State‐dependent barium block of wild‐type and inactivation‐deficient HERG channels in Xenopus oocytes

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Physiology

• Publication date

  2000-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1469-7793.2000.t01-1-00265.xPMID 10896755PMCID PMC2270020
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.

  1999cited by this paper
• Blockade of HERG channels expressed in Xenopus laevis oocytes by external divalent cations.

  1999influential reference
• C-terminal HERG mutations: the role of hypokalemia and a KCNQ1-associated mutation in cardiac event occurrence.

  1999cited by this paper
• Effects of divalent cations on the E-4031-sensitive repolarization current, I(Kr), in rabbit ventricular myocytes.

  1998cited by this paper
• Voltage‐dependent blockade of HERG channels expressed in Xenopus oocytes by external Ca2+ and Mg2+

  1998cited by this paper
• Molecular determinants of dofetilide block of HERG K+ channels.

  1998cited by this paper
• Pore accessibility during C‐type inactivation in Shaker K+ channels

  1998cited by this paper
• The effects of barium, dofetilide and 4-aminopyridine (4-AP) on ventricular repolarization in normal and hypertrophied rabbit heart.

  1998cited by this paper
• A permanent ion binding site located between two gates of the Shaker K+ channel.

  1998cited by this paper
• Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells.

  1998cited by this paper
• Effects of Divalent Cations on the E-4031-Sensitive Repolarization Current, IKr, in Rabbit Ventricular Myocytes

  1998cited by this paper
• A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation

  1998cited by this paper
• A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes

  1997cited by this paper
• Modulation of HERG affinity for E‐4031 by [K+]o and C‐type inactivation

  1997cited by this paper
• Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes.

  1997cited by this paper
• Fast inactivation causes rectification of the IKr channel

  1996cited by this paper
• Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.

  1996cited by this paper
• Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

  1996cited by this paper
• KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

  1996influential reference
• The inward rectification mechanism of the HERG cardiac potassium channel

  1996cited by this paper
• Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

  1996cited by this paper
• Evidence for two components of delayed rectifier K+ current in human ventricular myocytes.

  1996cited by this paper
• Molecular determinants of external barium block in Shaker potassium channels

  1996cited by this paper
• Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide.

  1996influential reference
• Myocardial potassium channels: electrophysiological and molecular diversity.

  1996cited by this paper
• HERG, a human inward rectifier in the voltage-gated potassium channel family.

  1995influential reference
• A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.

  1995cited by this paper
• Barium block of the muscarinic potassium current in guinea-pig atrial cells

  1995cited by this paper
• External barium block of Shaker potassium channels: evidence for two binding sites

  1995cited by this paper
• Voltage dependencies of the fast and slow gating modes of RIIA sodium channels

  1994cited by this paper
• Barium blockade of a clonal potassium channel and its regulation by a critical pore residue.

  1993cited by this paper
• Role of an inwardly rectifying potassium current in rabbit ventricular action potential.

  1992cited by this paper
• Delayed rectification in single cells isolated from guinea pig sinoatrial node.

  1992cited by this paper
• Pacemaker current in single cells and in aggregates of cells dissociated from the embryonic chick heart.

  1992cited by this paper
• Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells.

  1991cited by this paper
• Removal of sialic acid alters both T- and L-type calcium currents in cardiac myocytes.

  1991cited by this paper
• Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

  1990cited by this paper
• Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias.

  1990cited by this paper
• Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier

  1990cited by this paper
• Coupling of voltage-dependent gating and Ba++ block in the high- conductance, Ca++-activated K+ channel

  1987cited by this paper
• Characterization of the acetylcholine‐induced potassium current in rabbit cardiac Purkinje fibres.

  1986cited by this paper
• Voltage clamp of bull‐frog cardiac pace‐maker cells: a quantitative analysis of potassium currents.

  1985cited by this paper
• Barium-induced blockade of the inward rectifier in calf Purkinje fibres

  1984cited by this paper
• Block of squid axon K channels by internally and externally applied barium ions

  1982cited by this paper
• Effects of barium on the potassium conductance of squid axon

  1980cited by this paper
• The ionic channels in excitable membranes.

  1975influential reference
• Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres

  1969influential reference
• Graded and All-or-None Electrogenesis in Arthropod Muscle

  1961cited by this paper

• The voltage-sensing domain of a hERG1 mutant is a cation-selective channel

  2022cites this paper
• Translational Cardiovascular Medicine ( I ) Animal Models of Cardiovascular Disease

  2019cites this paper
• Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

  2019cites this paper
• An Emerging Malignant Arrhythmia Epidemic Due to Loperamide Abuse: Underlying Mechanisms and Clinical Relevance.

  2016cites this paper
• kinasesventricle by Src and EGFR protein tyrosine current - Antagonistic regulation of swelling-activated Cl

  2016cites this paper
• Characterization of cardiac repolarization in the Göttingen minipig.

  2011cites this paper
• Multiscale modelling of drug-induced effects on cardiac electrophysiological activity.

  2009cites this paper
• Modelos animales de enfermedad cardiovascular

  2009cites this paper
• [Animal models of cardiovascular disease].

  2009cites this paper
• Ether-à-gogo-related gene (erg1) potassium channels shape the dark response of horizontal cells in the mammalian retina

  2009cites this paper
• Contributions of HERG K+ current to repolarization of the human ventricular action potential.

  2008cites this paper
• Modelling effects of Sotalol on Action Potential morphology using a novel Markov model of the HERG channel

  2007cites this paper
• Death by QT: a new safety challenge

  2007cites this paper
• Characterization of Recombinant Human Cardiac KCNQ1/KCNE1 Channels (IKs) Stably Expressed in HEK 293 Cells

  2006influential citation
• Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases.

  2005cites this paper
• Microfluidic gradient-generating device for pharmacological profiling.

  2005cites this paper
• External Barium Affects the Gating of KCNQ1 Potassium Channels and Produces a Pore Block via Two Discrete Sites

  2004cites this paper
• Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels

  2004cites this paper
• Structure of the HERG K+ Channel S5P Extracellular Linker

  2003cites this paper
• Metal ion effects on ion channel gating

  2003cites this paper
• Activation-induced subcellular redistribution of G alpha(s) is dependent upon its unique N-terminus.

  2002cites this paper
• Combination IK1 and IKr channel blockade: no additive lowering of the defibrillation threshold.

  2002cites this paper
• Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve

  2002cites this paper
• Extracellular Sodium Interacts with the HERG Channel at an Outer Pore Site

  2002cites this paper