Natural history of multiple sclerosis with childhood onset.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  New England Journal of Medicine

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1056/nejmoa067597PMID 17582070
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multiple Sclerosis

  2007cited by this paper
• Prognostic Factors for Early Severity in a Childhood Multiple Sclerosis Cohort

  2006cited by this paper
• Age at disability milestones in multiple sclerosis.

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  2002cited by this paper
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  2002cited by this paper
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• Prospective study of multiple sclerosis with early onset

  2002cited by this paper
• Multiple sclerosis.

  2002cited by this paper
• Relapses and progression of disability in multiple sclerosis.

  2000cited by this paper
• Multiple sclerosis in children under 6 years of age

  1999cited by this paper
• Multiple sclerosis in childhood: clinical features of 149 cases

  1997cited by this paper
• Defining the clinical course of multiple sclerosis

  1996cited by this paper
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  1996cited by this paper
• A LONG PERSPECTIVE ON CHILDHOOD MULTIPLE SCLEROSIS

  1995cited by this paper
• Pediatric multiple sclerosis report of 14 cases.

  1995cited by this paper
• Natural history of multiple sclerosis

  1994cited by this paper
• Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up.

  1993cited by this paper
• Early onset MS under the age of 16: clinical and paraclinical features

  1992cited by this paper
• EDMUS, a European database for multiple sclerosis.

  1992cited by this paper
• Multiple sclerosis in childhood: report of 15 cases.

  1991cited by this paper
• Overview of azathioprine treatment in multiple sclerosis.

  1991cited by this paper
• The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability.

  1989cited by this paper
• Multiple Sclerosis in Children: Report of Clinical and Paraclinical Features of 19 Cases

  1988cited by this paper
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  1987cited by this paper
• MULTIPLE SCLEROSIS IN CHILDHOOD: A NEW LOOK

  1985cited by this paper
• New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

  1983cited by this paper
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  1983cited by this paper
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  1980cited by this paper
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  1965cited by this paper
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  1961cited by this paper
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  1958cited by this paper
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  1951cited by this paper

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