonoids Induced Differentiation of Peripheral Blood-derived Mononuclear Cells into Peripheral Blood-derived Endothelial Progenitor Cells and Suppressed Intracellular Reactive Oxygen Species Level of Peripheral Blood-derived Endothelial Progenitor Cells

  2016cites this paper
• Modulators of Amyloid β-Protein (Aβ) Self-Assembly

  2016influential citation
• Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity.

  2016influential citation
• Fisetin and Its Role in Chronic Diseases.

  2016cites this paper
• Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-κB signaling.

  2016cites this paper
• Effects and mechanisms of melatonin on the proliferation and neural differentiation of PC12 cells.

  2016cites this paper
• Polyphenols, Nerve Growth Factor, Brain-Derived Neurotrophic Factor, and the Brain

  2015cites this paper
• Neurodifferentiating Potential of 8-Prenylnaringenin and Related Compounds in Neural Precursor Cells and Correlation with Estrogen-Like Activity

  2015cites this paper
• How fisetin reduces the impact of age and disease on CNS function.

  2015cites this paper
• Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli.

  2015cites this paper
• Translating endoplasmic reticulum biology into the clinic: a role for ER-targeted natural products?

  2015cites this paper
• Cell and brain tissue imaging of the flavonoid fisetin using label-free two-photon microscopy.

  2015cites this paper
• Modulation of neurotrophic signaling pathways by polyphenols

  2015cites this paper
• Characterization of the Neuroprotective Potential of Derivatives of the Iron Chelating Drug Deferiprone

  2015influential citation
• Effect of flavonoids of extract of cichorium intybus L. leaf on induction of P19 stem-cells differentiation to insulin-producing cells

  2014cites this paper
• Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide.

  2014cites this paper
• 3,3',4',5'-Tetrahydroxyflavone induces formation of large aggregates of amyloid β protein.

  2014cites this paper
• Bioactivity-Guided Fractionation Identifies Amygdalin as a Potent Neurotrophic Agent from Herbal Medicine Semen Persicae Extract

  2014cites this paper
• Flavonoids as regulators of amyloid precursor protein processing

  2014cites this paper
• Antiglioma Potential of Flavonoides

  2014cites this paper
• Thyroid hormones differentially regulate phosphorylation of ERK and Akt via integrin αvβ3 receptor in undifferentiated and differentiated PC‐12 cells

  2014cites this paper
• Binding mode and free energy prediction of fisetin/β-cyclodextrin inclusion complexes

  2014cites this paper
• by fisetin maintains cognitive function in Alzheimer's disease transgenic mice.

  2014cites this paper
• Screening and identification of neuroprotective compounds relevant to Alzheimer׳s disease from medicinal plants of S. Tomé e Príncipe.

  2014cites this paper
• Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin.

  2013cites this paper
• Neurite Outgrowth of PC12 Cells by 4′-O-β-d-Glucopyranosyl-3′,4-Dimethoxychalcone from Brassica rapa L. ‘hidabeni’ was Enhanced by Pretreatment with p38MAPK Inhibitor

  2013cites this paper
• Contrasting binding of fisetin and daidzein in γ-cyclodextrin nanocavity.

  2013cites this paper
• Mechanisms of Neurotrophic Activities via Low-molecular-weight Compounds: Post-transcriptional Regulation in PC12 Cells and Neurons

  2013cites this paper
• Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer’s disease transgenic mice

  2013influential citation
• FISETIN, A FLAVONOID, INDUCES CELL CYCLE ARREST AND APOPTOSIS IN HUMAN BREAST CANCER CELLS

  2013cites this paper
• Chapter 3 – Phenolics

  2013cites this paper
• Yokukansan, a traditional Japanese herbal medicine, promotes neurite outgrowth in PC12 cells through the activation of extracellular signal regulated kinase 1/2 and phosphatidylinositol 3-kinase/Akt

  2013cites this paper
• Practical Strategies for Preserving Good Cognitive Function into Old Age

  2013cites this paper
• Fisetin: A Dietary Antioxidant for Health Promotion

  2013cites this paper
• Neurotrophic Effect of Citrus Auraptene: Neuritogenic Activity in PC12 Cells

  2012cites this paper
• Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways.

  2012cites this paper
• 3,3',4',5,5'-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation.

  2012cites this paper
• Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management.

  2012cites this paper
• Phytochemicals as Antidepressants: The Involvement of Serotonin Receptor Function, Stress Resistance and Neurogenesis

  2012cites this paper
• Phospholipase D1 mediates bFGF-induced Bcl-2 expression leading to neurite outgrowth in H19-7 cells.

  2012cites this paper
• Chemical modification of the multitarget neuroprotective compound fisetin.

  2012cites this paper
• Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity

  2012cites this paper
• The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth

  2012cites this paper
• The Neuroprotective Effect of Fisetin in the MPTP Model of Parkinson's Disease

  2012cites this paper
• Phospholipase D1 is an Important Regulator of bFGF-Induced Neurotrophin-3 Expression and Neurite Outgrowth in H19-7 Cells

  2012cites this paper
• Botanicals for the prevention and treatment of cutaneous melanoma

  2011cites this paper
• Genistein attenuates D-galactose-induced oxidative damage through decreased reactive oxygen species and NF-κB binding activity in neuronal PC12 cells.

  2011cites this paper