Claudins: emerging targets for cancer therapy

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Expert Reviews in Molecular Medicine

• Publication date

  2006-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1017/S1462399406000056PMID 16887048
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin.

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• Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity.

  2005cited by this paper
• Phosphorylation of Claudin-3 at Threonine 192 by cAMP-dependent Protein Kinase Regulates Tight Junction Barrier Function in Ovarian Cancer Cells*

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• Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis.

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• Increased expressions of claudin-1 and claudin-7 during the progression of cervical neoplasia.

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• EphA2 Phosphorylates the Cytoplasmic Tail of Claudin-4 and Mediates Paracellular Permeability*

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• A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells

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• Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes.

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• Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas.

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• Epidermal Growth Factor Receptor Activation Differentially Regulates Claudin Expression and Enhances Transepithelial Resistance in Madin-Darby Canine Kidney Cells*

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• Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4.

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• Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression

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• Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas.

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• Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail

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• Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast

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• Proinflammatory Cytokines Cause No·-Dependent and -Independent Changes in Expression and Localization of Tight Junction Proteins in Intestinal Epithelial Cells

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• CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.

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• Claudin-based tight junctions are crucial for the mammalian epidermal barrier

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• Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.

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• Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme

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• Claudins regulate the intestinal barrier in response to immune mediators.

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• The tight junction protein ZO‐1 and an interacting transcription factor regulate ErbB‐2 expression

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• Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands

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• Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis

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  2024cites this paper
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• Improving the response to oxaliplatin by targeting chemotherapy-induced CLDN1 in resistant metastatic colorectal cancer cells

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  2023cites this paper
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• Claudin-3 Loss of Expression Is a Prognostic Marker in Castration-Resistant Prostate Cancer

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• Visualization of a novel human monoclonal antibody against Claudin-3 for targeting ovarian cancer.

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• Investigation of clinical application of claudin 18 isoform 2 in pancreatic ductal adenocarcinoma: A retrospective analysis of 302 chinese patients.

  2022cites this paper
• Down-Regulated CLDN10 Predicts Favorable Prognosis and Correlates With Immune Infiltration in Gastric Cancer

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• Ablation of Red Stable Transfected Prostate Cancer Cell Lines by C-CPE Gold-Nanoparticle Mediated Laser Intervention

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• Context-Dependent Roles of Claudins in Tumorigenesis

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• CLDN10 associated with immune infiltration is a novel prognostic biomarker for clear cell renal cell carcinoma.

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• Claudin-1, A Double-Edged Sword in Cancer

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• Immunohistochemical Expression of Claudin-1, in Oral epithelial dysplasia of Qat Chewers.

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• Identification of claudin-2, -6, -11 and -14 as prognostic markers in human breast carcinoma.

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• MTT proliferation, Transwell and Matrigel assays indicated that Hep/5FU cells were significantly resistant to 5‐FU, and demonstrated increased migration and invasion abilities, compared with parental HepG2 cells. Furthermore, reverse transcription‐quantitative polymerase chain reaction and western b

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• Potential for Tight Junction Protein–Directed Drug Development Using Claudin Binders and Angubindin-1

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• Effects of claudin-1 downregulation on the physiological processes of gallbladder cancer SGC996 cells

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• Study of Expression of Claudin-1 In Thyroid Lesions

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• Retraction Note to: Differences in the expression profiles of claudin proteins in human nasopharyngeal carcinoma compared with non-neoplastic mucosa

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• Immunoreactivity patterns of tight junction proteins are useful for differential diagnosis of human salivary gland tumors

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• Increased expression of claudin-12 promotes the metastatic phenotype of human bronchial epithelial cells and is associated with poor prognosis in lung squamous cell carcinoma

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• Differences in the expression profiles of claudin proteins in human nasopharyngeal carcinoma compared with non-neoplastic mucosa

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• Claudins-4 and -7 might be valuable markers to distinguish hepatocellular carcinoma from cholangiocarcinoma

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• Roles of the first-generation claudin binder, Clostridium perfringens enterotoxin, in the diagnosis and claudin-targeted treatment of epithelium-derived cancers

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• Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2

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• Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells.

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