MITOCHONDRIAL DYSFUNCTION, BIOENERGETIC IMPAIRMENT, AND METABOLIC DOWN-REGULATION IN SEPSIS

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Shock

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1097/01.shk.0000235089.30550.2dPMID 17483747
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse.

  2006cited by this paper
• Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock*

  2006cited by this paper
• Hypothermia and sepsis.

  2006cited by this paper
• Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis.

  2005cited by this paper
• Hibernating myocardium

  2005cited by this paper
• Sepsis induces diaphragm electron transport chain dysfunction and protein depletion.

  2005cited by this paper
• Annual lipid cycles in hibernators: integration of physiology and behavior.

  2005cited by this paper
• Role of Interleukin-6 in Mortality from and Physiologic Response to Sepsis

  2005cited by this paper
• Some Components of Hibernation Rhythms

  2005cited by this paper
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

  2005cited by this paper
• Transcription

  2005cited by this paper
• Role of free radicals in sepsis: antioxidant therapy.

  2005cited by this paper
• Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia

  2005cited by this paper
• Evidence of myocardial hibernation in the septic heart*

  2005cited by this paper
• H2S Induces a Suspended Animation–Like State in Mice

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• Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats.

  2004cited by this paper
• Carbon monoxide-induced suspended animation protects against hypoxic damage in Caenorhabditis elegans

  2004influential reference
• Metabolic dysfunction and depletion of mitochondria in hearts of septic rats.

  2004influential reference
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  2004cited by this paper
• Cytochrome c oxidase as the target of the heat shock protective effect in septic liver

  2004cited by this paper
• Mitochondrial oxidative phosphorylation: Pitfalls and tips in measuring and interpreting enzyme activities

  2003cited by this paper
• Mitochondrial dysfunction in sepsis

  2003cited by this paper
• Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats

  2003cited by this paper
• Neonatal endotoxemia affects heart but not kidney bioenergetics.

  2003cited by this paper
• The pathophysiology and treatment of sepsis.

  2003cited by this paper
• Increased tissue oxygen extraction and acidosis with progressive severity of sepsis.

  2003cited by this paper
• Heat Shock Pretreatment Prevents Cardiac Mitochondrial Dysfunction During Sepsis

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• 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

  2003cited by this paper
• Microdialysis-evaluated myocardial cyclooxygenase-mediated inflammation and early circulatory depression in porcine endotoxemia.

  2003cited by this paper
• 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

  2003cited by this paper
• Endotoxin-Stimulated Nitric Oxide Production Inhibits Expression of Cytochrome c Oxidase in ANA-1 Murine Macrophages1

  2002cited by this paper
• Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity

  2002cited by this paper
• Bench-to-bedside review: Cytopathic hypoxia

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• Cytopathic hypoxia. Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?

  2002influential reference
• Competitive and Noncompetitive Inhibition of Myocardial Cytochrome C Oxidase in Sepsis

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• Mitochondrial Dysfunction in Sepsis: Evidence from Bacteraemic Baboons and Endotoxaemic Rabbits

  2002cited by this paper
• Dysfunction of the mitochondrial respiratory chain in the rostral ventrolateral medulla during experimental endotoxemia in the rat.

  2002cited by this paper
• Oxygen deprivation causes suspended animation in the zebrafish embryo

  2001cited by this paper
• Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function.

  2001cited by this paper
• Escherichia coli endotoxin reduces cytochrome aa3 redox status in pig skeletal muscle

  2000cited by this paper
• Role of endogenous carbon monoxide in endotoxin shock.

  2000cited by this paper
• Hibernating myocardium

  2000cited by this paper
• Oxidative phosphorylation at the fin de siècle.

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  1999cited by this paper
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• Altered mitochondrial redox responses in gram negative septic shock in primates.

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• Myocardial energy metabolism and morphology in a canine model of sepsis.

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• Effects of endotoxemia on the redox level of brain cytochrome a,a3 in rats.

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• Oxygen conformance of cellular respiration in hepatocytes.

  1993cited by this paper
• Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock

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• Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis.

  1992cited by this paper
• Pathophysiology and treatment of septic shock.

  1991cited by this paper
• Rapid reduction of intestinal cytochrome a,a3 during lethal endotoxemia.

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• Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole.

  1991cited by this paper
• Sepsis does not impair tricarboxylic acid cycle in the heart.

  1991cited by this paper
• Early myocardial dysfunction induced with endotoxin in rhesus monkeys.

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• Metabolic Rate Depression and Biochemical Adaptation in Anaerobiosis, Hibernation and Estivation

  1990cited by this paper
• Septic shock in children: bacterial etiologies and temporal relationships

  1990cited by this paper
• Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock.

  1987cited by this paper
• The coronary circulation in human septic shock.

  1986cited by this paper
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  1984cited by this paper
• Pathophysiology and treatment of septic shock.

  1984cited by this paper
• Cardiac output and redistribution of organ blood flow in hypermetabolic sepsis.

  1984cited by this paper
• Alterations of mitochondrial metabolism and protein concentrations in subacute septicemia

  1982cited by this paper
• Hemodynamic responses to sepsis: hypodynamic versus hyperdynamic states.

  1981cited by this paper

• Non-apoptotic Regulated Cell Death Mechanisms in Sepsis and their Therapeutic Potential

  2026cites this paper
• Assessing myocardial stunning during continuous renal replacement therapy in critically ill patients

  2025cites this paper
• Excessive HIF-1α driven by phospholipid metabolism causes septic cardiomyopathy through cytopathic hypoxia

  2025cites this paper
• Identification and validation of autophagy-related genes in sepsis based on bioinformatics studies

  2025cites this paper
• Understanding metabolic remodeling in shock through metabolomics lenses.

  2025cites this paper
• The Role of Mitochondrial Dysfunction and Inflammatory Response in the Pathogenesis of Sepsis-Induced Myocardial Injury: A Mechanistic Study

  2025cites this paper
• Investigating hub genes in the relationship between septic cardiomyopathy and cuproptosis and potential Chinese herbal drug candidates with bioinformatic tools.

  2024cites this paper
• α‐Ketoglutarate plays an inflammatory inhibitory role by regulating scavenger receptor class a expression through N6‐methyladenine methylation during sepsis

  2024cites this paper
• Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

  2024cites this paper
• Mechanisms of Acute Right Ventricular Injury in Cardiothoracic Surgical and Critical Care Settings: Part 2.

  2023cites this paper
• Current insight on the mechanisms of programmed cell death in sepsis-induced myocardial dysfunction

  2023cites this paper
• Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy.

  2023cites this paper
• Comprehensive Analysis of Molecular Subtypes and Hub Genes of Sepsis by Gene Expression Profiles

  2022cites this paper
• Transcriptomic changes in the large organs in lethal meningococcal shock are reflected in a porcine shock model

  2022cites this paper
• An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach

  2022cites this paper
• The Role of Peroxiredoxins in the Regulation of Sepsis

  2022cites this paper
• Progress in the mechanism of mitochondrial dysfunction in septic cardiomyopathy

  2022cites this paper
• The immune system as a driver of mitochondrial disease pathogenesis: a review of evidence

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• Pathophysiology of sepsis-induced cardiomyopathy

  2021cites this paper
• Organ dysfunction syndrome and mitochondrial adaptation in the septic patient.

  2021cites this paper
• Pyruvate-Driven Oxidative Phosphorylation is Downregulated in Sepsis-Induced Cardiomyopathy: A Study of Mitochondrial Proteome

  2021cites this paper
• Irisin Attenuates Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in the H9C2 Cellular Model of Septic Cardiomyopathy through Augmenting Fundc1-Dependent Mitophagy

  2021cites this paper
• Sepsis: Evidence-based pathogenesis and treatment

  2021cites this paper
• Metabolic Alterations in Sepsis

  2021cites this paper
• Extensive Changes in Transcriptomic “Fingerprints” and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis

  2020cites this paper
• ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration.

  2020cites this paper
• The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities*

  2020cites this paper
• Intermediarios del ciclo de Krebs en sepsis: una revisión sistemática

  2020cites this paper
• Induction of mitochondrial dysfunction in patients under cardiopulmonary by-pass: preliminary results.

  2019cites this paper
• Serum Levels of Mitochondrial and Microbial Metabolites Reflect Mitochondrial Dysfunction in Different Stages of Sepsis

  2019cites this paper
• Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.

  2019cites this paper
• To Explore the Protective Mechanism of PTEN-Induced Kinase 1 (PINK1)/Parkin Mitophagy-Mediated Extract of Periplaneta Americana on Lipopolysaccharide-Induced Cardiomyocyte Injury

  2019cites this paper
• Widespread time-dependent changes in tissue cytokine concentrations in brain regions during the acute phase of endotoxemia in mice.

  2019cites this paper
• PYOCYANIN, A VIRULENCE FACTOR PRODUCED BY SEPSIS-CAUSING PSEUDOMONAS AERUGINOSA, PROMOTES ADIPOSE WASTING AND CACHEXIA

  2019cites this paper
• Agomelatine protects heart and aorta against lipopolysaccharide-induced cardiovascular toxicity via inhibition of NF-kβ phosphorylation

  2019cites this paper
• The role of mitochondria in sepsis-induced cardiomyopathy.

  2019cites this paper
• Early Hyperbaric Oxygen Therapy Improves Survival in a Model of Severe Sepsis.

  2019cites this paper
• Scavenging of reactive oxygen and nitrogen species with nanomaterials

  2018cites this paper
• Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement

  2018cites this paper
• Histological Architecture Underlying Brain–Immune Cell–Cell Interactions and the Cerebral Response to Systemic Inflammation

  2017cites this paper
• Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome

  2017cites this paper
• Skeletal Muscle and Lymphocyte Mitochondrial Dysfunctions in Septic Shock Trigger ICU-Acquired Weakness and Sepsis-Induced Immunoparalysis

  2017cites this paper
• A Useful Device to Measure Kinetics of Platelet Contraction

  2017cites this paper
• Sepsis-Induced Cardiomyopathy: Oxidative Implications in the Initiation and Resolution of the Damage

  2017cites this paper
• Sepsis and Septic Shock Strategies.

  2017cites this paper
• Metabolic Inflammatory Complex in Sepsis: Septic Cachexia as a Novel Potential Therapeutic Target

  2017cites this paper
• Sepsis-induced multi-organ dysfunction syndrome—a mechanistic approach

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• Impaired Bioenergetics in Clinical Medicine: A Target to Tackle.

  2017cites this paper
• Septic Cardiomyopathy: Getting to the Heart of the Matter.

  2017cites this paper
• Pretreatment with Rho-kinase inhibitor ameliorates lethal endotoxemia-induced liver injury by improving mitochondrial function.

  2016cites this paper
• Oxidative-Nitrosative Stress and Myocardial Dysfunctions in Sepsis: Evidence from the Literature and Postmortem Observations

  2016cites this paper
• Sepsis results in an altered renal metabolic and osmolyte profile.

  2016cites this paper
• The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum

  2016cites this paper
• Mikrozirkulationsstörung, zytopathische Hypoxie und septische Kardiomyopathie

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• Myocardial mechanical dysfunction following endotoxemia: role of changes in energy substrate metabolism

  2016cites this paper
• The effects of phenolic microbial metabolites on the activities of mitochondrial enzymes

  2015cites this paper
• MKK3 deletion improves mitochondrial quality.

  2015cites this paper
• Sepsis pathophysiology and anesthetic consideration.

  2015cites this paper
• Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions

  2015cites this paper
• Engineering control into medicine.

  2015cites this paper
• Effect of coenzyme Q10 on organ damage in sepsis.

  2015cites this paper
• Bioinformatics analysis of transcription profiling of sepsis

  2015cites this paper
• Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation

  2015cites this paper
• The ERRor of Our Ways: Estrogen-Related Receptors are About Energy, Not Hormones, and are Potential New Targets for Trauma and Shock

  2015cites this paper
• Lipopolysaccharide Disrupts Mitochondrial Physiology in Skeletal Muscle via Disparate Effects on Sphingolipid Metabolism

  2015cites this paper
• Sepsis-induced brain mitochondrial dysfunction is associated with altered mitochondrial Src and PTP1B levels.

  2015cites this paper
• Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?

  2015cites this paper
• Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture

  2014cites this paper
• PGC-1α Expression Is Increased in Leukocytes in Experimental Acute Pancreatitis

  2014cites this paper
• Left-sided superior vena cava and venous hyperoxia masquerading as inadvertent carotid artery catheterization.

  2014cites this paper
• Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

  2014cites this paper
• Les effets délétères métaboliques et oxydants induits lors d'un sepsis sur la fonction rénale

  2014cites this paper
• Oxidative and Nitrosative Stress in Critical Illness and Injury

  2014cites this paper
• Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock

  2014cites this paper
• Sepsis-induced Cardiac Mitochondrial Damage and Potential Therapeutic Interventions in the Elderly.

  2014cites this paper
• The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS

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• Potentially neuroprotective gene modulation in an in vitro model of mild traumatic brain injury

  2013cites this paper
• Mitochondrial function in sepsis

  2013cites this paper
• The Role of Altered Lipid Metabolism in Septic Myocardial Dysfunction

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• Global and regional myocardial and circulatory function during anaesthesia in the normal heart and in the presence of threatening or overt myocardial ischemia

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• [Mitochondrial and microcirculatory distress syndrome in the critical patient. Therapeutic implications].

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• Disfunción mitocondrial como explicación del síndrome de disfunción orgánica múltiple en la sepsis

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• The role of thiol antioxidants in restoring mitochondrial functions modified by microbial metabolites

  2012cites this paper
• Positive effect of septimeb™ on mortality rate in severe sepsis: a novel non antibiotic strategy

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• Sepsis-Induced Cardiac Mitochondrial Dysfunction Involves Altered Mitochondrial-Localization of Tyrosine Kinase Src and Tyrosine Phosphatase SHP2

  2012cites this paper
• in a rat pneumonia-related sepsis model suppresses inflammation and improves cardiac function Specific inhibition of mitochondrial oxidative stress

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• Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils

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• Role of mitochondrial thiols of different localization in the generation of reactive oxygen species

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• Permissive hypotension does not reduce regional organ perfusion compared to normotensive resuscitation: animal study with fluorescent microspheres

  2012cites this paper
• BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis

  2012cites this paper
• Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model.

  2012cites this paper
• Differential Sensitivity to LPS-Induced Myocardial Dysfunction in the Isolated Brown Norway and DAHL S Rat Hearts: Roles of Mitochondrial Function, NF-&kgr;B Activation, and TNF-&agr; Production

  2012cites this paper
• Endotoxin-induced basal respiration alterations of renal HK-2 cells: a sign of pathologic metabolism down-regulation.

  2012cites this paper
• Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury.

  2012cites this paper
• Divergent Role OF Heme Oxygenase Inhibition in the Pathogenesis of Sepsis

  2011cites this paper
• Hyperoxic ventilation improves survival in pigs during endotoxaemia at the critical hemoglobin concentration.

  2011cites this paper
• Mitochondrial Antioxidants Alleviate Oxidative and Nitrosative Stress in a Cellular Model of Sepsis

  2011cites this paper
• Integrity of gut mucosa during anaesthesia in major abdominal surgery.

  2011cites this paper
• Glutamine restores myocardial cytochrome C oxidase activity and improves cardiac function during experimental sepsis.

  2011cites this paper
• Sepsis-associated encephalopathy: not just delirium

  2011cites this paper