The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  A M A Archives of Ophthalmology

• Publication date

  2002-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1001/ARCHOPHT.120.6.701PMID 12049574
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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