Application of the ELISPOT assay to the characterization of CD8(+) responses to Epstein-Barr virus antigens.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Blood

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V95.1.241PMID 10607708
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers.

  1999cited by this paper
• Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

  1998cited by this paper
• Immediate-Early Transactivator Rta of Epstein-Barr Virus (EBV) Shows Multiple Epitopes Recognized by EBV-Specific Cytotoxic T Lymphocytes

  1998cited by this paper
• Analysis of major histocompatibility complex class I, TAP expression, and LMP2 epitope sequence in Epstein-Barr virus-positive Hodgkin's disease.

  1998cited by this paper
• Treatment of relapsed Hodgkin's disease using EBV-specific cytotoxic T cells.

  1998cited by this paper
• Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients.

  1998cited by this paper
• Feasibility of Cellular Adoptive Immunotherapy for Epstein-Barr Virus-Associated Lymphomas Using Haploidentical Donors

  1998cited by this paper
• Molecular characterization of antigen-processing function in nasopharyngeal carcinoma (NPC): evidence for efficient presentation of Epstein-Barr virus cytotoxic T-cell epitopes by NPC cells.

  1998cited by this paper
• Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients.

  1998cited by this paper
• Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.

  1998cited by this paper
• Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

  1998cited by this paper
• Reconstitution of EBV-specific T cell immunity in solid organ transplant recipients.

  1998cited by this paper
• Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the treatment of patients with EBV-positive relapsed Hodgkin's disease.

  1998cited by this paper
• Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

  1998cited by this paper
• Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus–infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I–Peptide Complex

  1998cited by this paper
• Immunohistochemical Detection of the Epstein-Barr Virus–Encoded Latent Membrane Protein 2A in Hodgkin's Disease and Infectious Mononucleosis

  1997cited by this paper
• High frequency of Epstein–Barr virus (EBV) lymphoblastoid cell line‐reactive lymphocytes in cord blood: evaluation of cytolytic activity and IL‐2 production

  1997cited by this paper
• Analysis of the T cell response to tumor and viral peptide antigens by an IFNgamma-ELISPOT assay.

  1997cited by this paper
• Immediate Early and Early Lytic Cycle Proteins Are Frequent Targets of the Epstein-Barr Virus–induced Cytotoxic T Cell Response

  1997cited by this paper
• Immunohistochemical detection of the Epstein-Barr virus-encoded latent membrane protein 2A in Hodgkin's disease and infectious mononucleosis.

  1997cited by this paper
• Isolation of Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes that lyse Reed-Sternberg cells: implications for immune-mediated therapy of EBV+ Hodgkin's disease.

  1997cited by this paper
• Treatment of posttransplant lymphoproliferative disease in the central nervous system of a lung transplant recipient using allogeneic leukocytes.

  1997cited by this paper
• Analysis of the T cell response to tumor and viral peptide antigens by an IFNγ‐ELISPOT assay

  1997cited by this paper
• Cellular responses to interferon-gamma.

  1997cited by this paper
• Conserved CTL epitopes within EBV latent membrane protein 2: a potential target for CTL-based tumor therapy.

  1997cited by this paper
• Specific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man.

  1996cited by this paper
• BCL-2 but not its Epstein-Barr virus-encoded homologue, BHRF1, is commonly expressed in posttransplantation lymphoproliferative disorders.

  1996cited by this paper
• Phenotypic Analysis of Antigen-Specific T Lymphocytes

  1996cited by this paper
• Specific expression of surface interferon‐γ on interferon‐γ producing T cells from mouse and man

  1996cited by this paper
• The development of cellular immunity to Epstein-Barr virus after allogeneic bone marrow transplantation.

  1996cited by this paper
• Identification of Epstein-Barr virus lytic activity in post-transplantation lymphoproliferative disease.

  1996cited by this paper
• Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens.

  1996cited by this paper
• Role of interferon‐γ in immune cell regulation

  1995cited by this paper
• Role of interferon-gamma in immune cell regulation.

  1995cited by this paper
• Specific cytotoxic T lymphocytes recognize the immediate-early transactivator Zta of Epstein-Barr virus

  1995cited by this paper
• Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation.

  1995cited by this paper
• Quantification of antigen specific CD8+ T cells using an ELISPOT assay.

  1995cited by this paper
• Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells.

  1994cited by this paper
• Direct comparison of ELISPOT and ELISA-based assays for detection of individual cytokine-secreting cells.

  1994cited by this paper
• HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2

  1993cited by this paper
• The molecular cell biology of interferon-gamma and its receptor.

  1993cited by this paper
• Cryopreservation of whole blood and isolated lymphocytes for B-cell immortalization

  1993cited by this paper
• Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma

  1992cited by this paper
• Biology and clinical relevance of human natural killer cells.

  1990cited by this paper
• The pathogenesis of Burkitt's lymphoma.

  1990cited by this paper
• Detection of intracellular expression and secretion of interferon‐γ at the single‐cell level after activation of human T cells with tetanus toxoid in vitro

  1990cited by this paper
• Antigen recognition by class I-restricted T lymphocytes.

  1989cited by this paper
• Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization.

  1989cited by this paper
• HLA-B27 and HLA-A2 subtypes: structure, evolution and function

  1989cited by this paper
• Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease.

  1989cited by this paper
• HLA-B27 and HLA-A2 subtypes: structure, evolution and function.

  1989cited by this paper
• Latent and replicating forms of Epstein-Barr virus DNA in lymphomas and lymphoproliferative diseases.

  1989cited by this paper
• Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease.

  1989cited by this paper

• Limited Immunogenicity of an HLA-A*03:01-restricted Epitope of Erv-k-env in Non-hiv-1 Settings: Implications for Adoptive Cell Therapy in Cancer

  2024cites this paper
• A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope

  2024cites this paper
• CAF-associated genes putatively representing distinct prognosis by in silico landscape of stromal components of colon cancer

  2024cites this paper
• Immunodeficiency-Associated Epstein-Barr Virus-Positive B-cell Lymphoproliferative Disorders: A Review and New Paradigm.

  2023cites this paper
• The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells

  2023cites this paper
• Chronic-Relapsing cutaneous leukocytoclastic vasculitis in a young patient with reduced EBV-specific T cell response using enzyme-linked immunospot (ELISPOT) assay successfully treated with Valaciclovir

  2021cites this paper
• Efficacy of cascade-primed cell infusion as an adjuvant immunotherapy with concurrent chemotherapy for patients with non-small-cell lung cancer: A retrospective observational study with a 5-year follow-up.

  2020cites this paper
• A Synthetic Nanoparticle Based Vaccine Approach Targeting MSP4/5 Is Immunogenic and Induces Moderate Protection Against Murine Blood-Stage Malaria

  2019cites this paper
• Hypothesis: Multiple sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons.

  2018cites this paper
• Recent advances in understanding and managing infectious diseases in solid organ transplant recipients

  2018cites this paper
• Emergence of CD4+ and CD8+ Polyfunctional T Cell Responses Against Immunodominant Lytic and Latent EBV Antigens in Children With Primary EBV Infection

  2018cites this paper
• Generation of a Novel HLA Class I Transgenic Mouse Model Carrying a Knock-in Mutation at the β2-Microglobulin Locus

  2017cites this paper
• Viral Infections in Organ Transplant Recipients

  2017cites this paper
• Epstein‐Barr Virus Infection

  2016cites this paper
• Epstein-Barr Virus and Cytomegalovirus

  2016cites this paper
• Measurement of CD8+ and CD4+ T Cell Frequencies Specific for EBV LMP1 and LMP2a Using mRNA-Transfected DCs

  2015cites this paper
• Comparison of the proliferation, cytotoxic activity and cytokine secretion function of cascade primed immune cells and cytokine-induced killer cells in vitro

  2015cites this paper
• Approaches for monitoring of non virus-specific and virus-specific T-cell response in solid organ transplantation and their clinical applications.

  2015cites this paper
• Establishment of a memory B cell assay using recombinant Flavivirus protein for determinant of specific antiviral immunity

  2014cites this paper
• Virus-Specific CD8 Associated with Altered Epstein-Barr Holoendemic Malaria Exposure Is

  2014cites this paper
• Clinical immune-monitoring strategies for predicting infection risk in solid organ transplantation

  2014cites this paper
• Detection of Epstein–Barr virus‐specific memory CD4+ T cells using a peptide‐based cultured enzyme‐linked immunospot assay

  2013cites this paper
• for the adoptive Immunotherapy of EBV-associated malignancies Generating CTL against the subdominant Epstein-Barr virus LMP1 antigen

  2013cites this paper
• malignancies antigen for the adoptive immunotherapy of EBV-associated Generating CTLs against the subdominant Epstein-Barr virus LMP1

  2013cites this paper
• Lymphoma in Other Diseases

  2013cites this paper
• adenovirus-specific cytotoxic T lymphocytes for therapeutic applications Fiber-modified adenoviruses generate sub-group cross-reactive,

  2013cites this paper
• GroupeFrancophonedesMyelodysplasies,Bobigny,FranceandCentreHospitalierUniversitaire,Nantes,France GroupeFrancophonedesMyelodysplasies,Bobigny,FranceandCentreHospitalierMetz,Metz,France GroupeFrancophonedesMyelodysplasies,Bobigny,FranceandCentreHenriBecquerel,Rouen,France GroupeFrancophonedesMyelodys

  2012cites this paper
• Holoendemic Malaria Exposure Is Associated with Altered Epstein-Barr Virus-Specific CD8+ T-Cell Differentiation

  2012cites this paper
• CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines.

  2012cites this paper
• Monitoring and managing viral infections in pediatric renal transplant recipients

  2012cites this paper
• Monitoraggio e gestione delle infezioni virali in riceventi pediatrici di trapianto renale

  2011cites this paper
• Cytolytic T lymphocytes from HLA-B8+ donors frequently recognize the Hodgkin's lymphoma associated latent membrane protein 2 of Epstein Barr virus

  2011cites this paper
• Posttransplant Lymphoproliferative Disease (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT)

  2010cites this paper
• Diagnosis of post‐transplant lymphoproliferative disorder in solid organ transplant recipients – BCSH and BTS Guidelines

  2010cites this paper
• EBV LMP2A-specific T Cell Immune Responses Elicited by Dendritic Cells Loaded with LMP2A Protein

  2009cites this paper
• How I treat EBV lymphoproliferation.

  2009cites this paper
• Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies

  2009cites this paper
• Adoptive cell therapy against EBV-related malignancies: a survey of clinical results

  2008cites this paper
• Adoptive cell therapy against EBV-related malignancies: a survey of clinical results.

  2008cites this paper
• Quantifying EBV-specific CD8? T cell immunity in patients with post transplant lymph proliferative disease (PTLD) and other EBV-driven malignancies.

  2008cites this paper
• CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.

  2008cites this paper
• The role of regulatory T cells in primary infection with Epstein-Barr virus

  2008cites this paper
• Decreased T cell reactivity to Epstein–Barr virus infected lymphoblastoid cell lines in multiple sclerosis

  2008cites this paper
• Stimulation by means of dendritic cells followed by Epstein–Barr virus‐transformed B cells as antigen‐presenting cells is more efficient than dendritic cells alone in inducing Aspergillus f16‐specific cytotoxic T cell responses

  2007cites this paper
• Lymphoproliferative Disorders Related to Immunodeficiencies

  2007cites this paper
• alignancy in pediatric transplant recipients

  2006cites this paper
• Malignancy in pediatric transplant recipients.

  2006cites this paper
• Adoptive T-Cell therapy as treatment for Epstein Barr virus-associated malignancies : strategies to enhance potential and broaden application

  2006cites this paper
• Successful In Vitro Priming of EBV‐Specific CD8+ T Cells Endowed with Strong Cytotoxic Function from T Cells of EBV‐Seronegative Children

  2006cites this paper
• Hodgkin ’ s Lymphoma – Current Concepts Sachdeva A , Wallace WHB

  2005cites this paper
• Expansion of Peripheral CD 8 + CD 28 – T Cells in Response to Epstein-Barr Virus in Patients with Rheumatoid Arthritis

  2005cites this paper
• Expansion of peripheral CD8+ CD28- T cells in response to Epstein-Barr virus in patients with rheumatoid arthritis.

  2005cites this paper
• Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes.

  2005cites this paper
• Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes.

  2005cites this paper
• Chapter 51 – Viral Responses – Epstein-Barr Virus

  2005cites this paper
• gp 100209 – 2 M Peptide Immunization of Human Lymphocyte Antigen-A 2 Stage I-III Melanoma Patients Induces Significant Increase in Antigen-Specific Effector and Long-Term Memory CD 8 T Cells

  2004cites this paper
• Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications.

  2004cites this paper
• gp100209–2M Peptide Immunization of Human Lymphocyte Antigen-A2+ Stage I-III Melanoma Patients Induces Significant Increase in Antigen-Specific Effector and Long-Term Memory CD8+ T Cells

  2004cites this paper
• Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors.

  2004cites this paper
• Polyomavirus BK-specific immunity after kidney transplantation.

  2004cites this paper
• Humoral and cellular immune responses against Kaposi's sarcoma-associated herpesvirus (KSHV).

  2004cites this paper
• Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia

  2004cites this paper
• An interferon-γ ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies

  2004cites this paper
• Hodgkin's lymphoma: evolving concepts with implications for practice.

  2004cites this paper
• Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma.

  2004cites this paper
• Monitoring CD4+ T cell responses against viral and tumor antigens using T cells as novel target APC.

  2003cites this paper
• Lymphocyte subsets may discern treatment effects in children and young adults with post‐transplant lymphoproliferative disorder

  2003cites this paper
• Stealth technology: how Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection.

  2003cites this paper
• Preventing acute and chronic rejection after diagnosis of post‐transplantation lymphoproliferative disorder

  2003cites this paper
• Large-Scale Expansion of Dendritic Cell-Primed Polyclonal Human Cytotoxic T-Lymphocyte Lines Using Lymphoblastoid Cell Lines for Adoptive Immunotherapy

  2003cites this paper
• Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies.

  2003cites this paper
• Retransplantation after kidney graft loss due to polyoma BK virus nephropathy: successful outcome without original allograft nephrectomy.

  2003cites this paper
• Molecular diagnosis of Epstein-Barr virus

  2003cites this paper
• Immunotherapy for Epstein-Barr virus-associated cancers in children.

  2003cites this paper
• Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load

  2003cites this paper
• Epstein–Barr virus associated disease following blood or marrow transplant

  2003cites this paper
• Dendritic cells pulsed with polyomavirus BK antigen induce ex vivo polyoma BK virus-specific cytotoxic T-cell lines in seropositive healthy individuals and renal transplant recipients.

  2003cites this paper
• An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness.

  2003cites this paper
• Posttransplant EBV-Associated Disease

  2003cites this paper
• Fiber-modified Adenoviruses Generate Sub-group Cross-reactive, Adenovirus-specific Cytotoxic T Lymphocytes for Therapeutic Applications Short title: Adenovirus-specific, cytotoxic T lymphocytes for Immunotherapy purposes

  2003cites this paper
• Monocyte-Derived Dendritic Cells Generated After a Short-Term Culture with IFN-α and Granulocyte-Macrophage Colony-Stimulating Factor Stimulate a Potent Epstein-Barr Virus-Specific CD8+ T Cell Response1

  2003cites this paper
• Lymphoproliferation in Children After Liver Transplantation

  2002cites this paper
• Epstein–Barr virus‐related lymphoproliferation in children after liver transplant: Role of immunity, diagnosis, and management

  2002cites this paper
• Detection of CD4+- and CD8+-T-Cell Responses to Human Papillomavirus Type 1 Antigens Expressed at Various Stages of the Virus Life Cycle by Using an Enzyme-Linked Immunospot Assay of Gamma Interferon Release

  2002cites this paper
• Generating CTL against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive Immunotherapy of EBV-associated malignancies Running title: Generation of LMP1-specific CTL Scientific Section Heading: Immunotherapy

  2002cites this paper
• Immunotherapy for Post‐Transplant Lymphoproliferative Disease

  2002cites this paper
• Generation of EBV-Specific CD4+ Cytotoxic T Cells from Virus Naive Individuals1

  2002cites this paper
• Identification and prevalence of CD8+ T‐cell responses directed against Epstein‐Barr virus‐encoded latent membrane protein 1 and latent membrane protein 2

  2002cites this paper
• Treatment of Epstein-Barr virus-associated malignancies with specific T cells.

  2002cites this paper
• Diagnosis and treatment of posttransplantation lymphoproliferative disease after hematopoietic stem cell transplantation.

  2002cites this paper
• Identification of an HLA A*0201-restricted CD8(+) T-cell epitope for the glycoprotein B homolog of human herpesvirus 8.

  2002cites this paper
• Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease1

  2002cites this paper
• Contribution of HLA Class I Allele Expression to CD8+ T‐Cell Responses against Epstein–Barr Virus

  2002cites this paper
• Frequency of Epstein‐Barr virus‐specific cytotoxic T lymphocytes in the blood of Southern Chinese blood donors and nasopharyngeal carcinoma patients

  2002cites this paper
• Quantitation, selection, and functional characterization of Epstein-Barr virus-specific and alloreactive T cells detected by intracellular interferon-gamma production and growth of cytotoxic precursors.

  2002cites this paper
• Functional CD4(+) and CD8(+) T-cell responses induced by autologous mitomycin C treated Epstein-Barr virus transformed lymphoblastoid cell lines.

  2001cites this paper
• Immune reconstitution after hematopoietic stem cell transplantation: gaining experience without losing naivety.

  2001cites this paper
• Monitoring cellular immune responses to cancer immunotherapy.

  2001cites this paper
• Surrogate markers of response to cancer immunotherapy

  2001cites this paper
• Contrasting Epstein-Barr virus-specific cytotoxic T cell responses to HLA A2-restricted epitopes in humans and HLA transgenic mice: implications for vaccine design.

  2001cites this paper