Lipoplex morphologies and their influences on transfection efficiency in gene delivery.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Controlled Release

• Publication date

  2007-11-20

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.JCONREL.2007.08.022PMID 17913276
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.

  2007cited by this paper
• Dendritic cationic lipids with highly charged headgroups for efficient gene delivery.

  2006cited by this paper
• Optimized lipopolyplex formulations for gene transfer to human colon carcinoma cells under in vitro conditions

  2006cited by this paper
• A columnar phase of dendritic lipid-based cationic liposome-DNA complexes for gene delivery: hexagonally ordered cylindrical micelles embedded in a DNA honeycomb lattice.

  2006cited by this paper
• Influence of plasmid DNA topology on the transfection properties of DOTAP/DOPE lipoplexes.

  2006cited by this paper
• Transfection mediated by pH-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications

  2006cited by this paper
• The influence of physicochemical parameters on the efficacy of non-viral DNA transfection complexes: a comparative study.

  2006cited by this paper
• Lipoplexes formed from sugar-based gemini surfactants undergo a lamellar-to-micellar phase transition at acidic pH. Evidence for a non-inverted membrane-destabilizing hexagonal phase of lipoplexes.

  2006cited by this paper
• Wormlike lipid/DNA micelles in a non-polar solvent

  2006cited by this paper
• Structure of DNA-CTAB-hexanol complexes.

  2006cited by this paper
• Cationic lipids, lipoplexes and intracellular delivery of genes.

  2006cited by this paper
• Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery.

  2006cited by this paper
• An intracellular lamellar–nonlamellar phase transition rationalizes the superior performance of some cationic lipid transfection agents

  2006cited by this paper
• Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells

  2006cited by this paper
• Sunfish cationic amphiphiles: toward an adaptative lipoplex morphology.

  2005influential reference
• Lipoplex structures and their distinct cellular pathways.

  2005cited by this paper
• Factors affecting protein release from microcapsule prepared by liposome in alginate.

  2005cited by this paper
• Lipid‐mediated siRNA delivery down‐regulates exogenous gene expression in the mouse brain at picomolar levels

  2005cited by this paper
• Lipoplex Structures and Their Distinct Cellular Pathways.

  2005cited by this paper
• Polymorphism of pyridinium amphiphiles for gene delivery: influence of ionic strength, helper lipid content, and plasmid DNA complexation.

  2005cited by this paper
• Common co‐lipids, in synergy, impart high gene transfer properties to transfection‐incompetent cationic lipids

  2005cited by this paper
• Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency.

  2005influential reference
• Mesoscale computer modeling of lipid-DNA complexes for gene therapy.

  2005cited by this paper
• Gene therapy: twenty-first century medicine.

  2005cited by this paper
• New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid–DNA complexes for gene delivery

  2005cited by this paper
• Cationic lipid–DNA complexes for non-viral gene therapy: relating supramolecular structures to cellular pathways

  2005cited by this paper
• Reentrant phase transitions of DNA-surfactant complexes.

  2004cited by this paper
• Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis.

  2004cited by this paper
• Modeling of cationic lipid-DNA complexes.

  2004influential reference
• The effect of liposome size on the final lipid/DNA ratio of cationic lipoplexes.

  2004cited by this paper
• Cationic lipid-DNA complexes for gene therapy: understanding the relationship between complex structure and gene delivery pathways at the molecular level.

  2004cited by this paper
• Mechanisms of Lipoplex Formation: Dependence of the Biological Properties ofTransfection Complexes on Formulation Procedures

  2004cited by this paper
• Efficacy and cytotoxicity of cationic-agent-mediated nonviral gene transfer into osteoblasts.

  2004cited by this paper
• Lipoplex-mediated delivery of nucleic acids: factors affecting in vivo transfection

  2004cited by this paper
• Dependence of the cellular internalization and transfection efficiency on the structure and physicochemical properties of cationic detergent/DNA/liposomes

  2004cited by this paper
• Intracellular trafficking of nucleic acids

  2004cited by this paper
• Sunfish Amphiphiles: Conceptually New Carriers for DNA Delivery

  2004cited by this paper
• A mechanism for PARP-1 activation based on modeling studies of a ‘gain of function’ mutation

  2003cited by this paper
• Biophysical characterization of an integrin-targeted non-viral vector.

  2003cited by this paper
• Transfection mediated by gemini surfactants: engineered escape from the endosomal compartment.

  2003cited by this paper
• Structure-activity relationship in cationic lipid mediated gene transfection.

  2003cited by this paper
• Design and characterization of a novel lipid-DNA complex that resists serum-induced destabilization.

  2003cited by this paper
• Lipoplex size determines lipofection efficiency with or without serum

  2003cited by this paper
• Three-dimensional imaging of lipid gene-carriers: membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes.

  2003cited by this paper
• Lipoplex thermodynamics: determination of DNA-cationic lipoid interaction energies.

  2003cited by this paper
• The Structural Organization of Cationic Lipid-DNA Complexes*

  2002cited by this paper
• Cationic lipids in gene delivery: principles, vector design and therapeutical applications.

  2002cited by this paper
• Phase behavior of cationic amphiphiles and their mixtures with helper lipid influences lipoplex shape, DNA translocation, and transfection efficiency.

  2002cited by this paper
• Molecular Packing Parameter and Surfactant Self-Assembly: The Neglected Role of the Surfactant Tail†

  2002cited by this paper
• Development of non-viral vectors for systemic gene delivery.

  2002cited by this paper
• Cationic lipid-DNA complexes-lipoplexes-for gene transfer and therapy.

  2002cited by this paper
• Two-step mechanism in cationic lipoplex formation as observed by dynamic light scattering, dielectric relaxation and circular dichroism methods

  2002cited by this paper
• OPTIMIZATION OF CATIONIC LIPID MEDIATED GENE TRANSFER: STRUCTURE-FUNCTION, PHYSICO-CHEMICAL, AND CELLULAR STUDIES

  2002cited by this paper
• Hurdles and Hopes for Cancer Treatment

  2002cited by this paper
• Synthesis and properties of novel tetraalkyl cationic lipids.

  2002cited by this paper
• Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery.

  2002cited by this paper
• Thermodynamics of cationic lipid-DNA complex formation as studied by isothermal titration calorimetry.

  2002cited by this paper
• Structures of lipid-DNA complexes: supramolecular assembly and gene delivery.

  2001cited by this paper
• On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

  2001cited by this paper
• Safer and Virus-Free?

  2001cited by this paper
• Phase Behavior, DNA Ordering, and Size Instability of Cationic Lipoplexes

  2001cited by this paper
• Gene therapy. Safer and virus-free?

  2001cited by this paper
• Liposome-mediated DNA vaccination: the effect of vesicle composition.

  2001cited by this paper
• Synthesis of a novel series of cationic lipids that can act as efficient gene delivery vehicles through systematic heterocyclic substitution of cholesterol derivatives

  2001cited by this paper
• Molecular Shape of the Cationic Lipid Controls the Structure of Cationic Lipid/Dioleylphosphatidylethanolamine-DNA Complexes and the Efficiency of Gene Delivery*

  2001cited by this paper
• Structure and function of lipid-DNA complexes for gene delivery.

  2000cited by this paper
• Biophysical and Structural Properties of DNA·diC14-amidine Complexes

  2000cited by this paper
• Lipoplex formation under equilibrium conditions reveals a three-step mechanism.

  2000cited by this paper
• Formulations which increase the size of lipoplexes prevent serum‐associated inhibition of transfection

  2000cited by this paper
• Liposome-entrapped plasmid DNA: characterisation studies.

  2000cited by this paper
• Novel cationic amphiphilic 1,4-dihydropyridine derivatives for DNA delivery.

  2000cited by this paper
• The Phase Diagram

  2000cited by this paper
• Factors governing the assembly of cationic phospholipid-DNA complexes.

  2000cited by this paper
• Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency

  1999cited by this paper
• Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiency.

  1999cited by this paper
• Lipoplex size is a major determinant of in vitro lipofection efficiency

  1999cited by this paper
• Physicochemical characterization and purification of cationic lipoplexes.

  1999cited by this paper
• Influence of formulation parameters on the characteristics of poly(D, L-lactide-co-glycolide) microspheres containing poly(L-lysine) complexed plasmid DNA.

  1999cited by this paper
• Phase diagram, stability, and overcharging of lamellar cationic lipid-DNA self-assembled complexes.

  1999cited by this paper
• Biological barriers to cellular delivery of lipid-based DNA carriers.

  1999cited by this paper
• An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery.

  1998influential reference
• Cationic lipid-mediated gene transfer: effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes.

  1998cited by this paper
• Ultrastructural characterization of cationic liposome-DNA complexes showing enhanced stability in serum and high transfection activity in vivo.

  1998influential reference
• Gene-directed enzyme prodrug therapy.

  1998cited by this paper
• Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery.

  1998cited by this paper
• A triploblast origin for Myxozoa?

  1998cited by this paper
• Human gene therapy.

  1998cited by this paper
• Self-Assembling DNA-Lipid Particles for Gene Transfer

  1997cited by this paper
• DNA condensation by multivalent cations.

  1997cited by this paper
• Cationic lipid-mediated gene delivery to murine lung: correlation of lipid hydration with in vivo transfection activity.

  1997cited by this paper
• Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells.

  1997cited by this paper
• Sliding Columnar Phase of DNA-Lipid Complexes

  1997cited by this paper
• Gene transfer mediated by cationic lipids: lack of a correlation between lipid mixing and transfection.

  1997cited by this paper
• Structure of in‐serum transfecting DNA–cationic lipid complexes

  1997cited by this paper
• Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer.

  1997cited by this paper
• Biophysical characterization of cationic lipid: DNA complexes.

  1997cited by this paper
• Cationic lipids used in gene transfer.

  1997cited by this paper
• Phase behavior and phase structure for catanionic surfactant mixtures : Dodecyltrimethylammonium chloride-sodium nonanoate-water system

  1997cited by this paper
• Nomenclature for Synthetic Gene Delivery Systems

  1997cited by this paper
• Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes

  1997cited by this paper

• Microfluidic assembly and biomimetic lipid coating modulate the structure, stability, and biological interactions of P(DMAEMA-co-SMA)/DNA lipopolyplexes.

  2026cites this paper
• Soft nanoparticles as delivery agents for RNA-based anticancer therapy

  2026cites this paper
• Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives.

  2025cites this paper
• Targeting Respiratory Viruses: The Efficacy of Intranasal mRNA Vaccination in Generating Protective Mucosal and Systemic Immunity Against Influenza A (H1N1)

  2025cites this paper
• Lipoplex-based RNA delivery system enhances RNAi efficiency for targeted Pest control in Spodoptera litura.

  2025cites this paper
• Elevated cyclic hydrostatic pressure enhances the transfection activity of lipoplexes by activating clathrin-mediated endocytosis.

  2025cites this paper
• Enantiomeric Lysine-Based Cationic Lipids: Design, Synthesis, and Characterization for In Vitro Gene Delivery

  2025cites this paper
• Genosomes: An Introspection into Transfection, Future Perspectives and Applications

  2025cites this paper
• Cationic lipid-coated bPEI/pDNA complexes: correlation between physicochemical and morphological properties

  2024cites this paper
• Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

  2024cites this paper
• Lipid/polyelectrolyte complexes - effects of the polyelectrolyte architecture on the self-assembled structures.

  2024cites this paper
• Cationic and Ionizable Amphiphiles Based on Dihexadecyl Ester of L-Glutamic Acid for Liposomal Transport of RNA

  2024cites this paper
• Development of novel lipoplex formulation methodologies to improve large-scale transient transfection for lentiviral vector manufacture

  2024cites this paper
• Strategies for Improved pDNA Loading and Protection Using Cationic and Neutral LNPs with Industrial Scalability Potential Using Microfluidic Technology

  2024cites this paper
• Cationic Lipid Derived from a Basic Amino Acid: Design and Synthesis

  2024cites this paper
• A new era of targeting cystic fibrosis with non-viral delivery of genomic medicines.

  2024cites this paper
• The 60-year evolution of lipid nanoparticles for nucleic acid delivery

  2024cites this paper
• The nanostructure of polyelectrolyte complexes of QPDMAEMA-b-POEGMA copolymers and oppositely charged polyelectrolytes, and their stability in the presence of serum albumin.

  2023cites this paper
• Microfluidic production of nanogels as alternative triple transfection reagents for the manufacture of adeno-associated virus vectors.

  2023cites this paper
• A Complete Sojourn of Gene Therapy Along with its Targeting Approaches for the Treatment of the Major Depressive Disorder.

  2023cites this paper
• Dual-Targeted Therapy in HER2-Overexpressing Breast Cancer with Trastuzumab and Novel Cholesterol-Based Nioplexes Silencing Mcl-1

  2023cites this paper
• The effect of electrostatic high pressure nebulization on the stability, activity and ex vivo distribution of ionic self-assembled nanomedicines.

  2023cites this paper
• Multicomponent Lipid Nanoparticles for RNA Transfection

  2023cites this paper
• Understanding and optimising the transfection of lipopolyplexes formulated in saline: the effects of peptide and serum.

  2023cites this paper
• Matrices Activated with Messenger RNA

  2023cites this paper
• Transfection reagent artefact likely accounts for some reports of extracellular vesicle function

  2022cites this paper
• Rationale utilization of phospholipid excipients: a distinctive tool for progressing state of the art in research of emerging drug carriers

  2022cites this paper
• Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective

  2022cites this paper
• Overcoming barriers in non-viral gene delivery for neurological applications.

  2022cites this paper
• Sulfonium Lipids: Synthesis and Evaluation as DNA Delivery Vectors.

  2022cites this paper
• Complexation of Oligo- and Polynucleotides with Methoxyphenyl-Functionalized Imidazolium Surfactants

  2022cites this paper
• Use of soft nanoparticles as delivery agents in anticancer therapy

  2022cites this paper
• Decoding the Kinetic Pathways toward a Lipid/DNA Complex of Alkyl Alcohol Cationic Lipids Formed in a Microfluidic Channel.

  2022cites this paper
• PEGylation and folic-acid functionalization of cationic lipoplexes—Improved nucleic acid transfer into cancer cells

  2022cites this paper
• Design and Validation of a Process Based on Cationic Niosomes for Gene Delivery into Novel Urine-Derived Mesenchymal Stem Cells

  2021cites this paper
• Lipid monolayer spontaneous curvatures: A collection of published values.

  2021cites this paper
• Lipid- and polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines.

  2021cites this paper
• Transcript-Activated Coatings on Titanium Mediate Cellular Osteogenesis for Enhanced Osteointegration

  2021cites this paper
• Multifunctional Immunoadjuvants for Use in Minimalist Nucleic Acid Vaccines

  2021cites this paper
• The Process of Binding and Releasing of Genetic Material from Lipoplexes Based on Trimeric Surfactants and Phospholipids

  2021cites this paper
• Influence of Liposome Composition on Plasmid DNA Delivery to Eukaryotic Cells

  2021cites this paper
• Further Studies on Cationic Gemini Amphiphiles as Carriers for Gene Delivery—The Effect of Linkers in the Structure and Other Factors Affecting the Transfection Efficacy of These Amphiphiles

  2021cites this paper
• Polyplexes of retinoic acid: an in vitro study of complex nanostructures against colorectal cancer cell line (HCT-15)

  2021cites this paper
• A pH-Reversible Fluorescent Probe for in Situ Imaging of Extracellular Vesicles and Their Secretion from Living Cells.

  2021cites this paper
• Lipoplex-based therapeutics for effective oligonucleotide delivery: a compendious review

  2020cites this paper
• Strategies and Approaches for siRNA Delivery

  2020cites this paper
• Cationic Lipid/pDNA Complex Formation as Potential Generic Method to Generate Specific IRF Pathway Stimulators.

  2020cites this paper
• Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli.

  2020cites this paper
• Fluorescent Labels for Reduction Sensitive Polycationic Gene Carriers

  2020cites this paper
• A molecular view on the escape of lipoplexed DNA from the endosome

  2020cites this paper
• DNA Origami Templated Growth of Multilamellar Lipid Assemblies.

  2020cites this paper
• Arginine-modified chitosan complexed with liposome systems for plasmid DNA delivery.

  2020cites this paper
• Comprehensive Evaluation of Gene Expression in Negative and Positive Trigger-based Targeting Niosomes in HEK-293 Cell Line

  2020cites this paper
• Stimuli-responsive polysaccharide enveloped liposome for targeting and penetrating delivery of survivin-shRNA into breast tumor.

  2020cites this paper
• Exosomes isolated from two different cell lines using three different isolation techniques show variation in physical and molecular characteristics

  2020cites this paper
• DNA‐Origami‐Templated Growth of Multilamellar Lipid Assemblies

  2020cites this paper
• Cationic lipids for gene delivery: many players, one goal.

  2020cites this paper
• Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection.

  2019cites this paper
• The Impact of Alkyl‐Chain Purity on Lipid‐Based Nucleic Acid Delivery Systems – Is the Utilization of Lipid Components with Technical Grade Justified?

  2019cites this paper
• Peptide-Modified Gemini Surfactants: Preparation and Characterization for Gene Delivery.

  2019cites this paper
• Activity-Structure Study on the Peptide Fraction of AG2: a Potent In Vitro Transfection Agent

  2019cites this paper
• A microparticle approach for non-viral gene delivery within 3D human mesenchymal stromal cell aggregates.

  2019cites this paper
• A simplified method for manufacturing RNAi therapeutics for local administration.

  2019cites this paper
• Ammonium Gemini Surfactants Form Complexes with Model Oligomers of siRNA and dsDNA

  2019cites this paper
• Branched lipid chains to prepare cationic amphiphiles producing hexagonal aggregates: supramolecular behavior and application to gene delivery.

  2019cites this paper
• Recent Developments in Polydiacetylene-Based Sensors

  2019cites this paper
• DNA Delivery Systems Based on Peptide-Mimicking Cationic Lipids—The Effect of the Co-Lipid on the Structure and DNA Binding Capacity

  2019cites this paper
• pH sensitive N,N-dimethylalkane-1-amine N-oxides in DNA delivery: from structure to transfection efficiency.

  2019cites this paper
• Lipid‐ and polymer‐based plexes as therapeutic carriers for bioactive molecules

  2019cites this paper
• A centrifugal microfluidic pressure regulator scheme for continuous concentration control in droplet-based microreactors.

  2019cites this paper
• In vivo methods for acute modulation of gene expression in the central nervous system.

  2018cites this paper
• Lipoplex-Mediated Single-Cell Transfection via Droplet Microfluidics.

  2018cites this paper
• Role of cationic lipids for the formulation of lipoplexes

  2018cites this paper
• Synthesis and Comparative Evaluation of Novel Cationic Amphiphile C12-Man-Q as an Efficient DNA Delivery Agent In Vitro

  2018cites this paper
• Overcoming the polycation dilemma - Explorative studies to characterise the efficiency and biocompatibility of newly designed lipofection reagents.

  2018cites this paper
• Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles

  2018cites this paper
• Interactions of Cationic Lipids with DNA: A Structural Approach.

  2018cites this paper
• Design, Synthesis and Delivery of a Self-Cleaving Replicon System Yielding Biologically Active MicroRNAs in vivo

  2018cites this paper
• Photoresponsive endosomal escape enhances gene delivery using liposome-polycation-DNA (LPD) nanovectors.

  2018cites this paper
• Cationic Liposomes Carrying siRNA: Impact of Lipid Composition on Physicochemical Properties, Cytotoxicity and Endosomal Escape

  2018cites this paper
• Effect of lipopeptide structure on gene delivery system properties: Evaluation in 2D and 3D in vitro models.

  2018cites this paper
• Molecular Engineering as an Approach To Modulate Gene Delivery Efficiency of Peptide-Modified Gemini Surfactants.

  2018cites this paper
• Stem cell-based gene delivery mediated by cationic niosomes for bone regeneration.

  2018cites this paper
• Amino acid-based liposomal assemblies : Intracellular plasmid DNA delivery nanoparticles

  2018cites this paper
• Topical delivery of TRPsiRNA-loaded solid lipid nanoparticles confer reduced pain sensation via TRPV1 silencing, in rats

  2018cites this paper
• Incorporation of DNA/PEI polyplexes into gelatin/chitosan hydrogel scaffolds: a μ-DSC study

  2018cites this paper
• gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles

  2018cites this paper
• Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for the Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer.

  2018cites this paper
• Interaction of Different Divalent Metal Ions with Lipid Bilayer: Impact on the Encapsulation of Doxorubicin by Lipid Bilayer and Lipoplex Mediated Deintercalation.

  2017cites this paper
• Innovative nonviral vectors for small-interfering RNA delivery and therapy

  2017cites this paper
• The Use of Nanotechnology in Modern Pharmacotherapy

  2017cites this paper
• Studies of Lipid Monolayers Prepared from Native and Model Plant Membranes in Their Interaction with Zearalenone and Its Mixture with Selenium Ions

  2017cites this paper
• Inclusion of oligonucleotide antimicrobials in biocompatible cationic liposomes: A structural study.

  2017cites this paper
• Investigating self-assembling nanomaterials (Sans) within a biological environment

  2017cites this paper
• ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD

  2017cites this paper
• Interfacially Engineered Pyridinium Pseudogemini Surfactants as Versatile and Efficient Supramolecular Delivery Systems for DNA, siRNA, and mRNA.

  2017cites this paper
• Future prospects for gene delivery systems

  2017cites this paper
• Lipid Carriers: Role and Applications in Nano Drug Delivery

  2017cites this paper
• Structural analysis of nanoparticulate carriers for encapsulation of macromolecular drugs

  2017cites this paper
• Combinational use of lipid-based reagents for efficient transfection of primary fibroblasts and hepatoblasts.

  2017cites this paper