Recent Developments in the Immunology of Inflammatory Bowel Disease

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Scandinavian Journal of Immunology

• Publication date

  2000-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1365-3083.2000.00658.xPMID 10632969
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells.

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• An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease.

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• A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

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• Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

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• Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine.

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• Epithelial deposits of immunoglobulin G1 and activated complement colocalise with the M(r) 40 kD putative autoantigen in ulcerative colitis.

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• Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.

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• T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine.

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