Engineering synthetic optogenetic networks for biomedical applications

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Quantitative Biology

• Publication date

  2017-05-15

• Fields of study

  Biology, Medicine, Computer Science, Engineering

• Identifiers
  DOI 10.1007/s40484-017-0105-6
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes.

  2017cited by this paper
• Synthetic biology-application-oriented cell engineering.

  2016cited by this paper
• An Efficient Light-Inducible P53 Expression System for Inhibiting Proliferation of Bladder Cancer Cell

  2016cited by this paper
• Self-adjusting synthetic gene circuit for correcting insulin resistance

  2016cited by this paper
• Supervised autonomous robotic soft tissue surgery

  2016cited by this paper
• Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system

  2016cited by this paper
• Optimized second generation CRY2/CIB dimerizers and photoactivatable Cre recombinase

  2016cited by this paper
• Photoactivatable CRISPR-Cas9 for optogenetic genome editing

  2015cited by this paper
• Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

  2015cited by this paper
• Rationally engineered Cas9 nucleases with improved specificity

  2015cited by this paper
• Optical Control of Peroxisomal Trafficking

  2015cited by this paper
• Optogenetic control of organelle transport and positioning

  2015cited by this paper
• Optogenetic control of intracellular signaling pathways.

  2015cited by this paper
• Bacterial photosensory proteins: Regulatory functions and optogenetic applications

  2015cited by this paper
• Optical Control of CRISPR/Cas9 Gene Editing.

  2015cited by this paper
• Engram cells retain memory under retrograde amnesia

  2015cited by this paper
• Optogenetic control of molecular motors and organelle distributions in cells.

  2015cited by this paper
• A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes.

  2015cited by this paper
• A synthetic erectile optogenetic stimulator enabling blue-light-inducible penile erection.

  2015cited by this paper
• Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins

  2015cited by this paper
• CRISPR-Cas9-based photoactivatable transcription system.

  2015cited by this paper
• Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light

  2015cited by this paper
• Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation

  2015cited by this paper
• Control of gene expression using a red- and far-red light–responsive bi-stable toggle switch

  2014cited by this paper
• Optogenetic control of chemokine receptor signal and T-cell migration

  2014cited by this paper
• Optogenetic approaches to cell migration and beyond.

  2014cited by this paper
• An increased arginase activity is associated with corpus cavernosum impairment induced by hypercholesterolemia.

  2014cited by this paper
• Bidirectional switch of the valence associated with a hippocampal contextual memory engram

  2014cited by this paper
• The CRISPR/Cas system can be used as nuclease for in planta gene targeting and as paired nickases for directed mutagenesis in Arabidopsis resulting in heritable progeny.

  2014cited by this paper
• Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant

  2014cited by this paper
• Remote control of myosin and kinesin motors using light-activated gearshifting.

  2014cited by this paper
• Realizing the potential of synthetic biology

  2014cited by this paper
• Photocontrol of mitotic kinesin Eg5 facilitated by thiol-reactive photochromic molecules incorporated into the loop L5 functional loop.

  2014cited by this paper
• Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal

  2014cited by this paper
• Engineered UV-A light-responsive gene expression system for measuring sun cream efficacy in mammalian cell culture.

  2014cited by this paper
• Direct reactivation of a coherent neocortical memory of context.

  2014cited by this paper
• Insulin resistance and hyperglycaemia in cardiovascular disease development

  2014cited by this paper
• Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis.

  2014cited by this paper
• Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells

  2014cited by this paper
• Cortical representations are reinstated by the hippocampus during memory retrieval.

  2014cited by this paper
• Optogenetic control of cell function using engineered photoreceptors

  2013cited by this paper
• Reward-based hypertension control by a synthetic brain–dopamine interface

  2013cited by this paper
• Cardiovascular risk factors in men with ischemic heart disease and erectile dysfunction.

  2013cited by this paper
• Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.

  2013cited by this paper
• Creating a False Memory in the Hippocampus

  2013cited by this paper
• Optical Control of Mammalian Endogenous Transcription and Epigenetic States

  2013cited by this paper
• An optogenetic gene expression system with rapid activation and deactivation kinetics

  2013cited by this paper
• A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast

  2013cited by this paper
• Axonal transport deficits and neurodegenerative diseases

  2013cited by this paper
• A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells

  2013cited by this paper
• Newly diagnosed major depressive disorder and the risk of erectile dysfunction: a population-based cohort study in Taiwan.

  2013cited by this paper
• Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

  2013cited by this paper
• Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology.

  2013cited by this paper
• Ultraviolet-B-mediated induction of protein–protein interactions in mammalian cells

  2013cited by this paper
• Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells

  2012cited by this paper
• Targeting natural killer cells and natural killer T cells in cancer

  2012cited by this paper
• The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

  2012cited by this paper
• Adoptive immunotherapy for cancer: harnessing the T cell response

  2012cited by this paper
• New insights into hypertension-associated erectile dysfunction

  2012cited by this paper
• LOV to BLUF: flavoprotein contributions to the optogenetic toolkit.

  2012cited by this paper
• Optogenetic stimulation of a hippocampal engram activates fear memory recall

  2012cited by this paper
• Spatiotemporal control of gene expression by a light-switchable transgene system

  2012cited by this paper
• Crystal structure of the channelrhodopsin light-gated cation channel

  2012cited by this paper
• A photochromic ATP analogue driving a motor protein with reversible light-controlled motility: controlling velocity and binding manner of a kinesin-microtubule system in an in vitro motility assay.

  2012cited by this paper
• Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription.

  2011cited by this paper
• Emerging biomedical applications of synthetic biology

  2011cited by this paper
• A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

  2011cited by this paper
• Self-sufficient control of urate homeostasis in mice by a synthetic circuit

  2010cited by this paper
• Peroxisomes Are Oxidative Organelles

  2010cited by this paper
• Rapid blue light induction of protein interactions in living cells

  2010cited by this paper
• Synthetic biology: applications come of age

  2010cited by this paper
• Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.

  2010cited by this paper
• A synthetic genetic edge detection program.

  2009cited by this paper
• Induction of protein-protein interactions in live cells using light

  2009cited by this paper
• Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

  2009cited by this paper
• Appetitive and Aversive Visual Learning in Freely Moving Drosophila

  2009cited by this paper
• A Simple Cipher Governs DNA Recognition by TAL Effectors

  2009cited by this paper
• Retrograde episodic and semantic memory impairment correlates with side of temporal lobe damage

  2008cited by this paper
• A fast, robust, and tunable synthetic gene oscillator

  2008cited by this paper
• Photoexcited CRY2 Interacts with CIB1 to Regulate Transcription and Floral Initiation in Arabidopsis

  2008cited by this paper
• Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice.

  2008cited by this paper
• In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor

  2007cited by this paper
• Effect of lithium on endothelium-dependent and neurogenic relaxation of rat corpus cavernosum: role of nitric oxide pathway.

  2007cited by this paper
• Adoptive T‐cell transfer in cancer immunotherapy

  2006cited by this paper
• Drug therapy of the metabolic syndrome: minimizing the emerging crisis in polypharmacy

  2006cited by this paper
• Light-induced activation of distinct modulatory neurons triggers appetitive or aversive learning in Drosophila larvae.

  2006cited by this paper
• Improvement in erectile dysfunction after neurotrophic factor gene therapy in diabetic rats.

  2005cited by this paper
• A synthetic gene–metabolic oscillator

  2005cited by this paper
• Nitric oxide and penile erectile function.

  2005cited by this paper
• Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses.

  2005cited by this paper
• Millisecond-timescale, genetically targeted optical control of neural activity

  2005cited by this paper
• Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo.

  2004cited by this paper
• Design of artificial cell-cell communication using gene and metabolic networks.

  2004cited by this paper
• Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

  2003cited by this paper
• Immunotherapy: past, present and future

  2003cited by this paper
• Nitric oxide synthase gene transfer for erectile dysfunction in a rat model

  2003cited by this paper
• Gene Therapy of Erectile Dysfunction in the Rat with Penile Neuronal Nitric Oxide Synthase1

  2002cited by this paper
• Selective photostimulation of genetically chARGed neurons.

  2002cited by this paper
• Long-term retrograde amnesia . . . the crucial role of the hippocampus

  2002cited by this paper
• Construction of a genetic toggle switch in Escherichia coli

  2000cited by this paper

• Engineering of optogenetic devices for biomedical applications in mammalian synthetic biology

  2022cites this paper
• Engineering Mammalian Designer Cells for the Treatment of Metabolic Diseases

  2018cites this paper