Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Circulation

• Publication date

  2014-10-07

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/CIRCULATIONAHA.114.011590PMID 25124495PMCID PMC4189990
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease.

  2014cited by this paper
• Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis.

  2014cited by this paper
• ω-3 Fatty acids, atherosclerosis progression and cardiovascular outcomes in recent trials: new pieces in a complex puzzle

  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• A meta-analytic review of polyunsaturated fatty acid compositions in dementia.

  2012cited by this paper
• Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials.

  2012cited by this paper
• Multiple roles of dihomo-γ-linolenic acid against proliferation diseases

  2012cited by this paper
• Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart.

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Association of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids With Incident Atrial Fibrillation in Older Adults: The Cardiovascular Health Study

  2012influential reference
• U.S. Department of Agriculture and U.S. Department of Health and Human Services, Dietary Guidelines for Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, January 2011.

  2011cited by this paper
• Exchanging saturated fatty acids for (n-6) polyunsaturated fatty acids in a mixed meal may decrease postprandial lipemia and markers of inflammation and endothelial activity in overweight men.

  2011cited by this paper
• Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.

  2011cited by this paper
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  2011cited by this paper
• n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials

  2010cited by this paper
• Neuroprotective Effect of Lipoxin A4 Methyl Ester in a Rat Model of Permanent Focal Cerebral Ischemia

  2010cited by this paper
• Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris.

  2009cited by this paper
• Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies.

  2009cited by this paper
• Omega-6 Fatty Acids and Risk for Cardiovascular Disease: A Science Advisory From the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention

  2009cited by this paper
• Linoleate-Rich High-Fat Diet Decreases Mortality in Hypertensive Heart Failure Rats Compared With Lard and Low-Fat Diets

  2008cited by this paper
• Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study.

  2008cited by this paper
• The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

  2008influential reference
• Dietary arachidonic acid: harmful, harmless or helpful?

  2007cited by this paper
• Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study.

  2007cited by this paper
• Effects of arachidonate-enriched triacylglycerol supplementation on serum fatty acids and platelet aggregation in healthy male subjects with a fish diet

  2007cited by this paper
• The relationship between dose of vitamin E and suppression of oxidative stress in humans.

  2007cited by this paper
• Alcohol Consumption and Risk of Coronary Heart Disease in Older Adults: The Cardiovascular Health Study

  2006cited by this paper
• The Queen of Fats: Why Omega-3s Were Removed from the Western Diet and What We Can Do to Replace Them

  2006cited by this paper
• Interplay Between Different Polyunsaturated Fatty Acids and Risk of Coronary Heart Disease in Men

  2005cited by this paper
• Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids.

  2005cited by this paper
• Fish consumption and stroke risk in elderly individuals: the cardiovascular health study.

  2005cited by this paper
• Biomarkers of fat and fatty acid intake.

  2003cited by this paper
• Cardiac Benefits of Fish Consumption May Depend on the Type of Fish Meal Consumed: The Cardiovascular Health Study

  2003cited by this paper
• Habitual Dietary Intake of n-3 and n-6 Fatty Acids in Relation to Inflammatory Markers Among US Men and Women

  2003cited by this paper
• n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study.

  2003cited by this paper
• Cognitive decline and fatty acid composition of erythrocyte membranes--The EVA Study.

  2003cited by this paper
• Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials.

  2003cited by this paper
• Effects of ω-3 polyunsaturated fatty acids on cardiac sarcolemmal Na+/H+ exchange

  2002cited by this paper
• Effects of omega-3 polyunsaturated fatty acids on cardiac sarcolemmal Na(+)/H(+) exchange.

  2002cited by this paper
• Association between physical activity and markers of inflammation in a healthy elderly population.

  2001cited by this paper
• Plasma-Saturating Intakes of Vitamin C Confer Maximal Antioxidant Protection to Plasma

  2001cited by this paper
• Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies.

  1999cited by this paper
• Effects of dietary arachidonic acid on human immune response

  1997cited by this paper
• The effect of dietary arachidonic acid on plasma lipoprotein distributions, apoproteins, blood lipid levels, and tissue fatty acid composition in humans

  1997cited by this paper
• Dietary assessment using a picture-sort approach.

  1997cited by this paper
• Methods of assessing prevalent cardiovascular disease in the Cardiovascular Health Study.

  1995cited by this paper
• Surveillance and ascertainment of cardiovascular events. The Cardiovascular Health Study.

  1995cited by this paper
• Laboratory methods and quality assurance in the Cardiovascular Health Study.

  1995cited by this paper
• Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes.

  1994cited by this paper
• Fatty acid composition of serum cholesterol esters, and erythrocyte and platelet membranes as indicators of long-term adherence to fat-modified diets.

  1994cited by this paper
• Recruitment of adults 65 years and older as participants in the Cardiovascular Health Study.

  1993cited by this paper
• The Cardiovascular Health Study: design and rationale.

  1991cited by this paper

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  2026cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025influential citation
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Dietary intake, biomarkers and supplementation of fatty acids and risk of coronary events: a systematic review and dose-response meta-analysis of randomized controlled trials and prospective observational studies

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  2023cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019influential citation
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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